CA2170615A1 - Alkoxy-substituted .beta.-carbolines acting on the ampa-receptor - Google Patents
Alkoxy-substituted .beta.-carbolines acting on the ampa-receptorInfo
- Publication number
- CA2170615A1 CA2170615A1 CA002170615A CA2170615A CA2170615A1 CA 2170615 A1 CA2170615 A1 CA 2170615A1 CA 002170615 A CA002170615 A CA 002170615A CA 2170615 A CA2170615 A CA 2170615A CA 2170615 A1 CA2170615 A1 CA 2170615A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- formula
- alkoxy
- compounds
- carboline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP4330175.4 | 1993-08-31 | ||
| DE4330175A DE4330175A1 (de) | 1993-08-31 | 1993-08-31 | Alkoxy-substituierte beta-Carboline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2170615A1 true CA2170615A1 (en) | 1995-03-09 |
Family
ID=6497015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002170615A Abandoned CA2170615A1 (en) | 1993-08-31 | 1994-08-29 | Alkoxy-substituted .beta.-carbolines acting on the ampa-receptor |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0716657A1 (de) |
| JP (1) | JPH09501938A (de) |
| KR (1) | KR960704888A (de) |
| CN (1) | CN1129938A (de) |
| AU (1) | AU7530394A (de) |
| CA (1) | CA2170615A1 (de) |
| CZ (1) | CZ50596A3 (de) |
| DE (1) | DE4330175A1 (de) |
| FI (1) | FI960940A (de) |
| HU (1) | HUT73845A (de) |
| IL (1) | IL110745A0 (de) |
| NO (1) | NO960812D0 (de) |
| NZ (1) | NZ271615A (de) |
| PL (1) | PL313230A1 (de) |
| SK (1) | SK23896A3 (de) |
| WO (1) | WO1995006647A1 (de) |
| ZA (1) | ZA946670B (de) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10556013B2 (en) | 2017-06-20 | 2020-02-11 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
| US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY125942A (en) | 1999-09-07 | 2006-09-29 | Upjohn Co | Aminoalkoxy carbazoles for the treatment of cns diseases |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57123180A (en) * | 1980-12-17 | 1982-07-31 | Schering Ag | 3-substituted beta-carboline, manufacture and psychotropic drug containing same |
| DE3545776A1 (de) * | 1985-12-20 | 1987-06-25 | Schering Ag | 5-aminoalkyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| DE3608089A1 (de) * | 1986-03-08 | 1987-09-10 | Schering Ag | Heteroaryl-oxy-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| IL87563A (en) * | 1987-08-28 | 1993-08-18 | Schering Ag | Isoxazole-b-carboline derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
| DE3943225A1 (de) * | 1989-12-23 | 1991-06-27 | Schering Ag | Neue ss-carboline, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
| US5350750A (en) * | 1991-04-27 | 1994-09-27 | Schering Aktiengesellschaft | β-carboline-3-hydroxyalkylcarboxylic acid ester derivatives, process for their production and their use in pharmaceutical agents |
| DE4118741A1 (de) * | 1991-06-05 | 1992-12-10 | Schering Ag | Neue hetaryloxy-(beta)-carboline, deren herstellung und verwendung in arzneimitteln |
| DE4120109A1 (de) * | 1991-06-15 | 1992-12-17 | Schering Ag | 3-aryl- oder 3-hetaryl-(beta)-carboline, deren herstellung und verwendung in arzneimitteln |
| DE4130933A1 (de) * | 1991-09-13 | 1993-03-18 | Schering Ag | Neue (beta)-carbolinderivate, deren herstellung und verwendung in arzneimitteln |
| DE4212529A1 (de) * | 1992-04-10 | 1993-10-14 | Schering Ag | Verwendung von µ-Carbolinen als nicht-kompetitive Glutamat-Antagonisten |
-
1993
- 1993-08-31 DE DE4330175A patent/DE4330175A1/de not_active Withdrawn
-
1994
- 1994-08-22 IL IL11074594A patent/IL110745A0/xx unknown
- 1994-08-29 SK SK238-96A patent/SK23896A3/sk unknown
- 1994-08-29 NZ NZ271615A patent/NZ271615A/en unknown
- 1994-08-29 PL PL94313230A patent/PL313230A1/xx unknown
- 1994-08-29 AU AU75303/94A patent/AU7530394A/en not_active Abandoned
- 1994-08-29 HU HU9600505A patent/HUT73845A/hu unknown
- 1994-08-29 KR KR1019960701006A patent/KR960704888A/ko not_active Application Discontinuation
- 1994-08-29 JP JP7507876A patent/JPH09501938A/ja active Pending
- 1994-08-29 EP EP94925339A patent/EP0716657A1/de not_active Withdrawn
- 1994-08-29 CN CN94193211A patent/CN1129938A/zh active Pending
- 1994-08-29 WO PCT/DE1994/001009 patent/WO1995006647A1/de not_active Application Discontinuation
- 1994-08-29 CA CA002170615A patent/CA2170615A1/en not_active Abandoned
- 1994-08-29 CZ CZ96505A patent/CZ50596A3/cs unknown
- 1994-08-31 ZA ZA946670A patent/ZA946670B/xx unknown
-
1996
- 1996-02-28 FI FI960940A patent/FI960940A/fi not_active Application Discontinuation
- 1996-02-28 NO NO960812A patent/NO960812D0/no unknown
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10556013B2 (en) | 2017-06-20 | 2020-02-11 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
| US10918728B2 (en) | 2017-06-20 | 2021-02-16 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
| US10953102B2 (en) | 2017-06-20 | 2021-03-23 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
| US11376330B2 (en) | 2017-06-20 | 2022-07-05 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
| US11844840B2 (en) | 2017-06-20 | 2023-12-19 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
| US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11746090B2 (en) | 2020-06-30 | 2023-09-05 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4- trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US12065410B2 (en) | 2020-06-30 | 2024-08-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US12110275B2 (en) | 2020-06-30 | 2024-10-08 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl] piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA946670B (en) | 1995-04-21 |
| SK23896A3 (en) | 1996-11-06 |
| WO1995006647A1 (de) | 1995-03-09 |
| NO960812L (no) | 1996-02-28 |
| NZ271615A (en) | 1996-09-25 |
| CN1129938A (zh) | 1996-08-28 |
| DE4330175A1 (de) | 1995-03-02 |
| HU9600505D0 (en) | 1996-04-29 |
| NO960812D0 (no) | 1996-02-28 |
| IL110745A0 (en) | 1994-11-11 |
| PL313230A1 (en) | 1996-06-10 |
| FI960940A0 (fi) | 1996-02-28 |
| AU7530394A (en) | 1995-03-22 |
| EP0716657A1 (de) | 1996-06-19 |
| HUT73845A (en) | 1996-09-30 |
| CZ50596A3 (en) | 1996-06-12 |
| KR960704888A (ko) | 1996-10-09 |
| JPH09501938A (ja) | 1997-02-25 |
| FI960940A (fi) | 1996-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |