CA2417277A1 - 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3.beta. - Google Patents
3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3.beta. Download PDFInfo
- Publication number
- CA2417277A1 CA2417277A1 CA002417277A CA2417277A CA2417277A1 CA 2417277 A1 CA2417277 A1 CA 2417277A1 CA 002417277 A CA002417277 A CA 002417277A CA 2417277 A CA2417277 A CA 2417277A CA 2417277 A1 CA2417277 A1 CA 2417277A1
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- Canada
- Prior art keywords
- heteroalkyl
- compound
- hydrogen
- dione
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 title claims abstract description 61
- 239000003112 inhibitor Substances 0.000 title claims abstract description 22
- LKDTVSJUXXGXKE-UHFFFAOYSA-N 3-(1h-indol-2-yl)-4-phenylpyrrole-2,5-dione Chemical class C=1C2=CC=CC=C2NC=1C=1C(=O)NC(=O)C=1C1=CC=CC=C1 LKDTVSJUXXGXKE-UHFFFAOYSA-N 0.000 title abstract description 7
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- 239000000203 mixture Substances 0.000 claims description 67
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 65
- 125000000217 alkyl group Chemical group 0.000 claims description 63
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Landscapes
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| AU2001296959A1 (en) * | 2000-10-02 | 2002-04-15 | Reddy Us Therapeutics, Inc | Methods and compositions for the treatment of inflammatory diseases |
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| JP2005532982A (ja) * | 2001-09-24 | 2005-11-04 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 肥満の処置のためのピロール誘導体の製造及び使用 |
| EP1465610B1 (en) * | 2002-01-10 | 2008-12-31 | F. Hoffmann-La Roche Ag | Use of a gsk-3beta inhibitor in the manufacture of a medicament for increasing bone formation |
| KR100974770B1 (ko) | 2002-03-05 | 2010-08-06 | 일라이 릴리 앤드 캄파니 | 키나제 억제제로서의 퓨린 유도체 |
| MXPA04008671A (es) | 2002-03-08 | 2004-12-06 | Lilly Co Eli | Derivados de pirrol-2,5-diona y su uso como inhibidores de gsk-3. |
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| SE0200979D0 (sv) * | 2002-03-28 | 2002-03-28 | Astrazeneca Ab | New compounds |
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| RU2004135382A (ru) | 2002-06-05 | 2005-06-27 | Янссен Фармацевтика Н.В. (Be) | Замещенные пирролины в качестве ингибиторов киназы |
| CA2488798A1 (en) * | 2002-06-05 | 2003-12-18 | Janssen Pharmaceutica N.V. | Substituted pyrrolines as kinase inhibitors |
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| US7109436B2 (en) * | 2003-08-29 | 2006-09-19 | General Electric Company | Laser shock peening target |
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| WO2005107465A1 (en) * | 2004-05-12 | 2005-11-17 | Bayer Cropscience Gmbh | Plant growth regulation |
| CA2589127C (en) | 2004-12-08 | 2013-02-05 | Johannes Gutenberg-Universitat Mainz | 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors |
| JP4747364B2 (ja) | 2005-04-04 | 2011-08-17 | 独立行政法人産業技術総合研究所 | 紫外線皮膚炎抑止剤およびアトピー性皮膚炎抑止剤 |
| WO2006117212A2 (en) | 2005-05-04 | 2006-11-09 | Develogen Aktiengesellschaft | Use of gsk-3 inhibitors for preventing and treating pancreatic autoimmune disorders |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| EP2125683B1 (en) | 2006-12-19 | 2013-10-23 | The Board of Trustees of the University of Illinois | 3-benzofuranyl-4-indolyl-maleimides as potent gsk-3 inhibitors for neurodegenerative disorders |
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| WO2009158393A1 (en) * | 2008-06-25 | 2009-12-30 | Envivo Pharmaceuticals, Inc. | 1, 2 disubstituted heterocyclic compounds |
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| EP3045450B1 (en) * | 2010-09-08 | 2018-02-07 | Sumitomo Chemical Co., Ltd. | Intermediate compounds in processes for producing pyridazinone compounds |
| EP2474541A1 (en) | 2010-12-23 | 2012-07-11 | Johannes- Gutenberg-Universität Mainz | Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| KR20130034672A (ko) * | 2011-09-28 | 2013-04-08 | 김동식 | 보텍스타입 열교환기 |
| KR101440724B1 (ko) * | 2013-03-29 | 2014-09-18 | 중앙대학교 산학협력단 | 글리코겐 신타아제 키나아제-3베타 억제물질을 유효성분으로 포함하는 난소과립세포종양의 예방 또는 치료용 약학적 조성물 및 건강기능성식품 조성물 |
| WO2015155738A2 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
| TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ280738B6 (cs) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi |
| MC2096A1 (fr) | 1989-02-23 | 1991-02-15 | Hoffmann La Roche | Pyrroles substitues |
| GB8904161D0 (en) | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
| GB9123396D0 (en) | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
| CA2116460A1 (en) | 1993-03-02 | 1994-09-03 | Mitsubishi Chemical Corporation | Preventive or therapeutic agents for alzheimer's disease, a screening method of alzheimer's disease and tau-protein kinase i originated from human being |
| AU678435B2 (en) | 1993-05-10 | 1997-05-29 | F. Hoffmann-La Roche Ag | Substituted pyrroles |
| US5721230A (en) | 1993-05-10 | 1998-02-24 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| WO1997022360A2 (en) | 1995-12-20 | 1997-06-26 | Medical Research Council | Control of protein synthesis, and screening method for agents |
| EP1019043A4 (en) | 1996-05-07 | 2003-07-30 | Univ Pennsylvania | INHIBITORS OF GLYCOGEN SYNTHESIS KINASE 3 AND METHOD FOR THEIR IDENTIFICATION AND USE |
| SE9603285D0 (sv) | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
| EP1119548B1 (en) * | 1998-10-08 | 2004-12-08 | SmithKline Beecham plc | 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrole-2,5-dione as glycogen synthase kinase-3 inhibitor (gsk-3) |
| GB9828640D0 (en) * | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel method and compounds |
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