CA2470122C - Encapsulated inorganic antimicrobial additive for controlled release - Google Patents
Encapsulated inorganic antimicrobial additive for controlled release Download PDFInfo
- Publication number
- CA2470122C CA2470122C CA2470122A CA2470122A CA2470122C CA 2470122 C CA2470122 C CA 2470122C CA 2470122 A CA2470122 A CA 2470122A CA 2470122 A CA2470122 A CA 2470122A CA 2470122 C CA2470122 C CA 2470122C
- Authority
- CA
- Canada
- Prior art keywords
- antimicrobial
- polymer
- hydrophilic polymer
- weight
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 211
- 239000000654 additive Substances 0.000 title claims description 54
- 230000000996 additive effect Effects 0.000 title claims description 53
- 238000013270 controlled release Methods 0.000 title description 6
- 239000004599 antimicrobial Substances 0.000 claims abstract description 161
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 135
- 229920000642 polymer Polymers 0.000 claims abstract description 133
- 239000002245 particle Substances 0.000 claims abstract description 125
- 239000003094 microcapsule Substances 0.000 claims abstract description 85
- 239000000203 mixture Substances 0.000 claims abstract description 69
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 64
- 239000011159 matrix material Substances 0.000 claims abstract description 42
- 238000000034 method Methods 0.000 claims abstract description 38
- 238000000576 coating method Methods 0.000 claims abstract description 32
- 239000002243 precursor Substances 0.000 claims abstract description 22
- 239000011248 coating agent Substances 0.000 claims abstract description 18
- 238000013329 compounding Methods 0.000 claims abstract description 11
- 238000000227 grinding Methods 0.000 claims abstract description 4
- 239000010457 zeolite Substances 0.000 claims description 88
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical group O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 71
- 229910021536 Zeolite Inorganic materials 0.000 claims description 65
- 229910052709 silver Inorganic materials 0.000 claims description 63
- 239000004332 silver Substances 0.000 claims description 63
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 58
- 229910021645 metal ion Inorganic materials 0.000 claims description 57
- -1 silver ions Chemical class 0.000 claims description 25
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical group [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 claims description 22
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- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 12
- 239000012296 anti-solvent Substances 0.000 claims description 12
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- 229920002635 polyurethane Polymers 0.000 claims description 12
- 239000004814 polyurethane Substances 0.000 claims description 12
- LEHFSLREWWMLPU-UHFFFAOYSA-B zirconium(4+);tetraphosphate Chemical class [Zr+4].[Zr+4].[Zr+4].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LEHFSLREWWMLPU-UHFFFAOYSA-B 0.000 claims description 12
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- 239000011701 zinc Substances 0.000 claims description 11
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 6
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- 229910052804 chromium Inorganic materials 0.000 claims description 5
- 239000011651 chromium Substances 0.000 claims description 5
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims description 5
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- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims description 3
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- 125000005442 diisocyanate group Chemical group 0.000 claims description 3
- 239000011133 lead Substances 0.000 claims description 3
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 3
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- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 claims description 3
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- 239000004698 Polyethylene Substances 0.000 claims description 2
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- 239000004793 Polystyrene Substances 0.000 claims description 2
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 claims description 2
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- 239000003822 epoxy resin Substances 0.000 claims description 2
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims description 2
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- 239000002685 polymerization catalyst Substances 0.000 claims 1
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- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
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- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
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- 229940117958 vinyl acetate Drugs 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K9/00—Use of pretreated ingredients
- C08K9/10—Encapsulated ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K9/00—Use of pretreated ingredients
- C08K9/08—Ingredients agglomerated by treatment with a binding agent
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Materials For Medical Uses (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/032,372 US7357949B2 (en) | 2001-12-21 | 2001-12-21 | Encapsulated inorganic antimicrobial additive for controlled release |
| US10/032,372 | 2001-12-21 | ||
| PCT/US2002/039709 WO2003055941A1 (en) | 2001-12-21 | 2002-12-11 | Encapsulated inorganic antimicrobial additive for controlled release |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2470122A1 CA2470122A1 (en) | 2003-07-10 |
| CA2470122C true CA2470122C (en) | 2012-02-14 |
Family
ID=21864610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2470122A Expired - Fee Related CA2470122C (en) | 2001-12-21 | 2002-12-11 | Encapsulated inorganic antimicrobial additive for controlled release |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7357949B2 (https=) |
| EP (1) | EP1456291A1 (https=) |
| JP (1) | JP2005514402A (https=) |
| AU (1) | AU2002351366B2 (https=) |
| CA (1) | CA2470122C (https=) |
| MX (1) | MXPA04006185A (https=) |
| WO (1) | WO2003055941A1 (https=) |
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| AU2002351366B2 (en) | 2007-12-06 |
| MXPA04006185A (es) | 2005-06-20 |
| US7357949B2 (en) | 2008-04-15 |
| JP2005514402A (ja) | 2005-05-19 |
| US7354605B2 (en) | 2008-04-08 |
| EP1456291A1 (en) | 2004-09-15 |
| WO2003055941A1 (en) | 2003-07-10 |
| US20060121078A1 (en) | 2006-06-08 |
| CA2470122A1 (en) | 2003-07-10 |
| US20030118664A1 (en) | 2003-06-26 |
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