JP2009513713A - ｐ３８阻害剤化合物による心房細動の治療方法 - Google Patents

ｐ３８阻害剤化合物による心房細動の治療方法 Download PDF

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Publication number
JP2009513713A
JP2009513713A JP2008538997A JP2008538997A JP2009513713A JP 2009513713 A JP2009513713 A JP 2009513713A JP 2008538997 A JP2008538997 A JP 2008538997A JP 2008538997 A JP2008538997 A JP 2008538997A JP 2009513713 A JP2009513713 A JP 2009513713A
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inhibitor compound
group
phenyl
subject
alkyl
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JP2009513713A5 (https=
Inventor
ジェフ オルジン，
スーザン アイゼンバーグ，
ローレンス エム． ブラット，
スコット ザイベルト，
カール コッセン，
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University of California
University of California Los Angeles UCLA
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University of California San Diego UCSD
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Publication of JP2009513713A publication Critical patent/JP2009513713A/ja
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Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2008538997A 2005-11-01 2006-11-01 ｐ３８阻害剤化合物による心房細動の治療方法 Pending JP2009513713A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73267605P 2005-11-01 2005-11-01
PCT/US2006/042653 WO2007053685A2 (en) 2005-11-01 2006-11-01 Methods of treating atrial fibrillation with p38 inhibitor compounds

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JP2009513713A true JP2009513713A (ja) 2009-04-02
JP2009513713A5 JP2009513713A5 (https=) 2009-10-15

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JP2008538997A Pending JP2009513713A (ja) 2005-11-01 2006-11-01 ｐ３８阻害剤化合物による心房細動の治療方法

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US (2) US20100029578A1 (https=)
EP (1) EP1948178A4 (https=)
JP (1) JP2009513713A (https=)
CA (1) CA2627547A1 (https=)
WO (2) WO2007053610A2 (https=)

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JP2016176953A (ja) * 2009-09-18 2016-10-06 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
KR20170031712A (ko) 2014-07-30 2017-03-21 가부시키가이샤 아에타스 파루마 1,4-벤조티아제핀-1-옥사이드 유도체의 광학 이성질체, 및 그것을 사용한 의약 조성물
WO2018124236A1 (ja) * 2016-12-27 2018-07-05 国立大学法人大阪大学 難治性心疾患治療用医薬組成物

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ES2600460T3 (es) 2005-05-10 2017-02-09 Intermune, Inc. Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
WO2010065755A1 (en) 2008-12-04 2010-06-10 Concert Pharmaceuticals, Inc. Deuterated pyridinones
AP2011005824A0 (en) * 2009-01-26 2011-08-31 Intermune Inc Methods for treating acute myocardial infarctions and associated disorders.
KR101478133B1 (ko) 2009-05-25 2014-12-31 센트럴 사우스 유니버시티 1-（치환된 벤질기）-5-트리플루오로메틸-2-（1ｈ）피리돈 화합물 및 그 염의 제조방법 및 용도
WO2010135972A1 (zh) 2009-05-25 2010-12-02 中南大学 1-(取代芳基)-5-三氟甲基-2-（1h）吡啶酮化合物及其盐的制备方法及其用途
TWI508726B (zh) 2009-12-21 2015-11-21 Gilead Sciences Inc 治療心房纖維性顫動之方法
US10105356B2 (en) 2011-01-31 2018-10-23 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
WO2012106382A1 (en) 2011-01-31 2012-08-09 Genoa Pharmaceuticals, Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
CN102846555B (zh) * 2012-04-09 2014-06-25 珠海亿邦制药股份有限公司 一种以吡非尼酮为活性成分的固体制剂及其应用
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
AU2015204558B2 (en) 2014-01-10 2020-04-30 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
MX382781B (es) 2014-04-02 2025-03-13 Intermune Inc Piridinonas anti-fibroticas.
US10515284B2 (en) * 2014-09-30 2019-12-24 Qualcomm Incorporated Single-processor computer vision hardware control and application execution
AU2015369712B2 (en) 2014-12-22 2020-05-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Mutant IDH1 inhibitors useful for treating cancer
CN105878243B (zh) * 2016-06-14 2019-05-21 四川大学 吡非尼酮衍生物在制药中的应用
CN105998018B (zh) * 2016-06-16 2019-01-25 杨若一 吡非尼酮衍生物在制药中的应用
CN107556234A (zh) * 2016-06-30 2018-01-09 陕西合成药业股份有限公司 一种新型吡啶酮类化合物及其制备方法和在医学上的应用

