CA2609716C - Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile - Google Patents

Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile Download PDF

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Publication number
CA2609716C
CA2609716C CA2609716A CA2609716A CA2609716C CA 2609716 C CA2609716 C CA 2609716C CA 2609716 A CA2609716 A CA 2609716A CA 2609716 A CA2609716 A CA 2609716A CA 2609716 C CA2609716 C CA 2609716C
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CA
Canada
Prior art keywords
process according
formula
acid
compound
reaction
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Active
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CA2609716A
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English (en)
French (fr)
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CA2609716A1 (en
Inventor
Didier Philippe Robert Schils
Alfred Elisabeth Stappers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Sciences Ireland ULC
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Tibotec Pharmaceuticals Ltd
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Publication date
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Application filed by Tibotec Pharmaceuticals Ltd filed Critical Tibotec Pharmaceuticals Ltd
Publication of CA2609716A1 publication Critical patent/CA2609716A1/en
Application granted granted Critical
Publication of CA2609716C publication Critical patent/CA2609716C/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA2609716A 2005-05-26 2006-05-24 Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile Active CA2609716C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05104531 2005-05-26
EP05104531.8 2005-05-26
US68599305P 2005-05-31 2005-05-31
US60/685,993 2005-05-31
PCT/EP2006/062606 WO2006125809A1 (en) 2005-05-26 2006-05-24 Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino benzonitrile

Publications (2)

Publication Number Publication Date
CA2609716A1 CA2609716A1 (en) 2006-11-30
CA2609716C true CA2609716C (en) 2014-10-14

Family

ID=35822492

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2609716A Active CA2609716C (en) 2005-05-26 2006-05-24 Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile

Country Status (19)

Country Link
US (2) US8101752B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP1888537B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JP5148483B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN101248051B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU2006251163C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BRPI0611038B8 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2609716C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK1888537T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2437202T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HR (1) HRP20131133T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN2014DN04588A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ME (1) ME01612B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX2007014881A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL1888537T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT1888537E (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RS (1) RS53062B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (1) RU2458056C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SI (1) SI1888537T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO2006125809A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007014881A (es) * 2005-05-26 2008-02-15 Tibotec Pharm Ltd Procedimiento para preparar 4-(1,6-dihidro-6-oxo-2-pirimidinil) amino benzonitrilo.
WO2012125993A1 (en) 2011-03-17 2012-09-20 Teva Pharmaceutical Industries Ltd. Solid state forms of rilpivirine base, and rilipivirine salts
ES2642383T3 (es) 2012-03-13 2017-11-16 Octapharma Ag Procedimiento mejorado de producción de fibrinógeno y fibrinógeno producido por el mismo
CN103058936B (zh) * 2013-01-23 2016-01-06 宁波九胜创新医药科技有限公司 4-[(4-氯-2-嘧啶基)氨基]苯腈的制备方法
CN103193719B (zh) * 2013-04-08 2015-07-22 宁波九胜创新医药科技有限公司 一种4-[(4-羟基-2-嘧啶基)氨基]苯腈的制备方法
CN114933567B (zh) * 2022-04-29 2023-07-11 武汉工程大学 一种2-甲硫基-4-嘧啶酮的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63502B1 (en) 1989-04-21 1995-05-03 Zeneca Ltd Aminopyrimidine derivatives useful for treating cardiovascular disorders
DE3923979A1 (de) 1989-07-20 1991-01-24 Merck Patent Gmbh Verfahren zur herstellung von aromatischen nitrilen
RU2037483C1 (ru) * 1989-07-20 1995-06-19 Мерк Патент Гмбх Способ получения замещенных ароматических нитрилов
ATE232521T1 (de) 1998-03-27 2003-02-15 Janssen Pharmaceutica Nv Hiv hemmende pyrimidin derivate
AP1683A (en) * 1998-11-10 2006-11-29 Janssen Pharmaceutica Nv HIV replication inhibiting pyrimidines.
WO2001022938A1 (en) * 1999-09-24 2001-04-05 Janssen Pharmaceutica N.V. Antiviral compositions
JP4969010B2 (ja) * 2000-05-08 2012-07-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｈｉｖ複製阻害性ピリミジンのプロドラッグ
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
WO2003037891A1 (en) * 2001-11-01 2003-05-08 Janssen Pharmaceutica N.V. Heteroaryl amines as glycogen synthase kinase 3beta inhibitors (gsk3 inhibitors)
AU2003266413B2 (en) * 2002-08-09 2009-04-02 Janssen Pharmaceutica N.V. Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
ATE427303T1 (de) * 2003-09-30 2009-04-15 Janssen Pharmaceutica Nv Benzoimidazolverbindungen
MX2007014881A (es) * 2005-05-26 2008-02-15 Tibotec Pharm Ltd Procedimiento para preparar 4-(1,6-dihidro-6-oxo-2-pirimidinil) amino benzonitrilo.

Also Published As

Publication number Publication date
WO2006125809A1 (en) 2006-11-30
RU2458056C2 (ru) 2012-08-10
HRP20131133T1 (hr) 2014-01-03
IN2014DN04588A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2015-07-10
SI1888537T1 (sl) 2014-01-31
PL1888537T3 (pl) 2014-02-28
AU2006251163C1 (en) 2012-07-12
RU2007148968A (ru) 2009-07-10
JP2008545680A (ja) 2008-12-18
PT1888537E (pt) 2013-11-26
JP5580385B2 (ja) 2014-08-27
ES2437202T3 (es) 2014-01-09
US8618291B2 (en) 2013-12-31
CN101248051B (zh) 2013-07-17
CA2609716A1 (en) 2006-11-30
BRPI0611038B8 (pt) 2022-10-25
EP1888537B1 (en) 2013-09-11
US8101752B2 (en) 2012-01-24
EP1888537A1 (en) 2008-02-20
JP5148483B2 (ja) 2013-02-20
US20080171878A1 (en) 2008-07-17
DK1888537T3 (da) 2013-12-09
CN101248051A (zh) 2008-08-20
BRPI0611038B1 (pt) 2022-02-08
AU2006251163A1 (en) 2006-11-30
US20120083606A1 (en) 2012-04-05
HK1123551A1 (en) 2009-06-19
MX2007014881A (es) 2008-02-15
ME01612B (me) 2014-09-20
BRPI0611038A2 (pt) 2010-08-10
JP2013040194A (ja) 2013-02-28
AU2006251163B2 (en) 2012-03-08
RS53062B (en) 2014-04-30

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