CA2335300C - Macrocyclic analogs and methods and their use and preparation - Google Patents

Macrocyclic analogs and methods and their use and preparation Download PDF

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Publication number
CA2335300C
CA2335300C CA002335300A CA2335300A CA2335300C CA 2335300 C CA2335300 C CA 2335300C CA 002335300 A CA002335300 A CA 002335300A CA 2335300 A CA2335300 A CA 2335300A CA 2335300 C CA2335300 C CA 2335300C
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mmol
alkyl
compound
etoac
added
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CA002335300A
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English (en)
French (fr)
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CA2335300A1 (en
Inventor
Bruce A. Littlefield
Monica Palme
Boris M. Seletsky
Murray J. Towle
Melvin J. Yu
Wanjun Zheng
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Eisai Co Ltd
Eisai R&D Management Co Ltd
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Application filed by Eisai Co Ltd, Eisai R&D Management Co Ltd filed Critical Eisai Co Ltd
Priority to CA2632433A priority Critical patent/CA2632433C/en
Publication of CA2335300A1 publication Critical patent/CA2335300A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
CA002335300A 1998-06-17 1999-06-16 Macrocyclic analogs and methods and their use and preparation Expired - Lifetime CA2335300C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2632433A CA2632433C (en) 1998-06-17 1999-06-16 Methods for preparing macrocyclic analogs and intermediates for preparing same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8968298P 1998-06-17 1998-06-17
US60/089,682 1998-06-17
PCT/US1999/013677 WO1999065894A1 (en) 1998-06-17 1999-06-16 Macrocyclic analogs and methods of their use and preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2632433A Division CA2632433C (en) 1998-06-17 1999-06-16 Methods for preparing macrocyclic analogs and intermediates for preparing same

Publications (2)

Publication Number Publication Date
CA2335300A1 CA2335300A1 (en) 1999-12-23
CA2335300C true CA2335300C (en) 2008-10-07

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CA002335300A Expired - Lifetime CA2335300C (en) 1998-06-17 1999-06-16 Macrocyclic analogs and methods and their use and preparation
CA2632433A Expired - Lifetime CA2632433C (en) 1998-06-17 1999-06-16 Methods for preparing macrocyclic analogs and intermediates for preparing same
CA2755266A Expired - Lifetime CA2755266C (en) 1998-06-17 1999-06-16 Intermediates for preparing macrocyclic analogs

Family Applications After (2)

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CA2632433A Expired - Lifetime CA2632433C (en) 1998-06-17 1999-06-16 Methods for preparing macrocyclic analogs and intermediates for preparing same
CA2755266A Expired - Lifetime CA2755266C (en) 1998-06-17 1999-06-16 Intermediates for preparing macrocyclic analogs

Country Status (22)

Country Link
US (4) US6214865B1 (https=)
EP (4) EP2272839B1 (https=)
JP (1) JP4454151B2 (https=)
KR (1) KR100798600B1 (https=)
CN (1) CN1216051C (https=)
AT (1) ATE502932T1 (https=)
AU (1) AU762998B2 (https=)
BE (1) BE2011C028I2 (https=)
BR (1) BRPI9911326B8 (https=)
CA (3) CA2335300C (https=)
CY (2) CY1111516T1 (https=)
DE (2) DE69943296D1 (https=)
DK (1) DK1087960T3 (https=)
FR (1) FR11C0038I2 (https=)
HU (1) HU227912B1 (https=)
IL (1) IL139960A0 (https=)
LU (1) LU91854I2 (https=)
NO (5) NO328280B1 (https=)
NZ (1) NZ508597A (https=)
PT (1) PT1087960E (https=)
WO (1) WO1999065894A1 (https=)
ZA (1) ZA200007159B (https=)

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BRPI0817909B1 (pt) 2007-10-03 2022-06-21 Eisai R&D Management Co., Ltd Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos
CN101910180A (zh) 2007-11-16 2010-12-08 卫材R&D管理有限公司 用于软海绵素b类似物合成的新颖中间体和用于该中间体的新颖脱磺酰化反应
CA2720632C (en) 2008-04-04 2016-12-20 Eisai R&D Management Co., Ltd. Halichondrin b analogs
RU2579511C2 (ru) 2010-01-26 2016-04-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Производные фуро[3,2-в]пирана, применимые в синтезе аналогов

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