CA2305614A1 - Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids - Google Patents

Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids Download PDF

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Publication number
CA2305614A1
CA2305614A1 CA002305614A CA2305614A CA2305614A1 CA 2305614 A1 CA2305614 A1 CA 2305614A1 CA 002305614 A CA002305614 A CA 002305614A CA 2305614 A CA2305614 A CA 2305614A CA 2305614 A1 CA2305614 A1 CA 2305614A1
Authority
CA
Canada
Prior art keywords
cr4r5
alkyl
lithium
hydrogen
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002305614A
Other languages
English (en)
French (fr)
Inventor
Kevin Webb
Wilford Mendelson
Jian-Hoa Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2305614A1 publication Critical patent/CA2305614A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002305614A 1997-10-10 1998-10-07 Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids Abandoned CA2305614A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10
US60/061,613 1997-10-10
PCT/US1998/021061 WO1999018793A1 (en) 1997-10-10 1998-10-07 Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Publications (1)

Publication Number Publication Date
CA2305614A1 true CA2305614A1 (en) 1999-04-22

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002305614A Abandoned CA2305614A1 (en) 1997-10-10 1998-10-07 Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Country Status (30)

Country Link
EP (1) EP1043930A4 (ko)
JP (1) JP2001519363A (ko)
KR (1) KR100560038B1 (ko)
CN (1) CN1192025C (ko)
AP (1) AP1335A (ko)
AR (1) AR015952A1 (ko)
AU (1) AU741832B2 (ko)
BG (1) BG104302A (ko)
BR (1) BR9814064A (ko)
CA (1) CA2305614A1 (ko)
DZ (1) DZ2619A1 (ko)
EA (1) EA003609B1 (ko)
HU (1) HUP0003905A3 (ko)
ID (1) ID25536A (ko)
IL (1) IL135434A (ko)
MA (1) MA24670A1 (ko)
MY (1) MY122105A (ko)
NO (1) NO20001777L (ko)
NZ (1) NZ503759A (ko)
OA (1) OA11347A (ko)
PE (1) PE121599A1 (ko)
PL (1) PL191974B1 (ko)
SA (1) SA99191000A (ko)
SK (1) SK4902000A3 (ko)
TR (1) TR200000945T2 (ko)
TW (1) TW440557B (ko)
UA (1) UA67753C2 (ko)
UY (2) UY25201A1 (ko)
WO (1) WO1999018793A1 (ko)
ZA (1) ZA989228B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
EP1237851A4 (en) * 1999-12-15 2004-06-23 Smithkline Beecham SALES OF I CIS / I-4-CYANO-4-3- (CYCLOPENTYLOXY) -4-METHOXYPHENYL] CYCLHEXAN-1-CARBONIC ACID
DK1250313T3 (da) * 2000-01-26 2007-02-12 Smithkline Beecham Corp Monohydrat af cis-lithium-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexancarboxylat
EP2258689A1 (en) 2000-03-16 2010-12-08 Biolipox AB Benzylated PDE4 inhibitors
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
EP1355884A1 (en) 2001-01-31 2003-10-29 Pfizer Products Inc. Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
OA12541A (en) 2001-01-31 2006-06-05 Pfizer Prod Inc Ether derivatives useful as inhibitors of PDE4 isozymes.
EE200300362A (et) 2001-01-31 2003-12-15 Pfizer Products Inc. PDE4 isosüümide inhibiitoritena kasutatavad tiasolüül-, oksasolüül-, pürrolüül- ja imidasolüülhappeamiidi derivaadid
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
HU225869B1 (en) * 1992-04-02 2007-11-28 Smithkline Beecham Corp Compounds with antiallergic and antiinflammatory activity and pharmaceutical compns. contg. them
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
MY118813A (en) * 1997-02-12 2005-01-31 Smithkline Beecham Corp Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
PL191974B1 (pl) 2006-07-31
AP2000001782A0 (en) 2000-06-30
SK4902000A3 (en) 2000-11-07
EA003609B1 (ru) 2003-06-26
CN1275052A (zh) 2000-11-29
AP1335A (en) 2004-11-29
CN1192025C (zh) 2005-03-09
PL339759A1 (en) 2001-01-02
OA11347A (en) 2003-12-17
BR9814064A (pt) 2000-09-26
MY122105A (en) 2006-03-31
MA24670A1 (fr) 1999-07-01
UA67753C2 (uk) 2004-07-15
SA99191000A (ar) 2005-12-03
HUP0003905A2 (en) 2001-03-28
PE121599A1 (es) 2000-02-19
AU9687498A (en) 1999-05-03
ZA989228B (en) 1999-04-12
KR100560038B1 (ko) 2006-03-13
IL135434A (en) 2004-12-15
DZ2619A1 (fr) 2003-03-08
UY25524A1 (es) 2000-02-23
AR015952A1 (es) 2001-05-30
NO20001777L (no) 2000-05-03
KR20010015709A (ko) 2001-02-26
BG104302A (en) 2001-08-31
EP1043930A1 (en) 2000-10-18
ID25536A (id) 2000-10-12
NO20001777D0 (no) 2000-04-06
UY25201A1 (es) 2001-08-27
TW440557B (en) 2001-06-16
NZ503759A (en) 2002-03-01
WO1999018793A1 (en) 1999-04-22
JP2001519363A (ja) 2001-10-23
HUP0003905A3 (en) 2002-01-28
EP1043930A4 (en) 2004-09-15
IL135434A0 (en) 2001-05-20
EA200000406A1 (ru) 2000-10-30
AU741832B2 (en) 2001-12-13
TR200000945T2 (tr) 2000-10-23

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued