CA2498207C - Gel-stabilized nanoparticulate active agent compositions - Google Patents

Gel-stabilized nanoparticulate active agent compositions Download PDF

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Publication number
CA2498207C
CA2498207C CA2498207A CA2498207A CA2498207C CA 2498207 C CA2498207 C CA 2498207C CA 2498207 A CA2498207 A CA 2498207A CA 2498207 A CA2498207 A CA 2498207A CA 2498207 C CA2498207 C CA 2498207C
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CA
Canada
Prior art keywords
less
active agent
composition
gelatin
nanoparticulate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2498207A
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English (en)
French (fr)
Other versions
CA2498207A1 (en
Inventor
Simon L. Mcgurk
David A. Czekai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Pharma Ireland Ltd
Original Assignee
Elan Pharma International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharma International Ltd filed Critical Elan Pharma International Ltd
Publication of CA2498207A1 publication Critical patent/CA2498207A1/en
Application granted granted Critical
Publication of CA2498207C publication Critical patent/CA2498207C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Yarns And Mechanical Finishing Of Yarns Or Ropes (AREA)
CA2498207A 2002-09-11 2003-09-11 Gel-stabilized nanoparticulate active agent compositions Expired - Fee Related CA2498207C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40958702P 2002-09-11 2002-09-11
US60/409,587 2002-09-11
PCT/US2003/028380 WO2005000265A2 (en) 2002-09-11 2003-09-11 Gel-stabilized nanoparticulate active agent compositions

Publications (2)

Publication Number Publication Date
CA2498207A1 CA2498207A1 (en) 2005-01-06
CA2498207C true CA2498207C (en) 2012-03-13

Family

ID=33551184

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2498207A Expired - Fee Related CA2498207C (en) 2002-09-11 2003-09-11 Gel-stabilized nanoparticulate active agent compositions

Country Status (13)

Country Link
US (1) US7713551B2 (enExample)
EP (1) EP1553927B9 (enExample)
JP (1) JP4878839B2 (enExample)
AT (1) ATE487470T1 (enExample)
AU (1) AU2003304237A1 (enExample)
CA (1) CA2498207C (enExample)
CY (1) CY1110949T1 (enExample)
DE (1) DE60334924D1 (enExample)
DK (1) DK1553927T3 (enExample)
ES (1) ES2355723T3 (enExample)
PT (1) PT1553927E (enExample)
SI (1) SI1553927T1 (enExample)
WO (1) WO2005000265A2 (enExample)

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DE60334924D1 (de) 2010-12-23
WO2005000265A2 (en) 2005-01-06
AU2003304237A1 (en) 2005-01-13
EP1553927B9 (en) 2011-09-21
AU2003304237A8 (en) 2005-01-13
US7713551B2 (en) 2010-05-11
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JP2006514688A (ja) 2006-05-11
CY1110949T1 (el) 2015-06-10
DK1553927T3 (da) 2011-01-31
ATE487470T1 (de) 2010-11-15
JP4878839B2 (ja) 2012-02-15
EP1553927A2 (en) 2005-07-20
US20050031691A1 (en) 2005-02-10
CA2498207A1 (en) 2005-01-06
EP1553927B1 (en) 2010-11-10
PT1553927E (pt) 2010-11-22
SI1553927T1 (sl) 2010-12-31

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