CA2372720C - Androgen glycosides and androgenic activity thereof - Google Patents

Androgen glycosides and androgenic activity thereof Download PDF

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Publication number
CA2372720C
CA2372720C CA002372720A CA2372720A CA2372720C CA 2372720 C CA2372720 C CA 2372720C CA 002372720 A CA002372720 A CA 002372720A CA 2372720 A CA2372720 A CA 2372720A CA 2372720 C CA2372720 C CA 2372720C
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CA
Canada
Prior art keywords
hydrogen
glucoside
beta
compound
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002372720A
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English (en)
French (fr)
Other versions
CA2372720A1 (en
Inventor
John Antony Kanis
Michael Francis Holick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Strakan International Ltd Great Britain
Original Assignee
Strakan International Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Strakan International Ltd Great Britain filed Critical Strakan International Ltd Great Britain
Publication of CA2372720A1 publication Critical patent/CA2372720A1/en
Application granted granted Critical
Publication of CA2372720C publication Critical patent/CA2372720C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0063—Nitrogen and oxygen at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
CA002372720A 1999-05-04 2000-05-04 Androgen glycosides and androgenic activity thereof Expired - Fee Related CA2372720C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13250099P 1999-05-04 1999-05-04
US19529400P 2000-04-07 2000-04-07
US60/195,294 2000-04-07
US60/132,500 2000-04-07
PCT/GB2000/001700 WO2000066612A1 (en) 1999-05-04 2000-05-04 Androgen glycosides and androgenic activity thereof

Publications (2)

Publication Number Publication Date
CA2372720A1 CA2372720A1 (en) 2000-11-09
CA2372720C true CA2372720C (en) 2007-09-11

Family

ID=26830416

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002372720A Expired - Fee Related CA2372720C (en) 1999-05-04 2000-05-04 Androgen glycosides and androgenic activity thereof

Country Status (20)

Country Link
US (2) US6630453B1 (US06630453-20031007-C00016.png)
EP (1) EP1175433B1 (US06630453-20031007-C00016.png)
JP (1) JP5005127B2 (US06630453-20031007-C00016.png)
KR (1) KR20020013533A (US06630453-20031007-C00016.png)
CN (1) CN1250563C (US06630453-20031007-C00016.png)
AT (1) ATE301129T1 (US06630453-20031007-C00016.png)
AU (1) AU777770C (US06630453-20031007-C00016.png)
BR (1) BR0010708A (US06630453-20031007-C00016.png)
CA (1) CA2372720C (US06630453-20031007-C00016.png)
CZ (1) CZ20013912A3 (US06630453-20031007-C00016.png)
DE (1) DE60021720T2 (US06630453-20031007-C00016.png)
DK (1) DK1175433T3 (US06630453-20031007-C00016.png)
ES (1) ES2246234T3 (US06630453-20031007-C00016.png)
HU (1) HUP0200871A3 (US06630453-20031007-C00016.png)
IL (2) IL146284A0 (US06630453-20031007-C00016.png)
MX (1) MXPA01011227A (US06630453-20031007-C00016.png)
NO (1) NO321296B1 (US06630453-20031007-C00016.png)
NZ (1) NZ515134A (US06630453-20031007-C00016.png)
PT (1) PT1175433E (US06630453-20031007-C00016.png)
WO (1) WO2000066612A1 (US06630453-20031007-C00016.png)

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US20050107310A1 (en) * 2002-03-19 2005-05-19 Holick Michael F. Carboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
WO2003086475A1 (en) * 2002-04-12 2003-10-23 A & D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof
WO2003094842A2 (en) * 2002-05-07 2003-11-20 A & D Bioscience, Inc. Conjugates comprising central nervous system active drug
US20050215487A1 (en) * 2002-06-27 2005-09-29 Holick Michael F Conjugates comprising an nsaid and a sugar and uses thereof
US20070225354A1 (en) * 2006-03-21 2007-09-27 Eric Marchewitz Use of dihydrolipoamide for enhancing physical performance
CN107106429B (zh) 2014-11-10 2021-06-29 宝洁公司 具有两种有益相的个人护理组合物
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US10966916B2 (en) 2014-11-10 2021-04-06 The Procter And Gamble Company Personal care compositions
CN105388245A (zh) * 2015-12-25 2016-03-09 浙江省水产技术推广总站 适用于水产品中46种药物的筛查方法
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