JPS54157581A - Oxazaphosphorine derivative - Google Patents
Oxazaphosphorine derivativeInfo
- Publication number
- JPS54157581A JPS54157581A JP6468278A JP6468278A JPS54157581A JP S54157581 A JPS54157581 A JP S54157581A JP 6468278 A JP6468278 A JP 6468278A JP 6468278 A JP6468278 A JP 6468278A JP S54157581 A JPS54157581 A JP S54157581A
- Authority
- JP
- Japan
- Prior art keywords
- halogen
- formula
- oxazaphosphorine
- derivative
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An oxazaphosphorine derivative of formula I: [R1, R2, and R3 are H, lower alkyl, or phenyl groups; R4 is halogen, bis (2-hydroxyethyl) amino group].
EXAMPLE: 2(R)-3-[(S)-α-Phenylethyl]-tetrahydro-2-chloro-2H-1, 3, 2- oxazaphosphorine 2-oxide.
USE: An intermediate for the synthesis of optically active cyclophosphamides useful as a remedy for giant follicular lymphoadenopathy, lymphosarcoma, Hodgkin's disease, lymphocytic leukemia and reticulosarcoma, and antibacterials or carcinostatics.
PROCESS: An aminoalcohol derivative of formula II is reacted with a phosphorine compound of formula III: (X is halogen; R4 is halogen) to give the objective compound of formula I wherein R4 is halogen.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6468278A JPS54157581A (en) | 1978-05-29 | 1978-05-29 | Oxazaphosphorine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6468278A JPS54157581A (en) | 1978-05-29 | 1978-05-29 | Oxazaphosphorine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54157581A true JPS54157581A (en) | 1979-12-12 |
JPS63439B2 JPS63439B2 (en) | 1988-01-07 |
Family
ID=13265165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6468278A Granted JPS54157581A (en) | 1978-05-29 | 1978-05-29 | Oxazaphosphorine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54157581A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999012942A1 (en) * | 1997-09-06 | 1999-03-18 | Asta Medica Aktiengesellschaft | Method for preparing oxazaphosphorin-2-amines |
-
1978
- 1978-05-29 JP JP6468278A patent/JPS54157581A/en active Granted
Non-Patent Citations (1)
Title |
---|
TETRAHEDRON LETTEVS=1975 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999012942A1 (en) * | 1997-09-06 | 1999-03-18 | Asta Medica Aktiengesellschaft | Method for preparing oxazaphosphorin-2-amines |
Also Published As
Publication number | Publication date |
---|---|
JPS63439B2 (en) | 1988-01-07 |
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