CA2417789A1 - Peptides and their use in assays for cardiovascular disease - Google Patents
Peptides and their use in assays for cardiovascular disease Download PDFInfo
- Publication number
- CA2417789A1 CA2417789A1 CA002417789A CA2417789A CA2417789A1 CA 2417789 A1 CA2417789 A1 CA 2417789A1 CA 002417789 A CA002417789 A CA 002417789A CA 2417789 A CA2417789 A CA 2417789A CA 2417789 A1 CA2417789 A1 CA 2417789A1
- Authority
- CA
- Canada
- Prior art keywords
- peptide
- peptide according
- peptides
- autoantibodies
- mda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000003556 assay Methods 0.000 title claims abstract description 13
- 102000004196 processed proteins & peptides Human genes 0.000 title claims description 37
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- 108010007622 LDL Lipoproteins Proteins 0.000 claims abstract description 24
- 102000007330 LDL Lipoproteins Human genes 0.000 claims abstract description 24
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- 150000001299 aldehydes Chemical class 0.000 description 4
- 125000004122 cyclic group Chemical group 0.000 description 4
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
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- SVFRYKBZHUGKLP-QXEWZRGKSA-N Val-Met-Asn Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)N)C(=O)O)N SVFRYKBZHUGKLP-QXEWZRGKSA-N 0.000 description 1
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- 239000003446 ligand Substances 0.000 description 1
- 235000018977 lysine Nutrition 0.000 description 1
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0017641.2A GB0017641D0 (en) | 2000-07-18 | 2000-07-18 | Peptides and their use |
| GB0017641.2 | 2000-07-18 | ||
| PCT/GB2001/003212 WO2002006314A2 (en) | 2000-07-18 | 2001-07-18 | Peptides and their use in assays for cardiovascular disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2417789A1 true CA2417789A1 (en) | 2002-01-24 |
Family
ID=9895897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002417789A Abandoned CA2417789A1 (en) | 2000-07-18 | 2001-07-18 | Peptides and their use in assays for cardiovascular disease |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20040091934A1 (enExample) |
| EP (1) | EP1301537B1 (enExample) |
| JP (1) | JP2004504327A (enExample) |
| AT (1) | ATE408626T1 (enExample) |
| AU (1) | AU2001270851A1 (enExample) |
| CA (1) | CA2417789A1 (enExample) |
| DE (1) | DE60135846D1 (enExample) |
| DK (1) | DK1301537T3 (enExample) |
| ES (1) | ES2312455T3 (enExample) |
| GB (1) | GB0017641D0 (enExample) |
| PT (1) | PT1301537E (enExample) |
| WO (1) | WO2002006314A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030105003A1 (en) | 2001-04-05 | 2003-06-05 | Jan Nilsson | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
| SE0103754L (sv) * | 2001-04-05 | 2002-10-06 | Forskarpatent I Syd Ab | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
| AU2002362612B2 (en) | 2001-09-28 | 2007-11-15 | Cedars-Sinai Medical Center | Prevention and treatment of restenosis by local administration of drug |
| WO2005097206A2 (en) | 2004-04-06 | 2005-10-20 | Cedars-Sinai Medical Center | Prevention and treatment of vascular disease with recombinant adeno-associated virus vectors encoding apolipoprotein a-i and apolipoprotein a-i milano |
| US20080305512A1 (en) * | 2006-10-26 | 2008-12-11 | Mattingly Phillip G | Assay for cardiac troponin autoantibodies |
| US7776605B2 (en) * | 2006-10-26 | 2010-08-17 | Abbott Laboratories | Assay for cardiac troponin autoantibodies |
| WO2008051762A2 (en) * | 2006-10-26 | 2008-05-02 | Abbott Laboratories | Immunoassay of analytes in samples containing endogenous anti-analyte antibodies |
| EP2115466A4 (en) * | 2006-12-22 | 2010-07-28 | Abbott Lab | HEART CIRCUIT AUTOIMMUNE DISEASE TEST GROUP AND METHOD FOR USE THEREOF |
| AU2011336997A1 (en) | 2010-11-12 | 2013-05-30 | Cedars-Sinai Medical Center | Immunomodulatory methods and systems for treatment and/or prevention of hypertension |
| WO2012065133A1 (en) | 2010-11-12 | 2012-05-18 | Cedars-Sinai Medical Center | Immunomodulatory methods and systems for treatment and/or prevention of aneurysms |
| JP5857312B2 (ja) * | 2011-08-11 | 2016-02-10 | 積水メディカル株式会社 | 心疾患診断マーカー |
| CN107085025B (zh) * | 2016-02-15 | 2019-09-17 | 太原师范学院 | 一种自组装三层膜电极及其制备方法和用途 |
| US10858422B2 (en) | 2016-05-31 | 2020-12-08 | Abcentra, Llc | Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody |
| EP3463416A1 (en) | 2016-05-31 | 2019-04-10 | CardioVax, LLC | Methods for diagnosing and treating systemic lupus erythematosus |
| CN111855986A (zh) * | 2019-04-25 | 2020-10-30 | 常州博闻迪医药股份有限公司 | 联合定量检测五项心脏标志物试剂盒及制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5408038A (en) * | 1991-10-09 | 1995-04-18 | The Scripps Research Institute | Nonnatural apolipoprotein B-100 peptides and apolipoprotein B-100-apolipoprotein A-I fusion peptides |
| GB9609702D0 (en) * | 1996-05-09 | 1996-07-10 | Royal Free Hosp School Med | Anticoagulant peptides |
| GB9705831D0 (en) * | 1997-03-20 | 1997-05-07 | Univ Leicester | Oxidised ldl |
| US6635623B1 (en) * | 1997-06-13 | 2003-10-21 | Baylor College Of Medicine | Lipoproteins as nucleic acid vectors |
| EP1021728B8 (en) * | 1997-06-20 | 2008-04-23 | Leuven Research & Development VZW | Assays, antibodies, and standards for detection of oxidized and mda-modified low density lipoproteins |
-
2000
- 2000-07-18 GB GBGB0017641.2A patent/GB0017641D0/en not_active Ceased
-
2001
- 2001-07-18 WO PCT/GB2001/003212 patent/WO2002006314A2/en not_active Ceased
- 2001-07-18 US US10/333,313 patent/US20040091934A1/en not_active Abandoned
- 2001-07-18 ES ES01949734T patent/ES2312455T3/es not_active Expired - Lifetime
- 2001-07-18 PT PT01949734T patent/PT1301537E/pt unknown
- 2001-07-18 AU AU2001270851A patent/AU2001270851A1/en not_active Abandoned
- 2001-07-18 DE DE60135846T patent/DE60135846D1/de not_active Expired - Fee Related
- 2001-07-18 EP EP01949734A patent/EP1301537B1/en not_active Expired - Lifetime
- 2001-07-18 DK DK01949734T patent/DK1301537T3/da active
- 2001-07-18 JP JP2002512214A patent/JP2004504327A/ja not_active Withdrawn
- 2001-07-18 CA CA002417789A patent/CA2417789A1/en not_active Abandoned
- 2001-07-18 AT AT01949734T patent/ATE408626T1/de not_active IP Right Cessation
-
2007
- 2007-05-04 US US11/800,148 patent/US20080261234A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20080261234A1 (en) | 2008-10-23 |
| US20040091934A1 (en) | 2004-05-13 |
| ES2312455T3 (es) | 2009-03-01 |
| JP2004504327A (ja) | 2004-02-12 |
| EP1301537A2 (en) | 2003-04-16 |
| WO2002006314A2 (en) | 2002-01-24 |
| DK1301537T3 (da) | 2008-12-08 |
| PT1301537E (pt) | 2008-12-04 |
| EP1301537B1 (en) | 2008-09-17 |
| DE60135846D1 (de) | 2008-10-30 |
| WO2002006314A3 (en) | 2002-04-18 |
| GB0017641D0 (en) | 2000-09-06 |
| AU2001270851A1 (en) | 2002-01-30 |
| ATE408626T1 (de) | 2008-10-15 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |