CA2121148A1 - Apoptosis regulator - Google Patents

Apoptosis regulator

Info

Publication number
CA2121148A1
CA2121148A1 CA002121148A CA2121148A CA2121148A1 CA 2121148 A1 CA2121148 A1 CA 2121148A1 CA 002121148 A CA002121148 A CA 002121148A CA 2121148 A CA2121148 A CA 2121148A CA 2121148 A1 CA2121148 A1 CA 2121148A1
Authority
CA
Canada
Prior art keywords
group
lower alkyl
alkyl group
piperazinyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002121148A
Other languages
English (en)
French (fr)
Inventor
Satoru Nakai
Koutoku Aihara
Hideo Tanaka
Hitomi Iba
Kazuyoshi Kawai
Hiroyuki Ichikawa
Seiji Akamatsu
Fumio Saito
Michiaki Tominaga
Masakazu Adachi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of CA2121148A1 publication Critical patent/CA2121148A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002121148A 1992-08-19 1993-08-12 Apoptosis regulator Abandoned CA2121148A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP4/220373 1992-08-19
JP22037392 1992-08-19
PCT/JP1993/001144 WO1994004504A1 (fr) 1992-08-19 1993-08-12 Regulateur d'apoptose

Publications (1)

Publication Number Publication Date
CA2121148A1 true CA2121148A1 (en) 1994-03-03

Family

ID=16750110

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002121148A Abandoned CA2121148A1 (en) 1992-08-19 1993-08-12 Apoptosis regulator

Country Status (8)

Country Link
US (2) US5464833A (https=)
EP (1) EP0623598A4 (https=)
AU (1) AU666577B2 (https=)
CA (1) CA2121148A1 (https=)
MX (1) MX9305056A (https=)
PH (1) PH30152A (https=)
TW (1) TW240168B (https=)
WO (1) WO1994004504A1 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994020107A1 (fr) * 1993-03-02 1994-09-15 Otsuka Pharmaceutical Co., Ltd. Inhibiteur de rejet pour transplantations et inhibiteur de production d'interleukine 1
US5497913A (en) * 1993-12-15 1996-03-12 Denny D. Baker Mixing bag arrangement and method
AU2604795A (en) * 1994-05-26 1995-12-21 New York Medical College Detection of halogenated precursors incorporated into dna
US5504093A (en) * 1994-08-01 1996-04-02 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
CA2158822C (en) * 1994-09-27 2008-12-23 Kusuki Nishioka Therapeutic agent for rheumatic disease
US5620888A (en) * 1994-12-29 1997-04-15 Lxr Biotechnology, Inc. Cell strains for use in identifying potentially therapeutically effective agents
US5571523A (en) * 1995-03-09 1996-11-05 President And Fellows Of Harvard College Antioxidant-induced apoptosis in vascular smooth muscle cells
WO1998046229A1 (en) * 1995-06-21 1998-10-22 Otsuka Pharmaceutical Co., Ltd. Il-8 and mcaf production inhibitors
EP0851939A4 (en) * 1995-08-30 2001-02-28 New York Medical College METHOD FOR MARKING DNA ENDS WITH HALOGENATED NUCLEOTIDES AND DETECTING THEM WITH ANTIBODIES
US5846758A (en) * 1995-11-30 1998-12-08 His Excellency Ghassan I. Shaker Method for diagnosing autoimmune diseases
JP2000505471A (ja) * 1996-02-28 2000-05-09 メルク エンド カンパニー インコーポレーテッド フィブリノーゲン受容体拮抗物質
US5780480A (en) * 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
US20020151063A1 (en) * 1996-08-30 2002-10-17 Annette Lasham Methods for modulating apoptotic cell death
US5912168A (en) * 1996-08-30 1999-06-15 Genesis Research & Development Corporation Limited CD95 regulatory gene sequences
US6180402B1 (en) 1996-11-20 2001-01-30 Qlt Inc. Method for inhibiting apoptosis induced by photodynamic therapy using a cysteine or serine protease inhibitor
AU6854398A (en) * 1997-04-25 1998-11-24 Otsuka Pharmaceutical Co., Ltd. Hyaluronate synthesis inhibitors
TWI244484B (en) * 1998-06-09 2005-12-01 Takara Bio Inc Pharmaceutical composition containing oxy-containing hexacyclic compound
ATE276763T1 (de) 1998-07-13 2004-10-15 Univ Texas Verwendung von antikörper gegen aminophospholipide zur krebsbehandlung
SI1107795T1 (en) 1998-09-04 2003-06-30 The Regents Of The University Of Michigan Thiomolybdate associated with at least one carbohydrate, and its use for preventing or treating diseases characterized by aberrant vascularization, such as cancer, wet type macular degeneration, rheumatoid arthritis
AU5877500A (en) * 1999-06-15 2001-01-02 Neurogen Corporation Piperidinyl and piperazinyl substituted benzofused lactams
US6254888B1 (en) 2000-01-28 2001-07-03 Boehringer Ingelheim Pharmaceuticals, Inc. Method for coating pharmaceutical dosage forms
WO2002098425A1 (en) * 2001-06-04 2002-12-12 Cytovia, Inc. Substituted 4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1h)-quinolinones and analogs as activators of caspases and inducers of apoptosis and the use thereof
GB0124848D0 (en) * 2001-10-16 2001-12-05 Celltech R&D Ltd Chemical compounds
AU2002360335A1 (en) * 2001-11-01 2003-05-12 The Regents Of The University Of Michigan Small molecule inhibitors targeted at bcl-2
US20040014744A1 (en) * 2002-04-05 2004-01-22 Fortuna Haviv Substituted pyridines having antiangiogenic activity
EP2357009A1 (en) 2002-07-15 2011-08-17 Board of Regents, The University of Texas System Duramycin peptide binding to anionic phospholipids and aminophospholipids conjugates and their use in treating viral infections
US8431396B2 (en) 2003-03-21 2013-04-30 The Cleveland Clinic Foundation Anti-angiogenic peptides
ES2809302T3 (es) 2004-01-22 2021-03-03 Univ Miami Formulaciones de coenzima Q10 para tratar tumores sólidos mediante administración intravenosa
ES2572356T3 (es) 2007-11-09 2016-05-31 Peregrine Pharmaceuticals Inc Composiciones de anticuerpos dirigidos contra VEGF y procedimientos
GB2532990A (en) 2014-12-05 2016-06-08 Schlumberger Holdings Corrosion inhibition
GB2543498A (en) * 2015-10-19 2017-04-26 Schlumberger Holdings Corrosion inhibition
CN107174584B (zh) * 2016-03-12 2020-09-01 福建金乐医药科技有限公司 含哌嗪结构化合物在制备lsd1抑制剂中的应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2931741A1 (de) * 1979-08-04 1981-02-26 Thomae Gmbh Dr K Arzneimittel zur vermeidung von tumormetastierung
JPS6038384B2 (ja) * 1978-03-24 1985-08-31 大塚製薬株式会社 チオセミカルバゾン誘導体
JPS5742673A (en) * 1980-08-29 1982-03-10 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5777676A (en) * 1980-10-31 1982-05-15 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5883677A (ja) * 1981-11-11 1983-05-19 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JPS5929667A (ja) * 1982-08-13 1984-02-16 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体および強心剤
JPS59104378A (ja) * 1982-12-03 1984-06-16 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
US4677112A (en) * 1984-02-02 1987-06-30 Warner-Lambert Company 1,2,3,4-tetrahydro-2-oxo-8-quinolineacetic and -propanoic acids and derivatives as cognition activators
US4582909A (en) * 1984-02-02 1986-04-15 Warner-Lambert Company Benzobicyclic lactam acids and derivatives as cognition activators
JPH07100696B2 (ja) * 1984-12-18 1995-11-01 大塚製薬株式会社 カルボスチリル誘導体
US4760064A (en) * 1984-12-18 1988-07-26 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds, compositions containing same and processes for preparing same
DE3526044A1 (de) * 1985-07-20 1987-01-22 Hoechst Ag Dihydrochinolinon-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung, sowie zwischenprodukte zu ihrer herstellung
DK588486A (da) * 1985-12-09 1987-06-10 Otsuka Pharma Co Ltd Anvendelse af en forbindelse til behandling af hypoxi
JPS62135423A (ja) * 1985-12-09 1987-06-18 Otsuka Pharmaceut Co Ltd 低酸素症改善剤
JPS63225357A (ja) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
US5185346A (en) * 1988-11-29 1993-02-09 Hanssen Pharmaceutica (1H-azol-1-ylmethyl)substituted quinoline derivatives
TW201305B (https=) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
CA2090876A1 (en) * 1991-07-03 1993-01-04 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulating composition
JPH05320133A (ja) * 1991-07-18 1993-12-03 Japan Tobacco Inc ３，４−ジヒドロ−２（１ｈ）−キノリノン誘導体
WO1993011769A1 (fr) * 1991-12-10 1993-06-24 Otsuka Pharmaceutical Co., Ltd Agent anticancereux
JPH0612248A (ja) * 1992-04-02 1994-01-21 Hitachi Ltd プログラムの自動生成方式

