CA2503223C - Meso-substituted porphyrins - Google Patents

Meso-substituted porphyrins Download PDF

Info

Publication number
CA2503223C
CA2503223C CA2503223A CA2503223A CA2503223C CA 2503223 C CA2503223 C CA 2503223C CA 2503223 A CA2503223 A CA 2503223A CA 2503223 A CA2503223 A CA 2503223A CA 2503223 C CA2503223 C CA 2503223C
Authority
CA
Canada
Prior art keywords
phenyl
porphyrin
bis
tris
decyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2503223A
Other languages
English (en)
French (fr)
Other versions
CA2503223A1 (en
Inventor
Gabrio Roncucci
Donata Dei
Francesca Giuntini
Giacomo Chiti
Daniele Nistri
Lia Fantetti
Valentina Paschetta
Annalisa Cocchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molteni Therapeutics SRL
Original Assignee
L Molteni and C dei Fratelli Alitti Societa di Esercizio SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32104761&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2503223(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by L Molteni and C dei Fratelli Alitti Societa di Esercizio SpA filed Critical L Molteni and C dei Fratelli Alitti Societa di Esercizio SpA
Publication of CA2503223A1 publication Critical patent/CA2503223A1/en
Application granted granted Critical
Publication of CA2503223C publication Critical patent/CA2503223C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2503223A 2002-10-21 2003-10-21 Meso-substituted porphyrins Expired - Fee Related CA2503223C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITFI2002A000200 2002-10-21
IT000200A ITFI20020200A1 (it) 2002-10-21 2002-10-21 Porfirine meso-sostituite.
PCT/EP2003/011642 WO2004035590A2 (en) 2002-10-21 2003-10-21 Meso-substituted porphyrins

Publications (2)

Publication Number Publication Date
CA2503223A1 CA2503223A1 (en) 2004-04-29
CA2503223C true CA2503223C (en) 2010-11-23

Family

ID=32104761

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2503223A Expired - Fee Related CA2503223C (en) 2002-10-21 2003-10-21 Meso-substituted porphyrins

Country Status (17)

Country Link
US (2) US7947674B2 (https=)
EP (1) EP1558616B2 (https=)
JP (1) JP4751068B2 (https=)
CN (1) CN1714091A (https=)
AT (1) ATE387450T1 (https=)
AU (1) AU2003278118B8 (https=)
CA (1) CA2503223C (https=)
CY (1) CY1107963T1 (https=)
DE (1) DE60319406T3 (https=)
DK (1) DK1558616T4 (https=)
ES (1) ES2301840T5 (https=)
IL (1) IL168104A0 (https=)
IT (1) ITFI20020200A1 (https=)
PT (1) PT1558616E (https=)
SI (1) SI1558616T2 (https=)
WO (1) WO2004035590A2 (https=)
ZA (1) ZA200504102B (https=)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1356813T3 (da) * 2002-04-25 2005-12-05 Molteni & C Antibakterielle præparater der omfatter metal-phthalocyaninanaloger
ITFI20020200A1 (it) * 2002-10-21 2004-04-22 Molteni & C Dei Flii Alitti S P A Societa L Porfirine meso-sostituite.
GB2397067B (en) 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
WO2005000854A2 (en) * 2003-06-06 2005-01-06 Eukarion, Inc. Orally bioavailable low molecular weight metalloporphyrins as antioxidants
GB2415372A (en) * 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
GB2415373A (en) * 2004-06-23 2005-12-28 Destiny Pharma Ltd Porphyrins for sonodynamic therapy
GB0526474D0 (en) * 2005-12-24 2006-02-08 Destiny Pharma Ltd Novel process
WO2008108937A1 (en) 2007-03-05 2008-09-12 North Carolina State University Method of making porphyrins
ES2707228T3 (es) * 2008-09-18 2019-04-03 Biolitec Unternehmensbeteiligungs Ii Ag Nuevo método y aplicación de porfirinas y clorinas asimétricamente meso-sustituidas para TFD
CN102180881A (zh) * 2011-03-25 2011-09-14 西北农林科技大学 3,8,13-三碘-5,10,15-三烷基三聚吲哚的制备方法
EP2759546B1 (en) * 2011-09-21 2018-03-21 National University Corporation Okayama University Metalloporphyrin complex, manufacturing process therefor and its use as carbon dioxide fixation catalyst, as well as process for manufacturing cyclic carbonate
CN102499924B (zh) * 2011-11-23 2013-07-24 中国医学科学院生物医学工程研究所 二乙撑三胺五乙酸或乙二胺四乙酸或胺三乙酸修饰卟啉的用途
US9364537B2 (en) 2014-08-22 2016-06-14 University Of Dayton Transition metal porphyrin complexes and methods of treatment using same
CN104725388B (zh) * 2015-03-25 2017-03-15 南京林业大学 一种meso位芳胺基单取代卟啉衍生物及其制备方法
WO2017122697A1 (ja) * 2016-01-13 2017-07-20 Jsr株式会社 感放射線性樹脂組成物、レジストパターン形成方法、酸拡散制御剤及び化合物
CN106117227A (zh) * 2016-06-27 2016-11-16 桂林理工大学 苯并菲癸烷氧基桥连十二烷氧基苯基卟啉二元化合物盘状液晶材料的合成方法
CN106046010A (zh) * 2016-06-27 2016-10-26 桂林理工大学 5‑对苯甲酸基‑10, 15, 20‑三对异辛烷氧基苯基卟啉的合成方法
CN106118689A (zh) * 2016-06-27 2016-11-16 桂林理工大学 苯并菲己烷氧基桥连异辛烷氧基苯基卟啉二元化合物盘状液晶材料的合成方法
CN106117222A (zh) * 2016-06-27 2016-11-16 桂林理工大学 苯并菲十二烷氧基桥连异辛烷氧基苯基卟啉二元化合物盘状液晶材料合成方法
CN105949208A (zh) * 2016-06-27 2016-09-21 桂林理工大学 苯并菲己烷氧基桥连十二烷氧基苯基卟啉金属Zn配合物的合成方法
CN106117221A (zh) * 2016-06-27 2016-11-16 桂林理工大学 苯并菲己烷氧基桥连异辛烷氧基苯基卟啉金属Ni配合物的合成方法
CN106117228A (zh) * 2016-06-27 2016-11-16 桂林理工大学 苯并菲癸烷氧基桥连异辛烷氧基苯基卟啉金属Ni配合物的合成方法
CN106117220A (zh) * 2016-06-27 2016-11-16 桂林理工大学 苯并菲十二烷氧基桥连异辛烷氧基苯基卟啉金属Zn配合物的合成方法
CN106146522A (zh) * 2016-06-27 2016-11-23 桂林理工大学 苯并菲癸烷氧基桥连十二烷氧基苯基卟啉金属Ni配合物的合成方法
CN106118688A (zh) * 2016-06-27 2016-11-16 桂林理工大学 苯并菲癸烷氧基桥连异辛烷氧基苯基卟啉二元化合物盘状液晶材料的合成方法
CN106117223A (zh) * 2016-06-27 2016-11-16 桂林理工大学 苯并菲十二烷氧基桥连异辛烷氧基苯基卟啉金属Ni配合物的合成方法
CN106146523A (zh) * 2016-06-27 2016-11-23 桂林理工大学 苯并菲十二烷氧基桥连十二烷氧基苯基卟啉金属Ni配合物的合成方法
CN105924448A (zh) * 2016-06-27 2016-09-07 桂林理工大学 苯并菲己烷氧基桥连十二烷氧基苯基卟啉金属Ni配合物的合成方法
CN106117224A (zh) * 2016-06-27 2016-11-16 桂林理工大学 苯并菲十二烷氧基桥连十二烷氧基苯基卟啉二元化合物盘状液晶材料的合成方法
CN106047369A (zh) * 2016-06-27 2016-10-26 桂林理工大学 苯并菲己烷氧基桥连十二烷氧基苯基卟啉二元化合物盘状液晶材料的合成方法
CN106117225A (zh) * 2016-06-27 2016-11-16 桂林理工大学 苯并菲癸烷氧基桥连异辛烷氧基苯基卟啉金属Zn配合物的合成方法
CN106588942A (zh) * 2016-12-08 2017-04-26 桂林理工大学 并菲癸氧基桥连四苯基卟啉三元化合物盘状液晶材料的合成方法
CN106588941A (zh) * 2016-12-08 2017-04-26 桂林理工大学 苯并菲十二烷氧基桥连四苯基卟啉三元化合物盘状液晶材料的合成方法
CN106588940A (zh) * 2016-12-08 2017-04-26 桂林理工大学 苯并菲癸氧基桥连异辛烷氧基苯基卟啉三元化合物盘状液晶材料的合成方法
CN106749284A (zh) * 2016-12-08 2017-05-31 桂林理工大学 苯并菲十二烷氧基桥连异辛烷氧基苯基卟啉三元化合物盘状液晶材料的合成方法
CN106749285A (zh) * 2016-12-08 2017-05-31 桂林理工大学 苯并菲己氧基桥连异辛烷氧基苯基卟啉三元化合物盘状液晶材料的合成方法
CN107011349A (zh) * 2017-04-22 2017-08-04 桂林理工大学 苯并菲癸烷氧基桥连异辛烷氧基苯基卟啉金属Zn配合物的合成方法
CN107089987A (zh) * 2017-04-22 2017-08-25 桂林理工大学 苯并菲己烷氧基桥连异辛烷氧基苯基卟啉金属Zn配合物的合成方法
CN106905334A (zh) * 2017-04-22 2017-06-30 桂林理工大学 苯并菲十二烷氧基桥连甲氧羰基苯基卟啉金属Zn配合物的合成方法
CN107043381A (zh) * 2017-04-22 2017-08-15 桂林理工大学 苯并菲十二烷氧基桥连异辛烷氧基苯基卟啉金属Zn配合物的合成方法
CN106967075A (zh) * 2017-04-22 2017-07-21 桂林理工大学 苯并菲癸烷氧基桥连甲氧羰基苯基卟啉金属Zn配合物的合成方法
US10722582B2 (en) * 2018-04-12 2020-07-28 Purdue Research Foundation Targeted antimicrobial photodynamic therapy
CN110354770B (zh) * 2019-07-23 2022-10-04 中国石油大学(华东) 一种人工光合微反应器及制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8805849D0 (en) * 1988-03-11 1988-04-13 Efamol Holdings Porphyrins & cancer treatment
FR2632187B1 (fr) * 1988-06-02 1990-09-14 Centre Nat Rech Scient Derives de metalloporphyrines, leur preparation, leur application en therapeutique et leur utilisation pour la preparation de molecules hybrides
IL122451A0 (en) * 1995-06-07 1998-06-15 Univ Duke Oxidant scavengers
US6087493A (en) 1997-02-05 2000-07-11 Regents Of The University Of Texas System Porphyrin compounds as telomerase inhibitors
IT1294325B1 (it) 1997-08-14 1999-03-24 Molteni L E C Dei Fratelli Ali Zinco-ftalocianine e relativi coniugati, preparazione e uso nella terapia fotodinamica e come diagnostici
DE69922216T2 (de) * 1998-08-28 2005-12-01 Destiny Pharma Ltd. Porphyrin derivate, ihre verwendung in der photodynamischen therapie und diese enthaltende medizinische geräte
DK1164135T3 (da) 2000-06-15 2004-06-21 Molteni & C Substituerede metal-phthalocyaniner, fremstilling deraf og anvendelse deraf
FR2812637B1 (fr) 2000-08-01 2002-10-25 Anulm Ass Nantaise Pour L Util Nouveaux composes derives de dihydroporphyrine et leurs applications
DE60204767T2 (de) 2001-03-21 2006-05-18 L. Molteni & C. dei Fratelli Alitti Società di Esercizio S.p.A. Metallsubstituierte, nicht zentrosymmetrische phthalocyanin-analoga, deren herstellung und verwendung zur photodynamischen therapie, und als in-vivo-diagnostikum
ITFI20020200A1 (it) 2002-10-21 2004-04-22 Molteni & C Dei Flii Alitti S P A Societa L Porfirine meso-sostituite.
GB2397067B (en) 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation

