CA2082842A1 - Production d'acides nucleiques cibles - Google Patents

Production d'acides nucleiques cibles

Info

Publication number
CA2082842A1
CA2082842A1 CA2082842A CA2082842A CA2082842A1 CA 2082842 A1 CA2082842 A1 CA 2082842A1 CA 2082842 A CA2082842 A CA 2082842A CA 2082842 A CA2082842 A CA 2082842A CA 2082842 A1 CA2082842 A1 CA 2082842A1
Authority
CA
Canada
Prior art keywords
nucleic acid
primer
acid target
target generation
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2082842A
Other languages
English (en)
Other versions
CA2082842C (fr
Inventor
George T. Walker
Michael C. Little
James G. Nadeau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
George T. Walker
Michael C. Little
James G. Nadeau
Becton, Dickinson And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by George T. Walker, Michael C. Little, James G. Nadeau, Becton, Dickinson And Company filed Critical George T. Walker
Publication of CA2082842A1 publication Critical patent/CA2082842A1/fr
Application granted granted Critical
Publication of CA2082842C publication Critical patent/CA2082842C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6846—Common amplification features
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA002082842A 1991-11-19 1992-11-13 Production d'acides nucleiques cibles Expired - Lifetime CA2082842C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US794,399 1991-11-19
US07/794,399 US5270184A (en) 1991-11-19 1991-11-19 Nucleic acid target generation

Publications (2)

Publication Number Publication Date
CA2082842A1 true CA2082842A1 (fr) 1993-05-20
CA2082842C CA2082842C (fr) 2001-01-09

Family

ID=25162531

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002082842A Expired - Lifetime CA2082842C (fr) 1991-11-19 1992-11-13 Production d'acides nucleiques cibles

Country Status (6)

Country Link
US (1) US5270184A (fr)
EP (1) EP0543612B1 (fr)
JP (1) JPH0876B2 (fr)
AU (1) AU662937B2 (fr)
CA (1) CA2082842C (fr)
DE (1) DE69219727T2 (fr)

Families Citing this family (366)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455166A (en) * 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5994069A (en) * 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US5846717A (en) * 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
WO1994003624A1 (fr) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Procedes d'amplification isothermique de molecules d'acide nucleique
US5733733A (en) * 1992-08-04 1998-03-31 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
US5834202A (en) 1992-08-04 1998-11-10 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
CA2119188A1 (fr) * 1993-04-05 1994-10-06 Patricia A. Spears Detection et identification de mycobacteries
US5470723A (en) * 1993-05-05 1995-11-28 Becton, Dickinson And Company Detection of mycobacteria by multiplex nucleic acid amplification
CA2121659C (fr) * 1993-05-11 2000-11-28 Michael C. Little Methode de traitement de l'echantillon par des mycobacteries
CA2167838C (fr) * 1993-07-23 1999-11-23 Thomas B. Ryder Methodes pour ameliorer l'amplification de l'acide nucleique
FR2708288B1 (fr) * 1993-07-26 1995-09-01 Bio Merieux Procédé d'amplification d'acides nucléiques par transcription utilisant le déplacement, réactifs et nécessaire pour la mise en Óoeuvre de ce procédé.
US5523204A (en) * 1993-12-10 1996-06-04 Becton Dickinson And Company Detection of nucleic acids in cells by strand displacement amplification
CA2140081C (fr) 1994-01-13 2008-04-01 Dean L. Engelhardt Procede, construct et conjugue permettant de produire des copies multiples d'acides nucleiques
US6986985B1 (en) 1994-01-13 2006-01-17 Enzo Life Sciences, Inc. Process for producing multiple nucleic acid copies in vivo using a protein-nucleic acid construct
US5518884A (en) * 1994-02-28 1996-05-21 Becton, Dickinson And Company Nucleic acid sequences specific for mycbacterium kansasii
JPH09510351A (ja) * 1994-03-16 1997-10-21 ジェン−プローブ・インコーポレイテッド 等温鎖置換核酸増幅法
US5648211A (en) * 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US5547861A (en) * 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
CA2145719C (fr) * 1994-04-18 1998-06-30 James G. Nadeau Detection de l'amplification de l'acide nucleique
US5658729A (en) * 1994-10-11 1997-08-19 The University Of British Columbia Method, reagent and kit for evaluating susceptibility to premature atherosclerosis
CA2150986C (fr) * 1994-06-17 1999-11-02 Mary Kathryn Meyer Amorces et sondes d'oligonucleotides pour la detection de bacteries
US5500341A (en) 1994-09-19 1996-03-19 Becton, Dickinson And Company Species-specific detection of Mycobacterium kansasii
FR2726277B1 (fr) * 1994-10-28 1996-12-27 Bio Merieux Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
FR2737223B1 (fr) * 1995-07-24 1997-09-12 Bio Merieux Procede d'amplification de sequences d'acide nucleique par deplacement, a l'aide d'amorces chimeres
AU702896B2 (en) * 1995-09-21 1999-03-11 Becton Dickinson & Company Detection of nucleic acids in cells by thermophilic strand displacement amplification
US5916779A (en) * 1995-09-21 1999-06-29 Becton, Dickinson And Company Strand displacement amplification of RNA targets
US5800989A (en) * 1995-11-15 1998-09-01 Becton, Dickinson And Company Method for detection of nucleic acid targets by amplification and fluorescence polarization
US5641633A (en) * 1995-11-15 1997-06-24 Becton, Dickinson And Company Fluorescence polarization detection of nucleic acids
ES2262902T3 (es) 1995-12-05 2006-12-01 Jorn Erland Koch Una reaccion en cascada de amplificacion de acido nucleico.
EP0914462A4 (fr) * 1996-03-18 2002-05-22 Molecular Biology Resources Amplification de sequences d'acides nucleiques cibles
US5824478A (en) * 1996-04-30 1998-10-20 Vysis, Inc. Diagnostic methods and probes
US5702926A (en) * 1996-08-22 1997-12-30 Becton, Dickinson And Company Nicking of DNA using boronated nucleotides
US5858671A (en) * 1996-11-01 1999-01-12 The University Of Iowa Research Foundation Iterative and regenerative DNA sequencing method
WO1998022625A1 (fr) 1996-11-20 1998-05-28 The Regents Of The University Of Michigan Dispositifs microfabriques et procedes d'amplification isotherme d'acides nucleiques
US7803528B1 (en) * 1997-02-28 2010-09-28 Quest Diagnostics Incorporated Fluorescence energy transfer by competitive hybridization
US5863736A (en) * 1997-05-23 1999-01-26 Becton, Dickinson And Company Method, apparatus and computer program products for determining quantities of nucleic acid sequences in samples
US6054300A (en) * 1997-08-21 2000-04-25 The United States Of America As Represented By The Secretary Of Agiculture Single-site amplification (SSA): method for accelerated development of nucleic acid markers
US5935791A (en) * 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
JP4317953B2 (ja) * 1998-01-22 2009-08-19 独立行政法人理化学研究所 Ｄｎａの塩基配列決定方法
US6066458A (en) * 1998-05-18 2000-05-23 Becton, Dickinson And Company Methods, apparatus and computer program products for determining quantities of nucleic acid sequences in samples using standard curves and amplification ratio estimates
US6743605B1 (en) 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
US8445664B2 (en) * 1998-06-24 2013-05-21 Enzo Diagnostics, Inc. Kits for amplifying and detecting nucleic acid sequences
US6297365B1 (en) 1998-07-31 2001-10-02 Gen-Probe Incorporated Decoy probes
US6180408B1 (en) 1998-08-21 2001-01-30 Washington University Fluorescence polarization in nucleic acid analysis
ES2320814T3 (es) * 1998-11-09 2009-05-28 Eiken Kagaku Kabushiki Kaisha Procedimiento de sintesis de acido nucleico.
US6531302B1 (en) 1999-04-12 2003-03-11 Nanogen/Becton Dickinson Partnership Anchored strand displacement amplification on an electronically addressable microchip
US6309833B1 (en) 1999-04-12 2001-10-30 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures
CA2369016A1 (fr) * 1999-04-12 2000-10-19 Nanogen/Becton Dickinson Partnership Amplification et separation de sequences d'acide nucleique a l'aide de technologies d'amplification par deplacement de brin et de micropuce bioelectronique
US6238868B1 (en) 1999-04-12 2001-05-29 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
US6326173B1 (en) * 1999-04-12 2001-12-04 Nanogen/Becton Dickinson Partnership Electronically mediated nucleic acid amplification in NASBA
US20030165913A1 (en) * 1999-06-17 2003-09-04 Sha-Sha Wang Methods for detecting nucleic acid sequence variations
US20020025519A1 (en) * 1999-06-17 2002-02-28 David J. Wright Methods and oligonucleotides for detecting nucleic acid sequence variations
US6316200B1 (en) 2000-06-08 2001-11-13 Becton, Dickinson And Company Probes and methods for detection of nucleic acids
KR100527265B1 (ko) * 1999-09-13 2005-11-09 뉴젠 테크놀로지스 인코포레이티드 폴리뉴클레오티드 서열의 선형 등온 증폭을 위한 방법 및조성물
US6692918B2 (en) 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
US6379888B1 (en) 1999-09-27 2002-04-30 Becton, Dickinson And Company Universal probes and methods for detection of nucleic acids
US7118860B2 (en) * 1999-10-29 2006-10-10 Stratagene California Methods for detection of a target nucleic acid by capture
US7381532B2 (en) * 1999-10-29 2008-06-03 Stratagene California Compositions and methods for the detection of a nucleic acid using a cleavage reaction
GB2397416B (en) * 1999-11-06 2004-09-01 Dennis Sunga Fernandez Secure network client device
DE60025840T2 (de) 1999-11-08 2006-07-27 Eiken Kagaku K.K. Methode zum nachweis von variationen oder polymorphismen
JP4721603B2 (ja) * 1999-11-08 2011-07-13 栄研化学株式会社 変異および／または多型の検出方法
US6346384B1 (en) 2000-03-27 2002-02-12 Dade Behring Inc. Real-time monitoring of PCR using LOCI
AU2001244677A1 (en) * 2000-04-07 2001-10-23 Eiken Kagaku Kabushiki Kaisha Method of amplifying nucleic acid by using double-stranded nucleic acid as template
US6258546B1 (en) 2000-06-23 2001-07-10 Becton, Dickinson And Company Detection of nucleic acid amplification
EP1356094B1 (fr) 2000-06-26 2010-01-13 Nugen Technologies, Inc. Procedes et compositions permettant l'amplification d'acide nucleique fondee sur la transcription
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
ATE475720T1 (de) 2000-12-13 2010-08-15 Nugen Technologies Inc Methoden und zusammensetzungen zur generierung einer vielzahl von kopien von nukleinsäuresequenzen und methoden zur detektion derselben
WO2002062993A1 (fr) * 2001-02-06 2002-08-15 Takara Bio Inc. Acides nucleiques amplifies et produits immobilises de ces derniers
DE60220025T2 (de) 2001-03-09 2008-01-17 Nugen Technologies, Inc., San Carlos Methoden und zusammensetzungen zur vervielfältigung von rna sequenzen
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
US9777312B2 (en) * 2001-06-30 2017-10-03 Enzo Life Sciences, Inc. Dual polarity analysis of nucleic acids
US20040161741A1 (en) 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US7297485B2 (en) * 2001-10-15 2007-11-20 Qiagen Gmbh Method for nucleic acid amplification that results in low amplification bias
US6942972B2 (en) * 2001-10-24 2005-09-13 Beckman Coulter, Inc. Efficient synthesis of protein-oligonucleotide conjugates
AU2003222269A1 (en) 2002-03-11 2003-09-29 Nugen Technologies, Inc. Methods for generating double stranded dna comprising a 3' single stranded portion and uses of these complexes for recombination
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
US20040009574A1 (en) * 2002-07-09 2004-01-15 Nanibhushan Dattagupta Compositions and methods for detecting streptococcus agalactiae capsular polysaccharide synthesis genes
US20040009482A1 (en) * 2002-07-09 2004-01-15 Nanibhushan Dattagupta Compositions and methods for detecting streptococcus agalactiae surface immunogenic protein genes
US20060073475A1 (en) * 2002-08-09 2006-04-06 Nanibhushan Dattagupta Compositions and methods for detecting pathogenic bacteria expressing chaperonin proteins
AU2003287237A1 (en) 2002-10-28 2004-05-25 Xeotron Corporation Array oligomer synthesis and use.
US20050026161A1 (en) * 2002-11-01 2005-02-03 Edward Jablonski Displacement sandwich immuno-PCR
AU2003299818A1 (en) 2002-12-20 2004-07-22 Applera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
US7189512B2 (en) * 2003-02-20 2007-03-13 Noga Porat Methods for variation detection
WO2004092418A2 (fr) 2003-04-14 2004-10-28 Nugen Technologies, Inc. Amplification globale effectuee avec une amorce composite amorcee de maniere aleatoire
EP1615948B1 (fr) * 2003-04-18 2015-04-01 Becton Dickinson and Company Amplification immunologique
AU2004235349B2 (en) * 2003-04-25 2009-11-19 Becton, Dickinson And Company Detection of herpes simplex virus types 1 and 2 by nucleic acid amplification
AU2003229474A1 (en) * 2003-05-09 2004-11-26 Capital Biochip Company, Ltd. Methods and compositions for detecting sars virus
CN100494399C (zh) * 2003-06-30 2009-06-03 清华大学 一种基于dna芯片的基因分型方法及其应用
CN101415843B (zh) * 2003-09-12 2013-08-21 贝克顿·迪金森公司 通过扩增和检测复制酶序列分析sars冠状病毒
US20100136513A1 (en) * 2003-09-12 2010-06-03 Jianrong Lou Assay for sars coronavirus by amplification and detection of nucleocapsid rna sequence
JP2005110664A (ja) * 2003-09-16 2005-04-28 Nissui Pharm Co Ltd 核酸シグナルの増幅による標的ｄｎａの存在を検出する方法、及び免疫学的配位子の検出又は定量する方法
KR100571817B1 (ko) * 2003-09-19 2006-04-17 삼성전자주식회사 태그 서열에 혼성화하는 검출 프로브를 이용하는 표적핵산의 검출방법
CA3048093A1 (fr) 2003-11-26 2005-06-23 Celera Corporation Polymorphismes nucleotides simples associes a des troubles cardiovasculaires et a une reponse au medicament, leurs procedes de detection et d'utilisation
EP2107482B1 (fr) * 2003-12-06 2014-06-25 Abbott Laboratories Procédé et système pour analyser des réactions en utilisant un système d'information
US20050158710A1 (en) * 2004-01-16 2005-07-21 Shirley Tsang Detection of enterovirus nucleic acid
US7481997B1 (en) 2004-02-12 2009-01-27 Montana State University Snow mountain virus genome sequence, virus-like particles and methods of use
US20050233332A1 (en) * 2004-04-14 2005-10-20 Collis Matthew P Multiple fluorophore detector system
US7229800B2 (en) * 2004-04-16 2007-06-12 Becton, Dickinson And Company Neisseria gonorrhoeae assay
EP2412826B1 (fr) 2004-05-07 2014-01-08 Celera Corporation Polymorphisme génétique associée à des techniques de detection de cirrhose du foie et utilisation de ces polymorphismes
US20060030036A1 (en) 2004-05-28 2006-02-09 Victor Joseph Chips for multiplex analyses
US8124334B2 (en) * 2004-07-06 2012-02-28 Enzo Biochem, Inc. Selective detection of oncogenic HPV
WO2006017724A1 (fr) * 2004-08-06 2006-02-16 Becton, Dickinson And Company Sequences et procedes pour la detection de cytomegalovirus
EP1645640B1 (fr) 2004-10-05 2013-08-21 Affymetrix, Inc. Procédé pour la détection des translocations chromosomales
WO2006137933A2 (fr) * 2004-11-03 2006-12-28 Leucadia Technologies, Inc. Microbulles utilisees dans la separation par affinite
DE602005023529D1 (de) * 2004-11-03 2010-10-21 Iris Molecular Diagnostics Inc Homogener nachweis von analyten
JP2008526224A (ja) * 2005-01-07 2008-07-24 デルイター シーズ アール アンド ディー ビー．ブイ． トマトトラードウイルスと称される植物ウイルス
JP4398886B2 (ja) * 2005-03-07 2010-01-13 ソニー株式会社 通信端末装置、通信システム、通信方法、およびプログラム
US7759469B2 (en) 2005-03-10 2010-07-20 Roche Diagnostics Operations, Inc. Labeling reagent
EP1700922B1 (fr) 2005-03-10 2016-08-24 Roche Diagnostics GmbH Dérivés de 5-nitroindole 3-substitués et sondes oligonucléotidiques les contenant
JP5590697B2 (ja) 2005-03-11 2014-09-17 セレラ コーポレーション 冠動脈心疾患に関連する遺伝的多型、その検出方法および使用
DE602006017192D1 (de) 2005-04-12 2010-11-11 Olink Ab Verfahren zur herstellung von oligonukleotiden
EP1871896B1 (fr) 2005-04-12 2015-06-03 Olink AB Sondes circulaires pour l'identifcation des biomolécules
KR101637140B1 (ko) 2005-05-09 2016-07-06 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
US7939258B2 (en) 2005-09-07 2011-05-10 Nugen Technologies, Inc. Nucleic acid amplification procedure using RNA and DNA composite primers
AU2006291054B2 (en) 2005-09-12 2011-10-13 The Brigham And Women's Hospital, Inc. Recurrent gene fusions in prostate cancer
US9957569B2 (en) * 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
CA2627490A1 (fr) 2005-11-07 2007-05-18 Siemens Healthcare Diagnostics Inc. Sequences d'oligonucleotides specifiques a chlamydia trachomatis
EP1788389A1 (fr) * 2005-11-18 2007-05-23 Universitat De Girona Procédé pour la détection spécifique de Legionella pneumophila
ATE527383T1 (de) 2005-11-22 2011-10-15 Stichting Dienst Landbouwkundi Multiplex-nukleinsäurenachweis
EP1798292A1 (fr) 2005-12-19 2007-06-20 Nutreco Nederland B.V. Procédé pour augmenter la production de viande de dindon
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
BRPI0710601A2 (pt) 2006-04-07 2011-08-16 Siemens Healthcare Diagnostics seqüências de oligonucleotìdeo especìficas de neisseria gonorrhoeae
US8349556B2 (en) 2006-04-28 2013-01-08 Igor Kutyavin Use of base-modified deoxynucleoside triphosphates to improve nucleic acid detection
US9121056B2 (en) * 2006-04-28 2015-09-01 Igor Kutyavin Use of products of PCR amplification carrying elements of secondary structure to improve PCR-based nucleic acid detection
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
DK2017356T3 (da) 2006-06-06 2012-01-30 Gen Probe Inc Mærkede oligonukleotider og anvendelse deraf i fremgangsmåder til amplifikation af nukleinsyrer
EP1878803A1 (fr) * 2006-07-10 2008-01-16 Wageningen Universiteit Méthodes pour la détection des nématodes à galle
US7501254B2 (en) * 2006-07-20 2009-03-10 Ghc Technologies, Inc. Methods and compositions for amplification and capture of nucleic acid sequences
