CA2627547A1 - Methods of treating atrial fibrillation with p38 inhibitor compounds - Google Patents

Methods of treating atrial fibrillation with p38 inhibitor compounds Download PDF

Info

Publication number
CA2627547A1
CA2627547A1 CA002627547A CA2627547A CA2627547A1 CA 2627547 A1 CA2627547 A1 CA 2627547A1 CA 002627547 A CA002627547 A CA 002627547A CA 2627547 A CA2627547 A CA 2627547A CA 2627547 A1 CA2627547 A1 CA 2627547A1
Authority
CA
Canada
Prior art keywords
inhibitor compound
group
phenyl
administering
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002627547A
Other languages
English (en)
French (fr)
Inventor
Jeff Olgin
Lawrence M. Blatt
Scott Seiwert
Karl Kossen
Susan Eisenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intermune Inc
University of California San Diego UCSD
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2627547A1 publication Critical patent/CA2627547A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002627547A 2005-11-01 2006-11-01 Methods of treating atrial fibrillation with p38 inhibitor compounds Abandoned CA2627547A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73267605P 2005-11-01 2005-11-01
US60/732,676 2005-11-01
PCT/US2006/042653 WO2007053685A2 (en) 2005-11-01 2006-11-01 Methods of treating atrial fibrillation with p38 inhibitor compounds

Publications (1)

Publication Number Publication Date
CA2627547A1 true CA2627547A1 (en) 2007-05-10

Family

ID=38006459

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002627547A Abandoned CA2627547A1 (en) 2005-11-01 2006-11-01 Methods of treating atrial fibrillation with p38 inhibitor compounds

Country Status (5)

Country Link
US (2) US20100029578A1 (https=)
EP (1) EP1948178A4 (https=)
JP (1) JP2009513713A (https=)
CA (1) CA2627547A1 (https=)
WO (2) WO2007053610A2 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2600460T3 (es) 2005-05-10 2017-02-09 Intermune, Inc. Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
WO2010065755A1 (en) 2008-12-04 2010-06-10 Concert Pharmaceuticals, Inc. Deuterated pyridinones
AP2011005824A0 (en) * 2009-01-26 2011-08-31 Intermune Inc Methods for treating acute myocardial infarctions and associated disorders.
KR101478133B1 (ko) 2009-05-25 2014-12-31 센트럴 사우스 유니버시티 1-（치환된 벤질기）-5-트리플루오로메틸-2-（1ｈ）피리돈 화합물 및 그 염의 제조방법 및 용도
WO2010135972A1 (zh) 2009-05-25 2010-12-02 中南大学 1-(取代芳基)-5-三氟甲基-2-（1h）吡啶酮化合物及其盐的制备方法及其用途
EA201290106A1 (ru) * 2009-09-18 2012-12-28 Астьют Медикал, Инк. Способы и композиции для диагностики и прогнозирования повреждения почек и почечной недостаточности
TWI508726B (zh) 2009-12-21 2015-11-21 Gilead Sciences Inc 治療心房纖維性顫動之方法
US10105356B2 (en) 2011-01-31 2018-10-23 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
WO2012106382A1 (en) 2011-01-31 2012-08-09 Genoa Pharmaceuticals, Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
CN102846555B (zh) * 2012-04-09 2014-06-25 珠海亿邦制药股份有限公司 一种以吡非尼酮为活性成分的固体制剂及其应用
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
AU2015204558B2 (en) 2014-01-10 2020-04-30 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
MX382781B (es) 2014-04-02 2025-03-13 Intermune Inc Piridinonas anti-fibroticas.
JP6574773B2 (ja) 2014-07-30 2019-09-11 株式会社アエタスファルマ １，４−ベンゾチアゼピン−１−オキシド誘導体の光学異性体、及びそれを用いた医薬組成物
US10515284B2 (en) * 2014-09-30 2019-12-24 Qualcomm Incorporated Single-processor computer vision hardware control and application execution
AU2015369712B2 (en) 2014-12-22 2020-05-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Mutant IDH1 inhibitors useful for treating cancer
CN105878243B (zh) * 2016-06-14 2019-05-21 四川大学 吡非尼酮衍生物在制药中的应用
CN105998018B (zh) * 2016-06-16 2019-01-25 杨若一 吡非尼酮衍生物在制药中的应用
CN107556234A (zh) * 2016-06-30 2018-01-09 陕西合成药业股份有限公司 一种新型吡啶酮类化合物及其制备方法和在医学上的应用
EP3569249A4 (en) * 2016-12-27 2020-11-11 Osaka University PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF REFRACTORY HEART DISEASE

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052509A (en) * 1972-12-18 1977-10-04 Affiliated Medical Research, Inc. Method for reducing serum uric acid levels
US4042699A (en) * 1972-12-18 1977-08-16 Affiliated Medical Research, Inc. Method for reducing serum glucose levels
US3839346A (en) * 1972-12-18 1974-10-01 Affiliated Med Res N-substituted pyridone and general method for preparing pyridones
CA1049411A (en) * 1972-12-18 1979-02-27 Affiliated Medical Research N-substituted pyridone and general method for preparing pyridones
ES2152938T3 (es) * 1992-09-28 2001-02-16 Hoechst Ag 1(2h)-isoquinolinas sustituidas antiarritmicas y cardioprotectoras, procedimiento para su produccion, medicamento que las contiene y su uso para la produccion de un medicamento para combatir fallos cardiacos.
AU2440802A (en) * 2000-10-18 2002-04-29 Massachusetts Inst Technology Methods and products related to pulmonary delivery of polysaccharides
US7030141B2 (en) * 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
JP2006502142A (ja) * 2002-08-23 2006-01-19 ブリストル−マイヤーズ　スクイブ　カンパニー 虚血性損傷を減少させる方法
EP1551369A4 (en) * 2002-08-28 2007-05-09 Intermune Inc COMBINATION THERAPY FOR THE TREATMENT OF FIBROTIC DISEASES
US7407973B2 (en) * 2003-10-24 2008-08-05 Intermune, Inc. Use of pirfenidone in therapeutic regimens
US7550487B2 (en) * 2004-03-26 2009-06-23 Hoffmann-La Roche Inc. Pyrrolidine-3,4-dicarboxamide derivatives

Also Published As

Publication number Publication date
WO2007053685A2 (en) 2007-05-10
WO2007053610A3 (en) 2007-11-29
US20120046321A1 (en) 2012-02-23
EP1948178A4 (en) 2011-03-02
WO2007053685A3 (en) 2007-07-19
EP1948178A2 (en) 2008-07-30
US20100029578A1 (en) 2010-02-04
WO2007053610A2 (en) 2007-05-10
JP2009513713A (ja) 2009-04-02

Similar Documents

Publication Publication Date Title
US20120046321A1 (en) Methods of treating atrial fibrillation with p38 inhibitor compounds
US20100190731A1 (en) Methods for treating acute myocardial infarctions and associated disorders
KR20160108611A (ko) 심방세동의 치료 방법
EP2595620A2 (fr) Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide
CA2997671A1 (en) Combination therapies for treating cancer
KR20230060487A (ko) 칼륨 채널 조절제로 사용되는 화합물 및 이의 제조 및 응용
CZ20011807A3 (cs) Způsob výroby farmaceutického prostředku, farmaceutický prostředek a jeho použití
EP3906969A1 (en) Antihypertensive polyol compound and derivative thereof
JP5849336B2 (ja) アデニル酸シクラーゼの活性調節剤
US11155552B2 (en) Rutaecarpine analogs and applications thereof
JP4658919B2 (ja) フェニルカルボン酸アミドおよびＩＫｒチャンネル遮断剤の組み合わせならびに心房性不整脈を処置するためのその使用
DE69806062T2 (de) Kombinationstherapie zur behandlung von aids
RU2848695C2 (ru) Антигипертензивное полиольное соединение и его производное
KR20030002304A (ko) 3-페닐-3,7-디아자비시클로[3.3.1]노난 화합물들과 이들의제조방법 및 이러한 화합물들을 포함하는 약제들
WO2009129224A1 (en) Inhibitors of protein phosphatase-1 and uses thereof
US10385061B2 (en) Medicarpin, its derivatives, manufacturing method thereof
JP2004508336A (ja) 抗不整脈薬としてのプリンリボシド
JPH10139664A (ja) 抗不整脈薬
US20080081926A1 (en) Sulfonylaminobenzoic acid and salt
KR20240094390A (ko) 골질환의 예방 또는 치료용 약학 조성물
KR101598241B1 (ko) 카페오일 유도체를 포함하는 염증성 안질환의 예방 또는 치료용 약학적 조성물
RU2248208C2 (ru) Пуринрибозиды в качестве антиаритмических средств
JP2004256533A (ja) 不整脈治療剤
TW201943716A (zh) 吳茱萸次鹼類似物及其應用
CZ20001752A3 (cs) Farmaceutické prostředky obsahující kombinaci pro léčbu AIDS

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20131101