CA2278178C - Practical in vitro sialylation of recombinant glycoproteins - Google Patents

Practical in vitro sialylation of recombinant glycoproteins Download PDF

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Publication number
CA2278178C
CA2278178C CA2278178A CA2278178A CA2278178C CA 2278178 C CA2278178 C CA 2278178C CA 2278178 A CA2278178 A CA 2278178A CA 2278178 A CA2278178 A CA 2278178A CA 2278178 C CA2278178 C CA 2278178C
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Canada
Prior art keywords
sialyltransferase
glycoprotein
recombinant
sialic acid
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2278178A
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English (en)
French (fr)
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CA2278178A1 (en
Inventor
James C. Paulson
Robert J. Bayer
Eric Sjoberg
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Novo Nordisk AS
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Novo Nordisk AS
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Publication of CA2278178A1 publication Critical patent/CA2278178A1/en
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Publication of CA2278178C publication Critical patent/CA2278178C/en
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2278178A 1997-01-16 1998-01-15 Practical in vitro sialylation of recombinant glycoproteins Expired - Fee Related CA2278178C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3571097P 1997-01-16 1997-01-16
US60/035,710 1997-01-16
PCT/US1998/000835 WO1998031826A1 (en) 1997-01-16 1998-01-15 Practical in vitro sialylation of recombinant glycoproteins

Publications (2)

Publication Number Publication Date
CA2278178A1 CA2278178A1 (en) 1998-07-23
CA2278178C true CA2278178C (en) 2012-09-25

Family

ID=21884346

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2278178A Expired - Fee Related CA2278178C (en) 1997-01-16 1998-01-15 Practical in vitro sialylation of recombinant glycoproteins

Country Status (12)

Country Link
US (5) US6399336B1 (https=)
EP (1) EP1015622B1 (https=)
JP (2) JP2001507215A (https=)
AT (1) ATE263841T1 (https=)
AU (1) AU736993B2 (https=)
CA (1) CA2278178C (https=)
DE (1) DE69823046T2 (https=)
DK (1) DK1015622T3 (https=)
ES (1) ES2218806T3 (https=)
IL (2) IL130964A0 (https=)
NZ (1) NZ336780A (https=)
WO (1) WO1998031826A1 (https=)

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* Cited by examiner, † Cited by third party
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Also Published As

Publication number Publication date
IL130964A0 (en) 2001-01-28
IL130964A (en) 2006-06-11
ES2218806T3 (es) 2004-11-16
DK1015622T3 (da) 2004-08-02
JP2001507215A (ja) 2001-06-05
US20020119516A1 (en) 2002-08-29
AU6242798A (en) 1998-08-07
DE69823046D1 (de) 2004-05-13
EP1015622B1 (en) 2004-04-07
US20020160460A1 (en) 2002-10-31
EP1015622A4 (en) 2002-06-19
EP1015622A1 (en) 2000-07-05
WO1998031826A1 (en) 1998-07-23
NZ336780A (en) 2000-12-22
ATE263841T1 (de) 2004-04-15
AU736993B2 (en) 2001-08-09
DE69823046T2 (de) 2005-03-31
US20020142370A1 (en) 2002-10-03
US6399336B1 (en) 2002-06-04
JP2011024597A (ja) 2011-02-10
US20030124645A1 (en) 2003-07-03
US7220555B2 (en) 2007-05-22
CA2278178A1 (en) 1998-07-23

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