Also Published As

Publication number Publication date
IT1333697B (https=) 2006-05-09
DK1558616T3 (da) 2008-06-23
EP1558616B2 (en) 2011-08-24
SI1558616T1 (sl) 2008-08-31
ES2301840T3 (es) 2008-07-01
AU2003278118A1 (en) 2004-05-04
JP4751068B2 (ja) 2011-08-17
CA2503223A1 (en) 2004-04-29
DK1558616T4 (da) 2011-12-12
AU2003278118B2 (en) 2009-05-21
IL168104A0 (en) 2009-02-11
WO2004035590A3 (en) 2004-07-29
SI1558616T2 (sl) 2011-12-30
US8288528B2 (en) 2012-10-16
ZA200504102B (en) 2006-07-26
DE60319406T3 (de) 2012-02-23
PT1558616E (pt) 2008-05-12
US7947674B2 (en) 2011-05-24
AU2003278118B8 (en) 2009-09-17
CN1714091A (zh) 2005-12-28
DE60319406T2 (de) 2009-03-19
DE60319406D1 (de) 2008-04-10
US20110112464A1 (en) 2011-05-12
WO2004035590A2 (en) 2004-04-29
JP2006512301A (ja) 2006-04-13
CY1107963T1 (el) 2013-09-04
EP1558616A2 (en) 2005-08-03
ITFI20020200A1 (it) 2004-04-22
EP1558616B1 (en) 2008-02-27
US20060040914A1 (en) 2006-02-23
ES2301840T5 (es) 2012-01-13
ATE387450T1 (de) 2008-03-15

Similar Documents

Publication Publication Date Title
CA2503223C (en) Meso-substituted porphyrins
CA2412750C (en) Substituted metal-phthalocyanines, their preparation and the use thereof
PT906758E (pt) Zinco-ftalocianinas e correspondentes conjugados, sua preparação e uso em terapia fotodinâmica e como agentes de diagnóstico&
AU2001272463A1 (en) Substituted metal-phthalocyanines, their preparation and the use thereof
JP6911197B2 (ja) ヒポクレリンのペリ位及び２−位の両方がアミノ置換された誘導体、その調製方法及びそれを含む光増感薬
JP2002509932A (ja) 新規なポルフィリン類及びこれらの使用
CA2484070C (en) Antibacterial compositions comprising metal phthalocyanine analogues
CN105968118B (zh) 一种酞菁铱配合物及其制备方法和应用
CN102249939B (zh) 脂水两亲性亚苄基环戊酮染料及其制备方法与在光动力治疗中的用途
JP5058956B2 (ja) フタロシアニン色素およびそれらの製造および使用
CN103073553B (zh) 水溶性萘菁基化合物、制备方法及作为光敏剂的应用
CN100374442C (zh) 硼化金属酞菁类及其制备方法,包含它们的医药组合物及其用途
Lopez et al. Porphycenes as broad-spectrum antimicrobial photosensitizers. Potentiation with potassium iodide
Sasaki et al. Pyrobacteriopheophorbide‐a derivatives possessing various hydrophilic esterifying groups at the C17‐propionate residues for photodynamic therapy
CA2399217A1 (en) Porphyrins and related compounds
CN119039256B (zh) 一种用于肿瘤光动力治疗的高稳定荧光探针及其制备方法和用途
CN112574248A (zh) 二-((3-氯苯并噻吩-2-酯基)六氟苯氧基)轴向取代硅酞菁的制备方法
CN107935964B (zh) 一种多取代近红外竹红菌素衍生物及其制备方法和应用
CN112457341A (zh) 二-(4-二苯并噻吩-2-苯氧基)轴向取代硅酞菁的制备方法
CN120365259A (zh) 一种基于喹啉-丙二腈母核的光敏剂及其制备方法、应用

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20151021