PT1660047E - Formulação de dosagem sólida de sais de ácidos gordos em micropartículas para agentes terapêuticos - Google Patents

Formulação de dosagem sólida de sais de ácidos gordos em micropartículas para agentes terapêuticos Download PDF

Info

Publication number
PT1660047E
PT1660047E PT47811393T PT04781139T PT1660047E PT 1660047 E PT1660047 E PT 1660047E PT 47811393 T PT47811393 T PT 47811393T PT 04781139 T PT04781139 T PT 04781139T PT 1660047 E PT1660047 E PT 1660047E
Authority
PT
Portugal
Prior art keywords
micro
fatty acid
therapeutic agents
acid salt
solid dosage
Prior art date
Application number
PT47811393T
Other languages
English (en)
Inventor
Richard Soltero
Foyeke Opawale
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Publication of PT1660047E publication Critical patent/PT1660047E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT47811393T 2003-08-13 2004-08-13 Formulação de dosagem sólida de sais de ácidos gordos em micropartículas para agentes terapêuticos PT1660047E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49482103P 2003-08-13 2003-08-13

Publications (1)

Publication Number Publication Date
PT1660047E true PT1660047E (pt) 2014-02-27

Family

ID=34193244

Family Applications (1)

Application Number Title Priority Date Filing Date
PT47811393T PT1660047E (pt) 2003-08-13 2004-08-13 Formulação de dosagem sólida de sais de ácidos gordos em micropartículas para agentes terapêuticos

Country Status (12)

Country Link
US (1) US7635675B2 (pt)
EP (1) EP1660047B1 (pt)
JP (1) JP4880461B2 (pt)
KR (1) KR101152470B1 (pt)
CN (2) CN102552917A (pt)
AU (1) AU2004264958B2 (pt)
CA (1) CA2535013C (pt)
DK (1) DK1660047T3 (pt)
ES (1) ES2445947T3 (pt)
PL (1) PL1660047T3 (pt)
PT (1) PT1660047E (pt)
WO (1) WO2005016312A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090281023A9 (en) * 2001-06-04 2009-11-12 Nobex Corporation Mixtures Of Calcitonin Drug-Oligomer Conjugates And Methods Of Use In Pain Treatment
CN105801686B (zh) 2004-07-19 2020-04-07 比奥孔有限公司 胰岛素-低聚物共轭物、制剂及其用途
WO2007006320A1 (en) * 2005-07-12 2007-01-18 Sherine Hassan Abbas Helmy Drinkable oral insulin liquid and capsules
ES2546016T3 (es) 2005-10-13 2015-09-17 Biocon Limited Procedimiento para la preparación de conjugados de insulina
CN101541830A (zh) 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 蛋白酶抗性的胰岛素类似物
EP2152245B1 (en) 2007-04-30 2015-12-02 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US9241908B2 (en) 2007-10-16 2016-01-26 Biocon Limited Orally administrable solid pharmaceutical composition and a process thereof
US9260502B2 (en) 2008-03-14 2016-02-16 Novo Nordisk A/S Protease-stabilized insulin analogues
RU2571857C2 (ru) 2008-03-18 2015-12-20 Ново Нордиск А/С Стабилизированные по отношению к протеазам ацилированные аналоги инсулина
CA2723541A1 (en) * 2008-05-07 2009-11-12 Merrion Research Iii Limited Compositions of peptides and processes of preparation thereof
EP2334335A1 (en) * 2008-09-19 2011-06-22 Nektar Therapeutics Polymer conjugates of cd-np peptides
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
EP2720711A1 (en) 2011-06-15 2014-04-23 Novo Nordisk A/S Multi substituted insulins
CA2870313A1 (en) 2012-04-11 2013-10-17 Novo Nordisk A/S Insulin formulations
HUE036702T2 (hu) 2013-10-07 2018-07-30 Novo Nordisk As Inzulinanalóg új származéka
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
JP7211704B2 (ja) 2015-01-29 2023-01-24 ノヴォ ノルディスク アー／エス Ｇｌｐ－１アゴニスト及び腸溶コーティングを含む錠剤
EP3250225A1 (en) * 2015-01-29 2017-12-06 Novo Nordisk A/S Pharmaceutical composition for oral insulin administration comprising a tablet core and a polyvinyl alcohol coating
US9907323B2 (en) 2015-09-25 2018-03-06 Mead Johnson Nutrition Co. Infant formula tablets
TWI700091B (zh) 2016-12-16 2020-08-01 丹麥商諾佛 儂迪克股份有限公司 含胰島素醫藥組成物

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US187536A (en) * 1877-02-20 Improvement in discharge-nozzles for graiw-eievators
US3957662A (en) * 1972-08-08 1976-05-18 Hoffmann-La Roche Inc. Pharmaceutical lubricants
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS597683B2 (ja) 1976-06-23 1984-02-20 山之内製薬株式会社 顆粒剤
JPS55153712A (en) 1979-05-18 1980-11-29 Kao Corp Insulin pharmaceutical preparation and its production
JPS56131514A (en) 1980-03-17 1981-10-15 Nissan Chem Ind Ltd Ketoprofen composition for rectum administration
JPS5764610A (en) 1980-10-08 1982-04-19 Fujisawa Pharmaceut Co Ltd Pharmaceutical for rectal administration
JPS5764609A (en) 1980-10-09 1982-04-19 Nissan Chem Ind Ltd Cyclophosphamide composition for rectal administration
US4310543A (en) 1980-10-09 1982-01-12 Hoffmann-La Roche Inc. Prostaglandin compositions
JPS57158719A (en) 1981-03-24 1982-09-30 Fujisawa Pharmaceut Co Ltd Rectal administration pharmaceutical
JPS5813508A (ja) 1981-07-14 1983-01-26 Taiho Yakuhin Kogyo Kk ポリグリセロール飽和脂肪酸エステルを含む経口薬剤組成物
JPS58206515A (ja) 1982-05-25 1983-12-01 Fujisawa Pharmaceut Co Ltd 硬カプセル剤
US4704284A (en) 1982-08-12 1987-11-03 Pfizer Inc. Long-acting matrix tablet formulations
JPS5951223A (ja) 1982-09-17 1984-03-24 Sumitomo Chem Co Ltd 製剤組成物
US4439420A (en) * 1982-11-16 1984-03-27 Ethicon, Inc. Absorbable hemostatic composition
JPS59148735A (ja) 1983-02-14 1984-08-25 Fujisawa Pharmaceut Co Ltd ユビデカレノン組成物
JPS59175433A (ja) 1983-03-24 1984-10-04 Kanegafuchi Chem Ind Co Ltd Ｓ−アデノシル−ｌ−メチオニン含有組成物
JPS60146825A (ja) 1984-01-10 1985-08-02 Asahi Chem Ind Co Ltd 経口医薬製剤
JPS60214735A (ja) 1984-04-06 1985-10-28 Morishita Seiyaku Kk 脂肪酸の直腸投与組成物
JPS60218318A (ja) 1984-04-16 1985-11-01 Ss Pharmaceut Co Ltd 軟カプセル充填用組成物
JPS6112632A (ja) 1984-06-27 1986-01-21 Eisai Co Ltd 脂溶性薬剤含有組成物
JPS6176416A (ja) 1984-09-20 1986-04-18 Fujimoto Seiyaku Kk 活性型ビタミンｄ↓３誘導体のカプセル剤用組成物
JPS61233625A (ja) 1985-04-08 1986-10-17 Sanraku Inc γ−リノレン酸含有油脂組成物
NL8600050A (nl) 1986-01-13 1987-08-03 Sanico Nv Farmaceutisch preparaat met vertraagde afgifte van het werkzame bestanddeel en werkwijze voor de bereiding er van.
ZA87279B (en) 1986-01-17 1987-09-30 Chugai Pharmaceutical Co Ltd Method for production of stable nicorandil preparation
US5140021A (en) 1986-04-16 1992-08-18 Genesis Systems Corporation Method and dosage form for treatment of premenstrual syndrome
JPS6317821A (ja) 1986-07-11 1988-01-25 Taisho Pharmaceut Co Ltd 矯味経口製剤
GB8628359D0 (en) * 1986-11-27 1986-12-31 Zyma Sa Galenical formulation
DK130287D0 (da) * 1987-03-13 1987-03-13 Benzon As Alfred Oralt praeparat
JPS63280017A (ja) 1987-05-13 1988-11-17 R P Shiila- Kk 軟カプセル用の皮膜組成物
JPS6419018A (en) 1987-07-14 1989-01-23 Nippon Oils & Fats Co Ltd Cholesterol depressing agent
US4900734A (en) 1987-08-27 1990-02-13 Maxson Wayne S Novel pharmaceutical composition containing estradiol and progesterone for oral administration
