CA2284795C - Novel pyrimidine derivatives and processes for the preparation thereof - Google Patents

Novel pyrimidine derivatives and processes for the preparation thereof Download PDF

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Publication number
CA2284795C
CA2284795C CA002284795A CA2284795A CA2284795C CA 2284795 C CA2284795 C CA 2284795C CA 002284795 A CA002284795 A CA 002284795A CA 2284795 A CA2284795 A CA 2284795A CA 2284795 C CA2284795 C CA 2284795C
Authority
CA
Canada
Prior art keywords
methyl
pyrimidine
fluorophenylamino
dimethyl
tetrahydroisoquinolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002284795A
Other languages
English (en)
French (fr)
Other versions
CA2284795A1 (en
Inventor
Jong Wook Lee
Bong Yong Lee
Chang Seop Kim
Seung Kyu Lee
Keun Seog Song
Song Jin Lee
Woo Jeon Shim
Man Soon Hwang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yuhan Corp
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of CA2284795A1 publication Critical patent/CA2284795A1/en
Application granted granted Critical
Publication of CA2284795C publication Critical patent/CA2284795C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002284795A 1997-03-27 1998-03-24 Novel pyrimidine derivatives and processes for the preparation thereof Expired - Fee Related CA2284795C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR1997/10862 1997-03-27
KR1997/10863 1997-03-27
KR19970010862 1997-03-27
KR19970010863 1997-03-27
PCT/KR1998/000058 WO1998043968A1 (en) 1997-03-27 1998-03-24 Novel pyrimidine derivatives and processes for the preparation thereof

Publications (2)

Publication Number Publication Date
CA2284795A1 CA2284795A1 (en) 1998-10-08
CA2284795C true CA2284795C (en) 2004-01-20

Family

ID=26632616

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002284795A Expired - Fee Related CA2284795C (en) 1997-03-27 1998-03-24 Novel pyrimidine derivatives and processes for the preparation thereof

Country Status (21)

Country Link
US (1) US6352993B1 (instruction)
EP (1) EP1015444B1 (instruction)
JP (1) JP3176379B2 (instruction)
KR (1) KR100278857B1 (instruction)
CN (1) CN1118464C (instruction)
AR (1) AR012181A1 (instruction)
AT (1) ATE241613T1 (instruction)
AU (1) AU720385B2 (instruction)
BR (1) BR9808070A (instruction)
CA (1) CA2284795C (instruction)
DE (1) DE69815126T2 (instruction)
DK (1) DK1015444T3 (instruction)
ES (1) ES2200324T3 (instruction)
HU (1) HUP0000851A3 (instruction)
IN (1) IN188411B (instruction)
PT (1) PT1015444E (instruction)
RU (1) RU2203894C2 (instruction)
TR (1) TR199902383T2 (instruction)
TW (1) TW542831B (instruction)
UY (1) UY24938A1 (instruction)
WO (1) WO1998043968A1 (instruction)

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KR100272471B1 (ko) 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
AR038368A1 (es) 2002-02-01 2005-01-12 Novartis Ag Compuestos n-pirimidin-2-il-aminas sustituidas como inhibidores de ige, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento
US7211590B2 (en) 2002-08-01 2007-05-01 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
WO2005009980A1 (en) * 2003-07-22 2005-02-03 Neurogen Corporation Substituted pyridin-2-ylamine analogues
AU2004283751B2 (en) * 2003-10-24 2011-05-19 Exelixis, Inc. p70S6 kinase modulators and method of use
KR20060099524A (ko) 2003-11-03 2006-09-19 아스트라제네카 아베 무증상 위식도 역류의 치료를 위한 이미다조[1,2-a]피리딘유도체
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법
JP2009511548A (ja) * 2005-10-14 2009-03-19 ノイロサーチ アクティーゼルスカブ 新規ピリミジン−2,4−ジアミン誘導体及び小コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしてのこれらの使用
JP4946482B2 (ja) 2007-02-08 2012-06-06 船井電機株式会社 緩衝用梱包材及びtv受像機の緩衝用梱包材
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
WO2010016490A1 (ja) 2008-08-05 2010-02-11 第一三共株式会社 イミダゾピリジン-2-オン誘導体
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
MX2013005478A (es) 2010-11-15 2013-08-29 Univ Leuven Kath Compuestos heterociclicos condensados antivirales.
MX337477B (es) 2011-02-25 2016-03-07 Yuhan Corp Derivados de diaminopiridina y procesos para su preparacion.
CA2864825C (en) * 2012-02-17 2021-01-26 Abbvie Inc. Diaminopyrimidines useful as inhibitors of the human respiratory syncytial virus (rsv)
US9309271B2 (en) 2012-05-29 2016-04-12 Momentive Performance Materials Gmbh Preparation of isocyanato silanes
MA38208B1 (fr) 2012-11-21 2021-12-31 Ptc Therapeutics Inc Inhibiteurs de bmi-1 pyrimidines inversés substitués
US10035801B2 (en) 2013-03-13 2018-07-31 Genentech, Inc. Pyrazolo compounds and uses thereof
TWI692477B (zh) * 2013-08-30 2020-05-01 美商Ptc治療公司 經取代嘧啶bmi-1抑制劑
JP6507157B2 (ja) * 2013-10-07 2019-04-24 カドモン コーポレイション,リミティド ライアビリティ カンパニー Rhoキナーゼ阻害剤
WO2015076800A1 (en) 2013-11-21 2015-05-28 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
US10370360B2 (en) 2014-10-22 2019-08-06 The Board Of Regents Of The University Of Texas System Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
PL3397622T3 (pl) * 2016-01-04 2022-07-04 ObsEva S.A. Jednoczesne podawanie alfa-aminoestrowej pochodnej hydroksypropylotiazolidynokarboksyamidu i środka tokolitycznego
EP3606915A1 (de) * 2017-04-05 2020-02-12 Bayer CropScience Aktiengesellschaft 2-amino-5-oxyalkyl-pyrimidinderivate und deren verwendung zur bekämpfung unerwünschten pflanzenwachstums
EP3836932A2 (en) 2018-08-17 2021-06-23 PTC Therapeutics, Inc. Method for treating pancreatic cancer
CN114685369B (zh) * 2022-05-17 2024-02-02 河南省科学院高新技术研究中心 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法

Family Cites Families (25)

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Publication number Priority date Publication date Assignee Title
GB1182584A (en) 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
US3980781A (en) 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
US4000138A (en) 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US4044136A (en) 1972-09-09 1977-08-23 Pfizer Inc. Aminoquinazoline therapeutic agents
US3956495A (en) 1973-10-30 1976-05-11 Eli Lilly And Company 2,4-Diaminoquinazolines as antithrombotic agents
US4755218A (en) 1985-12-31 1988-07-05 Monsanto Company Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
US4966622A (en) 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
HU206337B (en) * 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
DE3901448A1 (de) 1989-01-19 1990-07-26 Basf Ag Emulsionscopolymerisate
FI95376C (fi) 1989-03-22 1996-01-25 Ciba Geigy Ag Mikrobisidiset 2-anilino-pyrimidiinijohdannaiset
GB8910722D0 (en) 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
CA2015981A1 (en) * 1989-05-10 1990-11-10 Thomas H. Brown Compounds
GB9012592D0 (en) 1990-06-06 1990-07-25 Smithkline Beecham Intercredit Compounds
US5444062A (en) 1990-11-06 1995-08-22 Pfizer Inc. Quinazolines derivatives for enhancing antitumor activity
FI934565A0 (fi) * 1991-04-17 1993-10-15 Pfizer Pyrimidinderivat foer att oeka antitumoeraktiviteten
US5276186A (en) 1992-03-11 1994-01-04 Ciba-Geigy Corporation Process for the production of guanidine derivatives
KR0144833B1 (ko) 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
WO1995005363A1 (en) * 1993-08-12 1995-02-23 Astra Aktiebolag Amidine derivatives with nitric oxide synthetase activities
ATE163647T1 (de) 1993-08-26 1998-03-15 Ono Pharmaceutical Co 4-aminopyrimidin derivate
WO1995010506A1 (en) 1993-10-12 1995-04-20 The Du Pont Merck Pharmaceutical Company 1n-alkyl-n-arylpyrimidinamines and derivatives thereof
ES2201112T3 (es) 1994-08-13 2004-03-16 Yuhan Corporation Nuevos derivados de pirimidina y procedimientos para su preparacion.
ES2165052T3 (es) 1996-05-04 2002-03-01 Yuhan Corp Procedimiento para la preparacion de derivados de pirimidina.

Also Published As

Publication number Publication date
ES2200324T3 (es) 2004-03-01
EP1015444A1 (en) 2000-07-05
JP3176379B2 (ja) 2001-06-18
CN1251586A (zh) 2000-04-26
TW542831B (en) 2003-07-21
AU720385B2 (en) 2000-06-01
IN188411B (instruction) 2002-09-21
HUP0000851A1 (hu) 2001-04-28
DE69815126T2 (de) 2004-04-08
TR199902383T2 (xx) 2000-06-21
ATE241613T1 (de) 2003-06-15
UY24938A1 (es) 2001-01-31
AR012181A1 (es) 2000-09-27
CN1118464C (zh) 2003-08-20
HK1026418A1 (en) 2000-12-15
KR19980080789A (ko) 1998-11-25
KR100278857B1 (ko) 2001-01-15
JP2000513014A (ja) 2000-10-03
HUP0000851A3 (en) 2002-04-29
EP1015444B1 (en) 2003-05-28
AU6523998A (en) 1998-10-22
BR9808070A (pt) 2000-03-08
DK1015444T3 (da) 2003-08-18
WO1998043968A1 (en) 1998-10-08
PT1015444E (pt) 2003-10-31
US6352993B1 (en) 2002-03-05
DE69815126D1 (de) 2003-07-03
RU2203894C2 (ru) 2003-05-10
CA2284795A1 (en) 1998-10-08

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