CA2653233C - 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors - Google Patents
2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors Download PDFInfo
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- CA2653233C CA2653233C CA2653233A CA2653233A CA2653233C CA 2653233 C CA2653233 C CA 2653233C CA 2653233 A CA2653233 A CA 2653233A CA 2653233 A CA2653233 A CA 2653233A CA 2653233 C CA2653233 C CA 2653233C
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- -1 2-(substituted-amino)-benzothiazole sulfonamide Chemical class 0.000 title abstract description 42
- 239000004030 hiv protease inhibitor Substances 0.000 title abstract description 7
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- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical group N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 claims description 32
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- 229910052722 tritium Inorganic materials 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06116003 | 2006-06-23 | ||
| EP06116003.2 | 2006-06-23 | ||
| PCT/EP2007/056235 WO2007147884A1 (en) | 2006-06-23 | 2007-06-22 | 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2653233A1 CA2653233A1 (en) | 2007-12-27 |
| CA2653233C true CA2653233C (en) | 2015-09-29 |
Family
ID=37596252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2653233A Active CA2653233C (en) | 2006-06-23 | 2007-06-22 | 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8202887B2 (OSRAM) |
| EP (1) | EP2035432B1 (OSRAM) |
| JP (1) | JP5232776B2 (OSRAM) |
| KR (1) | KR101419320B1 (OSRAM) |
| CN (1) | CN101479275B (OSRAM) |
| AP (1) | AP2069A (OSRAM) |
| AR (1) | AR061619A1 (OSRAM) |
| AT (1) | ATE544769T1 (OSRAM) |
| AU (1) | AU2007262943B2 (OSRAM) |
| BR (1) | BRPI0713487B1 (OSRAM) |
| CA (1) | CA2653233C (OSRAM) |
| CL (1) | CL2007001826A1 (OSRAM) |
| CY (1) | CY1112971T1 (OSRAM) |
| DK (1) | DK2035432T3 (OSRAM) |
| EA (1) | EA016387B1 (OSRAM) |
| ES (1) | ES2381129T3 (OSRAM) |
| IL (1) | IL195381A (OSRAM) |
| JO (1) | JO2841B1 (OSRAM) |
| MX (1) | MX2009000160A (OSRAM) |
| MY (1) | MY146805A (OSRAM) |
| NZ (1) | NZ573286A (OSRAM) |
| PE (1) | PE20080342A1 (OSRAM) |
| PL (1) | PL2035432T3 (OSRAM) |
| PT (1) | PT2035432E (OSRAM) |
| SI (1) | SI2035432T1 (OSRAM) |
| TW (1) | TWI415851B (OSRAM) |
| UA (1) | UA96445C2 (OSRAM) |
| UY (1) | UY30416A1 (OSRAM) |
| WO (1) | WO2007147884A1 (OSRAM) |
| ZA (1) | ZA200810350B (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3090B1 (ar) * | 2009-12-11 | 2017-03-15 | Janssen Sciences Ireland Uc | 5- امينو-4- هيدروكسي-بنتويل اميدات |
| TWI458711B (zh) | 2010-07-02 | 2014-11-01 | Gilead Sciences Inc | 治療性化合物 |
| EA201291300A1 (ru) | 2010-07-02 | 2013-06-28 | Джилид Сайэнс, Инк. | Производные нафт-2-илуксусной кислоты для лечения спида |
| US9024038B2 (en) | 2010-12-27 | 2015-05-05 | Purdue Research Foundation | Compunds and methods for treating HIV |
| PT2699558T (pt) * | 2011-04-21 | 2016-12-29 | Gilead Sciences Inc | Compostos de benzotiazole e a sua utilização farmacêutica |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| WO2013103738A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Napthalene acetic acid derivatives against hiv infection |
| MX2014005002A (es) | 2012-04-20 | 2014-07-09 | Gilead Sciences Inc | Derivados de acido benzotiazol-6-il acetico y su uso para tratar una infeccion por vih. |
| US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU229224B1 (en) * | 2001-02-14 | 2013-09-30 | Tibotec Pharmaceuticals Ltd Little Island | 2-(substituted-amino)-benzothiazole sulfonamide compounds having broadspectrum hiv protease inhibitor activity and medicaments containing them |
| TWI286476B (en) * | 2001-12-12 | 2007-09-11 | Tibotec Pharm Ltd | Combination of cytochrome P450 dependent protease inhibitors |
| AU2003262561B2 (en) * | 2002-08-02 | 2008-10-16 | Tibotec Pharmaceuticals Ltd. | Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors |
| PL1670448T3 (pl) * | 2003-09-30 | 2008-04-30 | Tibotec Pharm Ltd | Sulfonamidy inhibitujące HCV |
-
2007
- 2007-06-04 JO JO2007212A patent/JO2841B1/en active
- 2007-06-15 UY UY30416A patent/UY30416A1/es not_active Application Discontinuation
- 2007-06-21 CL CL2007001826A patent/CL2007001826A1/es unknown
- 2007-06-22 KR KR1020097000754A patent/KR101419320B1/ko not_active Expired - Fee Related
- 2007-06-22 EA EA200970052A patent/EA016387B1/ru not_active IP Right Cessation
- 2007-06-22 MY MYPI20085209A patent/MY146805A/en unknown
- 2007-06-22 ES ES07765554T patent/ES2381129T3/es active Active
- 2007-06-22 CN CN2007800236807A patent/CN101479275B/zh active Active
- 2007-06-22 AU AU2007262943A patent/AU2007262943B2/en not_active Ceased
- 2007-06-22 CA CA2653233A patent/CA2653233C/en active Active
- 2007-06-22 WO PCT/EP2007/056235 patent/WO2007147884A1/en not_active Ceased
- 2007-06-22 EP EP07765554A patent/EP2035432B1/en active Active
- 2007-06-22 TW TW096122406A patent/TWI415851B/zh not_active IP Right Cessation
- 2007-06-22 UA UAA200813950A patent/UA96445C2/ru unknown
- 2007-06-22 US US12/304,990 patent/US8202887B2/en not_active Expired - Fee Related
- 2007-06-22 AP AP2008004679A patent/AP2069A/en active
- 2007-06-22 NZ NZ573286A patent/NZ573286A/en not_active IP Right Cessation
- 2007-06-22 PE PE2007000802A patent/PE20080342A1/es active IP Right Grant
- 2007-06-22 PL PL07765554T patent/PL2035432T3/pl unknown
- 2007-06-22 PT PT07765554T patent/PT2035432E/pt unknown
- 2007-06-22 JP JP2009515891A patent/JP5232776B2/ja not_active Expired - Fee Related
- 2007-06-22 AT AT07765554T patent/ATE544769T1/de active
- 2007-06-22 AR ARP070102776A patent/AR061619A1/es active IP Right Grant
- 2007-06-22 BR BRPI0713487-8A patent/BRPI0713487B1/pt not_active IP Right Cessation
- 2007-06-22 MX MX2009000160A patent/MX2009000160A/es active IP Right Grant
- 2007-06-22 SI SI200730904T patent/SI2035432T1/sl unknown
- 2007-06-22 DK DK07765554.6T patent/DK2035432T3/da active
-
2008
- 2008-11-19 IL IL195381A patent/IL195381A/en active IP Right Grant
- 2008-12-05 ZA ZA200810350A patent/ZA200810350B/xx unknown
-
2012
- 2012-05-08 CY CY20121100429T patent/CY1112971T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |