JPS5742673A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS5742673A
JPS5742673A JP55120421A JP12042180A JPS5742673A JP S5742673 A JPS5742673 A JP S5742673A JP 55120421 A JP55120421 A JP 55120421A JP 12042180 A JP12042180 A JP 12042180A JP S5742673 A JPS5742673 A JP S5742673A
Authority
JP
Japan
Prior art keywords
carbostyril
formula
bond
remedy
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55120421A
Other languages
Japanese (ja)
Other versions
JPS6330896B2 (en
Inventor
Yasumitsu Tamura
Shiro Yoshizaki
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP55120421A priority Critical patent/JPS5742673A/en
Publication of JPS5742673A publication Critical patent/JPS5742673A/en
Publication of JPS6330896B2 publication Critical patent/JPS6330896B2/ja
Granted legal-status Critical Current

Links

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  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The carbostyril derivative of formula I (R1 is H or lower alkyl; R2 is lower alkyl; Y is OH or NH2; the bond between the 3- and the 4-carbon atoms of carbostyril skeleton is single or double bond) and its salt.
EXAMPLE: 7-Amino-5-(1-hydroxy-2-isopropylaminobutyl)carbostyril monohydrate.
USE: Remedy for asthma, hypotenson, anti-hyperlipemia, antiphlogistic agent, remedy for diabetes, and antiviral agent. It has extremely high selectivity to β2-receptor, and remarkably weak stimmulating activity to the heart.
PROCESS: The compound of formula I wherein Y is NH2 and the bond between the 3- and the 4-carbon atoms of the carbostyril skeleton is double bond, is prepared by reacting the carbostyril of formula II with an alkanesulfonyl halide or arysulfonyl halide, and catalytically reducing the resulted compound of formula III (R3 is alkanesulfonyl or arylsulfonyl).
COPYRIGHT: (C)1982,JPO&Japio
JP55120421A 1980-08-29 1980-08-29 Carbostyril derivative Granted JPS5742673A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55120421A JPS5742673A (en) 1980-08-29 1980-08-29 Carbostyril derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55120421A JPS5742673A (en) 1980-08-29 1980-08-29 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS5742673A true JPS5742673A (en) 1982-03-10
JPS6330896B2 JPS6330896B2 (en) 1988-06-21

Family

ID=14785800

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55120421A Granted JPS5742673A (en) 1980-08-29 1980-08-29 Carbostyril derivative

Country Status (1)

Country Link
JP (1) JPS5742673A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004504A1 (en) * 1992-08-19 1994-03-03 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulator
WO2004050657A3 (en) * 2002-11-27 2004-11-25 Artesian Therapeutics Inc COMPOUNDS WITH MIXED PDE-INHIBITORY AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51110576A (en) * 1975-03-20 1976-09-30 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
JPS5312872A (en) * 1976-07-16 1978-02-04 Otsuka Pharmaceut Co Ltd 5-carbostyrylmethanol derivatives
JPS5350182A (en) * 1976-10-13 1978-05-08 Otsuka Pharmaceut Co Ltd Carbostyril derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51110576A (en) * 1975-03-20 1976-09-30 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
JPS5312872A (en) * 1976-07-16 1978-02-04 Otsuka Pharmaceut Co Ltd 5-carbostyrylmethanol derivatives
JPS5350182A (en) * 1976-10-13 1978-05-08 Otsuka Pharmaceut Co Ltd Carbostyril derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004504A1 (en) * 1992-08-19 1994-03-03 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulator
WO2004050657A3 (en) * 2002-11-27 2004-11-25 Artesian Therapeutics Inc COMPOUNDS WITH MIXED PDE-INHIBITORY AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE
JP2006509790A (en) * 2002-11-27 2006-03-23 アルテシアン セラピューティック，インコーポレイティド Compounds with mixed PDE inhibition and beta-adrenergic antagonist activity or partial agonist activity for the treatment of heart failure

Also Published As

Publication number Publication date
JPS6330896B2 (en) 1988-06-21

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