CA1321994C (en) 1987-10-28 1993-09-07 Reid Von Borstel Acylated uridine and cytidine and uses thereof
JPH01224315A (ja) 1988-03-04 1989-09-07 Green Cross Corp:The 医薬組成物
JP2677613B2 (ja) 1988-06-24 1997-11-17 エーザイ株式会社 ビタミンｅ又はその誘導体の吸収促進組成物
US4908210A (en) 1988-10-28 1990-03-13 Eastman Kodak Company Lactylic salt tablet formulations and tablets
JP2818220B2 (ja) 1988-11-04 1998-10-30 フロイント産業株式会社 食品用の含水有機溶剤抽出物含有組成物および医薬用の含水有機溶剤抽出物含有組成物、並びにそれらの製造方法
GB8904182D0 (en) 1989-02-23 1989-04-05 Glaxo Canada Pharmaceutical compositions
US5324844A (en) 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
FI96169C (fi) 1989-07-10 1996-05-27 Eisai Co Ltd Menetelmä polyprenyyliyhdistettä sisältävän farmaseuttisen koostumuksen valmistamiseksi
US5532002A (en) 1989-08-17 1996-07-02 Cortecs Limited Gelatin pharmaceutical formulations
JPH03200715A (ja) 1989-12-27 1991-09-02 Lion Corp 口腔用組成物
JP2896185B2 (ja) 1990-02-27 1999-05-31 東京田辺製薬株式会社 胆汁酸内用液剤およびその製造方法
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
IL102003A0 (en) 1991-06-03 1992-12-30 Merck Sharp & Dohme Pharmaceutical formulation of a benzodiazepine
WO1994008610A1 (en) 1992-10-16 1994-04-28 Smithkline Beecham Corporation Pharmaceutical emulsion compositions
US5298643A (en) 1992-12-22 1994-03-29 Enzon, Inc. Aryl imidate activated polyalkylene oxides
US5349001A (en) 1993-01-19 1994-09-20 Enzon, Inc. Cyclic imide thione activated polyalkylene oxides
US5321095A (en) 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
US5359030A (en) 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5681811A (en) 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
AU7113594A (en) * 1993-06-21 1995-01-17 Enzon, Inc. Site specific synthesis of conjugated peptides
TW402506B (en) * 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
FR2710535B1 (fr) 1993-09-30 1995-11-24 Gattefosse Ets Sa Composition à usage pharmaceutique ou cosmétique apte à former une microémulsion.
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
GB9325395D0 (en) 1993-12-11 1994-02-16 Ciba Geigy Ag Compositions
JPH07215883A (ja) 1994-02-01 1995-08-15 Shiyugaa Redei:Kk 冷凍保存可能な高濃度ロイヤルゼリーソフトカプセル製剤
JP3429065B2 (ja) 1994-06-21 2003-07-22 サンスター株式会社 口腔用液体組成物
US6165976A (en) * 1994-06-23 2000-12-26 Astra Aktiebolag Therapeutic preparation for inhalation
ES2177652T3 (es) 1994-11-03 2002-12-16 Novartis Ag Nuevas formas de preparacion de ciclosporina para la aplicacion oral con composicion simple y alta biodisponibilidad, y procedimiento para su obtencion.
KR0167613B1 (ko) 1994-12-28 1999-01-15 한스 루돌프 하우스, 니콜 케르커 사이클로스포린-함유 연질캅셀제 조성물
US6057139A (en) * 1995-06-29 2000-05-02 Mcneil-Ppc, Inc. Preblend of microcrystalline cellulose and lactase for making tablets
GB9516268D0 (en) 1995-08-08 1995-10-11 Danbiosyst Uk Compositiion for enhanced uptake of polar drugs from the colon
EP0760237A1 (en) 1995-08-30 1997-03-05 Cipla Limited Oil-in-water microemulsions
FR2748209B1 (fr) 1996-05-06 1998-06-05 Adir Composition pharmaceutique a base de matrices lipophiles stabilisees pour la liberation controlee de principes actifs
KR20050084502A (ko) 1997-01-30 2005-08-26 노파르티스 아게 오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물
US5900402A (en) 1997-05-29 1999-05-04 Enzon, Inc. Method of reducing side effects associated with administration of oxygen-carrying proteins
GB9717428D0 (en) 1997-08-19 1997-10-22 Glaxo Group Ltd Pharmaceutical composition
US6054480A (en) 1997-09-18 2000-04-25 Nectra, Inc. Fatty acids as a diet supplement
US5985263A (en) 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US5965119A (en) 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6214330B1 (en) 1998-07-13 2001-04-10 Enzon, Inc. Coumarin and related aromatic-based polymeric prodrugs
US6703381B1 (en) 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
JP2000095676A (ja) 1998-09-21 2000-04-04 Tokai Capsule Kk ビタミンｂ１２含有ソフトカプセル剤
EP1156812A4 (en) * 1999-02-23 2004-09-29 Isis Pharmaceuticals Inc MULTIPARTICULAR FORMULATION
DE60006362T2 (de) 1999-02-23 2004-08-26 Yuhan Corp. Kapseln mit loratadin und pseudoephedrin enthaltenden zusammensetzungen
JP4538858B2 (ja) * 1999-03-09 2010-09-08 日油株式会社 滑沢剤およびそれを用いた固形製剤
CN1167462C (zh) 1999-03-09 2004-09-22 杭州华东医药集团生物工程研究所有限公司 一种含环孢素的药物组合物
JP3278427B2 (ja) 1999-03-26 2002-04-30 有限会社ゴトーコーポレーション カプセル剤の製造方法
GB9907715D0 (en) 1999-04-01 1999-05-26 Scherer Corp R P Pharmaceutical compositions
US6982281B1 (en) 2000-11-17 2006-01-03 Lipocine Inc Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
TWI232761B (en) 2000-07-01 2005-05-21 Pharmaceutical Ind Tech & Dev Capsule preparation for oral administration and the preparation method thereof
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6858580B2 (en) 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6720002B2 (en) 2001-07-20 2004-04-13 R.P. Scherer Technologies, Inc. Antihistamine formulations for soft capsule dosage forms
KR100425755B1 (ko) 2001-08-27 2004-04-03 주식회사 원진신약 이트라코나졸을 함유하는 조성물 및 그 제조방법
US6770625B2 (en) * 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
GB2391473B (en) 2002-08-02 2004-07-07 Satishchandra Punambhai Patel Pharmaceutical compositions
PL377813A1 (pl) 2002-11-26 2006-02-20 Biocon Limited Modyfikowane związki natriuretyczne, ich koniugaty oraz zastosowania
US20040115226A1 (en) 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
KR100525234B1 (ko) 2003-02-19 2005-10-28 한국유나이티드제약 주식회사 사이클로스포린 함유 연질캅셀제 및 그 제조방법
WO2005004919A2 (en) 2003-07-02 2005-01-20 Eurand, Inc. Extended release systems for macrolide antibiotics
GB0403247D0 (en) 2004-02-13 2004-03-17 Tillotts Pharma Ag A pharmaceutical composition
JP5057779B2 (ja) 2004-03-24 2012-10-24 武田薬品工業株式会社 エマルション安定化製剤
CA2595116A1 (en) 2004-04-28 2005-11-10 Procarrier, Inc. Oral formulation for delivery of poorly absorbed drugs
US20080044481A1 (en) 2004-05-27 2008-02-21 Mordechai Harel Microparticles for Oral Delivery

Also Published As

Publication number Publication date
US20050095216A1 (en) 2005-05-05
US7635675B2 (en) 2009-12-22
AU2004264958A1 (en) 2005-02-24
ES2445947T3 (es) 2014-03-06
KR101152470B1 (ko) 2012-06-01
JP2007502303A (ja) 2007-02-08
AU2004264958B2 (en) 2010-04-15
CN102552917A (zh) 2012-07-11
CA2535013C (en) 2013-02-12
JP4880461B2 (ja) 2012-02-22
EP1660047A1 (en) 2006-05-31
DK1660047T3 (en) 2014-03-10
CA2535013A1 (en) 2005-02-24
WO2005016312A1 (en) 2005-02-24
EP1660047B1 (en) 2013-11-27
KR20060082851A (ko) 2006-07-19
CN1863510A (zh) 2006-11-15
PL1660047T3 (pl) 2014-05-30

Similar Documents

Publication Publication Date Title
PT1660047E (pt) Formulação de dosagem sólida de sais de ácidos gordos em micropartículas para agentes terapêuticos
EP1631239A4 (en) PHARMACEUTICAL COMPOSITIONS CONTAINING ACTIVE COMPOUNDS OF VITAMIN D
EP1796632A4 (en) ORGANOGEL-BASED FORMULATIONS FOR THERAPEUTIC APPLICATIONS
IL180691A0 (en) Organo-gel formulations for therapeutic applications
GB0210397D0 (en) Pharmaceutical formulations
EP1729744A4 (en) PHARMACEUTICAL PREPARATIONS
GB0302671D0 (en) Pharmaceutical formulations
HUE040600T2 (hu) Állatgyógyászati gyógyszer-leadó készülék
GB0426301D0 (en) Pharmaceutical formulations
IL180031A0 (en) Stable pharmaceutical formulations of benzimidazole compounds
HK1113308A1 (en) Pharmaceutical formulations of gallium salts
AU2003295773A8 (en) Treatment of liver disease with active vitamin d compounds
EP1487411A4 (en) THERAPEUTIC FORMULATIONS SUPPORTED BREATHABLE
GB2391809B (en) Pharmaceutical composition comprising honey
EP1646355A4 (en) PHARMACEUTICAL FORMULATIONS
AU2003279911A8 (en) Therapeutic formulations
IL174336A0 (en) Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient
EP1602362A4 (en) DRUG COMPOSITION COMPRISING AN ADHESIVE ACTIVE INGREDIENT IN HIGH CONCENTRATION TO A SPHERICAL CORE
GB2392093B (en) Pharmaceutical formulations
EP1740541A4 (en) THERAPEUTIC FORMULATIONS OF DESOXYEPOTHILONES
GB0316206D0 (en) Pharmaceutical formulation
IL165069A0 (en) Immediate release pharmaceutical formulation
GB0302672D0 (en) Pharmaceutical formulations
AU2003231260A8 (en) Catechin multimers as therapeutic drug delivery agents
GB2392618B (en) Compositions for therapeutic use