NZ548731A (en) * 2006-07-24 2008-12-24 Zygem Corp Ltd Isothermal detection methods and uses thereof
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
WO2008016562A2 (fr) * 2006-07-31 2008-02-07 Wanli Bi Amplification d'acide nucléique à l'aide d'un oligonucléotide modifié de façon réversible
US9045522B2 (en) 2006-07-31 2015-06-02 Wanli Bi Nucleic acid amplification using a reversibly modified oligonucleotide
WO2008021290A2 (fr) 2006-08-09 2008-02-21 Homestead Clinical Corporation Protéines spécifiques d'organes et procédés d'utilisation
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
EP1897891A1 (fr) 2006-09-11 2008-03-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) Diagnose de paraplégie spastique héréditaire par detection d' une mutation dans le gene où la protéine KIAA1840
DE602007007227D1 (de) * 2006-09-14 2010-07-29 Univ Girona Verfahren zum spezifischen nachweis von salmonella spp
US20080076123A1 (en) * 2006-09-27 2008-03-27 Helicos Biosciences Corporation Polymerase variants for DNA sequencing
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
WO2008051511A2 (fr) 2006-10-20 2008-05-02 Applera Corporation Polymorphismes génétiques associés à la thrombose veineuse, procédés pour les détecter et utilisations
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
EP1939303A1 (fr) * 2006-12-27 2008-07-02 Wageningen Universiteit Méthode pour la détection de nématodes
CA2674907C (fr) 2007-01-31 2017-04-04 Celera Corporation Signature pronostique moleculaire pour predire des metastases distantes chez les femmes atteintes d'un cancer du sein, et ses utilisations
NL1033431C2 (nl) 2007-02-20 2008-08-21 Expressive Res Bv Bepaling van kwaliteitskenmerken bij land- of tuinbouwproducten.
EP1978111B1 (fr) 2007-04-02 2013-03-27 Gen-Probe Incorporated Compositions, kits et procédés associés pour la détection et/ou la surveillance de Pseudomonas aeruginosa
US20120115131A1 (en) 2007-05-31 2012-05-10 Yale University Genetic lesion associated with cancer
US9303291B2 (en) * 2007-07-06 2016-04-05 The Regents Of The University Of Michigan MIPOL1-ETV1 gene rearrangements
EP3018216B1 (fr) 2007-07-06 2018-09-12 The Regents Of The University Of Michigan Fusions de gène récurrentes dans le cancer de la prostate
US9689031B2 (en) * 2007-07-14 2017-06-27 Ionian Technologies, Inc. Nicking and extension amplification reaction for the exponential amplification of nucleic acids
US8143006B2 (en) * 2007-08-03 2012-03-27 Igor Kutyavin Accelerated cascade amplification (ACA) of nucleic acids comprising strand and sequence specific DNA nicking
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
JP5511669B2 (ja) 2007-10-02 2014-06-04 セラノス， インコーポレイテッド モジュール式ポイントオブケアデバイスおよびその使用
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
WO2009061640A2 (fr) * 2007-11-06 2009-05-14 Siemens Healthcare Diagnostics Inc. Séquences oligonucléotidiques spécifiques du virus de l'hépatite b (vhb)
KR20100126676A (ko) * 2008-01-08 2010-12-02 자이겜 코포레이션 리미티드 등온 검출 방법 및 그의 용도
US20090203531A1 (en) 2008-02-12 2009-08-13 Nurith Kurn Method for Archiving and Clonal Expansion
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
EP2252893B1 (fr) * 2008-02-21 2013-10-23 Iris International, Inc. Procédé pour la détermination précoce d'une récurrence après une thérapie pour le cancer de la prostate
US20090215050A1 (en) 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
US9695469B2 (en) 2008-03-17 2017-07-04 Stichting Genetwister Ip Expression-linked gene discovery
GB2470672B (en) 2008-03-21 2012-09-12 Nugen Technologies Inc Methods of RNA amplification in the presence of DNA
US20090304714A1 (en) * 2008-03-25 2009-12-10 The Regents Of The University Of Michigan IKKi Inhibitor Therapies and Screening Methods, and Related IKKi Diagnostics
EP2479287B1 (fr) 2008-05-13 2014-07-23 Gen-Probe Incorporated Oligomères de capture de cible inactivables pour une utilisation dans l'hybridation et la capture sélectives de séquences d'acide nucléique cibles
EP2806054A1 (fr) 2008-05-28 2014-11-26 Genomedx Biosciences Inc. Systèmes et procédés de discrimination basés sur l'expression d'états pathologiques cliniques distincts dans le cancer de la prostate
JP2011521649A (ja) 2008-05-30 2011-07-28 イェール ユニバーシティー 遺伝子発現を改変するための標的化オリゴヌクレオチド組成物
US8703421B2 (en) 2008-05-30 2014-04-22 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Salmonella
EP3093351B1 (fr) 2008-07-09 2018-04-18 Celera Corporation Polymorphismes génétiques associés à des maladies cardiovasculaires, procédés de détection et utilisations associées
US8198023B2 (en) 2008-08-05 2012-06-12 Pacific Biosciences Of California, Inc. Prevention and alleviation of steric hindrance during single molecule nucleic acid synthesis by a polymerase
WO2010030716A1 (fr) * 2008-09-10 2010-03-18 Igor Kutyavin Détection d’acides nucléiques par des sondes oligonucléotidiques coupées en présence d’endonucléase v
US20100167291A1 (en) * 2008-09-12 2010-07-01 Promega Corporation Assessing expression of endogenous and exogenous genes
US9090948B2 (en) * 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
CN102203788B (zh) * 2008-10-31 2015-05-20 Abbvie公司 用于装配成小组的癌细胞系以用于测试一种或多种药物组合物的功效的方法
WO2010068102A1 (fr) 2008-12-10 2010-06-17 Monsanto Invest N.V. Nouveau virus de plante
MX337685B (es) 2008-12-19 2016-03-15 Enza Zaden Beheer Bv Metodo para reproducir plantas de pepino resistentes al virus del amarilleo y enanismo de cucurbitaceas (cysdv).
AU2009335053B2 (en) 2008-12-30 2013-08-01 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Listeria
WO2010080691A1 (fr) * 2009-01-06 2010-07-15 Qimin You Amplification d'acides nucléiques cibles par amorçage croisé
CN102639709A (zh) 2009-01-09 2012-08-15 密歇根大学董事会 癌症中的复现性基因融合体
US8945842B2 (en) 2009-01-14 2015-02-03 Becton, Dickinson And Company Assay for Trichomonas vaginalis by amplification and detection of Trichomonas vaginalis AP65-1 gene
EP2411534B1 (fr) 2009-03-24 2016-06-01 INSERM - Institut National de la Santé et de la Recherche Médicale Méthode de diagnostic ou de prédiction d'une atrophie optique autosomique récessive non syndromique ou d'un risque d'une atrophie optique autosomique récessive non syndromique
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
AU2010265889A1 (en) 2009-06-25 2012-01-19 Yale University Single nucleotide polymorphisms in BRCA1 and cancer risk
EP2272980A1 (fr) 2009-07-09 2011-01-12 Bioesplora SRL Sondes moléculaires pour la détection et la quantification d'acides nucléiques cibles
CA2770888C (fr) 2009-08-31 2020-04-14 Gen-Probe Incorporated Essai du virus de la dengue
EP2294912A1 (fr) 2009-09-04 2011-03-16 Wageningen Universiteit Procédé pour augmenter le taux de zéaxanthine dans une lignée végétale, procédé de sélection d'une plante ou d'une partie de celle-ci, y compris la graine et le tubercule, et utilisations correspondantes
JP5800817B2 (ja) * 2009-09-17 2015-10-28 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 前立腺癌における再発性遺伝子融合
EP2483425B1 (fr) 2009-09-28 2016-08-24 Igor Kutyavin Procédés et compositions pour la détection d'acides nucléiques en se basant sur des complexes de sondes à oligonucléotides stabilisés
WO2011039650A1 (fr) 2009-10-02 2011-04-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédé de diagnostic/pronostic de la dégénérescence maculaire liée à l'âge
WO2011049439A1 (fr) 2009-10-19 2011-04-28 Universiteit Twente Procédé pour sélectionner des cellules souches mésenchymateuses formatrices d'os
SG10201502531SA (en) 2009-10-19 2015-05-28 Theranos Inc Integrated Health Data Capture And Analysis System
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
WO2011095475A1 (fr) 2010-02-02 2011-08-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de diagnostic et de thérapie de la rétinite pigmentaire
US9714446B2 (en) * 2010-02-11 2017-07-25 Nanostring Technologies, Inc. Compositions and methods for the detection of small RNAs
US8383793B2 (en) 2010-04-15 2013-02-26 St. Jude Children's Research Hospital Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
AU2011248625B2 (en) 2010-04-26 2017-01-05 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
CA2797362C (fr) 2010-04-27 2020-12-08 Atyr Pharma, Inc. Decouverte innovante de compositions therapeutiques, de diagnostic et d'anticorps se rapportant a des fragments proteiques d'isoleucyl arnt synthetases
CA2797271C (fr) 2010-04-28 2021-05-25 Atyr Pharma, Inc. Compositions therapeutiques, diagnostiques et d'anticorps a base de fragments de proteines d'aminoacyl-arnt synthetases
AU2011248490B2 (en) 2010-04-29 2016-11-10 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
AU2011248457B2 (en) 2010-04-29 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases
US9034321B2 (en) 2010-05-03 2015-05-19 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
EP2566496B1 (fr) 2010-05-03 2018-02-28 aTyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, diagnostiques et à base d'anticorps liées des fragments protéiques de méthionyl-arnt-synthétases
CA2797277C (fr) 2010-05-03 2021-02-23 Atyr Pharma, Inc. Decouverte innovante de compositions therapeutiques, de diagnostic et d'anticorps liees a des fragments proteiques d'arginyle-arnt synthetases
AU2011248101B2 (en) 2010-05-04 2016-10-20 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex
CA2799197C (fr) 2010-05-14 2019-10-29 Atyr Pharma, Inc. Decouverte de compositions inedites de nature therapeutique, diagnostique et a base d'anticorps contenant des fragments proteiques de phenylalanyl-beta-arnt synthetases
JP6046607B2 (ja) 2010-05-27 2016-12-21 エータイアー ファーマ， インコーポレイテッド グルタミニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
WO2011153277A2 (fr) 2010-06-01 2011-12-08 Atyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, diagnostiques, et d'anticorps associés à des fragments de protéine de lysyl-tarn synthétases
WO2011162612A1 (fr) 2010-06-25 2011-12-29 Wageningen Universiteit Procédé permettant de moduler le niveau de phosphorylation de l'amidon dans une lignée végétale, procédé permettant de sélectionner une plante ou une partie de celle-ci, incluant une graine et un tubercule, et son utilisation
EP2588629B1 (fr) 2010-06-30 2017-05-17 Gen-Probe Incorporated Methode et appareil pour l'identification d'echantillons contenant un analyte utilisant une determination de l'analyte en lecture simple et des signaux de controle du procede.
EP2591363B1 (fr) 2010-07-07 2017-09-20 The Regents Of The University Of Michigan Diagnostic et traitement du cancer du sein
AU2011289831C1 (en) 2010-07-12 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
EP2593787B1 (fr) 2010-07-16 2018-07-04 Stichting VUmc Méthode d'analyser une prise de sang d'un sujet pour la présence d'un marqueur de la maladie
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US11031095B2 (en) 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US10167508B2 (en) 2010-08-06 2019-01-01 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
US20130137627A1 (en) 2010-08-12 2013-05-30 Christophe Delacourt Methods and kits for identifying a premature infant at risk of having or developing bronchopulmonary dysplasia
EP2608801B1 (fr) 2010-08-25 2019-08-21 aTyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, diagnostiques et d'anticorps associées à des fragments protéiniques des tyrosyl-arnt synthétases
WO2012049279A1 (fr) 2010-10-14 2012-04-19 Universitaet Des Saarlandes Moyens et procédés d'application d'extension d'amorce de nucléotide simple avec une chromatographie hplc de paire d'ions en phase inverse (sirph) pour le diagnostic de polymorphismes de nucléotides simples (snp)
US10233501B2 (en) 2010-10-19 2019-03-19 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US20150225792A1 (en) 2014-01-17 2015-08-13 Northwestern University Compositions and methods for identifying depressive disorders
US20150218639A1 (en) 2014-01-17 2015-08-06 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US10093981B2 (en) 2010-10-19 2018-10-09 Northwestern University Compositions and methods for identifying depressive disorders
BR112013010856B1 (pt) 2010-11-01 2020-12-22 Becton, Dickinson And Company método para detectar se uma sequência alvo de gardnerella vaginalis (gv) está presente em uma amostra e kit para uma reação de amplificação ou de detecção de gardnerella vaginalis
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
CA3012765A1 (fr) 2010-11-19 2012-05-24 The Regents Of The University Of Michigan Arnnc et utilisations de celui-ci
CN106290159A (zh) 2011-01-21 2017-01-04 提拉诺斯公司 样品使用最大化的系统和方法
US8756020B2 (en) 2011-01-25 2014-06-17 Ariosa Diagnostics, Inc. Enhanced risk probabilities using biomolecule estimations
WO2012103031A2 (fr) 2011-01-25 2012-08-02 Ariosa Diagnostics, Inc. Détection d'anomalies génétiques
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
EP2675275B1 (fr) 2011-02-14 2017-12-20 The Regents Of The University Of Michigan Compositions et méthodes utilisables en vue du traitement de l'obésité et des troubles associés
US20120219950A1 (en) 2011-02-28 2012-08-30 Arnold Oliphant Assay systems for detection of aneuploidy and sex determination
NL2006378C2 (en) 2011-03-11 2012-09-12 Univ Wageningen Tyclv resistance.
JP5934726B2 (ja) 2011-03-18 2016-06-15 フェレニヒング フォール クリステリック ホーヘル オンデルウィス，ウェテンシャペリク オンデルツォーケン パティエンテンツォルフ 疾患マーカーの存在を被験者の血液サンプルで分析する方法
WO2012165943A1 (fr) 2011-05-27 2012-12-06 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Procédé d'analyse d'un échantillon de sang prélevé chez un sujet en vue de rechercher un marqueur d'une maladie infectieuse
WO2012169887A2 (fr) 2011-06-06 2012-12-13 Stichting Katholieke Universiteit, More Particularly The Radboud University Nijmegen Medical Centre Utilisation de nouveaux marqueurs dans un dosage de diagnostic pour la détermination de la sévérité d'une infection par rsv
WO2013022342A1 (fr) 2011-08-09 2013-02-14 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Procédé d'analyse de prélèvement de sang d'un sujet pour détermination de la présence d'un marqueur de maladie fœtale ou d'état fœtal
EP3620533B1 (fr) 2011-09-06 2023-01-18 Gen-Probe Incorporated Structures d'acide nucléique fermée
EP2753714B1 (fr) 2011-09-06 2017-04-12 Gen-Probe Incorporated Gabarits mis sous forme circulaire pour séquençage
WO2013034645A1 (fr) 2011-09-06 2013-03-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et kits pour prévoir le risque de mélanome d'un sujet
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
WO2013052318A1 (fr) 2011-09-25 2013-04-11 Theranos, Inc. Systèmes et procédés pour multi-analyse
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
WO2013044097A1 (fr) 2011-09-21 2013-03-28 Gen-Probe Incorporated Procédés d'amplification d'acide nucléique à l'aide d'un déplacement à médiation par étiquette
US9352312B2 (en) 2011-09-23 2016-05-31 Alere Switzerland Gmbh System and apparatus for reactions
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US9416153B2 (en) 2011-10-11 2016-08-16 Enzo Life Sciences, Inc. Fluorescent dyes
CA2853760A1 (fr) 2011-11-04 2013-05-10 Oslo Universitetssykehus Hf Procedes et biomarqueurs pour l'analyse du cancer colorectal
AU2012318290B2 (en) 2011-11-04 2015-07-30 Gen-Probe Incorporated Molecular assay reagents and methods
US20130189679A1 (en) 2011-12-20 2013-07-25 The Regents Of The University Of Michigan Pseudogenes and uses thereof
US9803188B2 (en) 2011-12-22 2017-10-31 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids
US9334491B2 (en) 2011-12-22 2016-05-10 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids from cellular samples
US9970061B2 (en) 2011-12-27 2018-05-15 Ibis Biosciences, Inc. Bioagent detection oligonucleotides
EP2802673B1 (fr) 2012-01-09 2019-07-03 Oslo Universitetssykehus HF Procédés et biomarqueurs pour l'analyse d'un cancer colorectal
NZ628126A (en) 2012-02-16 2016-10-28 Atyr Pharma Inc Histidyl-trna synthetases for treating autoimmune and inflammatory diseases
EP2817627A2 (fr) 2012-02-21 2014-12-31 Oslo Universitetssykehus HF Méthodes et biomarqueurs permettant de dépister et de pronostiquer le cancer du col utérin
IN2014DN08312A (fr) 2012-03-06 2015-05-15 Univ Oslo Hf
ES2716995T3 (es) 2012-04-03 2019-06-18 Univ Michigan Regents Biomarcadores asociados con el síndrome del intestino irritable y la enfermedad de Crohn
EP2836605A1 (fr) 2012-04-11 2015-02-18 Institut National de la Santé et de la Recherche Médicale (INSERM) Méthode de diagnostic d'une ciliopathie à présentation squelettique
US10289800B2 (en) 2012-05-21 2019-05-14 Ariosa Diagnostics, Inc. Processes for calculating phased fetal genomic sequences
CN109082462B (zh) 2012-05-21 2022-10-28 斯克利普斯研究所 样品制备方法
WO2014005076A2 (fr) 2012-06-29 2014-01-03 The Regents Of The University Of Michigan Procédés et biomarqueurs pour la détection de troubles rénaux
CA2878280A1 (fr) 2012-07-19 2014-01-23 Ariosa Diagnostics, Inc. Detection a base de ligature sequentielle multiplexe de variants genetiques
CA2881627A1 (fr) 2012-08-16 2014-02-20 Genomedx Biosciences Inc. Diagnostic du cancer au moyen de biomarqueurs
CN104769134A (zh) 2012-09-11 2015-07-08 赛拉诺斯股份有限公司 使用生物签名的信息管理系统和方法
SG11201502189UA (en) 2012-09-23 2015-04-29 Univ Erasmus Medical Ct Human betacoronavirus lineage c and identification of n-terminal dipeptidyl peptidase as its virus receptor
US20160046997A1 (en) 2012-10-18 2016-02-18 Oslo Universitetssykehus Hf Biomarkers for cervical cancer
EP2925886B1 (fr) 2012-11-27 2019-04-24 Pontificia Universidad Católica de Chile Compositions et procédés de diagnostic de tumeurs de la thyroïde
EP3524691A1 (fr) 2012-12-07 2019-08-14 SuppreMol GmbH Stratification et traitement de patients du purpura thrombocytopénique idiopathique
AU2014216060A1 (en) 2013-02-18 2015-08-20 Theranos Ip Company, Llc Systems and methods for collecting and transmitting assay results
US10590474B2 (en) 2013-03-11 2020-03-17 Elitechgroup B.V. Methods for true isothermal strand displacement amplification
US10975423B2 (en) 2013-03-11 2021-04-13 Elitechgroup, Inc. Methods for true isothermal strand displacement amplification
US20140255928A1 (en) 2013-03-11 2014-09-11 Elitech Holding B.V. Methods for true isothermal strand displacement amplification
CN105378108A (zh) 2013-03-13 2016-03-02 雅培分子公司 用于分离核酸的系统和方法
CA2905429A1 (fr) 2013-03-14 2014-10-02 Abbott Molecular Inc. Minimisation d'erreurs utilisant de l'uracil-adn-n-glycosylase
EP2971171A4 (fr) 2013-03-14 2016-11-02 Abbott Molecular Inc Systèmes et procédés d'amplification multiplexe spécifiques de la méthylation
EP2971139A4 (fr) 2013-03-15 2016-12-07 Abbott Molecular Inc Systèmes et procédés pour la détection de changements de nombre de copie de génome
WO2014150910A1 (fr) 2013-03-15 2014-09-25 Ibis Biosciences, Inc. Séquences d'adn pour estimer la contamination dans le séquençage d'adn
CA2910553A1 (fr) 2013-04-30 2014-11-06 Universite De Montreal Nouveaux biomarqueurs pour la leucemie myeloide aigue
WO2014179734A1 (fr) 2013-05-02 2014-11-06 The Regents Of The University Of Michigan Amléxanox deutéré
GB201308313D0 (en) 2013-05-09 2013-06-19 Medical Res Council Assay Method
CA2898747C (fr) 2013-06-13 2021-09-21 Ariosa Diagnostics, Inc. Analyse statistique pour determination non-invasive d'une l'aneuploidie des chromosomes sexuels
CN110592244A (zh) 2013-07-25 2019-12-20 德诚分子诊断 用于检测细菌污染的方法和组合物
US11545241B1 (en) 2013-09-07 2023-01-03 Labrador Diagnostics Llc Systems and methods for analyte testing and data management
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
CN109706222A (zh) 2013-12-11 2019-05-03 安可济控股有限公司 用于检测罕见序列变体的组合物和方法
US9909181B2 (en) 2013-12-13 2018-03-06 Northwestern University Biomarkers for post-traumatic stress states
WO2015188178A1 (fr) 2014-06-06 2015-12-10 The Regents Of The University Of Michigan Compositions et méthodes de caractérisation et de diagnostic d'une maladie parodontale
CA2960821A1 (fr) 2014-09-09 2016-03-17 Igenomx International Genomics Corporation Methodes et compositions pour la preparation de banques d'acides nucleiques rapides
US10570463B2 (en) 2014-10-29 2020-02-25 Biotium, Inc. Nucleic acid modifying agents and uses thereof
WO2016077426A1 (fr) 2014-11-11 2016-05-19 Abbott Molecular Inc. Sondes d'hybridation et procédés associés
WO2016133764A1 (fr) * 2015-02-17 2016-08-25 Complete Genomics, Inc. Séquençage de l'adn à l'aide d'un déplacement de brin régulé
US10208339B2 (en) 2015-02-19 2019-02-19 Takara Bio Usa, Inc. Systems and methods for whole genome amplification
EP3259602B9 (fr) 2015-02-20 2021-05-19 Takara Bio USA, Inc. Procédé permettant une distribution, une visualisation et une analyse précises et rapides de cellules individuelles
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
ES2961374T3 (es) 2015-04-24 2024-03-11 Atila Biosystems Incorporated Amplificación con cebadores de composición de nucleótidos limitada
