CA2284996A1 - 4,4-disubstituees-3,4-dihydro-2(1h)-quinazolinones utilisees comme inhibiteurs de la transcriptase inverse du vih - Google Patents

4,4-disubstituees-3,4-dihydro-2(1h)-quinazolinones utilisees comme inhibiteurs de la transcriptase inverse du vih Download PDF

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Publication number
CA2284996A1
CA2284996A1 CA002284996A CA2284996A CA2284996A1 CA 2284996 A1 CA2284996 A1 CA 2284996A1 CA 002284996 A CA002284996 A CA 002284996A CA 2284996 A CA2284996 A CA 2284996A CA 2284996 A1 CA2284996 A1 CA 2284996A1
Authority
CA
Canada
Prior art keywords
ch2ch2
pyridyl
dihydro
trifluoromethyl
quinazolinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002284996A
Other languages
English (en)
Inventor
Jeffrey W. Corbett
Soo Sung Ko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2284996A1 publication Critical patent/CA2284996A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne 4,4-disubstituées-3,4-dihydro-2(1H)-quinazolinones de la formule (I) ou leurs formes stéréoisomères, leurs mélanges stéréoisomères ou encore leurs formes de sels pharmaceutiquement acceptables, ces composés étant utilisés comme inhibiteurs de la transcriptase inverse du VIH. L'invention concerne également des compositions et des kits de diagnostic comprenant ces composés, ainsi que leurs procédés d'utilisation dans le traitement des infections virales. Ces composés peuvent être également utilisés comme solutions étalons ou réactifs pour le dosage.
CA002284996A 1997-04-09 1998-04-07 4,4-disubstituees-3,4-dihydro-2(1h)-quinazolinones utilisees comme inhibiteurs de la transcriptase inverse du vih Abandoned CA2284996A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US83854097A 1997-04-09 1997-04-09
US08/838540 1997-04-09
US7132298P 1998-01-14 1998-01-14
US60/071322 1998-01-14
PCT/US1998/006733 WO1998045276A2 (fr) 1997-04-09 1998-04-07 4,4-disubstituees-3,4-dihydro-2(1h)-quinazolinones utilisees comme inhibiteurs de la transcriptase inverse du vih

Publications (1)

Publication Number Publication Date
CA2284996A1 true CA2284996A1 (fr) 1998-10-15

Family

ID=26752095

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002284996A Abandoned CA2284996A1 (fr) 1997-04-09 1998-04-07 4,4-disubstituees-3,4-dihydro-2(1h)-quinazolinones utilisees comme inhibiteurs de la transcriptase inverse du vih

Country Status (19)

Country Link
EP (1) EP0973753A2 (fr)
JP (1) JP2002504095A (fr)
KR (1) KR20010006146A (fr)
CN (1) CN1252063A (fr)
AR (1) AR012340A1 (fr)
AU (1) AU734928B2 (fr)
BR (1) BR9808513A (fr)
CA (1) CA2284996A1 (fr)
EA (1) EA001991B1 (fr)
EE (1) EE9900452A (fr)
HR (1) HRP980143A2 (fr)
HU (1) HUP0001446A3 (fr)
IL (1) IL132188A0 (fr)
NO (1) NO314936B1 (fr)
NZ (1) NZ500592A (fr)
PL (1) PL336305A1 (fr)
SK (1) SK137899A3 (fr)
TW (1) TW587078B (fr)
WO (1) WO1998045276A2 (fr)

Families Citing this family (46)

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WO1999050253A1 (fr) * 1998-03-27 1999-10-07 Du Pont Pharmaceuticals Company 3,4-dihydro-2(1h)-quinazolinthiones substitues en 4,4, leur preparation et leur utilisation en tant qu'inhibiteurs de la transcriptase inverse du vih
AU6508899A (en) 1998-10-13 2000-05-01 Du Pont Pharmaceuticals Company Selective eradication of virally-infected cells by combined use of a cytotoxic agent and an antiviral agent
US6225317B1 (en) * 1998-11-19 2001-05-01 Dupont Pharmaceuticals Company Crystalline (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-3,4-dihydro-2(1H)-quinazolinone
HRP990359A2 (en) * 1998-11-19 2000-08-31 Du Pont Pharm Co A process for the preparation of quinazolinones
US6175009B1 (en) 1999-11-18 2001-01-16 Dupont Pharmaceuticals Company Process for the preparation of quinazolinones
ATE305787T1 (de) 1999-11-23 2005-10-15 Smithkline Beecham Corp 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US6555686B2 (en) 2000-03-23 2003-04-29 Bristol-Myers Squibb Pharma Asymmetric synthesis of quinazolin-2-ones useful as HIV reverse transcriptase inhibitors
AU2001249161A1 (en) * 2000-03-23 2001-10-03 Bristol-Myers Squibb Pharma Company Asymmetric synthesis of quinazolin-2-ones useful as hiv reverse transcriptase inhibitors
US6596729B2 (en) * 2000-07-20 2003-07-22 Bristol-Myers Squibb Company Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors
ZA200300255B (en) 2000-07-20 2004-09-28 Bristol Myers Squibb Pharma Co Tricyclic 2-pyridone compounds useful as HIV reverse transcriptase inhibitors.
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
AU2003295940A1 (en) * 2002-12-16 2004-07-29 Boehringer Ingelheim Pharmaceuticals, Inc. Treatment of hiv infection through combined administration of tipranavir and capravirine
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
WO2006001797A1 (fr) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Element penetrant peu douloureux
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
EP1680014A4 (fr) 2003-10-14 2009-01-21 Pelikan Technologies Inc Procede et appareil fournissant une interface-utilisateur variable
WO2005065414A2 (fr) 2003-12-31 2005-07-21 Pelikan Technologies, Inc. Procede et appareil permettant d'ameliorer le flux fluidique et le prelevement d'echantillons
WO2006011062A2 (fr) 2004-05-20 2006-02-02 Albatros Technologies Gmbh & Co. Kg Hydrogel imprimable pour biocapteurs
EP1765194A4 (fr) 2004-06-03 2010-09-29 Pelikan Technologies Inc Procede et appareil pour la fabrication d'un dispositif d'echantillonnage de liquides
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2009126900A1 (fr) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Procédé et appareil pour dispositif de détection d’analyte
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8440693B2 (en) 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
CN102060786A (zh) * 2011-01-20 2011-05-18 天津大学 4-(取代-1,3-二炔基)-4-(三氟甲基)-3,4-二氢取代喹唑啉-2-酮类化合物及其制备方法和应用
EP3173096A1 (fr) * 2011-04-06 2017-05-31 Biovaxim Limited Compositions pharmaceutiques pour prévenir et/ou traiter une maladie vih chez l'homme
US9365576B2 (en) 2012-05-24 2016-06-14 Novartis Ag Pyrrolopyrrolidinone compounds
US9556180B2 (en) 2013-01-22 2017-01-31 Novartis Ag Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction
WO2014115077A1 (fr) 2013-01-22 2014-07-31 Novartis Ag Composés de purinone substitués
MX2015016344A (es) 2013-05-27 2016-03-01 Novartis Ag Derivados de imidazo-pirrolidinona y su uso en el tratamiento de enfermedades.
PL3004112T3 (pl) 2013-05-28 2018-02-28 Novartis Ag Pochodne pirazolo-pirolidyn-4-onu oraz ich zastosowanie w leczeniu choroby
MX2015016421A (es) 2013-05-28 2016-03-03 Novartis Ag Derivados de pirazolo-pirrolidin-4-ona como inhibidores de bet y su uso en el tratamiento de enfermedades.
EP3071571A1 (fr) 2013-11-21 2016-09-28 Novartis AG Dérivés de pyrrolopyrrolone et leur utilisation en tant qu'inhibiteurs de protéines bet

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
IL102764A0 (en) * 1991-08-16 1993-01-31 Merck & Co Inc Quinazoline derivatives,and pharmaceutical compositions containing them
AU2436792A (en) * 1991-08-16 1993-03-16 Merck & Co., Inc. Quinazoline derivatives as inhibitors of hiv reverse transcriptase
WO1993022292A1 (fr) * 1992-05-07 1993-11-11 Merck & Co., Inc. Nouvelles quinazolines inhibant la transcriptase inverse du vih
US5665720A (en) * 1992-08-07 1997-09-09 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
DE4320347A1 (de) * 1993-06-19 1994-12-22 Boehringer Mannheim Gmbh Quinazolin-Derivate und diese enthaltende Arzneimittel
GB2281297A (en) * 1993-08-27 1995-03-01 Merck & Co Inc Quinazoline compounds
AU1046895A (en) * 1993-11-05 1995-05-23 Merck & Co., Inc. New quinazolines as inhibitors of hiv reverse transcriptase
US5434152A (en) * 1993-11-08 1995-07-18 Merck & Co., Inc. Asymmetric synthesis of (S)-(-)-6-chloro-4- cyclopropyl-3,4-dihydro-4-[(2-pyridyl)ethynyl]-2(1H)-quinazolinone

Also Published As

Publication number Publication date
BR9808513A (pt) 2000-05-23
NZ500592A (en) 2001-09-28
NO314936B1 (no) 2003-06-16
WO1998045276A3 (fr) 1999-01-14
AU6796098A (en) 1998-10-30
EP0973753A2 (fr) 2000-01-26
EA199900907A1 (ru) 2000-04-24
IL132188A0 (en) 2001-03-19
NO994904L (no) 1999-12-01
TW587078B (en) 2004-05-11
EA001991B1 (ru) 2001-10-22
AR012340A1 (es) 2000-10-18
SK137899A3 (en) 2000-05-16
KR20010006146A (ko) 2001-01-26
HRP980143A2 (en) 1999-02-28
HUP0001446A2 (hu) 2001-05-28
AU734928B2 (en) 2001-06-28
CN1252063A (zh) 2000-05-03
JP2002504095A (ja) 2002-02-05
EE9900452A (et) 2000-04-17
PL336305A1 (en) 2000-06-19
HUP0001446A3 (en) 2001-11-28
NO994904D0 (no) 1999-10-08
WO1998045276A2 (fr) 1998-10-15

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued