DE69806062T2 - Kombinationstherapie zur behandlung von aids - Google Patents

Kombinationstherapie zur behandlung von aids

Info

Publication number
DE69806062T2
DE69806062T2 DE69806062T DE69806062T DE69806062T2 DE 69806062 T2 DE69806062 T2 DE 69806062T2 DE 69806062 T DE69806062 T DE 69806062T DE 69806062 T DE69806062 T DE 69806062T DE 69806062 T2 DE69806062 T2 DE 69806062T2
Authority
DE
Germany
Prior art keywords
aids
treatment
combination therapy
therapy
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69806062T
Other languages
English (en)
Other versions
DE69806062D1 (de
Inventor
P Vacca
H Lin
C Yeh
A Chodakewitz
J Deutsch
D Ju
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9807938.7A external-priority patent/GB9807938D0/en
Priority claimed from GBGB9819590.2A external-priority patent/GB9819590D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69806062D1 publication Critical patent/DE69806062D1/de
Publication of DE69806062T2 publication Critical patent/DE69806062T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
DE69806062T 1997-11-13 1998-11-12 Kombinationstherapie zur behandlung von aids Expired - Fee Related DE69806062T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6542197P 1997-11-13 1997-11-13
GBGB9807938.7A GB9807938D0 (en) 1998-04-15 1998-04-15 Combination therapy for the treatment of AIDS
US9094098P 1998-06-26 1998-06-26
GBGB9819590.2A GB9819590D0 (en) 1998-09-08 1998-09-08 Combination therapy for the treatment of aids
PCT/US1998/024097 WO1999025352A1 (en) 1997-11-13 1998-11-12 Combination therapy for the treatment of aids

Publications (2)

Publication Number Publication Date
DE69806062D1 DE69806062D1 (de) 2002-07-18
DE69806062T2 true DE69806062T2 (de) 2003-03-20

Family

ID=27451773

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69806062T Expired - Fee Related DE69806062T2 (de) 1997-11-13 1998-11-12 Kombinationstherapie zur behandlung von aids

Country Status (24)

Country Link
EP (1) EP1044000B1 (de)
JP (1) JP2001522889A (de)
KR (1) KR20010032055A (de)
CN (1) CN1285747A (de)
AR (1) AR013758A1 (de)
AT (1) ATE218866T1 (de)
AU (1) AU749795B2 (de)
BG (1) BG104507A (de)
BR (1) BR9814146A (de)
CA (1) CA2309164A1 (de)
CO (1) CO4970782A1 (de)
DE (1) DE69806062T2 (de)
EA (1) EA200000513A1 (de)
ES (1) ES2177103T3 (de)
HU (1) HUP0100365A3 (de)
ID (1) ID24922A (de)
IL (1) IL135994A0 (de)
IS (1) IS5481A (de)
NO (1) NO20002481L (de)
PE (1) PE20000020A1 (de)
PL (1) PL340430A1 (de)
SK (1) SK6842000A3 (de)
TR (1) TR200001938T2 (de)
WO (1) WO1999025352A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9820417D0 (en) * 1998-09-18 1998-11-11 Glaxo Group Ltd Antiviral combinations
AU2002355739A1 (en) 2001-07-30 2003-02-17 University Of Southern California Preparation and use of alpha-keto phosphonates
EP1923063A3 (de) * 2003-01-14 2009-04-08 Gilead Sciences, Inc. Zusammensetzungen und Verfahren für antivirale Kombinationstherapie
GB2400553A (en) * 2003-04-14 2004-10-20 Cipla Ltd Antiviral pharmaceutical combination of lamivudine, stavudine and efavirenz, or derivatives thereof
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT74681A (en) * 1993-12-15 1997-01-28 Merck & Co Inc N-(2-hydroxy-1-indenyl)-2-phenylmethyl-4-hydroxy-5-(2-carboxamido-piperazinyl)-pentaneamide derivatives of hiv protease inhibitor activity and phrmaceutical compositions contining them

Also Published As

Publication number Publication date
PL340430A1 (en) 2001-02-12
NO20002481L (no) 2000-07-12
IS5481A (is) 2000-05-09
WO1999025352A1 (en) 1999-05-27
EA200000513A1 (ru) 2000-10-30
AR013758A1 (es) 2001-01-10
AU749795B2 (en) 2002-07-04
EP1044000A1 (de) 2000-10-18
CO4970782A1 (es) 2000-11-07
BR9814146A (pt) 2000-10-03
ATE218866T1 (de) 2002-06-15
CN1285747A (zh) 2001-02-28
KR20010032055A (ko) 2001-04-16
PE20000020A1 (es) 2000-01-27
DE69806062D1 (de) 2002-07-18
CA2309164A1 (en) 1999-05-27
ES2177103T3 (es) 2002-12-01
NO20002481D0 (no) 2000-05-12
EP1044000B1 (de) 2002-06-12
AU1522599A (en) 1999-06-07
JP2001522889A (ja) 2001-11-20
IL135994A0 (en) 2001-05-20
HUP0100365A3 (en) 2002-06-28
BG104507A (bg) 2001-03-30
HUP0100365A2 (hu) 2002-05-29
ID24922A (id) 2000-08-31
SK6842000A3 (en) 2000-12-11
TR200001938T2 (tr) 2001-07-23

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee