CA2437940C - Methods of treating diabetes mellitus - Google Patents
Methods of treating diabetes mellitus Download PDFInfo
- Publication number
- CA2437940C CA2437940C CA2437940A CA2437940A CA2437940C CA 2437940 C CA2437940 C CA 2437940C CA 2437940 A CA2437940 A CA 2437940A CA 2437940 A CA2437940 A CA 2437940A CA 2437940 C CA2437940 C CA 2437940C
- Authority
- CA
- Canada
- Prior art keywords
- insulin
- moiety
- human
- polypeptide
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 89
- 238000000034 method Methods 0.000 title claims abstract description 88
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract description 695
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 89
- 239000008103 glucose Substances 0.000 claims description 86
- 239000000203 mixture Substances 0.000 claims description 74
- 125000000217 alkyl group Chemical group 0.000 claims description 68
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- 125000003827 glycol group Chemical group 0.000 claims description 51
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 35
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- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical group C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 claims description 30
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- 101000976075 Homo sapiens Insulin Proteins 0.000 claims description 23
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- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 11
- 239000004026 insulin derivative Substances 0.000 claims description 11
- 229920000642 polymer Polymers 0.000 claims description 10
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 10
- GNVMUORYQLCPJZ-UHFFFAOYSA-M Thiocarbamate Chemical group NC([S-])=O GNVMUORYQLCPJZ-UHFFFAOYSA-M 0.000 claims description 9
- 230000002194 synthesizing effect Effects 0.000 claims description 9
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- 229940079593 drug Drugs 0.000 abstract description 62
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- 230000014101 glucose homeostasis Effects 0.000 abstract description 10
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 83
- -1 but not limited to Chemical compound 0.000 description 60
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 39
- 125000004432 carbon atom Chemical group C* 0.000 description 34
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 27
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
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- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
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- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
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- Neurosurgery (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26919801P | 2001-02-15 | 2001-02-15 | |
| US60/269,198 | 2001-02-15 | ||
| US34771302P | 2002-01-11 | 2002-01-11 | |
| US60/347,713 | 2002-01-11 | ||
| PCT/US2002/004440 WO2002065985A2 (en) | 2001-02-15 | 2002-02-14 | Methods of treating diabetes mellitus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2437940A1 CA2437940A1 (en) | 2002-08-29 |
| CA2437940C true CA2437940C (en) | 2012-07-10 |
Family
ID=26953561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2437940A Expired - Lifetime CA2437940C (en) | 2001-02-15 | 2002-02-14 | Methods of treating diabetes mellitus |
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| US (3) | US7060675B2 (enExample) |
| EP (1) | EP1409006B1 (enExample) |
| JP (1) | JP4113778B2 (enExample) |
| KR (1) | KR100896945B1 (enExample) |
| AT (1) | ATE503490T1 (enExample) |
| AU (1) | AU2002244020B2 (enExample) |
| BR (1) | BRPI0207700B8 (enExample) |
| CA (1) | CA2437940C (enExample) |
| CY (1) | CY1112034T1 (enExample) |
| DE (1) | DE60239612D1 (enExample) |
| DK (1) | DK1409006T3 (enExample) |
| MX (1) | MXPA03007374A (enExample) |
| NO (1) | NO327586B1 (enExample) |
| NZ (1) | NZ527392A (enExample) |
| PT (1) | PT1409006E (enExample) |
| WO (1) | WO2002065985A2 (enExample) |
| ZA (1) | ZA200306332B (enExample) |
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2002
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- 2002-02-14 KR KR1020037010645A patent/KR100896945B1/ko not_active Expired - Lifetime
- 2002-02-14 DK DK02709541.3T patent/DK1409006T3/da active
- 2002-02-14 MX MXPA03007374A patent/MXPA03007374A/es active IP Right Grant
- 2002-02-14 AT AT02709541T patent/ATE503490T1/de active
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- 2002-02-14 BR BRPI0207700A patent/BRPI0207700B8/pt not_active IP Right Cessation
- 2002-02-14 WO PCT/US2002/004440 patent/WO2002065985A2/en not_active Ceased
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|---|---|
| US7423014B2 (en) | 2008-09-09 |
| US20030050228A1 (en) | 2003-03-13 |
| DE60239612D1 (de) | 2011-05-12 |
| ZA200306332B (en) | 2005-07-27 |
| US7060675B2 (en) | 2006-06-13 |
| CY1112034T1 (el) | 2015-11-04 |
| KR100896945B1 (ko) | 2009-05-14 |
| EP1409006B1 (en) | 2011-03-30 |
| CA2437940A1 (en) | 2002-08-29 |
| JP4113778B2 (ja) | 2008-07-09 |
| NO327586B1 (no) | 2009-08-24 |
| WO2002065985A2 (en) | 2002-08-29 |
| ATE503490T1 (de) | 2011-04-15 |
| US7381702B2 (en) | 2008-06-03 |
| NZ527392A (en) | 2008-01-31 |
| BRPI0207700B8 (pt) | 2021-05-25 |
| DK1409006T3 (da) | 2011-06-14 |
| BR0207700A (pt) | 2005-07-19 |
| NO20033617L (no) | 2003-10-15 |
| US20060100137A1 (en) | 2006-05-11 |
| EP1409006A4 (en) | 2005-01-19 |
| MXPA03007374A (es) | 2003-12-04 |
| NO20033617D0 (no) | 2003-08-14 |
| AU2002244020B2 (en) | 2007-08-16 |
| EP1409006A2 (en) | 2004-04-21 |
| KR20040043113A (ko) | 2004-05-22 |
| PT1409006E (pt) | 2011-07-01 |
| BRPI0207700B1 (pt) | 2016-06-07 |
| JP2004527487A (ja) | 2004-09-09 |
| WO2002065985A3 (en) | 2004-02-19 |
| US20060293219A1 (en) | 2006-12-28 |
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