Also Published As

Publication number Publication date
US5691341A (en) 1997-11-25
AU666577B2 (en) 1996-02-15
EP0623598A4 (en) 1997-05-02
MX9305056A (es) 1994-04-29
PH30152A (en) 1997-01-21
WO1994004504A1 (fr) 1994-03-03
US5464833A (en) 1995-11-07
EP0623598A1 (en) 1994-11-09
AU4761593A (en) 1994-03-15
TW240168B (https=) 1995-02-11

Similar Documents

Publication Publication Date Title
US5691341A (en) Apoptosis regulating composition
US5916890A (en) Apoptosis regulating composition
TWI615144B (zh) 隻重選擇性ＰＩ３δ及γ激酶抑制劑
US7071158B2 (en) Antioxidant enhancement of therapy for hyperproliferative conditions
US20120245147A1 (en) Inhibitors of thapsigargin-induced cell death
JP2001322933A (ja) Ｃｄ４０シグナル遮断剤
CA2492022A1 (en) Treatment of neuropathic pain with 6h-pyrrolo[3,4-d]pyridazine compounds
Jaju et al. Synthesis and antimycobacterial activity of a novel series of isonicotinylhydrazide derivatives
JP2009525306A (ja) 化合物
US5658912A (en) Apoptosis regulating composition
CN113332439A (zh) 包含双重PI3Kδ-γ激酶抑制剂和皮质类固醇的治疗方法及组合物
JPWO1994004504A1 (ja) アポトーシス調整剤
JP2005522490A (ja) Ｐｔｘ３遺伝子発現抑制方法
JP2628106B2 (ja) アポトーシス調整剤
JPH11228415A (ja) Ｉｌ−１産生抑制剤
JP2946377B2 (ja) ＴＮＦ−α及びＩＬ−６産生抑制剤
HK1004469B (en) Apoptosis regulator
EP4138839A1 (en) Diazine and triazine compounds to treat cytokine storm syndrome
JPWO1995028154A1 (ja) アポトーシス誘導剤
US20080221097A1 (en) Imidazopyridine Derivatives as Cannabinoid Receptor Ligands
JP3008010B2 (ja) Ｉｌ−８産生抑制剤及びｍｃａｆ産生抑制剤
JPWO1993000902A1 (ja) アポトーシス調整剤
JPH0769893A (ja) 制癌剤
EP3152193B1 (en) Tetrahydroisoquinolinone derivatives and their use in the inhibition of the hsp70 protein
JPH08245393A (ja) アポトーシス調整剤

Legal Events

Date Code Title Description
FZDE Discontinued