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US4052509A (en) * 1972-12-18 1977-10-04 Affiliated Medical Research, Inc. Method for reducing serum uric acid levels
US4042699A (en) * 1972-12-18 1977-08-16 Affiliated Medical Research, Inc. Method for reducing serum glucose levels
US3839346A (en) * 1972-12-18 1974-10-01 Affiliated Med Res N-substituted pyridone and general method for preparing pyridones
CA1049411A (en) * 1972-12-18 1979-02-27 Affiliated Medical Research N-substituted pyridone and general method for preparing pyridones
ES2152938T3 (es) * 1992-09-28 2001-02-16 Hoechst Ag 1(2h)-isoquinolinas sustituidas antiarritmicas y cardioprotectoras, procedimiento para su produccion, medicamento que las contiene y su uso para la produccion de un medicamento para combatir fallos cardiacos.
AU2440802A (en) * 2000-10-18 2002-04-29 Massachusetts Inst Technology Methods and products related to pulmonary delivery of polysaccharides
US7030141B2 (en) * 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
JP2006502142A (ja) * 2002-08-23 2006-01-19 ブリストル−マイヤーズ　スクイブ　カンパニー 虚血性損傷を減少させる方法
EP1551369A4 (en) * 2002-08-28 2007-05-09 Intermune Inc COMBINATION THERAPY FOR THE TREATMENT OF FIBROTIC DISEASES
US7407973B2 (en) * 2003-10-24 2008-08-05 Intermune, Inc. Use of pirfenidone in therapeutic regimens
US7550487B2 (en) * 2004-03-26 2009-06-23 Hoffmann-La Roche Inc. Pyrrolidine-3,4-dicarboxamide derivatives

Non-Patent Citations (4)

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JPN6011069619; Ｂｒｉｔｉｓｈ　Ｊｏｕｒｎａｌ　ｏｆ　Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．１３３，　Ｎｏ．５, 2001, ｐ．６８７-６９４ *
JPN6011069620; Ｂｒｉｔｉｓｈ　Ｊｏｕｒｎａｌ　ｏｆ　Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．１３５，　Ｎｏ．４, 2002, ｐ．９６１-９６８ *
JPN6011069622; 順天堂医学 第５０巻，第３号, 2004, ｐ．２２３-２３５ *
JPN6011069623; 日本内科学会雑誌 第８９巻，第１２号, 2000, ｐ．２５４１-２５４６ *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016176953A (ja) * 2009-09-18 2016-10-06 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
KR20170031712A (ko) 2014-07-30 2017-03-21 가부시키가이샤 아에타스 파루마 1,4-벤조티아제핀-1-옥사이드 유도체의 광학 이성질체, 및 그것을 사용한 의약 조성물
US10071996B2 (en) 2014-07-30 2018-09-11 Aetas Pharma Co., Ltd. Optical isomer of 1,4-benzothiazepine-1-oxide derivative, and pharmaceutical composition prepared using same
WO2018124236A1 (ja) * 2016-12-27 2018-07-05 国立大学法人大阪大学 難治性心疾患治療用医薬組成物
JPWO2018124236A1 (ja) * 2016-12-27 2019-11-14 国立大学法人大阪大学 難治性心疾患治療用医薬組成物

Also Published As

Publication number Publication date
WO2007053685A2 (en) 2007-05-10
WO2007053610A3 (en) 2007-11-29
US20120046321A1 (en) 2012-02-23
EP1948178A4 (en) 2011-03-02
WO2007053685A3 (en) 2007-07-19
CA2627547A1 (en) 2007-05-10
EP1948178A2 (en) 2008-07-30
US20100029578A1 (en) 2010-02-04
WO2007053610A2 (en) 2007-05-10

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