JPS54157581A - Oxazaphosphorine derivative - Google Patents

Oxazaphosphorine derivative

Info

Publication number
JPS54157581A
JPS54157581A JP6468278A JP6468278A JPS54157581A JP S54157581 A JPS54157581 A JP S54157581A JP 6468278 A JP6468278 A JP 6468278A JP 6468278 A JP6468278 A JP 6468278A JP S54157581 A JPS54157581 A JP S54157581A
Authority
JP
Japan
Prior art keywords
halogen
formula
oxazaphosphorine
derivative
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6468278A
Other languages
Japanese (ja)
Other versions
JPS63439B2 (en
Inventor
Tadao Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP6468278A priority Critical patent/JPS54157581A/en
Publication of JPS54157581A publication Critical patent/JPS54157581A/en
Publication of JPS63439B2 publication Critical patent/JPS63439B2/ja
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An oxazaphosphorine derivative of formula I: [R1, R2, and R3 are H, lower alkyl, or phenyl groups; R4 is halogen, bis (2-hydroxyethyl) amino group].
EXAMPLE: 2(R)-3-[(S)-α-Phenylethyl]-tetrahydro-2-chloro-2H-1, 3, 2- oxazaphosphorine 2-oxide.
USE: An intermediate for the synthesis of optically active cyclophosphamides useful as a remedy for giant follicular lymphoadenopathy, lymphosarcoma, Hodgkin's disease, lymphocytic leukemia and reticulosarcoma, and antibacterials or carcinostatics.
PROCESS: An aminoalcohol derivative of formula II is reacted with a phosphorine compound of formula III: (X is halogen; R4 is halogen) to give the objective compound of formula I wherein R4 is halogen.
COPYRIGHT: (C)1979,JPO&Japio
JP6468278A 1978-05-29 1978-05-29 Oxazaphosphorine derivative Granted JPS54157581A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6468278A JPS54157581A (en) 1978-05-29 1978-05-29 Oxazaphosphorine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6468278A JPS54157581A (en) 1978-05-29 1978-05-29 Oxazaphosphorine derivative

Publications (2)

Publication Number Publication Date
JPS54157581A true JPS54157581A (en) 1979-12-12
JPS63439B2 JPS63439B2 (en) 1988-01-07

Family

ID=13265165

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6468278A Granted JPS54157581A (en) 1978-05-29 1978-05-29 Oxazaphosphorine derivative

Country Status (1)

Country Link
JP (1) JPS54157581A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999012942A1 (en) * 1997-09-06 1999-03-18 Asta Medica Aktiengesellschaft Method for preparing oxazaphosphorin-2-amines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TETRAHEDRON LETTEVS=1975 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999012942A1 (en) * 1997-09-06 1999-03-18 Asta Medica Aktiengesellschaft Method for preparing oxazaphosphorin-2-amines

Also Published As

Publication number Publication date
JPS63439B2 (en) 1988-01-07

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