CA2523859C - Methods and devices for the sustained release of multiple drugs - Google Patents

Methods and devices for the sustained release of multiple drugs Download PDF

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Publication number
CA2523859C
CA2523859C CA2523859A CA2523859A CA2523859C CA 2523859 C CA2523859 C CA 2523859C CA 2523859 A CA2523859 A CA 2523859A CA 2523859 A CA2523859 A CA 2523859A CA 2523859 C CA2523859 C CA 2523859C
Authority
CA
Canada
Prior art keywords
drug
segment
delivery device
drug delivery
unitary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2523859A
Other languages
English (en)
French (fr)
Other versions
CA2523859A1 (en
Inventor
Eyal S. Ron
Robert S. Langer
William F. Crowley, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Massachusetts Institute of Technology
Original Assignee
General Hospital Corp
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp, Massachusetts Institute of Technology filed Critical General Hospital Corp
Publication of CA2523859A1 publication Critical patent/CA2523859A1/en
Application granted granted Critical
Publication of CA2523859C publication Critical patent/CA2523859C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
    • A61F6/142—Wirelike structures, e.g. loops, rings, spirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2523859A 2003-04-29 2004-04-29 Methods and devices for the sustained release of multiple drugs Expired - Lifetime CA2523859C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US46631803P 2003-04-29 2003-04-29
US60/466,318 2003-04-29
US47357903P 2003-05-27 2003-05-27
US60/473,579 2003-05-27
PCT/US2004/013172 WO2004096151A2 (en) 2003-04-29 2004-04-29 Methods and devices for the sustained release of multiple drugs

Publications (2)

Publication Number Publication Date
CA2523859A1 CA2523859A1 (en) 2004-11-11
CA2523859C true CA2523859C (en) 2011-08-02

Family

ID=33423604

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2523859A Expired - Lifetime CA2523859C (en) 2003-04-29 2004-04-29 Methods and devices for the sustained release of multiple drugs

Country Status (8)

Country Link
US (7) US7833545B2 (https=)
EP (1) EP1620060B1 (https=)
JP (1) JP4898431B2 (https=)
AT (1) ATE461681T1 (https=)
AU (1) AU2004233997C1 (https=)
CA (1) CA2523859C (https=)
DE (1) DE602004026173D1 (https=)
WO (1) WO2004096151A2 (https=)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
US7169178B1 (en) 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
AU2004274000B2 (en) 2003-09-19 2009-07-30 Drugtech Corporation Pharmaceutical delivery system
CA2573266C (en) 2004-07-09 2011-11-08 The Population Council, Inc. Sustained release compositions containing progesterone receptor modulators
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
EP1827328B1 (en) * 2004-12-14 2011-08-17 Poly-Med, Inc. Intravaginal ringed mesh device
JP5193196B2 (ja) 2006-06-02 2013-05-08 ペア ツリー ウーマンズ ヘルス ケア 萎縮性膣炎の治療の方法
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
MX2009000053A (es) * 2006-07-12 2009-02-23 Controlled Therapeutics Sct Polimero para el suministro de medicamentos con sal clorhidrato de clindamicina.
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
EP2121107B1 (en) * 2006-12-18 2012-10-31 Eatlittle Inc. Device for delivery of a substance
US20090118253A1 (en) * 2007-11-05 2009-05-07 Repros Therapeutics Inc. Compositions and methods for treating dysfunctional uterine bleeding
EP2057972A1 (en) * 2007-11-07 2009-05-13 N.V. Organon Intrauterine deposit
PL2062569T3 (pl) * 2007-11-22 2011-10-31 Bayer Oy Dopochwowy układ dostarczania leku
EP2062568A1 (en) * 2007-11-22 2009-05-27 Bayer Schering Pharma Oy Vaginal delivery system
EP2359807B1 (en) * 2008-02-04 2017-07-26 Ferring B.V. Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof
WO2009129459A1 (en) * 2008-04-18 2009-10-22 Combinent Biomedical Systems, Inc. Devices that include ethylene-vinyl acetate copolymers and methods of making and using same
TWI477276B (zh) 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
US9034365B2 (en) 2008-05-20 2015-05-19 Poly-Med, Inc. Biostable, multipurpose, microbicidal intravaginal devices
EP2140860A1 (en) * 2008-07-03 2010-01-06 Bayer Schering Pharma Oy An improved method of contraception
US20100040671A1 (en) * 2008-08-12 2010-02-18 Ahmed Salah U Intravaginal Devices With a Rigid Support, Methods of Making, and Uses Thereof
EP2352544A4 (en) * 2008-11-07 2013-12-25 Combinent Biomedical Systems Inc DEVICES AND METHOD FOR THE TREATMENT AND / OR PREVENTION OF DISEASES
FI121000B (fi) * 2008-11-19 2010-06-15 Bayer Schering Pharma Oy Intravaginaalinen antojärjestelmä ja menetelmä sen valmistamiseksi
US8568374B2 (en) * 2009-05-04 2013-10-29 Merck Sharp & Dohme B.V. Intrauterine system
EP2437684B1 (en) 2009-06-03 2022-06-15 ForSight Vision5, Inc. Anterior segment drug delivery
BR112012001353B8 (pt) 2009-07-21 2021-05-25 The Population Council Inc anel vaginal, e, método para fabricar um anel vaginal
EP3689364A1 (en) * 2010-02-08 2020-08-05 Shenzhen Evergreen Therapeutics Co., Ltd. Methods for the use of progestogen as a glucocorticoid sensitizer
RU2648827C2 (ru) * 2010-03-28 2018-03-28 Эвестра, Инк. Внутривлагалищное устройство для доставки лекарственного средства
CA2798084A1 (en) 2010-05-17 2011-11-24 Aerie Pharmaceuticals, Inc. Drug delivery devices for delivery of ocular therapeutic agents
US20120053534A1 (en) * 2010-06-22 2012-03-01 Anu Mahashabde Intravaginal devices comprising anticholinergic agents, and methods of making thereof
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
WO2012065073A2 (en) * 2010-11-12 2012-05-18 The University Of Utah Research Foundation Intravaginal devices for controlled delivery of lubricants
KR101263916B1 (ko) 2011-01-11 2013-05-13 이장희 성 호르몬 방출 장치 및 이를 이용한 동물 피임 및 발정 유도 방법
WO2012121811A1 (en) * 2011-03-04 2012-09-13 Arstat, Inc. Treatment of excessive menstrual blood loss by intravaginal administration of low doses of antifibronlytic or hemostatic agent
EP2731587B1 (en) 2011-07-15 2024-12-04 Universiteit Gent Intravaginal delivery system
EP2755615B1 (en) 2011-09-14 2022-04-06 Forsight Vision5, Inc. Ocular insert apparatus
WO2013039993A1 (en) * 2011-09-14 2013-03-21 Royer Biomedical, Inc. Bioresorbable drug delivery matrices based on cross-linked polysaccharides, dosage forms designed for delayed/controlled release
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
BR112014012444B1 (pt) 2011-11-23 2021-12-14 Therapeuticsmd, Inc Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US20130166931A1 (en) * 2011-12-23 2013-06-27 Lsi Corporation Reducing power consumption of memory
CN103040090B (zh) * 2012-01-20 2016-03-30 奥驰亚客户服务公司 脱除烟草的口腔用产品
CN102754907B (zh) 2012-01-20 2015-06-24 奥驰亚客户服务公司 口腔用产品
US9854831B2 (en) 2012-01-20 2018-01-02 Altria Client Services Llc Oral product
CN103039688B (zh) 2012-01-20 2016-01-06 奥驰亚客户服务公司 口腔用产品
CN102754908B (zh) 2012-01-20 2015-06-10 奥驰亚客户服务公司 口腔用烟草产品
DE102012009057A1 (de) 2012-05-09 2013-11-14 Dr. Arabin GmbH & Co. KG Rotationspessar mit zusätzlicher Wirkstoffkomponente
SG11201407397WA (en) 2012-05-31 2014-12-30 Repros Therapeutics Inc Formulations and methods for vaginal delivery of antiprogestins
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
DK2911623T3 (da) 2012-10-26 2019-10-28 Forsight Vision5 Inc Oftalmisk system til langvarig frigivelse af lægemiddel til øjet
ES2688821T3 (es) 2012-11-02 2018-11-07 Repros Therapeutics Inc. Métodos y composiciones para tratar afecciones dependientes de la progesterona
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
PL2982352T3 (pl) 2014-06-28 2019-01-31 Laboratorios Andrómaco S.A. Krążek szyjki macicy zawierający progesteron do długotrwałego, przedłużonego i ciągłego uwalniania, stosowany w celu zapobiegania przed przedwczesnym porodem
CN105277633B (zh) * 2014-07-26 2017-06-23 浙江仙琚制药股份有限公司 一种炔诺酮衍生物及其中间体的杂质检测分析方法
RU2016141135A (ru) 2014-07-29 2018-08-28 Терапьютиксмд, Инк. Трансдермальный крем
AR101476A1 (es) 2014-08-07 2016-12-21 Acerta Pharma Bv Métodos para tratar cánceres, enfermedades inmunes y autoinmunes, y enfermedades inflamatorias en base a la tasa de ocupación de la tirosin quinasa de bruton (btk) y a la tasa de resíntesis de la tirosin quinasa de bruton (btk)
EP3017809A1 (en) 2014-11-07 2016-05-11 Ferring B.V. Drug-device unit containing quinagolide
CA2974167C (en) 2015-01-21 2023-05-16 Bayer Oy Drug delivery system comprising a non-steroidal anti-inflammatory (nsaid) and a progestogenic compound and methods for manufacturing
JP2018509389A (ja) * 2015-01-30 2018-04-05 リ・ガリ・ベスローテン・フエンノートシャップＬｉ Ｇａｌｌｉ Ｂ．Ｖ． 膣用薬物送達デバイス
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
CN108135910B (zh) * 2015-05-13 2022-12-02 拜耳股份有限公司 长效药物递送装置及其在避孕中的用途
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
GB201517523D0 (en) * 2015-10-05 2015-11-18 Ostara Biomedical Ltd Methods and compositions for managing reproduction
WO2017123577A1 (en) * 2016-01-12 2017-07-20 Repros Therapeutics Inc. Trans-clomiphene and progesterone receptor antagonist combination therapy for treating hormone-dependent conditions
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
GB201708224D0 (en) 2017-05-23 2017-07-05 Juniper Pharmaceuticals Uk Ltd Device
FR3070619B1 (fr) * 2017-09-01 2024-10-04 Ab7 Innovation Piece moulee monolithique en matrice multiple pour la diffusion d’actifs et son procede d’obtention
BR112020008231A2 (pt) 2017-10-27 2020-10-27 Renovia, Inc. dispositivos, sistemas e métodos para treinamento dos músculos do assoalho pélvico
CN108186553B (zh) * 2018-02-13 2020-10-02 广东药科大学 一种黄体酮长效栓剂及其制备方法
CN111971039A (zh) * 2018-04-10 2020-11-20 里加利私人有限公司 阴道全身药物递送
BR112020021994A2 (pt) * 2018-04-27 2021-01-26 Evestra, Inc. pró-fármacos de estrogênio e métodos de administração de pró-fármacos de estrogênio
KR20260007295A (ko) 2018-05-24 2026-01-13 셀라니즈 이브이에이 퍼포먼스 폴리머스 엘엘씨 거대 분자 약물 화합물의 지속적인 방출을 위한 이식가능 장치
US11689849B2 (en) 2018-05-24 2023-06-27 Nureva, Inc. Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones
US11690806B2 (en) 2018-05-24 2023-07-04 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
AU2020256291A1 (en) * 2019-03-29 2021-11-18 Martin DOORBAR Eva segmented intravaginal rings containing progesterone
WO2021068239A1 (zh) * 2019-10-12 2021-04-15 国家卫生健康委科学技术研究所 用于黄体支持的阴道缓释给药系统及其制备方法与应用
KR20220133177A (ko) * 2019-11-18 2022-10-04 데어 바이오사이언스, 인크. 질내 링 장치
FR3107203B1 (fr) * 2020-02-14 2023-11-24 Ab7 Innovation Matrice solide composite pour la délivrance prolongée d’actifs
USD935018S1 (en) * 2020-04-07 2021-11-02 The Population Council, Inc. Contraceptive
BR112023022439A2 (pt) 2021-04-26 2023-12-26 Celanese Eva Performance Polymers Llc Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular
WO2023031218A1 (en) 2021-08-31 2023-03-09 Ferring B.V. Diagnosis and treatment of ectopic endometriosis
KR20240126051A (ko) * 2021-12-30 2024-08-20 텔리플렉스 메디컬 인코포레이티드 열가소성 중합체 조성물 중의 배합 활성 약제학적 제제 및 제조 방법
CA3251695A1 (en) * 2022-02-22 2023-08-31 Celanese Eva Performance Polymers Llc Intravaginal ring device for the administration of an aromatase inhibitor
CN118843488A (zh) * 2022-03-08 2024-10-25 塞拉尼斯伊娃高性能聚合物公司 用于递送芳香化酶抑制剂的植入式医疗器件
JP2026501812A (ja) * 2023-01-09 2026-01-16 デア バイオサイエンス， インコーポレイテッド ホルモン補充療法のための方法及びデバイス
WO2024155777A2 (en) 2023-01-19 2024-07-25 Dare Bioscience, Inc. Compositions and techniques for treatment of polycystic ovarian syndrome (pcos) and endometriosis
WO2024155775A2 (en) 2023-01-19 2024-07-25 Dare Bioscience, Inc. Compositions and techniques for treatment of polycystic ovarian syndrome (pcos) and endometriosis
WO2025174767A1 (en) * 2024-02-13 2025-08-21 Biraj Investments, Llc Highly loaded implantable devices with high tensile strength for drug delivery

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1945275U (de) * 1965-04-30 1966-09-01 Ortho Pharma Corp Intrauterine vorrichtung zur empfaengnisverhuetung.
US3454004A (en) * 1967-08-18 1969-07-08 Holland Rantos Co Inc Intrauterine contraceptive device
US3545439A (en) 1968-01-04 1970-12-08 Upjohn Co Medicated devices and methods
NL6903028A (https=) 1969-02-26 1970-08-28
US3903880A (en) 1972-08-17 1975-09-09 Alza Corp Intrauterine device for managing the reproductive process
US4069307A (en) * 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US3920805A (en) 1971-12-09 1975-11-18 Upjohn Co Pharmaceutical devices and method
US3938515A (en) 1971-12-20 1976-02-17 Alza Corporation Novel drug permeable wall
US3708511A (en) 1972-01-18 1973-01-02 Organon Novel {66 -steroids of the oestrane series
NL7204025A (https=) 1972-03-24 1973-09-26
US3780935A (en) 1972-07-10 1973-12-25 Lukacs & Jacoby Ass Serum separating method
NL7210262A (https=) 1972-07-26 1974-01-29
US4016251A (en) * 1972-08-17 1977-04-05 Alza Corporation Vaginal drug dispensing device
US3963119A (en) 1973-10-13 1976-06-15 Lucaks And Jacoby Associates Serum separating apparatus
US4043928A (en) 1973-10-31 1977-08-23 Lukacs And Jacoby Associates Serum separating composition of matter
IL48277A (en) 1974-10-18 1978-03-10 Schering Ag Vaginal ring
US4155991A (en) * 1974-10-18 1979-05-22 Schering Aktiengesellschaft Vaginal ring
US4093709A (en) 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4096860A (en) 1975-10-08 1978-06-27 Mclaughlin William F Dual flow encatheter
US3995633A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal Medicament dispensing device
US3995634A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal cavity dispensing means and method
US4219426A (en) 1976-03-19 1980-08-26 Organon Teknika B.V. Dialysis device
US4237885A (en) 1978-10-23 1980-12-09 Alza Corporation Delivery system with mated members for storing and releasing a plurality of beneficial agents
US4292965A (en) 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
DE3040978A1 (de) 1980-10-28 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Vaginalring
US4484559A (en) * 1982-03-01 1984-11-27 Mcdermott Incorporated Apparatus for removing material such as concrete from underwater pipelines
DE3214667C2 (de) 1982-04-21 1985-07-18 Akzo Gmbh, 5600 Wuppertal Zusammengesetzter Körper für die Langzeitabgabe von Wirkstoffen
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4629449A (en) * 1982-07-29 1986-12-16 Alza Corporation Vaginal dispenser for dispensing beneficial hormone
NL8301035A (nl) 1983-03-23 1984-10-16 Organon Teknika Bv Macromoleculair materiaal met carbonylgroepen geschikt als sorbent voor stikstofverbindingen.
US4558996A (en) 1983-06-30 1985-12-17 Organon Teknika Corporation Easy load peristaltic pump
US4484599A (en) 1983-09-23 1984-11-27 Organon Teknika Corporation Pinch-type pressure- or flow-regulating valve
US4596576A (en) * 1984-10-12 1986-06-24 Akzo N.V. Release system for two or more active substances
ZA857643B (en) * 1984-10-12 1986-05-28 Akzo Nv Release system for two or more active substances
US4645502A (en) 1985-05-03 1987-02-24 Alza Corporation Transdermal delivery of highly ionized fat insoluble drugs
US4762717A (en) * 1986-03-21 1988-08-09 The General Hospital Corporation Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive
SE8602666D0 (sv) 1986-06-16 1986-06-16 Leo Ab Intravaginal devices
US4938759A (en) 1986-09-02 1990-07-03 Alza Corporation Transdermal delivery device having a rate controlling adhesive
CA1331563C (en) 1987-08-03 1994-08-23 Gaylen M. Zentner Device for the controlled release of drugs with donnan-like modulation by charged insoluble resins
ES2054784T3 (es) 1987-08-08 1994-08-16 Akzo Nv Un metodo para la fabricacion de un implante.
US5474783A (en) 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
NZ228285A (en) 1988-03-11 1991-08-27 Teikoku Seiyaku Kk Pharmaceutical composition comprising a polypeptide and adapted for intravaginal administration
US5034229A (en) 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US5002540A (en) 1989-05-22 1991-03-26 Warren Kirschbaum Intravaginal device and method for delivering a medicament
US5252334A (en) 1989-09-08 1993-10-12 Cygnus Therapeutic Systems Solid matrix system for transdermal drug delivery
HU208495B (en) 1990-06-27 1993-11-29 Alkaloida Vegyeszeti Gyar Process for producing retarde pharmaceutical compositions
IE67345B1 (en) 1991-03-12 1996-03-20 Akzo Nv Low dose dry pharmaceutical preparations
US5211952A (en) 1991-04-12 1993-05-18 University Of Southern California Contraceptive methods and formulations for use therein
US5340585A (en) 1991-04-12 1994-08-23 University Of Southern California Method and formulations for use in treating benign gynecological disorders
US5302397A (en) * 1991-11-19 1994-04-12 Amsden Brian G Polymer-based drug delivery system
US6013853A (en) 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5482706A (en) 1992-04-17 1996-01-09 Takeda Chemical Industries, Ltd. Transmucosal therapeutic composition
CA2098889A1 (en) 1992-07-06 1994-01-07 Takashi Chinuki Slow-releasing medicated resin moldings and process for producing the same
US5482702A (en) * 1993-04-27 1996-01-09 Church & Dwight Co., Inc. Hydrophilic polymer-coated microcrystallites of bicarbonate salt
US5919478A (en) 1993-06-25 1999-07-06 Alza Corporation Incorporating poly-N-vinyl amide in a transdermal system
GB2282384B8 (en) 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
US5543150A (en) 1993-09-15 1996-08-06 Columbia Laboratories, Inc. Method of progesterone delivery and affect thereof
HUT75159A (en) 1993-12-27 1997-04-28 Akzo Nobel Nv Percutaneously absorbable preparation, containing 3-ketodesogestrel and 17 beta-estradiol
FR2717688B1 (fr) 1994-03-28 1996-07-05 Lhd Lab Hygiene Dietetique Système matriciel transdermique d'administration d'un oestrogène et/ou un progestatif à base d'EVA.
FI97944C (fi) * 1994-07-05 1997-03-25 Leiras Oy Vaikuttavaa ainetta luovuttava laite
US5681568A (en) 1994-08-19 1997-10-28 Cambridge Neuroscience, Inc. Device for delivery of substances and methods of use thereof
US5593965A (en) 1994-10-20 1997-01-14 Creighton University Anti-tumor effects of GnRH-III
IL116433A (en) 1994-12-19 2002-02-10 Galen Chemicals Ltd INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS
MX9707585A (es) 1995-04-03 1997-12-31 Abbott Lab Mezclas homogeneas de farmacos y aditivos de fusion a baja temperatura para liberacion controlada.
US5601839A (en) 1995-04-26 1997-02-11 Theratech, Inc. Triacetin as a penetration enhancer for transdermal delivery of a basic drug
US6572879B1 (en) 1995-06-07 2003-06-03 Alza Corporation Formulations for transdermal delivery of pergolide
WO1997002015A1 (en) * 1995-07-04 1997-01-23 Akzo Nobel N.V. Ring-shaped devices
FR2739032B1 (fr) 1995-09-27 1997-11-21 Lhd Lab Hygiene Dietetique Systeme matriciel transdermique d'administration d'un oestrogene et/ou d'un progestatif a base d'eva, procede de preparation et utilisation en therapeutique
US5780435A (en) 1995-12-15 1998-07-14 Praecis Pharmaceuticals Incorporated Methods for treating prostate cancer with LHRH-R antagonists
US6156331A (en) 1996-02-02 2000-12-05 Alza Corporation Sustained delivery of an active agent using an implantable system
US5869081A (en) 1996-06-28 1999-02-09 The Population Council Progesterone vaginal ring for treatment of infertility
US6139873A (en) 1996-07-10 2000-10-31 Cedars-Sinai Medical Center Combined pharmaceutical estrogen-androgen-progestin
US5972372A (en) * 1996-07-31 1999-10-26 The Population Council, Inc. Intravaginal rings with insertable drug-containing core
US5945128A (en) 1996-09-04 1999-08-31 Romano Deghenghi Process to manufacture implants containing bioactive peptides
DE69730093T2 (de) 1996-10-31 2006-07-20 Takeda Pharmaceutical Co. Ltd. Zubereitung mit verzögerter Freisetzung
US5985861A (en) 1996-11-04 1999-11-16 Columbia Laboratories, Inc. Progesterone for treating or reducing ischemia
JPH10138432A (ja) 1996-11-14 1998-05-26 Teijin Ltd 磁気テープ用二軸配向積層ポリエステルフィルム
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
JPH10279499A (ja) 1997-04-04 1998-10-20 Takeda Chem Ind Ltd 子宮粘膜適用製剤
IL123813A0 (en) 1997-04-11 1998-10-30 Akzo Nobel Nv Drug delivery system for two or more active substances
AR012448A1 (es) 1997-04-18 2000-10-18 Ipsen Pharma Biotech Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada
US6416779B1 (en) 1997-06-11 2002-07-09 Umd, Inc. Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections
US6572874B1 (en) 1998-05-15 2003-06-03 Umd, Inc. Vaginal delivery of bisphosphonates
US6197327B1 (en) 1997-06-11 2001-03-06 Umd, Inc. Device and method for treatment of dysmenorrhea
US6905701B2 (en) 1997-06-11 2005-06-14 Umd, Inc. Formulations for transmucosal vaginal delivery of bisphosphonates
US6039968A (en) * 1997-06-24 2000-03-21 Hoechst Marion Roussel Intravaginal drug delivery device
US5941844A (en) 1997-11-17 1999-08-24 Alza Corporation Method and device for controlling mammalian reproductive cycle
WO1999033449A1 (en) 1997-12-30 1999-07-08 Alza Corporation Beneficial agent delivery system with membrane plug
USD442688S1 (en) 1998-01-28 2001-05-22 N.V. Organon Vaginal ring applicator
EP0940678A1 (en) 1998-03-02 1999-09-08 Akzo Nobel N.V. Analytical test device
US5945123A (en) 1998-04-02 1999-08-31 K-V Pharmaceutical Company Maximizing effectiveness of substances used to improve health and well being
AU748653B2 (en) 1998-05-01 2002-06-06 John F. Cline Method for injection molding manufacture of controlled release devices
US6218367B1 (en) 1998-09-15 2001-04-17 Organomed Corporation Paclitaxel-carbohydrate conjugates: design, synthesis and biological evaluations
US6143314A (en) 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US6159491A (en) 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
WO2001014478A1 (en) 1999-08-25 2001-03-01 Dai-Ichi Kogyo Seiyaku Co., Ltd Gel-form molded resin composition, packaged volatile gel-form chemical, and process for producing the same
US6264973B1 (en) 1999-08-26 2001-07-24 Fei Enterprises, Ltd. Apparatus and method for anesthetizing the cervical region of a female
WO2001026648A1 (en) 1999-10-13 2001-04-19 Senju Pharmaceutical Co., Ltd. Ophthalmic adhesive preparations for percutaneous absorption
US6264981B1 (en) 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
US6687178B1 (en) * 2001-02-23 2004-02-03 Western Digital (Fremont), Inc. Temperature dependent write current source for magnetic tunnel junction MRAM

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US20080286322A1 (en) 2008-11-20
US7883718B2 (en) 2011-02-08
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US20120202742A1 (en) 2012-08-09
US7829112B2 (en) 2010-11-09
EP1620060B1 (en) 2010-03-24
ATE461681T1 (de) 2010-04-15
AU2004233997C1 (en) 2014-01-30
US20080248017A1 (en) 2008-10-09
DE602004026173D1 (de) 2010-05-06
US7833545B2 (en) 2010-11-16
AU2004233997B9 (en) 2013-01-10
US20080286339A1 (en) 2008-11-20
US20090060982A1 (en) 2009-03-05
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JP2007525461A (ja) 2007-09-06
US20090274654A1 (en) 2009-11-05
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CA2523859A1 (en) 2004-11-11
WO2004096151A3 (en) 2006-05-11

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