CA2359562A1 - Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents - Google Patents

Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents Download PDF

Info

Publication number
CA2359562A1
CA2359562A1 CA002359562A CA2359562A CA2359562A1 CA 2359562 A1 CA2359562 A1 CA 2359562A1 CA 002359562 A CA002359562 A CA 002359562A CA 2359562 A CA2359562 A CA 2359562A CA 2359562 A1 CA2359562 A1 CA 2359562A1
Authority
CA
Canada
Prior art keywords
carbons
methyl
alkyl
nitrophenylimino
thiazolidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002359562A
Other languages
English (en)
French (fr)
Inventor
Brian R. Dixon
Cedo M. Bagi
Catherine R. Brennan
David R. Brittelli
William H. Bullock
Jinshan Chen
William L. Collibee
Robert Dally
Jeffrey S. Johnson
Harold C. E. Kluender
William F. Lathrop
Peiying Liu
Carol Ann Mase
Aniko M. Redman
William J. Scott
Klaus Urbahns
Donald J. Wolanin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2359562A1 publication Critical patent/CA2359562A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
CA002359562A 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents Abandoned CA2359562A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23190699A 1999-01-14 1999-01-14
US09/231,906 1999-01-14
PCT/US1999/029601 WO2000042031A2 (en) 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

Publications (1)

Publication Number Publication Date
CA2359562A1 true CA2359562A1 (en) 2000-07-20

Family

ID=22871101

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002359562A Abandoned CA2359562A1 (en) 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

Country Status (21)

Country Link
EP (1) EP1144396A2 (cs)
JP (1) JP2002534517A (cs)
KR (1) KR20010089831A (cs)
CN (1) CN1337955A (cs)
AR (1) AR022214A1 (cs)
AU (1) AU2708700A (cs)
BG (1) BG105761A (cs)
BR (1) BR9916999A (cs)
CA (1) CA2359562A1 (cs)
CO (1) CO5160338A1 (cs)
CZ (1) CZ20012530A3 (cs)
GT (1) GT200000003A (cs)
HU (1) HUP0105134A2 (cs)
ID (1) ID30514A (cs)
IL (1) IL144031A0 (cs)
NO (1) NO20013318L (cs)
SK (1) SK10032001A3 (cs)
SV (1) SV2002000005A (cs)
TR (1) TR200102041T2 (cs)
WO (1) WO2000042031A2 (cs)
ZA (1) ZA200105253B (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8193252B1 (en) 1999-08-31 2012-06-05 Bayer Pharma AG Mesoprogestins (progesterone receptor modulators) for the treatment and prevention of benign hormone dependent gynecological disorders
EA007854B1 (ru) * 1999-08-31 2007-02-27 Шеринг Акциенгезельшафт Мезопрогестины (модуляторы рецептора прогестерона) в качестве средств лечения и предупреждения доброкачественных зависящих от гормонов гинекологических нарушений
HUP0202460A3 (en) * 1999-08-31 2004-04-28 Schering Ag Mesoprogestins (progesterone receptor modulators) as a component of compositions for hormone replacement therapy (hrt)
ATE393150T1 (de) * 1999-09-14 2008-05-15 Shionogi & Co 2-imino-1,3-thiazin-derivate
JPWO2001072723A1 (ja) * 2000-03-28 2004-01-08 日本曹達株式会社 オキサ（チア）ゾリジン誘導体および抗炎症薬
EP1317456A2 (en) * 2000-09-07 2003-06-11 Bayer Corporation Cyclic and acyclic amidines and pharmaceutical compositions containing them for use as progesterone receptor binding agents
CA2440186C (en) * 2001-03-08 2009-01-13 Shionogi & Co., Ltd. Medicinal composition containing 1,3-thiazine derivative
US7189751B2 (en) 2001-06-25 2007-03-13 Nippon Soda Co., Ltd. Oxa(thia)zolidine compounds, process for preparation thereof and anti-inflammatory agents
EP1465882B1 (en) 2001-12-21 2011-08-24 X-Ceptor Therapeutics, Inc. Hetrocyclic modulators of nuclear receptors
US20060142387A1 (en) * 2003-06-10 2006-06-29 Rodolfo Cadilla Chemical compounds
CN103382158B (zh) * 2013-07-29 2015-11-18 张家港市大伟助剂有限公司 一种2-环戊基氨基乙醇的制备方法
BR112022000188A2 (pt) * 2019-07-10 2022-02-22 Bayer Ag Método para a preparação de 2-(fenilimino)-1,3-tiazolidin-4-onas
CN114507143A (zh) * 2022-02-26 2022-05-17 江苏壹药新材料有限公司 一种2-乙基-1-氟-4-硝基苯的合成方法
CN114671828B (zh) * 2022-04-28 2024-05-31 蔚林新材料科技股份有限公司 一种3-甲基-2-噻唑硫酮的制备方法
CN114957288B (zh) * 2022-06-07 2024-02-13 苏州华道生物药业股份有限公司 一种盐酸四咪唑的合成方法
CN115925559B (zh) * 2022-11-11 2024-12-17 上海泰坦科技股份有限公司 一种1-氨基-1-环戊基甲醇的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670754A1 (de) * 1966-09-27 1970-12-23 Bayer Ag Verfahren zur Herstellung von 2-Phenylimino-oxazolidinen
FR1510015A (fr) * 1966-12-05 1968-01-19 Aquitaine Petrole Préparation d'imino-thiazolidines
DE1767335A1 (de) * 1968-04-27 1971-09-02 Bayer Ag Anaesthetikum fuer Tiere
DE1963193A1 (de) * 1969-12-17 1971-06-24 Bayer Ag N-substituierte 2-Arylimino-oxazolidine,Verfahren zu ihrer Herstellung und ihre Verwendung als Ektoparasiticide
FR2117337A5 (en) * 1970-12-04 1972-07-21 Eastman Kodak Co Merocyanine dye sensitisers - contg basic and acidic gps for silver halide emulsions
US3787575A (en) * 1970-12-17 1974-01-22 Bayer Ag N-substituted-2-arylimino-oxazolidines used as acaricides
GB1342232A (en) * 1971-07-29 1974-01-03 Bayer Ag Aryliminothiazolidines a process for their preparation and their use as acaricides
CH614946A5 (cs) * 1975-05-07 1979-12-28 Ciba Geigy Ag
DE2658138A1 (de) * 1976-12-22 1978-07-06 Bayer Ag Substituierte 2-phenylimino-thiazolidine, verfahren zu ihrer herstellung sowie ihre verwendung als ektoparasitizide
DE2926771A1 (de) * 1979-07-03 1981-01-15 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
DE3049460A1 (de) * 1980-12-30 1982-07-29 Hoechst Ag, 6000 Frankfurt "thiazolinderivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
DE3505432A1 (de) * 1985-02-16 1986-08-21 Hoechst Ag, 6230 Frankfurt Pflanzenschutz- und schaedlingsbekaempfungsmittel auf der basis von thiazolidinderivaten sowie neue thiazolidinderivate und verfahren zu ihrer herstellung
EP0265162B1 (en) * 1986-10-17 1991-03-06 Stauffer Chemical Company Iminooxazolidines, process of preparation and method of use
US4806653A (en) * 1986-10-17 1989-02-21 Stauffer Chemical Company Process for preparation of iminooxazolidines
EP0270138B1 (en) * 1986-11-04 1991-05-29 Duphar International Research B.V Substituted 2-phenylimino-oxazolidine compounds having herbicidal activity
WO1989004595A2 (en) * 1987-11-19 1989-06-01 The Upjohn Company Ectoparasiticides

Also Published As

Publication number Publication date
WO2000042031A2 (en) 2000-07-20
WO2000042031A3 (en) 2000-11-09
SV2002000005A (es) 2002-07-16
TR200102041T2 (tr) 2001-12-21
EP1144396A2 (en) 2001-10-17
CN1337955A (zh) 2002-02-27
HUP0105134A2 (hu) 2002-04-29
CO5160338A1 (es) 2002-05-30
NO20013318D0 (no) 2001-07-04
IL144031A0 (en) 2002-04-21
KR20010089831A (ko) 2001-10-08
ZA200105253B (en) 2002-09-05
NO20013318L (no) 2001-08-30
AU2708700A (en) 2000-08-01
AR022214A1 (es) 2002-09-04
BR9916999A (pt) 2001-10-30
SK10032001A3 (sk) 2002-05-09
ID30514A (id) 2001-12-13
BG105761A (en) 2002-03-29
JP2002534517A (ja) 2002-10-15
CZ20012530A3 (cs) 2002-02-13
GT200000003A (es) 2001-07-06

Similar Documents

Publication Publication Date Title
US6353006B1 (en) Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
CA2359562A1 (en) Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
US7517876B2 (en) Anti-infective agents
JP5264890B2 (ja) アミロイドベータの調節剤としてのヘタリールアニリン
RS52824B (cs)
SK293392A3 (en) Biosynthesis leucotriene inhibitors
EP0772606A1 (en) Substituted thiazoles for the treatment of inflammation
CN1336375A (zh) 螺环和双环二嗪基和咔嗪基噁唑烷酮类
JPH09504028A (ja) 酸化窒素シンターゼ抑制剤として有用なアミジノ誘導体
US20060252807A1 (en) Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders
EP1545517A1 (en) Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
AU2015339089B2 (en) Thiazoles as modulators of RORgammat
WO2007015866A2 (en) Inhibitors of p38 kinase and methods of treating inflammatory disorders
EA012607B1 (ru) НОВЫЕ ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ NF-κB
US20220235043A1 (en) Substituted sulfonamide pyrrolopyridines as jak inhibitors
JP2005537235A (ja) Ｅｐ４受容体作動薬、組成物及びその方法
US20060189639A1 (en) Antagonists of the mGlu receptor and uses thereof
WO2007137098A2 (en) Sulfonyl-substituted bicyclic compounds as modulators of ppar
US7307093B2 (en) Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof
US20060014740A1 (en) Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof
DE69201451T2 (de) Thiazolidinone und Oxazolidenonederivate, ihre Herstellung und ihre Anwendung als Vasodilatatoren.
BG60587B1 (bg) Имуностимулиращи 6-арил-5,6-дихидроимидазо(2,1-в)тиазолови производни
EP0259085B1 (en) 2-guanidino-4-arylthiazoles for treatment of peptic ulcers
WO2007047431A2 (en) Sulfonyl-substituted aryl compounds as modulators of peroxisome proliferator activated receptors
FI93953C (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten sykloalkyylitiatsolijohdannaisten valmistamiseksi

Legal Events

Date Code Title Description
FZDE Discontinued