CA2278541C - Pharmaceutical preparations and methods for their regional administration - Google Patents
Pharmaceutical preparations and methods for their regional administration Download PDFInfo
- Publication number
- CA2278541C CA2278541C CA002278541A CA2278541A CA2278541C CA 2278541 C CA2278541 C CA 2278541C CA 002278541 A CA002278541 A CA 002278541A CA 2278541 A CA2278541 A CA 2278541A CA 2278541 C CA2278541 C CA 2278541C
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- Prior art keywords
- drug
- formulation
- treatment
- effective
- endometriosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
- Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/795—Composed of biological material
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3672797P | 1997-01-24 | 1997-01-24 | |
| US60/036,727 | 1997-01-24 | ||
| US5257897P | 1997-07-15 | 1997-07-15 | |
| US60/052,578 | 1997-07-15 | ||
| US08/971,346 | 1997-11-17 | ||
| US08/971,346 US5993856A (en) | 1997-01-24 | 1997-11-17 | Pharmaceutical preparations and methods for their administration |
| PCT/US1998/000916 WO1998032422A1 (en) | 1997-01-24 | 1998-01-23 | Pharmaceutical preparations and methods for their regional administration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2278541A1 CA2278541A1 (en) | 1998-07-30 |
| CA2278541C true CA2278541C (en) | 2006-10-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002278541A Expired - Lifetime CA2278541C (en) | 1997-01-24 | 1998-01-23 | Pharmaceutical preparations and methods for their regional administration |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5993856A (https=) |
| EP (2) | EP0977555B1 (https=) |
| JP (2) | JP2001511773A (https=) |
| AT (1) | ATE321532T1 (https=) |
| AU (1) | AU743157B2 (https=) |
| CA (1) | CA2278541C (https=) |
| DE (1) | DE69834025T2 (https=) |
| DK (1) | DK0977555T3 (https=) |
| ES (1) | ES2260828T3 (https=) |
| PT (1) | PT977555E (https=) |
| WO (1) | WO1998032422A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2327459C1 (ru) * | 2007-06-26 | 2008-06-27 | Евгений Сергеевич Северин | Лекарственное средство противомикробного действия, способ получения лекарственного препарата направленного действия, содержащего наночастицы |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050065161A1 (en) * | 1996-02-02 | 2005-03-24 | Nitromed, Inc. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses |
| US6416778B1 (en) * | 1997-01-24 | 2002-07-09 | Femmepharma | Pharmaceutical preparations and methods for their regional administration |
| US6630168B1 (en) * | 1997-02-20 | 2003-10-07 | Biomedicines, Inc. | Gel delivery vehicles for anticellular proliferative agents |
| US6416779B1 (en) * | 1997-06-11 | 2002-07-09 | Umd, Inc. | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections |
| US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
| US6958148B1 (en) | 1998-01-20 | 2005-10-25 | Pericor Science, Inc. | Linkage of agents to body tissue using microparticles and transglutaminase |
| US6919076B1 (en) | 1998-01-20 | 2005-07-19 | Pericor Science, Inc. | Conjugates of agents and transglutaminase substrate linking molecules |
| WO1999060938A1 (en) | 1998-05-23 | 1999-12-02 | Focal, Inc. | Method of treatment for premature rupture of membranes in pregnancy (prom) |
| IL127129A (en) * | 1998-11-18 | 2004-06-01 | Ferring Bv | Method for preparation of progesterone tablets for vaginal delivery and tablets so prepared |
| US20070178139A1 (en) * | 1998-11-18 | 2007-08-02 | Yankov Vladimir I | Vaginally administratable progesterone-containing tablets and method for preparing same |
| US6350464B1 (en) | 1999-01-11 | 2002-02-26 | Guilford Pharmaceuticals, Inc. | Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same |
| US6537566B1 (en) | 1999-03-11 | 2003-03-25 | John Alton Copland | Compositions and methods for the non-invasive treatment of uterine fibroid cells |
| US6537585B1 (en) | 1999-03-26 | 2003-03-25 | Guilford Pharmaceuticals, Inc. | Methods and compositions for treating solid tumors |
| US6375970B1 (en) * | 1999-07-07 | 2002-04-23 | Andre Bieniarz | Methods and materials for preterm birth prevention |
| WO2001085013A2 (en) * | 2000-05-09 | 2001-11-15 | Nitromed, Inc. | Infrared thermography and methods of use |
| US20050042194A1 (en) * | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| US6613355B2 (en) | 2000-05-11 | 2003-09-02 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| EP1315777B1 (en) | 2000-09-06 | 2007-10-31 | AP Pharma, Inc. | Degradable polyacetal polymers |
| WO2002028660A2 (en) | 2000-10-02 | 2002-04-11 | Kimberly-Clark Worldwide, Inc. | Nanoparticle based inks and methods of making the same |
| US6590059B2 (en) | 2001-05-11 | 2003-07-08 | Ap Pharma, Inc. | Bioerodible polyorthoesters from dioxolane-based diketene acetals |
| US20030134892A1 (en) * | 2001-07-19 | 2003-07-17 | Wenbin Dang | Compositions for treatment of head and neck cancers, and methods of making and using the same |
| WO2003007914A2 (en) * | 2001-07-19 | 2003-01-30 | Guilford Pharmaceuticals, Inc. | Biocompatible polymer containing composition for treatment of prostate cancers |
| US8425892B2 (en) * | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
| US20030114394A1 (en) * | 2001-10-29 | 2003-06-19 | Levine Howard L. | Vaginally administered anti-dysrhythmic agents for treating pelvic pain |
| US20080182841A1 (en) * | 2001-10-29 | 2008-07-31 | Levine Howard L | Vaginally administered anti-dysrhythmic agents for treating pelvic pain |
| US6524606B1 (en) | 2001-11-16 | 2003-02-25 | Ap Pharma, Inc. | Bioerodible polyorthoesters containing amine groups |
| JP2005513080A (ja) * | 2001-12-20 | 2005-05-12 | フェムファーマ， インコーポレイテッド | 薬物の膣送達 |
| US20060177495A1 (en) * | 2001-12-21 | 2006-08-10 | Christine Allen | Polymer-lipid delivery vehicles |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| EP1543841A4 (en) * | 2002-08-15 | 2011-03-16 | Yunqing Liu | SOLID PHARMACEUTICAL NANO FORMULATION AND MANUFACTURING METHOD THEREFOR |
| US7045589B2 (en) * | 2002-11-15 | 2006-05-16 | A.P. Pharma, Inc. | Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them |
| US8409618B2 (en) | 2002-12-20 | 2013-04-02 | Kimberly-Clark Worldwide, Inc. | Odor-reducing quinone compounds |
| US7666410B2 (en) | 2002-12-20 | 2010-02-23 | Kimberly-Clark Worldwide, Inc. | Delivery system for functional compounds |
| US6780896B2 (en) | 2002-12-20 | 2004-08-24 | Kimberly-Clark Worldwide, Inc. | Stabilized photoinitiators and applications thereof |
| US9173836B2 (en) * | 2003-01-02 | 2015-11-03 | FemmeParma Holding Company, Inc. | Pharmaceutical preparations for treatments of diseases and disorders of the breast |
| MXPA05007266A (es) * | 2003-01-02 | 2006-01-17 | Femmepharma Holding Co Inc | Preparaciones farmaceuticas para tratamientos de enfermedades y trastornos del seno. |
| AU2007216882B2 (en) * | 2003-01-02 | 2010-03-11 | Femmepharma Holding Company, Inc. | Pharmaceutical preparations for treatment of diseases and disorders of the breast |
| JP2004323454A (ja) * | 2003-04-25 | 2004-11-18 | Chisso Corp | 薬剤 |
| JP5651279B2 (ja) | 2003-09-03 | 2015-01-07 | ミスコン トレイディング エス．エー． | 子宮内膜症の処置のための方法 |
| US20060140990A1 (en) * | 2003-09-19 | 2006-06-29 | Drugtech Corporation | Composition for topical treatment of mixed vaginal infections |
| AU2004274000B2 (en) * | 2003-09-19 | 2009-07-30 | Drugtech Corporation | Pharmaceutical delivery system |
| US20050222106A1 (en) * | 2004-04-01 | 2005-10-06 | Stefan Bracht | Drospirenone-containing preparations for transdermal use |
| US20060040904A1 (en) * | 2004-08-17 | 2006-02-23 | Ahmed Salah U | Vaginal cream compositions, kits thereof and methods of using thereof |
| US7919453B2 (en) | 2005-03-25 | 2011-04-05 | Kimberly-Clark Worldwide, Inc. | Dosage cap assembly for an applicator |
| US7993667B2 (en) | 2005-03-25 | 2011-08-09 | Kimberly-Clark Worldwide, Inc. | Methods of manufacturing a medicated tampon assembly |
| US7744556B2 (en) | 2005-03-25 | 2010-06-29 | Kimberly-Clark Worldwide, Inc. | Delivery tube assembly for an applicator |
| US7527614B2 (en) | 2005-03-25 | 2009-05-05 | Kimberly-Clark Worldwide, Inc. | Protective tube for a medicated tampon |
| US7708726B2 (en) | 2005-04-28 | 2010-05-04 | Kimberly-Clark Worldwide, Inc. | Dosage form cap for an applicator |
| CA2605341A1 (en) * | 2005-05-09 | 2006-11-16 | Drugtech Corporation | Modified-release pharmaceutical compositions |
| CN101282646B (zh) * | 2005-07-12 | 2013-03-27 | Dmi生物科学公司 | 治疗疾病的方法和产品 |
| WO2007076144A2 (en) * | 2005-12-27 | 2007-07-05 | Duramed Pharmaceuticals, Inc. | Conjugated estrogen compositions, applicators, kits, and methods of making and use thereof |
| CN101374501A (zh) * | 2006-01-05 | 2009-02-25 | 药物技术公司 | 组合物及其使用方法 |
| WO2007079391A2 (en) * | 2006-01-05 | 2007-07-12 | Drugtech Corporation | Drug delivery system for bioadhesion to a vulvovaginal surface |
| US20070265329A1 (en) * | 2006-05-12 | 2007-11-15 | Devang Shah T | Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) |
| US20070264338A1 (en) * | 2006-05-12 | 2007-11-15 | Shah Devang T | Base-stabilized polyorthoester formulations |
| US8080540B2 (en) * | 2006-09-19 | 2011-12-20 | Abbott Products Gmbh | Therapeutically active triazoles and their use |
| US8288367B2 (en) | 2006-11-30 | 2012-10-16 | Solvay Pharmaceuticals Gmbh | Substituted estratriene derivatives as 17BETA HSD inhibitors |
| EP2104489A2 (en) * | 2006-12-26 | 2009-09-30 | FemmePharma Holding Company, Inc. | Topical administration of danazol |
| WO2008144143A1 (en) * | 2007-05-14 | 2008-11-27 | Drugtech Corporation | Endometriosis treatment |
| WO2009073782A2 (en) * | 2007-12-04 | 2009-06-11 | Ams Research Corporation | Apparatus and methods for treatment of pathologic proliferative conditions of uterine tissue |
| EP2359807B1 (en) | 2008-02-04 | 2017-07-26 | Ferring B.V. | Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof |
| WO2010068827A1 (en) * | 2008-12-11 | 2010-06-17 | A.P. Pharma, Inc. | Methods for enhancing stability of polyorthoesters and their formulations |
| US9504274B2 (en) * | 2009-01-27 | 2016-11-29 | Frito-Lay North America, Inc. | Methods of flavor encapsulation and matrix-assisted concentration of aqueous foods and products produced therefrom |
| ES2523769T3 (es) | 2009-06-22 | 2014-12-01 | Ampio Pharmaceuticals, Inc. | Procedimiento de tratamiento de enfermedades |
| SG177302A1 (en) * | 2009-06-22 | 2012-02-28 | Dmi Acquisition Corp | Methods and products for treatment of diseases |
| US20110003000A1 (en) * | 2009-07-06 | 2011-01-06 | Femmepharma Holding Company, Inc. | Transvaginal Delivery of Drugs |
| US8597262B2 (en) * | 2009-07-09 | 2013-12-03 | Ams Research Corporation | Apparatus and methods of treatment of pathologic proliferative conditions uterine tissue |
| US20110033545A1 (en) * | 2009-08-06 | 2011-02-10 | Absize, Inc. | Topical pharmaceutical preparations having both a nanoparticle solution and a nanoparticle suspension and methods for the treatment of acute and chronic pain therewith |
| EP3865502A1 (en) * | 2010-03-22 | 2021-08-18 | Allergan Pharmaceuticals International Limited | Compositions and methods for non-toxic delivery of cdb-2914 |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| EP2934546A4 (en) | 2012-12-19 | 2016-06-22 | Ampio Pharmaceuticals Inc | METHOD OF DISEASE TREATMENT |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| US20160008310A1 (en) | 2014-07-11 | 2016-01-14 | Azanta A/S | Misoprostol dispersible tablet |
| DK3166597T3 (en) | 2014-07-11 | 2025-09-01 | Azanta Danmark As | Misoprostol dispersibel tablet |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| KR20200019735A (ko) * | 2017-06-22 | 2020-02-24 | 비라말 리미티드 | 약물 전달을 위한 조성물 및 그의 사용 방법 |
| BR112021007877A2 (pt) | 2018-10-26 | 2021-08-03 | Viramal Limited | composição em gel mucoadesiva |
| EP3659583B1 (en) | 2018-11-30 | 2023-06-07 | Viramal Limited | A method of preparing a gelling agent, the gelling agent obtained thereby, and the use of said gelling agent |
| JP2023515918A (ja) | 2020-01-13 | 2023-04-17 | デュレクト コーポレーション | 不純物が低減された徐放性薬物送達システム及び関連の方法 |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| CA3203561A1 (en) | 2021-01-12 | 2022-07-21 | Adrian Neil Verity | Sustained release drug delivery systems and related methods |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3921636A (en) * | 1973-01-15 | 1975-11-25 | Alza Corp | Novel drug delivery device |
| US4107288A (en) * | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US4081533A (en) * | 1976-09-01 | 1978-03-28 | Regents Of The University Of California | Method of reducing mammalian fertility and drugs therefor |
| US4391797A (en) * | 1977-01-05 | 1983-07-05 | The Children's Hospital Medical Center | Systems for the controlled release of macromolecules |
| US4292315A (en) * | 1977-12-30 | 1981-09-29 | Nichols Vorys | Follicular phase estrogen or progestin with physiologic estrogen/progestin luteal phase replacement drug delivery system |
| US4291028A (en) * | 1977-12-30 | 1981-09-22 | Nichols Vorys | Follicular phase estrogen or progestin with physiologic estrogen/progestin luteal phase replacement drug delivery system |
| US4272398A (en) * | 1978-08-17 | 1981-06-09 | The United States Of America As Represented By The Secretary Of Agriculture | Microencapsulation process |
| US4286587A (en) * | 1978-10-11 | 1981-09-01 | Alza Corporation | Vaginal drug delivery system made from polymer |
| JPS5555114A (en) * | 1978-10-17 | 1980-04-22 | Stolle Res & Dev | Fine drug |
| DE3214667C2 (de) * | 1982-04-21 | 1985-07-18 | Akzo Gmbh, 5600 Wuppertal | Zusammengesetzter Körper für die Langzeitabgabe von Wirkstoffen |
| US4673405A (en) * | 1983-03-04 | 1987-06-16 | Alza Corporation | Osmotic system with instant drug availability |
| US4591496A (en) * | 1984-01-16 | 1986-05-27 | Massachusetts Institute Of Technology | Process for making systems for the controlled release of macromolecules |
| NL8401912A (nl) * | 1984-06-15 | 1986-01-02 | Tno | Met aktieve stof beladen biodegradeerbare polymeersubstraten, geschikt voor het gecontroleerd afgeven van de aktieve stof door middel van een membraan. |
| US4762717A (en) * | 1986-03-21 | 1988-08-09 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive |
| US5057317A (en) * | 1987-03-24 | 1991-10-15 | Chugai Seiyaku Kabushiki Kaisha | Slow-release pharmaceutical agent |
| US4861627A (en) * | 1987-05-01 | 1989-08-29 | Massachusetts Institute Of Technology | Preparation of multiwall polymeric microcapsules |
| US4873092A (en) * | 1987-05-21 | 1989-10-10 | Murata Kikai Kabushiki Kaisha | Slow-releasing preparation |
| JP2590358B2 (ja) * | 1988-03-01 | 1997-03-12 | 正雄 五十嵐 | 子宮内膜症治療用の子宮内又は膣内投与製剤 |
| US5130137A (en) * | 1989-08-09 | 1992-07-14 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use in treating benign ovarian secretory disorders |
| JP2927830B2 (ja) * | 1989-09-01 | 1999-07-28 | 東京田辺製薬株式会社 | ダナゾール坐剤 |
| FR2663224B1 (fr) * | 1990-06-14 | 1995-01-20 | Applicationes Farmaceuticas Sa | Forme galenique parenterale. |
| US5156851A (en) * | 1990-06-20 | 1992-10-20 | Monsanto Company | Coated veterinary implants |
| US5091185A (en) * | 1990-06-20 | 1992-02-25 | Monsanto Company | Coated veterinary implants |
| US5410016A (en) | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| AU1442592A (en) * | 1991-02-20 | 1992-09-15 | Nova Pharmaceutical Corporation | Controlled release microparticulate delivery system for proteins |
| DE69216873T2 (de) * | 1991-02-21 | 1997-08-21 | Sankyo Co | Benzolderivate zum Fördern der Produktion des Nervenwachstumsfaktors |
| JPH0735335B2 (ja) * | 1991-02-28 | 1995-04-19 | 五十嵐 正雄 | 子宮内膜症の治療薬 |
| US5340585A (en) * | 1991-04-12 | 1994-08-23 | University Of Southern California | Method and formulations for use in treating benign gynecological disorders |
| IT1250421B (it) * | 1991-05-30 | 1995-04-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive. |
| US5330768A (en) * | 1991-07-05 | 1994-07-19 | Massachusetts Institute Of Technology | Controlled drug delivery using polymer/pluronic blends |
| DE69224809T2 (de) * | 1991-12-30 | 1998-07-09 | Akzo Nobel Nv | Thyroaktive Zusammensetzung mit kontrollierter Freigabe |
| AU668384B2 (en) * | 1992-03-12 | 1996-05-02 | Alkermes Controlled Therapeutics, Inc. | Controlled release ACTH containing microspheres |
| US5482706A (en) * | 1992-04-17 | 1996-01-09 | Takeda Chemical Industries, Ltd. | Transmucosal therapeutic composition |
| US5665383A (en) * | 1993-02-22 | 1997-09-09 | Vivorx Pharmaceuticals, Inc. | Methods for the preparation of immunostimulating agents for in vivo delivery |
| US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| US5651976A (en) * | 1993-06-17 | 1997-07-29 | The United States Of America As Represented By The Secretary Of The Navy | Controlled release of active agents using inorganic tubules |
| GB9318641D0 (en) * | 1993-09-08 | 1993-10-27 | Edko Trading Representation | Compositions |
| US5417982A (en) * | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
| NL9400410A (nl) * | 1994-03-16 | 1995-11-01 | M D Ph D Willem Arthur Adriaan | Intra-uterine anticonceptiemiddel. |
| US5718388A (en) * | 1994-05-25 | 1998-02-17 | Eastman Kodak | Continuous method of grinding pharmaceutical substances |
| TW384224B (en) * | 1994-05-25 | 2000-03-11 | Nano Sys Llc | Method of preparing submicron particles of a therapeutic or diagnostic agent |
| US5587143A (en) * | 1994-06-28 | 1996-12-24 | Nanosystems L.L.C. | Butylene oxide-ethylene oxide block copolymer surfactants as stabilizer coatings for nanoparticle compositions |
| US5633011A (en) * | 1994-08-04 | 1997-05-27 | Alza Corporation | Progesterone replacement therapy |
| US5573783A (en) * | 1995-02-13 | 1996-11-12 | Nano Systems L.L.C. | Redispersible nanoparticulate film matrices with protective overcoats |
| US5510118A (en) * | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
| ES2093562B1 (es) * | 1995-05-26 | 1997-07-01 | Univ Santiago Compostela | Estabilizacion de sistemas coloidales mediante formacion de complejos ionicos lipido-polisacarido. |
-
1997
- 1997-11-17 US US08/971,346 patent/US5993856A/en not_active Expired - Lifetime
-
1998
- 1998-01-23 AU AU59227/98A patent/AU743157B2/en not_active Ceased
- 1998-01-23 WO PCT/US1998/000916 patent/WO1998032422A1/en not_active Ceased
- 1998-01-23 CA CA002278541A patent/CA2278541C/en not_active Expired - Lifetime
- 1998-01-23 EP EP98902614A patent/EP0977555B1/en not_active Expired - Lifetime
- 1998-01-23 AT AT98902614T patent/ATE321532T1/de active
- 1998-01-23 ES ES98902614T patent/ES2260828T3/es not_active Expired - Lifetime
- 1998-01-23 DE DE69834025T patent/DE69834025T2/de not_active Expired - Lifetime
- 1998-01-23 JP JP53206098A patent/JP2001511773A/ja active Pending
- 1998-01-23 PT PT98902614T patent/PT977555E/pt unknown
- 1998-01-23 EP EP10185383A patent/EP2316424A1/en not_active Withdrawn
- 1998-01-23 DK DK98902614T patent/DK0977555T3/da active
-
2010
- 2010-03-09 JP JP2010052254A patent/JP2010138196A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2327459C1 (ru) * | 2007-06-26 | 2008-06-27 | Евгений Сергеевич Северин | Лекарственное средство противомикробного действия, способ получения лекарственного препарата направленного действия, содержащего наночастицы |
Also Published As
| Publication number | Publication date |
|---|---|
| US5993856A (en) | 1999-11-30 |
| AU743157B2 (en) | 2002-01-17 |
| EP0977555A1 (en) | 2000-02-09 |
| ES2260828T3 (es) | 2006-11-01 |
| DK0977555T3 (da) | 2006-07-10 |
| DE69834025D1 (de) | 2006-05-18 |
| EP0977555B1 (en) | 2006-03-29 |
| CA2278541A1 (en) | 1998-07-30 |
| AU5922798A (en) | 1998-08-18 |
| DE69834025T2 (de) | 2006-11-09 |
| JP2010138196A (ja) | 2010-06-24 |
| EP2316424A1 (en) | 2011-05-04 |
| PT977555E (pt) | 2006-06-30 |
| ATE321532T1 (de) | 2006-04-15 |
| JP2001511773A (ja) | 2001-08-14 |
| WO1998032422A1 (en) | 1998-07-30 |
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