CA2182966A1 - Enzymatic antimicrobial compositions - Google Patents
Enzymatic antimicrobial compositionsInfo
- Publication number
- CA2182966A1 CA2182966A1 CA002182966A CA2182966A CA2182966A1 CA 2182966 A1 CA2182966 A1 CA 2182966A1 CA 002182966 A CA002182966 A CA 002182966A CA 2182966 A CA2182966 A CA 2182966A CA 2182966 A1 CA2182966 A1 CA 2182966A1
- Authority
- CA
- Canada
- Prior art keywords
- chloroperoxidase
- vanadium
- hypochlorite
- enzymatic
- hydrogen peroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 51
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 36
- 230000002255 enzymatic effect Effects 0.000 title claims description 30
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 63
- 108010035722 Chloride peroxidase Proteins 0.000 claims abstract description 59
- 101710143559 Vanadium-dependent bromoperoxidase Proteins 0.000 claims abstract description 27
- 241001537312 Curvularia inaequalis Species 0.000 claims abstract description 24
- 150000004820 halides Chemical class 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims description 30
- 108010016350 vanadium chloroperoxidase Proteins 0.000 claims description 27
- 108090000623 proteins and genes Proteins 0.000 claims description 23
- 230000000694 effects Effects 0.000 claims description 22
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 9
- 239000008103 glucose Substances 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 8
- 108010015776 Glucose oxidase Proteins 0.000 claims description 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 7
- 235000019420 glucose oxidase Nutrition 0.000 claims description 7
- 230000012010 growth Effects 0.000 claims description 7
- 239000001257 hydrogen Substances 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 239000004366 Glucose oxidase Substances 0.000 claims description 6
- 230000014509 gene expression Effects 0.000 claims description 6
- 229940116332 glucose oxidase Drugs 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
- 108010073450 Lactate 2-monooxygenase Proteins 0.000 claims description 2
- 230000000813 microbial effect Effects 0.000 claims description 2
- 102000016938 Catalase Human genes 0.000 claims 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 238000011012 sanitization Methods 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 134
- 229940088598 enzyme Drugs 0.000 description 45
- 102000004190 Enzymes Human genes 0.000 description 44
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- 239000000243 solution Substances 0.000 description 42
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- 239000007979 citrate buffer Substances 0.000 description 35
- 238000006243 chemical reaction Methods 0.000 description 34
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 30
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- 229960002163 hydrogen peroxide Drugs 0.000 description 20
- 238000011534 incubation Methods 0.000 description 19
- 229910052720 vanadium Inorganic materials 0.000 description 19
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 description 19
- 239000011550 stock solution Substances 0.000 description 17
- -1 hypothiocyanite ions Chemical class 0.000 description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 12
- 239000003599 detergent Substances 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
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- VOBIHUAWDXUCPH-UHFFFAOYSA-N 2-chloro-5,5-dimethylcyclohexane-1,3-dione Chemical compound CC1(C)CC(=O)C(Cl)C(=O)C1 VOBIHUAWDXUCPH-UHFFFAOYSA-N 0.000 description 7
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- 239000006228 supernatant Substances 0.000 description 7
- LSGOVYNHVSXFFJ-UHFFFAOYSA-N vanadate(3-) Chemical compound [O-][V]([O-])([O-])=O LSGOVYNHVSXFFJ-UHFFFAOYSA-N 0.000 description 7
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
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- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
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- 241000266330 Alternaria chartarum Species 0.000 description 5
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
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- 125000000217 alkyl group Chemical group 0.000 description 5
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- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 5
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- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/16—Antifouling paints; Underwater paints
- C09D5/1606—Antifouling paints; Underwater paints characterised by the anti-fouling agent
- C09D5/1612—Non-macromolecular compounds
- C09D5/1625—Non-macromolecular compounds organic
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38654—Preparations containing enzymes, e.g. protease or amylase containing oxidase or reductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biomedical Technology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94200893.9 | 1994-03-31 | ||
| EP94200893 | 1994-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2182966A1 true CA2182966A1 (en) | 1995-10-12 |
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ID=8216755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002182966A Abandoned CA2182966A1 (en) | 1994-03-31 | 1995-03-31 | Enzymatic antimicrobial compositions |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0753055A1 (pt) |
| JP (1) | JPH09511396A (pt) |
| CN (1) | CN1146782A (pt) |
| AU (1) | AU2215495A (pt) |
| BR (1) | BR9507226A (pt) |
| CA (1) | CA2182966A1 (pt) |
| CZ (1) | CZ288041B6 (pt) |
| HU (1) | HUT74967A (pt) |
| NL (1) | NL9401048A (pt) |
| PL (2) | PL181397B1 (pt) |
| SK (1) | SK123096A3 (pt) |
| WO (1) | WO1995027046A2 (pt) |
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| DE69737828T2 (de) * | 1996-04-29 | 2008-03-06 | Novozymes A/S | Flüssige, nichtwässrige enzyme enthaltende zusammensetzungen |
| EP0912097B1 (en) * | 1996-05-09 | 2002-08-07 | Novozymes A/S | Antimicrobial peroxidase compositions |
| WO1998042370A1 (en) * | 1997-03-24 | 1998-10-01 | The Clorox Company | A CHLOROPEROXIDASE ENZYME SYSTEM FOR GENERATING HYPOCHLOROUS ACID AND HYPOCHLORITE $i(IN SITU) |
| ATE233806T1 (de) * | 1997-07-09 | 2003-03-15 | Procter & Gamble | Oxidoreductase enthaltende reinigungszusammensetzungen |
| US6080391A (en) * | 1997-08-14 | 2000-06-27 | Novo Nordisk A/S | Reduction of malodour |
| CN1265561A (zh) * | 1997-08-14 | 2000-09-06 | 诺沃挪第克公司 | 含有卤素过氧化物酶、过氧化氢源、卤化物源和铵源的抗微生物组合物 |
| US6074631A (en) * | 1997-08-14 | 2000-06-13 | Novo Nordisk A/S | Reduction of malodour |
| US6025186A (en) * | 1997-08-14 | 2000-02-15 | Novo Nordisk A/S | Reduction of malodor |
| US6228128B1 (en) | 1997-11-10 | 2001-05-08 | Charlotte Johansen | Antimicrobial activity of laccases |
| US6232457B1 (en) | 1998-09-10 | 2001-05-15 | The Regents Of The University Of California | Recombinant vanadium haloperoxidases and their uses |
| US6656715B1 (en) | 1998-09-10 | 2003-12-02 | The Regents Of The University Of California | Recombinant minimal catalytic vanadium haloperoxidases and their uses |
| US6592867B2 (en) * | 1998-11-09 | 2003-07-15 | Novozymes A/S | Antimicrobial composition containing an oxidoreductase and an enhancer of the N-hydroxyanilide-type |
| WO2000068324A2 (en) * | 1999-05-06 | 2000-11-16 | Novozymes A/S | Enzymatic preservation of water based paints |
| US7063970B1 (en) | 1999-05-06 | 2006-06-20 | Norozymes A/S | Enzymatic preservation of water based paints |
| WO2001010195A1 (en) * | 1999-08-10 | 2001-02-15 | Novozymes A/S | Reduction of malodour in soiled animal litter |
| AU6558100A (en) * | 1999-08-13 | 2001-03-13 | Novozymes A/S | Enzymatic method for killing or inhibiting microbial cells at high ph |
| AU2001246404A1 (en) | 2000-04-14 | 2001-10-30 | Novozymes A/S | Polypeptides having haloperoxidase activity |
| WO2001079458A2 (en) * | 2000-04-14 | 2001-10-25 | Novozymes A/S | Polypeptides having haloperoxidase activity |
| US6509181B1 (en) | 2000-04-14 | 2003-01-21 | Novozymes, A/S | Polypeptides having haloperoxide activity |
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| US6410292B1 (en) | 2000-04-14 | 2002-06-25 | Novozymes A/S | Nucleic acids encoding polypeptides having haloperoxidase activity |
| US6511835B1 (en) | 2000-04-14 | 2003-01-28 | Novozymes, A/S | Nucleic acids encoding polypeptides having haloperoxidase activity |
| AU2001246405A1 (en) * | 2000-04-14 | 2001-10-30 | Maxygen, Inc. | Nucleic acids encoding polypeptides having haloperoxidase activity |
| WO2002047483A1 (en) * | 2000-12-15 | 2002-06-20 | Novozymes A/S | Use of haloperoxidase, peroxide and carboxylic acid |
| EP1453381B1 (en) | 2001-12-04 | 2007-10-10 | Novozymes A/S | Methods for killing spores |
| EP1497382A1 (en) * | 2002-04-12 | 2005-01-19 | Biolocus Aps | Antifouling composition comprising an enzyme in the absence of its substrate |
| DK2140016T3 (da) | 2007-04-24 | 2012-11-12 | Novozymes North America Inc | Detoksificering af forbehandlede lignocelluloseholdige materialer |
| CA2702796A1 (en) * | 2007-10-23 | 2009-04-30 | Novozymes A/S | Methods for killing spores and disinfecting or sterilizing devices |
| EP2362732B1 (en) * | 2008-10-23 | 2015-05-20 | Getinge Disinfection AB | A method of obtaining high-level disinfection in a washer disinfector, and a washer disinfector |
| US20120020946A1 (en) | 2009-04-03 | 2012-01-26 | Novozymes A/S | Methods for Inactivating Viruses |
| US20120034203A1 (en) | 2009-04-22 | 2012-02-09 | Novozymes A/S | Methods for Killing or Inhibiting Growth of Mycobacteria |
| EP2510944A1 (en) * | 2011-04-15 | 2012-10-17 | National University of Ireland, Galway | Treatment of bacterial infections |
| WO2013164429A1 (en) | 2012-05-02 | 2013-11-07 | Novozymes A/S | Enzymatic solubilization of metals |
| WO2014106593A1 (en) | 2013-01-03 | 2014-07-10 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| US20160024440A1 (en) | 2013-03-14 | 2016-01-28 | Novozymes A/S | Enzyme and Inhibitor Containing Water-Soluble Films |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4707446A (en) * | 1983-05-24 | 1987-11-17 | Cetus Corporation | Stable haloperoxidase method |
| AU642980B2 (en) * | 1990-03-21 | 1993-11-04 | Quest International B.V. | Ultilization of enzymes |
| GB9015910D0 (en) * | 1990-07-19 | 1990-09-05 | Univ Bruxelles | Novel use |
| JP3399549B2 (ja) * | 1990-11-16 | 2003-04-21 | サントリー株式会社 | 微生物由来ペルオキシダーゼ遺伝子 |
| AU663869B2 (en) * | 1991-02-21 | 1995-10-26 | Exoxemis, Inc. | Methods and compositions for the treatment of infection and control of flora |
| US5262151A (en) * | 1991-11-25 | 1993-11-16 | Montgomery Robert E | Stabilized enzymatic antimicrobial compositions |
-
1994
- 1994-06-24 NL NL9401048A patent/NL9401048A/nl not_active Application Discontinuation
-
1995
- 1995-03-31 CN CN95192407A patent/CN1146782A/zh active Pending
- 1995-03-31 CA CA002182966A patent/CA2182966A1/en not_active Abandoned
- 1995-03-31 AU AU22154/95A patent/AU2215495A/en not_active Abandoned
- 1995-03-31 SK SK1230-96A patent/SK123096A3/sk unknown
- 1995-03-31 PL PL95341279A patent/PL181397B1/pl unknown
- 1995-03-31 JP JP7525418A patent/JPH09511396A/ja active Pending
- 1995-03-31 PL PL95316571A patent/PL181389B1/pl unknown
- 1995-03-31 HU HU9602673A patent/HUT74967A/hu unknown
- 1995-03-31 WO PCT/EP1995/001229 patent/WO1995027046A2/en active IP Right Grant
- 1995-03-31 CZ CZ19962850A patent/CZ288041B6/cs not_active IP Right Cessation
- 1995-03-31 BR BR9507226A patent/BR9507226A/pt not_active Application Discontinuation
- 1995-03-31 EP EP95915183A patent/EP0753055A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| PL181397B1 (pl) | 2001-07-31 |
| CZ288041B6 (cs) | 2001-04-11 |
| CZ285096A3 (en) | 1997-10-15 |
| AU2215495A (en) | 1995-10-23 |
| PL181389B1 (pl) | 2001-07-31 |
| SK123096A3 (en) | 1997-06-04 |
| EP0753055A1 (en) | 1997-01-15 |
| WO1995027046A3 (en) | 1995-11-30 |
| BR9507226A (pt) | 1997-09-09 |
| CN1146782A (zh) | 1997-04-02 |
| WO1995027046A2 (en) | 1995-10-12 |
| NL9401048A (nl) | 1995-11-01 |
| HUT74967A (en) | 1997-03-28 |
| HU9602673D0 (en) | 1996-11-28 |
| JPH09511396A (ja) | 1997-11-18 |
| PL316571A1 (en) | 1997-01-20 |
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| FZDE | Discontinued |