CA2468771C - Pharmaceutical composition for use in ophthalmology and rhinology - Google Patents
Pharmaceutical composition for use in ophthalmology and rhinology Download PDFInfo
- Publication number
- CA2468771C CA2468771C CA002468771A CA2468771A CA2468771C CA 2468771 C CA2468771 C CA 2468771C CA 002468771 A CA002468771 A CA 002468771A CA 2468771 A CA2468771 A CA 2468771A CA 2468771 C CA2468771 C CA 2468771C
- Authority
- CA
- Canada
- Prior art keywords
- use according
- pharmaceutical composition
- hyaluronate
- weight
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 61
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 50
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims abstract description 50
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 50
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 50
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims abstract description 36
- 229940014041 hyaluronate Drugs 0.000 claims abstract description 36
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 33
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 26
- 239000011619 pantothenol Substances 0.000 claims abstract description 26
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229940101267 panthenol Drugs 0.000 claims abstract description 25
- 235000019161 pantothenic acid Nutrition 0.000 claims abstract description 25
- 239000011713 pantothenic acid Substances 0.000 claims abstract description 25
- 229940055726 pantothenic acid Drugs 0.000 claims abstract description 25
- 230000007257 malfunction Effects 0.000 claims abstract description 13
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 4
- 210000004400 mucous membrane Anatomy 0.000 claims description 28
- 210000004087 cornea Anatomy 0.000 claims description 17
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 15
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 15
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical group [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 15
- 239000000243 solution Substances 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 206010039083 rhinitis Diseases 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 208000021386 Sjogren Syndrome Diseases 0.000 claims description 7
- 235000004866 D-panthenol Nutrition 0.000 claims description 6
- 239000011703 D-panthenol Substances 0.000 claims description 6
- 206010039705 Scleritis Diseases 0.000 claims description 6
- 229960003949 dexpanthenol Drugs 0.000 claims description 6
- 239000002674 ointment Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 239000000499 gel Substances 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 238000009736 wetting Methods 0.000 claims description 5
- 206010010741 Conjunctivitis Diseases 0.000 claims description 4
- 206010015084 Episcleritis Diseases 0.000 claims description 4
- 239000000872 buffer Substances 0.000 claims description 4
- 201000009151 chronic rhinitis Diseases 0.000 claims description 3
- 210000000795 conjunctiva Anatomy 0.000 claims description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 239000006072 paste Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 206010057380 Allergic keratitis Diseases 0.000 claims description 2
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 206010069664 atopic keratoconjunctivitis Diseases 0.000 claims description 2
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 2
- 229960002079 calcium pantothenate Drugs 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 201000000942 orbital tenonitis Diseases 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- GQTHJBOWLPZUOI-FJXQXJEOSA-M sodium D-pantothenate Chemical group [Na+].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O GQTHJBOWLPZUOI-FJXQXJEOSA-M 0.000 claims description 2
- 229940068459 sodium pantothenate Drugs 0.000 claims description 2
- 230000007480 spreading Effects 0.000 claims description 2
- 238000003892 spreading Methods 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 239000000080 wetting agent Substances 0.000 claims description 2
- 210000001508 eye Anatomy 0.000 description 55
- 210000001331 nose Anatomy 0.000 description 24
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 12
- 206010013774 Dry eye Diseases 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 210000000981 epithelium Anatomy 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 208000011580 syndromic disease Diseases 0.000 description 9
- 239000003889 eye drop Substances 0.000 description 8
- 229940012356 eye drops Drugs 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 230000006378 damage Effects 0.000 description 7
- 238000002560 therapeutic procedure Methods 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 6
- 210000000744 eyelid Anatomy 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 230000003902 lesion Effects 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 239000007921 spray Substances 0.000 description 5
- 230000029663 wound healing Effects 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- -1 formaldehyde, sulphur oxides Chemical class 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 238000010008 shearing Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 239000004166 Lanolin Substances 0.000 description 3
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 208000027720 dry mucous membrane Diseases 0.000 description 3
- 239000003885 eye ointment Substances 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 231100001032 irritation of the eye Toxicity 0.000 description 3
- 235000019388 lanolin Nutrition 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 229940100662 nasal drops Drugs 0.000 description 3
- MWUXSHHQAYIFBG-UHFFFAOYSA-N nitrogen oxide Inorganic materials O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000012188 paraffin wax Substances 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000004397 blinking Effects 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000000644 isotonic solution Substances 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000007922 nasal spray Substances 0.000 description 2
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- JDEUUKYNTHHAQH-UHFFFAOYSA-N 2,2-dimethylbutanamide Chemical compound CCC(C)(C)C(N)=O JDEUUKYNTHHAQH-UHFFFAOYSA-N 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000561734 Celosia cristata Species 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010041235 Snoring Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- QEVGBDAVCSPCLP-UHFFFAOYSA-N acetic acid;boric acid Chemical compound CC(O)=O.OB(O)O QEVGBDAVCSPCLP-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 239000000607 artificial tear Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000004321 blink reflex Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 210000001520 comb Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000002900 effect on cell Effects 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 210000005081 epithelial layer Anatomy 0.000 description 1
- 210000003560 epithelium corneal Anatomy 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000000110 microvilli Anatomy 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 210000000492 nasalseptum Anatomy 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 239000012748 slip agent Substances 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000004489 tear production Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10161110A DE10161110A1 (de) | 2001-12-12 | 2001-12-12 | Pharmazeutische Zusammensetzung zur ophthalmologischen und rhinologischen Anwendung |
| DE10161110.2 | 2001-12-12 | ||
| PCT/DE2002/004527 WO2003049747A1 (de) | 2001-12-12 | 2002-12-11 | Pharmazeutische zusammensetzung zur ophtalmologischen und rhinologischen anwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2468771A1 CA2468771A1 (en) | 2003-06-19 |
| CA2468771C true CA2468771C (en) | 2007-01-30 |
Family
ID=7708986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002468771A Expired - Lifetime CA2468771C (en) | 2001-12-12 | 2002-12-11 | Pharmaceutical composition for use in ophthalmology and rhinology |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20050164979A1 (enExample) |
| EP (1) | EP1455803B2 (enExample) |
| JP (1) | JP3994089B2 (enExample) |
| CN (1) | CN1310651C (enExample) |
| AT (1) | ATE300306T1 (enExample) |
| AU (1) | AU2002360895A1 (enExample) |
| CA (1) | CA2468771C (enExample) |
| DE (2) | DE10161110A1 (enExample) |
| ES (1) | ES2244831T5 (enExample) |
| MX (1) | MXPA04005387A (enExample) |
| WO (1) | WO2003049747A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE20318634U1 (de) | 2003-11-13 | 2004-02-26 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Pharmazeutische Zusammensetzung zur Behandlung von Rhinitiden |
| DE102004002001A1 (de) * | 2004-01-14 | 2005-08-11 | Reinmüller, Johannes, Dr.med. | Mittel zur Behandlung von entzündlichen Erkrankungen |
| CN1285382C (zh) * | 2004-12-20 | 2006-11-22 | 凌沛学 | 含海藻糖和玻璃酸的鼻腔用药传递系统及其制备方法 |
| DE102005055275A1 (de) * | 2005-11-17 | 2007-05-24 | Ursapharm Arzneimittel Gmbh & Co. Kg | Phosphatfreie pharmazeutische Zusammensetzung sowie deren Verwendung |
| MX2009000885A (es) | 2006-07-25 | 2009-02-05 | Osmotica Corp | Soluciones oftalmicas. |
| WO2008068866A1 (en) * | 2006-11-30 | 2008-06-12 | Menicon Co., Ltd. | Ophthalmic composition |
| KR100927579B1 (ko) * | 2006-12-13 | 2009-11-23 | 주식회사 엘지생명과학 | 히아루론산 및/또는 그것의 염을 함유하는 아토피성피부염의 개선 및 치료를 위한 조성물 |
| FR2919185B1 (fr) | 2007-07-23 | 2010-09-10 | Ard Sa | Utilisation d'acide hyaluronique pour la preparation de compositions destinees a l'amelioration notamment de l'etat des muqueuses |
| DE202008016517U1 (de) * | 2008-12-12 | 2009-03-05 | Ratiopharm Gmbh | Wässrige Zusammensetzung enthaltend Dexpanthenol und Natriumchlorid |
| US9473792B2 (en) * | 2009-11-06 | 2016-10-18 | Texas Instruments Incorporated | Method and system to improve the performance of a video encoder |
| FR2962044B1 (fr) * | 2010-04-21 | 2013-02-22 | Horus Pharma | Emulsion lacrymimetique |
| JP2013534527A (ja) * | 2010-07-02 | 2013-09-05 | ブライエン ホールデン ビジョン インスティテュート | コンタクトレンズ乳頭結膜炎及びアレルギー性眼疾患の予防及び処置のための組成物 |
| DE202010012255U1 (de) * | 2010-09-07 | 2010-11-18 | Krewel Meuselbach Gmbh | Nasenspray |
| WO2012119261A1 (en) * | 2011-03-10 | 2012-09-13 | Biocia Inc. | Enhanced artificial mucus composition comprising hyaluronan for the treatment of rhinitis |
| CN102579478A (zh) * | 2012-03-30 | 2012-07-18 | 济南康众医药科技开发有限公司 | 玻璃酸钠在制备药物中的应用 |
| DE102012011447B4 (de) | 2012-05-14 | 2022-11-24 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Verwendung von Pantothenol oder Pantothensäure in einem Kombinationstherapeutikum für die Behandlung von Rhinitis zur Verringerung der systemischen Resorption imidazolinbasierter alpha-Sympathomimetika |
| EP2664330A1 (de) * | 2012-05-15 | 2013-11-20 | F. Holzer GmbH | Zusammensetzung und Arzneimittel enthaltend Omega-3-Fettsäuren sowie einen Glucosaminoglucan |
| CN102989045B (zh) * | 2012-11-12 | 2015-02-25 | 广州共禾医药科技有限公司 | 生物相容的水性组合物及其用途 |
| CA2945604C (en) * | 2014-08-08 | 2022-08-23 | Shenzhen Hightide Biopharmaceutical, Ltd. | Liquid formulation compositions, medicament delivery devices, and methods of preparation and use thereof |
| EP2985019B1 (en) | 2014-08-16 | 2021-10-20 | Church & Dwight Co., Inc. | Nasal composition having anti-viral properties |
| EP2985027B1 (en) | 2014-08-16 | 2021-03-31 | Church & Dwight Co., Inc. | Nasal composition comprising mixture of hyaluronic acids and saline solution |
| ES2827426T3 (es) | 2015-03-26 | 2021-05-21 | Dmg Italia Srl | Composición oftálmica para la protección corneal |
| DE102016203696A1 (de) * | 2016-03-07 | 2017-09-07 | Ursapharm Arzneimittel Gmbh | Ophthalmologische Zusammensetzung |
| DE102016204472A1 (de) * | 2016-03-17 | 2017-09-21 | Ursapharm Arzneimittel Gmbh | Kit zur kosmetischen Behandlung des Auges und der Haut und Kosmetikum zur Anwendung am Auge und auf der Haut |
| TWI609957B (zh) * | 2016-06-27 | 2018-01-01 | 晶碩光學股份有限公司 | 用以處理隱形眼鏡之溶液及隱形眼鏡的包裝系統 |
| JP7044467B2 (ja) * | 2017-01-16 | 2022-03-30 | ロート製薬株式会社 | 眼科組成物 |
| DE202017104738U1 (de) * | 2017-07-31 | 2018-08-01 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Neue Zusammensetzung für die nasale Applikation |
| CN107260657B (zh) * | 2017-08-03 | 2019-02-05 | 广东莱恩医药研究院有限公司 | 一种缓释型连翘苷滴眼液及其制备方法 |
| ES2972897T3 (es) * | 2017-08-10 | 2024-06-17 | Elixir Ilac Arastirma Ve Gelistirme A S | Composiciones descongestionantes nasales que comprenden mentol, dexpantenol e hialuronato de sodio |
| WO2019202017A1 (en) * | 2018-04-18 | 2019-10-24 | i.com medical GmbH | High molecular weight hyaluronic acid for treatment and prevention of severe ocular surface disease |
| EP3781116A1 (en) * | 2018-04-18 | 2021-02-24 | i.com Medical GmbH | High molecular weight hyaluronic acid for enhancing epithelial survival and reconstitution of body surfaces |
| US11576926B2 (en) * | 2018-09-12 | 2023-02-14 | Neilos S.r.l. | Composition for use in the prevention and/or treatment of epistaxis |
| US12268706B2 (en) | 2019-01-31 | 2025-04-08 | i.com medical GmbH | Hyaluronic acid for relief of idiopathic ocular pain |
| EP3827818A1 (en) * | 2019-11-26 | 2021-06-02 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic composition |
| CN112870216A (zh) * | 2021-01-29 | 2021-06-01 | 张宽才 | 一种药物组合物及制剂和用途 |
| EP4039248A1 (en) * | 2021-02-04 | 2022-08-10 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic composition |
| FR3151481A1 (fr) * | 2023-07-28 | 2025-01-31 | Horus Pharma | Emulsion de type huile dans eau comprenant de l’acide hyaluronique et du dexpanthenol |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| JPS6479103A (en) * | 1987-06-09 | 1989-03-24 | Lion Corp | External preparation |
| DE3832401A1 (de) † | 1988-09-23 | 1990-03-29 | Cassella Ag | Pharmazeutische zubereitung zur behandlung entzuendeter nasenschleimhaeute |
| US5141741A (en) * | 1988-12-09 | 1992-08-25 | Lion Corporation | Anti-sunburn skin-care preparation |
| IL101056A (en) † | 1992-02-24 | 1997-03-18 | Res & Dev Co Ltd | Composition for nasal treatment |
| IT1273011B (it) * | 1994-07-25 | 1997-07-01 | Trhecnopharma S A | Preparato oftalmico per l'uso come lacrima artificiale |
| DE19517251A1 (de) * | 1995-05-11 | 1996-11-14 | Klosterfrau Mcm Vetrieb Gmbh | Verwendung von Dexpanthenol zur Behandlung trockener Nasenschleimhäute |
| DE19541919C2 (de) † | 1995-11-10 | 1997-11-20 | Klosterfrau Mcm Vetrieb Gmbh | Pharmazeutische Zubereitung zur Behandlung akuter Rhinitiden |
| DE19549421C2 (de) † | 1995-11-10 | 1999-11-18 | Klosterfrau Mcm Vetrieb Gmbh | Pharmazeutische Zubereitung zur Behandlung akuter Rhinitiden |
| KR100514963B1 (ko) * | 1997-07-11 | 2005-09-15 | 도레이 가부시끼가이샤 | 4,5-에폭시모르피난 유도체를 함유하는 안정한 의약품 조성물 |
| DE19923829A1 (de) * | 1999-05-17 | 2000-11-23 | Ulrich Kluegel | Hyaluronat-Wirkstoff-Wasser-Komplex, dessen Herstellung und Verwendung |
| PL198969B1 (pl) * | 2001-01-09 | 2008-08-29 | Louis Johan Wagenaar | Zastosowanie dekspantenolu jako składnika kompozycji do pielęgnacji soczewek kontaktowych |
-
2001
- 2001-12-12 DE DE10161110A patent/DE10161110A1/de not_active Ceased
-
2002
- 2002-12-11 AU AU2002360895A patent/AU2002360895A1/en not_active Abandoned
- 2002-12-11 MX MXPA04005387A patent/MXPA04005387A/es active IP Right Grant
- 2002-12-11 WO PCT/DE2002/004527 patent/WO2003049747A1/de not_active Ceased
- 2002-12-11 AT AT02794984T patent/ATE300306T1/de active
- 2002-12-11 JP JP2003550796A patent/JP3994089B2/ja not_active Expired - Lifetime
- 2002-12-11 US US10/496,456 patent/US20050164979A1/en not_active Abandoned
- 2002-12-11 CN CNB028248309A patent/CN1310651C/zh not_active Expired - Lifetime
- 2002-12-11 EP EP02794984.1A patent/EP1455803B2/de not_active Expired - Lifetime
- 2002-12-11 DE DE50203788T patent/DE50203788D1/de not_active Expired - Lifetime
- 2002-12-11 CA CA002468771A patent/CA2468771C/en not_active Expired - Lifetime
- 2002-12-11 ES ES02794984.1T patent/ES2244831T5/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04005387A (es) | 2005-03-23 |
| CN1602198A (zh) | 2005-03-30 |
| ES2244831T3 (es) | 2005-12-16 |
| JP3994089B2 (ja) | 2007-10-17 |
| WO2003049747A8 (de) | 2003-10-02 |
| CA2468771A1 (en) | 2003-06-19 |
| DE50203788D1 (de) | 2005-09-01 |
| EP1455803A1 (de) | 2004-09-15 |
| US20050164979A1 (en) | 2005-07-28 |
| DE10161110A1 (de) | 2003-06-26 |
| EP1455803B2 (de) | 2016-03-23 |
| ATE300306T1 (de) | 2005-08-15 |
| JP2006501133A (ja) | 2006-01-12 |
| ES2244831T5 (es) | 2016-05-10 |
| EP1455803B1 (de) | 2005-07-27 |
| CN1310651C (zh) | 2007-04-18 |
| AU2002360895A1 (en) | 2003-06-23 |
| WO2003049747A1 (de) | 2003-06-19 |
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