CA2222493A1 - Process for obtaining acyloins, pyruvate decarboxylases suitable therefor and their production and dna sequence of the pdc gene coding them - Google Patents

Process for obtaining acyloins, pyruvate decarboxylases suitable therefor and their production and dna sequence of the pdc gene coding them Download PDF

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Publication number
CA2222493A1
CA2222493A1 CA002222493A CA2222493A CA2222493A1 CA 2222493 A1 CA2222493 A1 CA 2222493A1 CA 002222493 A CA002222493 A CA 002222493A CA 2222493 A CA2222493 A CA 2222493A CA 2222493 A1 CA2222493 A1 CA 2222493A1
Authority
CA
Canada
Prior art keywords
codon
rest
pdc
dna sequence
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002222493A
Other languages
English (en)
French (fr)
Inventor
Heike Bruhn
Martina Pohl
Katrin Mesch
Maria-Regina Kula
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Juelich GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2222493A1 publication Critical patent/CA2222493A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA002222493A 1995-05-26 1996-05-22 Process for obtaining acyloins, pyruvate decarboxylases suitable therefor and their production and dna sequence of the pdc gene coding them Abandoned CA2222493A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19518809 1995-05-26
DE19518809.8 1995-05-26
DE19523269A DE19523269C2 (de) 1995-05-26 1995-06-29 Verfahren zur Gewinnung von Acyloinen, dafür geeignete Pyruvat-decarboxylase sowie deren Herstellung und DNA-Sequenz des für diese kodierenden PDC-Gens
DE19522269.0 1995-06-29

Publications (1)

Publication Number Publication Date
CA2222493A1 true CA2222493A1 (en) 1996-11-28

Family

ID=26015375

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002222493A Abandoned CA2222493A1 (en) 1995-05-26 1996-05-22 Process for obtaining acyloins, pyruvate decarboxylases suitable therefor and their production and dna sequence of the pdc gene coding them

Country Status (12)

Country Link
US (1) US6004789A (en, 2012)
EP (1) EP0828841A2 (en, 2012)
JP (1) JPH11505710A (en, 2012)
KR (1) KR19990021965A (en, 2012)
CN (1) CN1192244A (en, 2012)
AU (1) AU714414B2 (en, 2012)
BR (1) BR9608798A (en, 2012)
CA (1) CA2222493A1 (en, 2012)
CZ (1) CZ287619B6 (en, 2012)
DE (1) DE19523269C2 (en, 2012)
IN (2) IN186507B (en, 2012)
WO (1) WO1996037620A2 (en, 2012)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19736104A1 (de) * 1997-08-20 1999-02-25 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Phenylacetylcarbinolen aus Acetaldchyd und Benzaldehyd in Gegenwart von Pyruvatdecarboxylase aus Zymomonas
DE19918935A1 (de) * 1999-04-27 2000-11-02 Forschungszentrum Juelich Gmbh Stereoselektive Synthese von 2-Hydroxyketonen
JP2005508629A (ja) 2001-05-04 2005-04-07 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． ピルビン酸デカルボキシラーゼ（ｐｄｃ）遺伝子の細菌からのクローニングおよび配列決定、ならびにその用途
DE10142467A1 (de) 2001-08-31 2003-03-20 Basf Ag Neue Pyruvatdecarboxylase, ihre Herstellung und Verwendung
DE10142574A1 (de) * 2001-09-01 2003-03-20 Basf Ag Verfahren zur Herstellung von R-Phenylacetylcarbinol durch ein enzymatisches verfahren in einem Zweiphasensystem
IL147823A (en) 2002-01-24 2008-06-05 Univ Ben Gurion Process for the preparation of alpha-hydroxy aromatic chiral ketones using acetohydroxyacide synthase
DE10313971A1 (de) * 2003-03-27 2004-10-21 Degussa Ag Gekoppeltes cofaktorabhängiges enzymatisches Reaktionssystem
DE102014013644A1 (de) * 2014-09-16 2016-03-17 Forschungszentrum Jülich GmbH Lyase und für die Lyase kodierende DNA, die DNA enthaltende Vektoren, sowie Verfahren zur asymmetrischen Synthese von (S)-Phenylacetylcarbinol
CN107630049B (zh) * 2017-04-01 2018-09-21 武汉茵茂特生物技术有限公司 麻黄碱的生物制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE548459C (de) * 1930-04-09 1932-04-13 Gustav Hildebrandt Dr Verfahren zur Herstellung von 1-1-Phenyl-2-methylaminopropan-1-ol

Also Published As

Publication number Publication date
DE19523269A1 (de) 1996-11-28
AU5810296A (en) 1996-12-11
DE19523269C2 (de) 2000-05-31
BR9608798A (pt) 1999-02-17
IN189539B (en, 2012) 2003-03-22
EP0828841A2 (de) 1998-03-18
JPH11505710A (ja) 1999-05-25
WO1996037620A2 (de) 1996-11-28
CZ369197A3 (cs) 1998-02-18
CN1192244A (zh) 1998-09-02
KR19990021965A (ko) 1999-03-25
AU714414B2 (en) 2000-01-06
WO1996037620A3 (de) 1997-02-06
US6004789A (en) 1999-12-21
CZ287619B6 (en) 2001-01-17
IN186507B (en, 2012) 2001-09-22

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued