CA2235371A1 - Formes polymorphes d'un agent de secretion d'hormone de croissance - Google Patents
Formes polymorphes d'un agent de secretion d'hormone de croissance Download PDFInfo
- Publication number
- CA2235371A1 CA2235371A1 CA002235371A CA2235371A CA2235371A1 CA 2235371 A1 CA2235371 A1 CA 2235371A1 CA 002235371 A CA002235371 A CA 002235371A CA 2235371 A CA2235371 A CA 2235371A CA 2235371 A1 CA2235371 A1 CA 2235371A1
- Authority
- CA
- Canada
- Prior art keywords
- growth hormone
- polymorphic form
- amino
- carbonyl
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Fodder In General (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Cette invention se rapporte à des formes polymorphes du composé N-[1(R)-[(1,2-dihydro-1-méthanesulfonylspiro[3H-indole-3,4'-piperdin]-1'-yl)carbonyl]-2-(phénylméthyloxy)éthyl]-2-amino-2-méthylpropanamide méthanesulfonate qui est un agent de sécrétion d'hormone de croissance s'avérant utile d'une part pour favoriser la croissance des animaux destinés à l'alimentation, ce qui permet d'optimiser la production de produits carnés comestibles, et d'autre part pour traiter, chez des sujets humains, des troubles physiologiques ou médicaux caractérisés par une carence en sécrétion d'hormone de croissance de même que des états pathologiques qui sont améliorés par les effets anabolisants de l'hormone de croissance. Les formes polymorphes instantanées possèdent des avantages sur les autres formes connues de N-[1(R)-[(1,2-dihydro-1-méthanesulfonylspiro[3H-indole-3,4'-piperdin]-1'-yl)carbonyl]-2-(phénylméthyloxy)éthyl]-2-amino-2-méthylpropanamide méthanesulfonate en ce qui concerne la stabilité thermodynamique et l'aptitude à l'incorporation à des formulations pharmaceutiques. La présente invention se rapporte également à des procédés de préparation de ces formes polymorphes, à des formulations pharmaceutiques contenant lesdites formes polymorphes en tant qu'ingrédients actifs ainsi qu'à l'utilisation des formes polymorphes du composé et de leurs formulations pour le traitement de certains troubles.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US590095P | 1995-10-27 | 1995-10-27 | |
| US60/005,900 | 1995-10-27 | ||
| GBGB9603361.8A GB9603361D0 (en) | 1996-02-16 | 1996-02-16 | Polymorphic forms of a growth hormone secretagogue |
| GB9603361.8 | 1996-02-16 | ||
| PCT/US1996/016955 WO1997015574A1 (fr) | 1995-10-27 | 1996-10-23 | Formes polymorphes d'un agent de secretion d'hormone de croissance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2235371A1 true CA2235371A1 (fr) | 1997-05-01 |
Family
ID=26308741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002235371A Abandoned CA2235371A1 (fr) | 1995-10-27 | 1996-10-23 | Formes polymorphes d'un agent de secretion d'hormone de croissance |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1019402A1 (fr) |
| JP (1) | JP3204266B2 (fr) |
| KR (1) | KR19990067098A (fr) |
| CN (1) | CN1067687C (fr) |
| AU (1) | AU707946B2 (fr) |
| BG (1) | BG102476A (fr) |
| BR (1) | BR9611229A (fr) |
| CA (1) | CA2235371A1 (fr) |
| CO (1) | CO4770956A1 (fr) |
| CZ (1) | CZ128098A3 (fr) |
| EA (1) | EA000528B1 (fr) |
| EE (1) | EE9800147A (fr) |
| HK (1) | HK1017894A1 (fr) |
| HU (1) | HUP9902208A3 (fr) |
| IS (1) | IS4721A (fr) |
| NO (1) | NO310556B1 (fr) |
| NZ (1) | NZ321370A (fr) |
| PL (1) | PL327511A1 (fr) |
| SK (1) | SK51398A3 (fr) |
| TR (1) | TR199800726T2 (fr) |
| WO (1) | WO1997015574A1 (fr) |
| YU (1) | YU56696A (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6046333A (en) * | 1996-10-25 | 2000-04-04 | Merck & Co., Inc. | Convergent process for the preparation of a growth hormone secretagogue |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| WO2017075535A1 (fr) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Méthodes de traitement de troubles neurodégénératifs |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ151495A3 (en) * | 1992-12-11 | 1995-12-13 | Merck & Co Inc | Spiropiperidine derivatives, process of their preparation and a pharmaceutical composition containing thereof |
-
1996
- 1996-10-23 AU AU74686/96A patent/AU707946B2/en not_active Expired
- 1996-10-23 NZ NZ321370A patent/NZ321370A/xx not_active IP Right Cessation
- 1996-10-23 KR KR1019980703038A patent/KR19990067098A/ko not_active Application Discontinuation
- 1996-10-23 EP EP96936869A patent/EP1019402A1/fr not_active Withdrawn
- 1996-10-23 CZ CZ981280A patent/CZ128098A3/cs unknown
- 1996-10-23 EA EA199800335A patent/EA000528B1/ru not_active IP Right Cessation
- 1996-10-23 HU HU9902208A patent/HUP9902208A3/hu unknown
- 1996-10-23 TR TR1998/00726T patent/TR199800726T2/xx unknown
- 1996-10-23 CN CN96199328A patent/CN1067687C/zh not_active Expired - Lifetime
- 1996-10-23 PL PL96327511A patent/PL327511A1/xx unknown
- 1996-10-23 BR BR9611229A patent/BR9611229A/pt not_active IP Right Cessation
- 1996-10-23 EE EE9800147A patent/EE9800147A/xx unknown
- 1996-10-23 CA CA002235371A patent/CA2235371A1/fr not_active Abandoned
- 1996-10-23 WO PCT/US1996/016955 patent/WO1997015574A1/fr not_active Application Discontinuation
- 1996-10-23 SK SK513-98A patent/SK51398A3/sk unknown
- 1996-10-23 JP JP51673797A patent/JP3204266B2/ja not_active Expired - Lifetime
- 1996-10-25 YU YU56696A patent/YU56696A/sh unknown
- 1996-10-25 CO CO96056663A patent/CO4770956A1/es unknown
-
1998
- 1998-04-21 IS IS4721A patent/IS4721A/is unknown
- 1998-04-24 NO NO19981867A patent/NO310556B1/no not_active IP Right Cessation
- 1998-05-21 BG BG102476A patent/BG102476A/xx unknown
-
1999
- 1999-07-12 HK HK99102961A patent/HK1017894A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ128098A3 (cs) | 1998-09-16 |
| EA000528B1 (ru) | 1999-10-28 |
| JP3204266B2 (ja) | 2001-09-04 |
| SK51398A3 (en) | 1998-12-02 |
| JPH10512295A (ja) | 1998-11-24 |
| CO4770956A1 (es) | 1999-04-30 |
| EP1019402A1 (fr) | 2000-07-19 |
| YU56696A (sh) | 1999-09-27 |
| CN1205703A (zh) | 1999-01-20 |
| NO981867D0 (no) | 1998-04-24 |
| NO310556B1 (no) | 2001-07-23 |
| MX9803351A (es) | 1998-09-30 |
| AU7468696A (en) | 1997-05-15 |
| CN1067687C (zh) | 2001-06-27 |
| WO1997015574A1 (fr) | 1997-05-01 |
| EE9800147A (et) | 1998-12-15 |
| KR19990067098A (ko) | 1999-08-16 |
| NZ321370A (en) | 1999-11-29 |
| EA199800335A1 (ru) | 1998-12-24 |
| BG102476A (en) | 1999-04-30 |
| BR9611229A (pt) | 1999-05-25 |
| HUP9902208A3 (en) | 2001-05-28 |
| NO981867L (no) | 1998-06-29 |
| AU707946B2 (en) | 1999-07-22 |
| PL327511A1 (en) | 1998-12-21 |
| HK1017894A1 (en) | 1999-12-03 |
| TR199800726T2 (xx) | 1998-08-21 |
| HUP9902208A2 (hu) | 1999-10-28 |
| IS4721A (is) | 1998-04-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6123964A (en) | Wet granulation formulation of a growth hormone secretagogue | |
| US5767124A (en) | Polymorphic forms of a growth hormone secretagogue | |
| US5777112A (en) | Piperazine compounds promote release of growth hormone | |
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| DE60112753T2 (de) | Verbindungen zur stimulation der sekretion von wachstumshormonen | |
| WO1998010653A1 (fr) | Piperidines, pyrrolidines et hexahydro-1h-azepines favorisant la secretion d'hormone de croissance | |
| AU2001266066A1 (en) | Growth hormone secretagogues | |
| JPH10506914A (ja) | ４−複素環式ピペリジンは成長ホルモンの放出を促進する | |
| AU7522896A (en) | Wet granulation formulation of a growth hormone secretagogue | |
| WO1997036873A1 (fr) | Piperidines, pyrrolidines et hexahydro-1h-azepines declenchant la liberation de l'hormone de croissance | |
| KR100699404B1 (ko) | 성장 호르몬 분비촉진제로서의 신규 아미드 유도체 | |
| GB2297972A (en) | Camphor compounds promote release of growth hormone | |
| US6420376B1 (en) | Amido spiropiperidines promote the release of growth hormone | |
| AU707946B2 (en) | Polymorphic forms of a growth hormone secretagogue | |
| US7022677B1 (en) | Amide derivatives as growth hormone secretagogues | |
| MXPA98003351A (en) | ot. POLYMORPHIC FORMS OF A GROWTH HORMONE SECRETAGOGUE | |
| BRPI9611229B1 (pt) | Polymorphic form of the compound of N- [1 (R) - [(1,2-dihydro-1-methanesulfonyl-spiro [3 H -indol-3,4'-piperdin] -1'-yl) carbonyl] -2- - (phenylmethyl oxy) ethyl] -2-amino-2-methylpropanamide and pharmaceutical composition | |
| CZ20003152A3 (cs) | Soli N-methyi-N-((lR)-l-(N-methyl-N-((lR)-l- (methylkarbamoyl)-2-fenylethyl)karbamoyl)-2 (2-naftyl)ethyl)amidu (2E)-5-amino-5-methylhex- 2-enové kyseliny | |
| UA61056C2 (en) | Componuds with properties of growth hormone release, as pharmaceutical composition, a method for stimulating the growth hormone release from the pituitary and a method for increasing animal growth rate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |