CA2301104C - Process for the preparation of oxazaphosphorine-2-amines - Google Patents

Process for the preparation of oxazaphosphorine-2-amines Download PDF

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Publication number
CA2301104C
CA2301104C CA002301104A CA2301104A CA2301104C CA 2301104 C CA2301104 C CA 2301104C CA 002301104 A CA002301104 A CA 002301104A CA 2301104 A CA2301104 A CA 2301104A CA 2301104 C CA2301104 C CA 2301104C
Authority
CA
Canada
Prior art keywords
chloroethyl
formula
process according
compound
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002301104A
Other languages
English (en)
French (fr)
Other versions
CA2301104A1 (en
Inventor
Ulf Niemeyer
Harald Niegel
Bernhard Kutscher
Ion Neda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Publication of CA2301104A1 publication Critical patent/CA2301104A1/en
Application granted granted Critical
Publication of CA2301104C publication Critical patent/CA2301104C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA002301104A 1997-09-06 1998-08-14 Process for the preparation of oxazaphosphorine-2-amines Expired - Fee Related CA2301104C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19739159A DE19739159C1 (de) 1997-09-06 1997-09-06 Verfahren zur Herstellung von Oxazaphosphorin-2-aminen
DE19739159.1 1997-09-06
PCT/EP1998/005170 WO1999012942A1 (de) 1997-09-06 1998-08-14 Verfahren zur herstellung von oxazaphosphorin-2-aminen

Publications (2)

Publication Number Publication Date
CA2301104A1 CA2301104A1 (en) 1999-03-18
CA2301104C true CA2301104C (en) 2009-10-20

Family

ID=7841505

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002301104A Expired - Fee Related CA2301104C (en) 1997-09-06 1998-08-14 Process for the preparation of oxazaphosphorine-2-amines

Country Status (18)

Country Link
US (1) US6187941B1 (enFirst)
EP (1) EP1012152B1 (enFirst)
JP (1) JP4278859B2 (enFirst)
CN (1) CN1147498C (enFirst)
AR (1) AR013467A1 (enFirst)
AT (1) ATE225797T1 (enFirst)
BR (1) BR9814266B1 (enFirst)
CA (1) CA2301104C (enFirst)
DE (2) DE19739159C1 (enFirst)
DK (1) DK1012152T3 (enFirst)
ES (1) ES2185220T3 (enFirst)
HU (1) HU226887B1 (enFirst)
IL (1) IL134507A (enFirst)
IN (1) IN186170B (enFirst)
PL (1) PL190097B1 (enFirst)
PT (1) PT1012152E (enFirst)
WO (1) WO1999012942A1 (enFirst)
ZA (1) ZA987741B (enFirst)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2196775C2 (ru) * 2001-03-27 2003-01-20 Государственный научный центр Российской Федерации "НИОПИК" Способ получения 2-[бис-(2-хлорэтил)амино]тетрагидро-2н-1,3,2-оксазафосфорин-2-оксида, моногидрата
CN1607204B (zh) * 2003-10-13 2011-10-26 北京大学 环磷酰胺季铵盐衍生物及其合成和应用
US20110054081A1 (en) * 2009-09-02 2011-03-03 Frank Dierschke Formulation and its use
FR2968662B1 (fr) * 2010-12-10 2013-11-22 Roussy Inst Gustave Nouveaux derives d'oxazaphosphorines pre-activees, utilisation et methode de preparation
US20180086780A1 (en) 2015-04-02 2018-03-29 Przedsiebiorstwo Produkcyjno-Wdrozeniowe Ifotam Sp. Z O.O. Method of production of n,n-bis(2-chloroethyl)tetrahydro-2h-1,3,2-oxazaphosphorine-2-amine 2-oxide
CN107936061B (zh) * 2017-12-28 2019-08-06 山东铂源药业有限公司 一种环磷酰胺的合成方法
CN109535201B (zh) * 2019-01-25 2020-04-03 连云港贵科药业有限公司 一种环磷酰胺的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL222157A (enFirst) * 1956-12-20
DE1645921C3 (de) * 1966-07-11 1978-10-12 Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld 2-Oxo-13,2-osazaphosphorinane, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US3732340A (en) * 1966-07-11 1973-05-08 Asta Werke Ag Chem Fab N',o-propylene phosphoric acid ester diamides
GB1235022A (en) * 1969-06-04 1971-06-09 Laeaeke Ag A new method for the production of cyclophosphamide
JPS54157580A (en) * 1978-05-29 1979-12-12 Otsuka Pharmaceut Co Ltd Optically active oxazaphosphorine derivative
JPS54157581A (en) * 1978-05-29 1979-12-12 Otsuka Pharmaceut Co Ltd Oxazaphosphorine derivative
PL119971B1 (en) * 1978-11-06 1982-02-27 Polska Akad Nauk Centrum Process for preparing optically active derivatives of 1,3,2-oxazaphosphorinane,2-oksazofosforinata
JPS5826919B2 (ja) * 1978-11-07 1983-06-06 大塚製薬株式会社 シクロ↓−１，３，２↓−オキサアザホスホル誘導体の製造法
JPS5931787A (ja) * 1982-08-13 1984-02-20 Otsuka Pharmaceut Co Ltd １，３，２−オキサアザホスホリナン−２−オキシド誘導体
PL149593B1 (pl) * 1986-12-18 1990-02-28 Sposób wytwarzania n-acylowych pochodnych 1 , 3 , 2-oksazafosforinanu

Also Published As

Publication number Publication date
PT1012152E (pt) 2003-02-28
US6187941B1 (en) 2001-02-13
JP2001515910A (ja) 2001-09-25
HU226887B1 (en) 2010-01-28
ES2185220T3 (es) 2003-04-16
PL339188A1 (en) 2000-12-04
ZA987741B (en) 1998-10-08
JP4278859B2 (ja) 2009-06-17
CN1268950A (zh) 2000-10-04
CA2301104A1 (en) 1999-03-18
IN186170B (enFirst) 2001-06-30
ATE225797T1 (de) 2002-10-15
DK1012152T3 (da) 2003-02-10
IL134507A (en) 2004-06-20
HK1030422A1 (en) 2001-05-04
PL190097B1 (pl) 2005-10-31
BR9814266A (pt) 2001-10-09
DE19739159C1 (de) 1999-01-28
IL134507A0 (en) 2001-04-30
EP1012152B1 (de) 2002-10-09
HUP0003496A3 (en) 2002-12-28
BR9814266B1 (pt) 2009-05-05
WO1999012942A1 (de) 1999-03-18
HUP0003496A2 (hu) 2002-11-28
DE59805920D1 (de) 2002-11-14
AR013467A1 (es) 2000-12-27
EP1012152A1 (de) 2000-06-28
CN1147498C (zh) 2004-04-28

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