CA2533433A1 - Novel n-substituted indolyl-3-glyoxylic acid amides, use thereof as a medicament, and method for the production thereof - Google Patents
Novel n-substituted indolyl-3-glyoxylic acid amides, use thereof as a medicament, and method for the production thereof Download PDFInfo
- Publication number
- CA2533433A1 CA2533433A1 CA002533433A CA2533433A CA2533433A1 CA 2533433 A1 CA2533433 A1 CA 2533433A1 CA 002533433 A CA002533433 A CA 002533433A CA 2533433 A CA2533433 A CA 2533433A CA 2533433 A1 CA2533433 A1 CA 2533433A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- general formula
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 CN(*)C(C(c1c(*)[n](*)c2c1c(*)c(*)c(*)c2*)=*)=* Chemical compound CN(*)C(C(c1c(*)[n](*)c2c1c(*)c(*)c(*)c2*)=*)=* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10334040.8 | 2003-07-25 | ||
| DE10334040A DE10334040A1 (de) | 2003-07-25 | 2003-07-25 | Neue N-substituierte Indolyl-3-glyoxylsäureamide, deren Verwendung als Arzneimittel und Verfahren zu deren Herstellung |
| PCT/EP2004/007573 WO2005014542A2 (de) | 2003-07-25 | 2004-07-09 | Neue n-substituierte indolyl-3-glyoxylsäureamide, deren verwendung als arzneimittel gegen krebs und verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2533433A1 true CA2533433A1 (en) | 2005-02-17 |
Family
ID=34129467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002533433A Abandoned CA2533433A1 (en) | 2003-07-25 | 2004-07-09 | Novel n-substituted indolyl-3-glyoxylic acid amides, use thereof as a medicament, and method for the production thereof |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1651600A2 (xx) |
| JP (1) | JP2007503376A (xx) |
| KR (1) | KR20060037398A (xx) |
| CN (1) | CN1839129A (xx) |
| AR (1) | AR045928A1 (xx) |
| AU (1) | AU2004263238A1 (xx) |
| BR (1) | BRPI0412898A (xx) |
| CA (1) | CA2533433A1 (xx) |
| DE (1) | DE10334040A1 (xx) |
| IL (1) | IL173335A0 (xx) |
| MX (1) | MXPA06000995A (xx) |
| NO (1) | NO20060697L (xx) |
| RS (1) | RS20060049A (xx) |
| RU (1) | RU2317293C9 (xx) |
| TW (1) | TW200524863A (xx) |
| UA (1) | UA83498C2 (xx) |
| WO (1) | WO2005014542A2 (xx) |
| ZA (1) | ZA200601300B (xx) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2610244A1 (en) | 2006-08-07 | 2013-07-03 | Ironwood Pharmaceuticals, Inc. | Indole compounds |
| AR084433A1 (es) | 2010-12-22 | 2013-05-15 | Ironwood Pharmaceuticals Inc | Inhibidores de la faah y composiciones farmaceuticas que los contienen |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002323474B2 (en) * | 2001-09-13 | 2006-10-05 | Synta Pharmaceuticals Corp | 3-glyoxlylamideindoles for treating cancer |
-
2003
- 2003-07-25 DE DE10334040A patent/DE10334040A1/de not_active Withdrawn
-
2004
- 2004-07-09 KR KR1020067001636A patent/KR20060037398A/ko not_active Application Discontinuation
- 2004-07-09 AU AU2004263238A patent/AU2004263238A1/en not_active Abandoned
- 2004-07-09 RS YUP-2006/0049A patent/RS20060049A/sr unknown
- 2004-07-09 RU RU2006105708/04A patent/RU2317293C9/ru not_active IP Right Cessation
- 2004-07-09 JP JP2006521430A patent/JP2007503376A/ja not_active Withdrawn
- 2004-07-09 WO PCT/EP2004/007573 patent/WO2005014542A2/de active Application Filing
- 2004-07-09 CA CA002533433A patent/CA2533433A1/en not_active Abandoned
- 2004-07-09 BR BRPI0412898-2A patent/BRPI0412898A/pt not_active IP Right Cessation
- 2004-07-09 EP EP04740854A patent/EP1651600A2/de not_active Withdrawn
- 2004-07-09 MX MXPA06000995A patent/MXPA06000995A/es unknown
- 2004-07-09 CN CNA2004800240832A patent/CN1839129A/zh active Pending
- 2004-07-19 TW TW093121509A patent/TW200524863A/zh unknown
- 2004-07-23 AR ARP040102632A patent/AR045928A1/es not_active Application Discontinuation
- 2004-09-07 UA UAA200601216A patent/UA83498C2/uk unknown
-
2006
- 2006-01-24 IL IL173335A patent/IL173335A0/en unknown
- 2006-02-13 ZA ZA200601300A patent/ZA200601300B/xx unknown
- 2006-02-14 NO NO20060697A patent/NO20060697L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2317293C2 (ru) | 2008-02-20 |
| RS20060049A (xx) | 2008-08-07 |
| NO20060697L (no) | 2006-02-14 |
| TW200524863A (en) | 2005-08-01 |
| IL173335A0 (en) | 2006-06-11 |
| CN1839129A (zh) | 2006-09-27 |
| MXPA06000995A (es) | 2006-04-11 |
| RU2317293C9 (ru) | 2008-05-10 |
| JP2007503376A (ja) | 2007-02-22 |
| BRPI0412898A (pt) | 2006-10-03 |
| WO2005014542A3 (de) | 2006-10-19 |
| AR045928A1 (es) | 2005-11-16 |
| ZA200601300B (en) | 2007-03-28 |
| WO2005014542A2 (de) | 2005-02-17 |
| DE10334040A1 (de) | 2005-03-10 |
| KR20060037398A (ko) | 2006-05-03 |
| EP1651600A2 (de) | 2006-05-03 |
| RU2006105708A (ru) | 2006-06-27 |
| UA83498C2 (uk) | 2008-07-25 |
| AU2004263238A1 (en) | 2005-02-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114269735B (zh) | 二氢或四氢喹唑啉类化合物及其中间体、制备方法和应用 | |
| CN108349981B (zh) | 新型的吡唑并[3，4－d]嘧啶化合物或其盐 | |
| CN108383836B (zh) | 作为mek抑制剂的杂环基化合物 | |
| CA2524525C (en) | Novel pyridopyrazines and use thereof as kinase modulators | |
| KR20050072824A (ko) | 과다증식성 질환 및 혈관신생과 관련된 질병의 치료에유용한 인돌릴 피라지논 유도체 | |
| WO2012136099A1 (zh) | 4-(取代苯氨基)喹唑啉衍生物及其制备方法、药物组合物和用途 | |
| WO2015077193A1 (en) | Inhibitors of lysine methyl transferase | |
| JP2007502822A (ja) | ｃ−Ｋｉｔ阻害剤としてのＮ３−置換イミダゾピリジン誘導体 | |
| AU2003246571B2 (en) | Arylcarbonylpiperazines and heteroarylcarbonylpiperazines and the use thereof for treating benign and malignant tumour diseases | |
| ES2450067T3 (es) | Derivados de pirido[2,3-d]pirimidina, proceso para su preparación y su uso terapéutico | |
| WO2005080392A1 (ja) | ピラゾロキノロン誘導体およびその用途 | |
| JP5583201B2 (ja) | キノキサリン誘導体並びに良性の及び悪性の腫瘍疾患の治療のためのその使用 | |
| JP5518088B2 (ja) | 四置換ピリダジンヘッジホッグ経路アンタゴニスト | |
| JP2022503943A (ja) | Ｆｌｔ３およびａｘｌの阻害剤としての３，９－ジアザスピロ［５，５］ウンデカン系化合物 | |
| US7211588B2 (en) | N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation | |
| CN110229171B (zh) | 一种噁嗪并喹唑啉与噁嗪并喹啉类化合物及其制备方法和应用 | |
| JP4878285B2 (ja) | アポトーシス誘発作用を有するインドール誘導体 | |
| US20050009809A1 (en) | Acridine derivatives and their use as medicaments | |
| CA2533433A1 (en) | Novel n-substituted indolyl-3-glyoxylic acid amides, use thereof as a medicament, and method for the production thereof | |
| EP4242207A1 (en) | Kras inhibitors for treatment of cancers | |
| WO2011078226A1 (ja) | 三環系化合物 | |
| CN111875583A (zh) | 三氮唑衍生物及其制备方法和用途 | |
| CN110229172B (zh) | 一种酰基取代的噁嗪并喹唑啉类化合物、制备方法及其应用 | |
| CN108948003B (zh) | 作为mTOR抑制剂的吡嗪并[2,3-c]喹啉-2（1H）-酮类化合物的制备及用途 | |
| CN115894520A (zh) | 一种大环k-ras g12c抑制剂及其制备方法和在药学上的应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |