CA2386932C - Dispersion with nonionic emulsifier - Google Patents

Dispersion with nonionic emulsifier Download PDF

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Publication number
CA2386932C
CA2386932C CA2386932A CA2386932A CA2386932C CA 2386932 C CA2386932 C CA 2386932C CA 2386932 A CA2386932 A CA 2386932A CA 2386932 A CA2386932 A CA 2386932A CA 2386932 C CA2386932 C CA 2386932C
Authority
CA
Canada
Prior art keywords
weight
dispersion
polyoxyethylene
degree
dispersion according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2386932A
Other languages
English (en)
French (fr)
Other versions
CA2386932A1 (en
Inventor
Christian Meier
Johanna Eisele
Michael Schnabel
Klaus Schultes
Stefan Grimm
Hans-Ulrich Petereit
Thomas Sufke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Roehm GmbH Darmstadt
Evonik Operations GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roehm GmbH Darmstadt, Evonik Operations GmbH filed Critical Roehm GmbH Darmstadt
Publication of CA2386932A1 publication Critical patent/CA2386932A1/en
Application granted granted Critical
Publication of CA2386932C publication Critical patent/CA2386932C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/12—Polymerisation in non-solvents
    • C08F2/16—Aqueous medium
    • C08F2/22—Emulsion polymerisation
    • C08F2/24—Emulsion polymerisation with the aid of emulsifying agents
    • C08F2/30—Emulsion polymerisation with the aid of emulsifying agents non-ionic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C08F220/1802—C2-(meth)acrylate, e.g. ethyl (meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C08F220/1803—C3-(meth)acrylate, e.g. (iso)propyl (meth)acrylate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2386932A 2000-03-10 2001-02-02 Dispersion with nonionic emulsifier Expired - Lifetime CA2386932C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10011447.4 2000-03-10
DE10011447A DE10011447A1 (de) 2000-03-10 2000-03-10 Dispersion mit nichtionischem Emulgator
PCT/EP2001/001108 WO2001068767A1 (de) 2000-03-10 2001-02-02 Dispersion mit nichtionischem emulgator

Publications (2)

Publication Number Publication Date
CA2386932A1 CA2386932A1 (en) 2001-09-20
CA2386932C true CA2386932C (en) 2010-08-24

Family

ID=7634069

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2386932A Expired - Lifetime CA2386932C (en) 2000-03-10 2001-02-02 Dispersion with nonionic emulsifier

Country Status (11)

Country Link
US (1) US6998140B2 (https=)
EP (1) EP1200521B1 (https=)
JP (1) JP4944334B2 (https=)
AT (1) ATE282067T1 (https=)
AU (1) AU3023201A (https=)
CA (1) CA2386932C (https=)
DE (2) DE10011447A1 (https=)
DK (1) DK1200521T3 (https=)
ES (1) ES2228799T3 (https=)
PL (1) PL199225B1 (https=)
WO (1) WO2001068767A1 (https=)

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DE10220470A1 (de) * 2002-04-30 2003-11-20 Roehm Gmbh ph-sensitives Polymer
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DE10043868A1 (de) * 2000-09-04 2002-04-04 Roehm Gmbh PMMA Formmassen mit verbesserter Schlagzähigkeit
CN1233765C (zh) * 2001-02-07 2005-12-28 罗姆两合公司 用于对聚丙烯和聚苯乙烯施用的铝箔的热封物料
DE10127134A1 (de) * 2001-06-05 2002-12-12 Roehm Gmbh verfahren zur Herstellung von Formkörpern aus (Meth)acrylat-Copolymeren mittels Spritzguß
DE10204890A1 (de) * 2002-02-06 2003-08-14 Roehm Gmbh Schlagzähe Formmasse und Formkörper
DE10208335A1 (de) * 2002-02-27 2003-09-04 Roehm Gmbh Arzneiform und Verfahren zu ihrer Herstellung
DE10214002A1 (de) * 2002-03-27 2003-10-09 Roehm Gmbh Pharmazeutische Formulierung für den Wirkstoff Budesonid
DE10243062A1 (de) * 2002-09-16 2004-03-25 Röhm GmbH & Co. KG Heißwasserwechseltestbeständiges Sanitärmaterial aus PMMA-Formmasse oder schlagzäher PMMA-Formmasse
DE10250543A1 (de) * 2002-10-29 2004-05-19 Röhm GmbH & Co. KG Mehrschichtige Arzneiform
DE10260065A1 (de) * 2002-12-19 2004-07-01 Röhm GmbH & Co. KG Kern-Schale-Teilchen zur Schlagzähmodifizierung von Poly(meth)acrylat-Formmassen
DE10260089A1 (de) * 2002-12-19 2004-07-01 Röhm GmbH & Co. KG Verfahren zur Herstellung von wässrigen Dispersionen
MXPA04010956A (es) * 2003-01-30 2005-01-25 Roehm Gmbh Forma de dosis farmaceutica y metodo para la produccion de la misma.
DE10345045A1 (de) * 2003-09-26 2005-04-14 Röhm GmbH & Co. KG Verfahren zur Oberflächenvergütung von Werkstoffen durch Aufbringen insbesondere transparenter Schichten auf Basis von Polymethacrylaten
DE10349144A1 (de) * 2003-10-17 2005-05-12 Roehm Gmbh Polymermischung für mattierte Spritzgußteile
MX2007008855A (es) * 2003-10-18 2008-03-13 Roehm Gmbh Masas de pieza moldeada de poli (met) acrilato resistentes a impactos con alta estabilidad termica.
DE10351535A1 (de) 2003-11-03 2005-06-09 Röhm GmbH & Co. KG Mehrschichtfolie aus (Meth)acrylatcopolymer und Polycarbonat
DE10354379A1 (de) 2003-11-20 2005-06-23 Röhm GmbH & Co. KG Formmasse, enthaltend ein Mattierungsmittel
US20050202079A1 (en) * 2004-03-15 2005-09-15 Mylan Pharmaceuticals Inc. Novel orally administrable formulation of nitrofurantoin and a method for preparing said formulation
US9498563B2 (en) * 2004-04-23 2016-11-22 Boston Scientific Scimed, Inc. Medical articles having therapeutic-agent-containing regions formed from coalesced polymer particles
DE102004022540A1 (de) * 2004-05-05 2005-12-08 Röhm GmbH & Co. KG Formmasse für Formkörper mit hoher Witterungsbeständigkeit
DE102004045296A1 (de) * 2004-09-16 2006-03-23 Röhm GmbH & Co. KG Verwendung von Polyalkyl (meth) acrylat-Perlpolymerisaten und Formmasse zur Herstellung von extrudierten Formteilen mit mattierter Oberfläche
DE102004058083A1 (de) 2004-12-01 2006-06-08 Röhm GmbH & Co. KG Gedeckt eingefärbte, infrarotreflektierende Kunststoffformmasse
JP4537870B2 (ja) * 2005-03-16 2010-09-08 ガンツ化成株式会社 アルキル（メタ）アクリレート共重合体エマルジョンの製造法。
BRPI0609111A2 (pt) * 2005-04-18 2010-02-23 Roehm Gmbh processo para a preparação de um material de moldagem ou um molde, material de moldagem ou molde e seu uso
DE102005021335A1 (de) * 2005-05-04 2006-11-09 Röhm Gmbh Verfahren zur Herstellung von Perlpolymerisaten mit einer mittleren Teilchengröße im Bereich von 1 µm bis 40 µm sowie Perlpolymerisat aufweisende Formmassen und Formkörper
DE102005055793A1 (de) 2005-11-21 2007-05-24 Röhm Gmbh Transparente TPU (thermoplastische Polyurethane)/ PMMA (Polymethyl(meth)acrylat) Abmischungen mit verbesserter Kältesschlagzähigkeit
US20070190141A1 (en) * 2006-02-16 2007-08-16 Aaron Dely Extended release opiate composition
DE102006029613A1 (de) * 2006-06-26 2007-12-27 Röhm Gmbh Transparenter Kunststoff-Verbund
US20080035703A1 (en) * 2006-08-09 2008-02-14 Daewoong Suh Oxidation resistant solder preform
US20080081067A1 (en) * 2006-10-03 2008-04-03 Gupta Manishkumar Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof
DE102007005432A1 (de) * 2007-01-30 2008-07-31 Evonik Röhm Gmbh Formmassen für mattierte Polyacrylat-Formkörper
DE102007009243A1 (de) 2007-02-22 2008-09-18 Evonik Röhm Gmbh Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets
DE102007009242A1 (de) 2007-02-22 2008-09-18 Evonik Röhm Gmbh Pellets mit magensaftresistenter Wirkstoff-Matix
DE102007026201A1 (de) * 2007-06-04 2008-12-11 Evonik Röhm Gmbh Eingefärbte Zusammensetzung mit erhöhter Spannungsrissbeständigkeit
DE102007026200A1 (de) * 2007-06-04 2008-12-11 Evonik Röhm Gmbh Zusammensetzung mit erhöhter Spannungsrissbeständigkeit
DE102007028601A1 (de) * 2007-06-19 2008-12-24 Evonik Röhm Gmbh Reaktivgemisch zur Beschichtung von Formkörpern mittels Reaktionsspritzguss sowie beschichteter Formkörper
DE102007029263A1 (de) * 2007-06-22 2008-12-24 Evonik Röhm Gmbh PMMA/PVDF-Folie mit besonders hoher Witterungsbeständigkeit und hoher UV-Schutzwirkung
DE102007051482A1 (de) * 2007-10-25 2009-04-30 Evonik Röhm Gmbh Verfahren zur Herstellung von beschichteten Formkörpern
DE102008001231A1 (de) * 2008-04-17 2009-10-22 Evonik Röhm Gmbh Flammfeste PMMA-Formmasse
DE102008001695A1 (de) * 2008-05-09 2009-11-12 Evonik Röhm Gmbh Poly(meth)acrylimide mit verbesserten optischen und Farbeigenschaften, insbesondere bei thermischer Belastung
US9492394B2 (en) 2010-08-18 2016-11-15 Evonik Roehm Gmbh Gastric resistant pharmaceutical or nutraceutical formulation comprising one or more salts of alginic acid
BR112013027484A8 (pt) 2011-06-17 2022-07-05 Evonik Roehm Gmbh Composição farmacêutica ou nutracêutica com resistência gástrica, e uso de um polímero de (met)acrilato
RU2606588C2 (ru) 2011-06-17 2017-01-10 Эвоник Рем ГмбХ Композиция покрытия, подходящая для фармацевтических или нутрицевтических дозированных форм
WO2013031654A1 (ja) * 2011-08-30 2013-03-07 住友精化株式会社 吸水性樹脂の製造方法、及びそれにより得られる吸水性樹脂
RU2015110825A (ru) 2012-08-27 2016-10-20 Эвоник Индустрис Аг Устойчивая к действию желудочного сока фармацевтическая или нутрицевтическая композиция со стойкостью к влиянию этанола
WO2014032742A1 (en) 2012-08-27 2014-03-06 Evonik Industries Ag Pharmaceutical or nutraceutical composition with sustained release characteristic and with resistance against the influence of ethanol
CN105007902A (zh) 2013-02-13 2015-10-28 赢创罗姆有限公司 包含大量的两种丸粒的多颗粒药物组合物
EP3107529A1 (en) 2014-02-17 2016-12-28 Evonik Röhm GmbH Pharmaceutical or nutraceutical composition with sustained release characteristic and with resistance against the influence of ethanol
MX2017006858A (es) 2014-11-26 2017-11-15 Evonik Roehm Gmbh Composición farmacéutica o nutracéutica con resistencia a la influencia del etanol.
JP6824197B2 (ja) 2015-06-05 2021-02-03 エボニック オペレーションズ ゲーエムベーハー エタノールの影響に対する耐性を有する医薬品組成物または栄養機能食品組成物
ES3006512T3 (en) 2017-11-17 2025-03-18 Evonik Operations Gmbh Process for preparing a coated hard shell capsule
WO2020229178A1 (en) 2019-05-15 2020-11-19 Evonik Operations Gmbh Process for preparing filled hard-shell capsules with (meth)acrylate copolymer based coatings with a capsule-filling machine
US20220257517A1 (en) 2019-06-13 2022-08-18 Evonik Operations Gmbh Powder composition comprising a copolymer mixture and a water-soluble cellulose
WO2022248334A1 (en) 2021-05-25 2022-12-01 Evonik Operations Gmbh Hard shell capsules with modified release coating
CN117377466A (zh) 2021-05-25 2024-01-09 赢创运营有限公司 防止胃液流入的硬壳胶囊
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WO2023174722A1 (en) 2022-03-15 2023-09-21 Evonik Operations Gmbh Pre-functionalized hard shell capsule with accelerated drug release at ph value 5 to 5.5
EP4518841B1 (en) 2022-05-06 2025-12-17 Evonik Operations GmbH Dosage form with drug release at ph 3 to 6 using double coating system with at least one release acceleration agent

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Also Published As

Publication number Publication date
AU3023201A (en) 2001-09-24
US20030060381A1 (en) 2003-03-27
DE10011447A1 (de) 2001-09-20
JP2003526724A (ja) 2003-09-09
WO2001068767A1 (de) 2001-09-20
ES2228799T3 (es) 2005-04-16
ATE282067T1 (de) 2004-11-15
PL199225B1 (pl) 2008-08-29
EP1200521B1 (de) 2004-11-10
CA2386932A1 (en) 2001-09-20
US6998140B2 (en) 2006-02-14
JP4944334B2 (ja) 2012-05-30
DK1200521T3 (da) 2005-03-14
DE50104475D1 (de) 2004-12-16
EP1200521A1 (de) 2002-05-02
PL350610A1 (en) 2003-01-27

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Effective date: 20210202