CA2469833C - Canine immunoglobulin variable domains, caninized antibodies, and methods for making and using them - Google Patents
Canine immunoglobulin variable domains, caninized antibodies, and methods for making and using them Download PDFInfo
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- CA2469833C CA2469833C CA002469833A CA2469833A CA2469833C CA 2469833 C CA2469833 C CA 2469833C CA 002469833 A CA002469833 A CA 002469833A CA 2469833 A CA2469833 A CA 2469833A CA 2469833 C CA2469833 C CA 2469833C
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- canine
- variable domain
- immunoglobulin
- chain variable
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Classifications
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- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
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- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
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| US34487401P | 2001-12-21 | 2001-12-21 | |
| US60/344,874 | 2001-12-21 | ||
| PCT/US2002/041362 WO2003060080A2 (en) | 2001-12-21 | 2002-12-20 | Canine immunoglobulin variable domains, caninized antibodies, and methods for making and using them |
Publications (2)
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| CA2469833A1 CA2469833A1 (en) | 2003-07-24 |
| CA2469833C true CA2469833C (en) | 2008-05-20 |
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| WO (1) | WO2003060080A2 (enExample) |
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| TR201808537T4 (tr) * | 2004-09-23 | 2018-07-23 | Genentech Inc | Sistein değiştirilmiş antikorlar ve konjugatlar. |
| AU2007230868B2 (en) * | 2006-01-13 | 2012-02-02 | Irm Llc | Antibodies against thymic stromal lymphopoietin receptor for treating allergic diseases |
| NZ584514A (en) | 2007-10-19 | 2012-07-27 | Genentech Inc | Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates |
| HUE028589T2 (en) | 2008-07-10 | 2016-12-28 | Toray Industries | Pharmaceutical preparation for the treatment and prevention of cancer |
| HUE035804T2 (en) * | 2008-07-10 | 2018-05-28 | Toray Industries | Immunity inducing agent and method for detecting cancer |
| WO2010027488A2 (en) | 2008-09-04 | 2010-03-11 | Vet Therapeutics, Inc. | Monoclonal antibodies |
| AU2014200771B2 (en) * | 2008-09-04 | 2016-05-26 | Vet Therapeutics, Inc. | Monoclonal antibodies |
| WO2010110838A2 (en) | 2009-03-25 | 2010-09-30 | Vet Therapeutics Inc. | Antibody constant domain regions and uses thereof |
| WO2010117448A2 (en) * | 2009-04-05 | 2010-10-14 | Provenance Biopharmaceuticals Corp. | Chimeric immunocytokines and methods of use thereof |
| WO2010128372A1 (en) | 2009-05-08 | 2010-11-11 | Allergosystem S.R.L. | A device for protecting pets from allergy |
| PH12018501083A1 (en) | 2010-03-04 | 2019-02-18 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| US9616120B2 (en) * | 2010-03-04 | 2017-04-11 | Vet Therapeutics, Inc. | Monoclonal antibodies directed to CD20 |
| WO2011109108A1 (en) * | 2010-03-04 | 2011-09-09 | Vet Therapeutics Inc. | Monoclonal antibodies directed to cd20 |
| JP2013520999A (ja) * | 2010-03-04 | 2013-06-10 | ベット・セラピューティクス・インコーポレイテッド | Ｃｄ５２に対するモノクローナル抗体 |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| AU2011265054B2 (en) | 2010-06-08 | 2016-09-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| JP6121903B2 (ja) | 2010-08-19 | 2017-04-26 | ゾエティス・ベルジャム・エス・アー | 抗ｎｇｆ抗体およびその使用 |
| GB2528401A (en) * | 2011-05-06 | 2016-01-20 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| CA2835094C (en) * | 2011-05-06 | 2020-12-22 | David Gearing | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| HRP20211869T1 (hr) * | 2011-05-06 | 2022-03-04 | Zoetis Services Llc | Protutijela protiv faktora rasta živca i postupci za njihovu proizvodnju i uporabu |
| KR101783929B1 (ko) * | 2011-05-06 | 2017-10-11 | 넥스베트 오스트레일리아 피티와이 리미티드 | 항신경성 성장 인자 항체 및 그의 제조방법과 이용방법 |
| GB2504889C (en) * | 2011-05-06 | 2015-08-26 | Nvip Pty Ltd | Therapeutic canine immunoglobulins and methods of using the same |
| GB201114858D0 (en) | 2011-08-29 | 2011-10-12 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of using the same |
| ES2758884T3 (es) | 2011-06-24 | 2020-05-06 | Stephen D Gillies | Proteínas de fusión de inmunoglobulina a través de cadena ligera y métodos de uso de ellas |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| HK1201281A1 (en) * | 2011-10-13 | 2015-08-28 | Nexvet Australia Pty Ltd | Canine/feline cd20 binding epitope and compositions for binding thereto |
| WO2013119419A1 (en) | 2012-02-08 | 2013-08-15 | North Carolina State University | Treatment of allergic diseases with recombinant antibodies |
| JP6629069B2 (ja) | 2012-06-06 | 2020-01-15 | ゾエティス・エルエルシー | イヌ化抗ｎｇｆ抗体およびその方法 |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| BR112016014284A2 (pt) | 2013-12-20 | 2017-12-05 | Intervet Int Bv | anticorpo caninizado isolado ou um fragmento de ligação de antígeno do mesmo, ácido nucleico isolado, vetor de expressão, célula hospedeira, composição farmacêutica, e, métodos para aumentar a atividade de uma célula imune e para produzir um anticorpo caninizado ou fragmento de ligação de antígeno do mesmo |
| BR112017003236A2 (pt) | 2014-09-12 | 2017-11-28 | Genentech Inc | anticorpos elaborados com cisteína, conjugados de droga e anticorpos, método de preparação de conjugado de droga e anticorpo e composição farmacêutica |
| US9758575B2 (en) | 2015-04-06 | 2017-09-12 | Yung Shin Pharmaceutical Industrial Co. Ltd. | Antibodies which specifically bind to canine vascular endothelial growth factor and uses thereof |
| WO2017011316A1 (en) | 2015-07-10 | 2017-01-19 | The Trustees Of The University Of Pennsylvania | Treatment of a canine cd20 positive disease or condition using a canine cd20-specific chimeric antigen receptor |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| PT3390451T (pt) * | 2015-12-18 | 2025-03-12 | Intervet Int Bv | Anticorpos humanos caninizados para il-4r alfa humano e canino |
| EP3442574A4 (en) | 2016-04-15 | 2019-12-11 | MacroGenics, Inc. | Novel B7-H3 binding MOLECULES, ANTIBODY-ACTIVE CONJUGATES AND METHOD OF USE THEREOF |
| EP3538558A4 (en) | 2016-11-09 | 2020-07-15 | North Carolina State University | TREATMENT OF ALLERGIC DISEASES USING CHIMERIC PROTEIN |
| WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| GB2561352B (en) * | 2017-04-10 | 2023-01-18 | Genome Res Ltd | Animal models and therapeutic molecules |
| CN111819197B (zh) | 2018-03-12 | 2025-03-11 | 硕腾服务有限责任公司 | 抗ngf抗体及其方法 |
| BR112020017715A2 (pt) | 2018-03-16 | 2020-12-29 | Zoetis Services Llc | Vacinas de peptídeo contra interleucina-31 |
| KR102828306B1 (ko) | 2018-03-16 | 2025-07-01 | 조에티스 서비시즈 엘엘씨 | 수의학적 용도를 위한 인터류킨-31 단클론성 항체 |
| US12060437B2 (en) | 2018-03-23 | 2024-08-13 | North Carolina State University | Methods and compositions for antibody to high affinity receptor for IgE |
| GB2578867A (en) * | 2018-10-09 | 2020-06-03 | Genome Res Ltd | Animal models and therapeutic molecules |
| KR102885855B1 (ko) | 2018-11-19 | 2025-11-14 | 바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 | 항-pd-1 항체 및 이의 용도 |
| US20220119502A1 (en) * | 2019-02-28 | 2022-04-21 | Ann And Robert H. Lurie Children's Hospital Of Chicago | Kawasaki disease antibodies identify hepacivirus peptides |
| BR112022000604A2 (pt) * | 2019-07-15 | 2022-03-03 | Intervet Int Bv | Anticorpos caninizados para ctla-4 humana |
| US12435143B2 (en) | 2019-07-15 | 2025-10-07 | Intervet Inc. | Caninized antibodies against canine CTLA-4 |
| US20220324960A1 (en) * | 2019-08-29 | 2022-10-13 | Kindred Biosciences, Inc. | Anti-IL31 Antibodies for Veterinary Use |
| US20220119513A1 (en) | 2020-06-08 | 2022-04-21 | Zoetis Services Llc | Anti-tgfb antibodies and therapeutic uses thereof |
| EP4225788A2 (en) | 2020-10-07 | 2023-08-16 | Zoetis Services LLC | Anti-ngf antibodies and methods of use thereof |
| WO2022226102A1 (en) * | 2021-04-21 | 2022-10-27 | The Trustees Of The University Of Pennsylvania | Canine monoclonal antibodies against canine cytotoxic t lymphocyte associated protein 4 (ctla-4) |
| US20230192834A1 (en) * | 2021-09-27 | 2023-06-22 | Zoetis Services Llc | Anti- tgfb1,2,3 antibodies and therapeutic uses thereof |
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| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| JP2837240B2 (ja) | 1990-06-07 | 1998-12-14 | 財団法人化学及血清療法研究所 | イヌ免疫グロブリンγ鎖の定常領域をコードする遺伝子断片およびマウス×イヌキメラ抗体 |
| AU640397B2 (en) | 1989-08-25 | 1993-08-26 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Dog-mouse heterohybridoma and gene fragment coding for constant region of canine immunoglobulin |
| JP2811096B2 (ja) | 1989-09-30 | 1998-10-15 | 財団法人化学及血清療法研究所 | イヌ免疫グロブリンκ鎖の定常領域をコードする遺伝子断片およびマウス×イヌキメラ抗体 |
| JP2811089B2 (ja) | 1989-08-25 | 1998-10-15 | 財団法人化学及血清療法研究所 | イヌ×マウスヘテロハイブリドーマおよびイヌ免疫グロブリンλ鎖の定常領域をコードする遺伝子断片 |
| US5330883A (en) | 1992-06-29 | 1994-07-19 | Lsi Logic Corporation | Techniques for uniformizing photoresist thickness and critical dimension of underlying features |
| US5622842A (en) | 1994-11-09 | 1997-04-22 | Merck & Co., Inc. | DNA encoding canine immunoglobulin A |
| WO1997020859A1 (en) * | 1995-12-08 | 1997-06-12 | Idexx Laboratories, Inc. | Methods and compositions concerning allergy in dogs |
| JPH09169795A (ja) | 1995-12-22 | 1997-06-30 | Hitachi Chem Co Ltd | イヌ免疫グロブリンｅペプチド断片、それをコードするｄｎａ、そのｄｎａを含む組換えベクター、その組換えベクターを含む形質転換体及び抗イヌ免疫グロブリンｅ抗体の製造法 |
| US6504013B1 (en) * | 2000-02-01 | 2003-01-07 | Idexx Laboratories, Inc. | Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody |
| DE69922873T2 (de) * | 1998-04-09 | 2005-12-29 | Idexx Laboratories, Inc. | Spezifische Bindungsproteine zur Behandlung von Allergien beim Hund |
| AU2001253282A1 (en) * | 2000-04-07 | 2001-10-23 | Heska Corporation | Compositions and methods related to canine igg and canine il-13 receptors |
-
2002
- 2002-12-20 WO PCT/US2002/041362 patent/WO2003060080A2/en not_active Ceased
- 2002-12-20 US US10/327,598 patent/US7261890B2/en not_active Expired - Fee Related
- 2002-12-20 EP EP02794415A patent/EP1485126A4/en not_active Withdrawn
- 2002-12-20 JP JP2003560167A patent/JP2005514063A/ja active Pending
- 2002-12-20 AU AU2002359851A patent/AU2002359851A1/en not_active Abandoned
- 2002-12-20 CA CA002469833A patent/CA2469833C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003060080A2 (en) | 2003-07-24 |
| EP1485126A4 (en) | 2007-03-21 |
| AU2002359851A8 (en) | 2003-07-30 |
| US7261890B2 (en) | 2007-08-28 |
| JP2005514063A (ja) | 2005-05-19 |
| CA2469833A1 (en) | 2003-07-24 |
| US20040181039A1 (en) | 2004-09-16 |
| EP1485126A2 (en) | 2004-12-15 |
| WO2003060080A3 (en) | 2004-02-12 |
| AU2002359851A1 (en) | 2003-07-30 |
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