WO2016196478A1 (fr) 2015-06-01 2016-12-08 St. Jude Children's Research Hospital Procédés et compositions pour les pronostics et/ou la gestion clinique de la maladie du greffon contre l'hôte et du rejet de greffe
ES2955883T3 (es) 2015-06-19 2023-12-07 Sera Prognostics Inc Pares de biomarcadores para la predicción del parto prematuro
EP3124619B1 (fr) 2015-07-31 2019-03-06 Menicon Co., Ltd Réactifs, procédé et kit pour le diagnostic du glaucome de races canines
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
CN114807323A (zh) 2015-10-09 2022-07-29 安可济控股有限公司 用于富集扩增产物的方法及组合物
EP3156497A1 (fr) 2015-10-16 2017-04-19 Centre National de la Recherche Scientifique (C.N.R.S.) Trpv2 en tant que biomarqueur et cible thérapeutique pour un mélanome
EP3373723A1 (fr) 2015-11-10 2018-09-19 Vilmorin & Cie Résistance au virus tolcndv de la courge
US20180363039A1 (en) 2015-12-03 2018-12-20 Accuragen Holdings Limited Methods and compositions for forming ligation products
EP3181699A1 (fr) 2015-12-17 2017-06-21 Oniris Micro-arn comme biomarqueurs prédictifs des diabètes de type 1
US10894985B2 (en) 2016-01-12 2021-01-19 Sitokine Limited Methods for predicting response to treatment
WO2017132538A1 (fr) 2016-01-29 2017-08-03 The Regents Of The University Of Michigan Analogues d'amlexanox
WO2017155858A1 (fr) 2016-03-07 2017-09-14 Insilixa, Inc. Identification de séquence d'acide nucléique à l'aide d'une extension de base unique cyclique en phase solide
CA3024630A1 (fr) 2016-05-16 2017-11-23 Accuragen Holdings Limited Procede de sequencage ameliore par identification de brin
US11091795B2 (en) 2016-07-11 2021-08-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias
CN109070044B (zh) 2016-07-21 2021-07-30 宝生物工程（美国)有限公司 使用多孔装置进行的多z平面成像和分配
SG10202111825YA (en) 2016-08-15 2021-12-30 Accuragen Holdings Ltd Compositions and methods for detecting rare sequence variants
EP3504348B1 (fr) 2016-08-24 2022-12-14 Decipher Biosciences, Inc. Utilisation de signatures génomiques en vue d'une prédiction de la réactivité de patients atteints d'un cancer de la prostate à une radiothérapie postopératoire
CN109923203A (zh) 2016-09-30 2019-06-21 多伦多大学管理委员会 用于鉴定和靶向异质群体中的个体细胞以选择性提取细胞内容物的系统
WO2018127786A1 (fr) 2017-01-06 2018-07-12 Oslo Universitetssykehus Hf Compositions et méthodes permettant de déterminer un plan d'action thérapeutique
US10329620B2 (en) 2017-01-12 2019-06-25 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
US11208697B2 (en) 2017-01-20 2021-12-28 Decipher Biosciences, Inc. Molecular subtyping, prognosis, and treatment of bladder cancer
WO2018165600A1 (fr) 2017-03-09 2018-09-13 Genomedx Biosciences, Inc. Sous-typage du cancer de la prostate pour prédire la réponse à une thérapie hormonale
US11078542B2 (en) 2017-05-12 2021-08-03 Decipher Biosciences, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness
WO2019036032A1 (fr) 2017-08-18 2019-02-21 Sera Prognostics, Inc Protéines d'horloge de grossesse pour prévoir la date et le moment prévus de la naissance
CA3068477A1 (fr) 2017-09-27 2019-04-04 Abbott Molecular Inc. Analyse pour la detection du virus de l'hepatite b (vhb)
CA3068482A1 (fr) 2017-10-03 2019-04-11 Abbott Molecular Inc. Dosage pour la detection du virus de l'hepatite c (vhc)
WO2019070731A1 (fr) 2017-10-03 2019-04-11 Abbott Molecular Inc. Dosage pour la détection du virus de l'immunodéficience humaine (vih)
US10724083B1 (en) 2017-12-06 2020-07-28 Cepheid Inhibition of nucleic acid polymerases by endonuclease V-cleavable oligonucleotide ligands
US10724017B1 (en) 2017-12-06 2020-07-28 Cepheid Inhibition of DNA polymerases by uracil-DNA glycosylase-cleavable oligonucleotide ligands
US10689629B1 (en) 2017-12-06 2020-06-23 Cepheid Inhibition of nucleic acid polymerases by endonuclease V-cleavable circular oligonucleotide ligands
WO2019139792A1 (fr) 2018-01-09 2019-07-18 Abbott Molecular Inc. Dosage pour détecter chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis, et mycoplasma genitalium
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
WO2019202536A1 (fr) 2018-04-18 2019-10-24 St. Jude Children's Research Hospital Essais de génotypage pour identifier des mutations dans xaf1
WO2019213619A1 (fr) 2018-05-04 2019-11-07 Abbott Laboratories Méthodes et produits de diagnostic, de pronostic et de thérapie du vhb
CN113508182B (zh) 2018-12-18 2024-03-08 雅培分子公司 用于检测人乳头状瘤病毒(hpv)的测定
JP2022525322A (ja) 2019-03-14 2022-05-12 インシリクサ， インコーポレイテッド 時間ゲート蛍光ベースの検出のための方法およびシステム
US20220249660A1 (en) 2019-06-06 2022-08-11 Sitokine Limited Compositions and methods for treating lung, colorectal and breast cancer
WO2021028469A1 (fr) 2019-08-12 2021-02-18 Sitokine Limited Compositions et méthodes de traitement du syndrome de libération de cytokines et de neurotoxicité
WO2021080629A1 (fr) 2019-10-23 2021-04-29 Elitechgroup, Inc. Procédés d'amplification par déplacement de brin isotherme véritable
WO2021095798A1 (fr) 2019-11-15 2021-05-20 公立大学法人横浜市立大学 Procédé de détection sensible pour des gènes marqueurs indifférenciés
WO2021205013A1 (fr) 2020-04-09 2021-10-14 Sitokine Limited Compositions et méthodes de traitement de la covid-19
WO2021252574A1 (fr) 2020-06-10 2021-12-16 Sera Prognostics, Inc. Biomarqueurs d'acide nucléique pour un dysfonctionnement placentaire
WO2023021330A1 (fr) 2021-08-16 2023-02-23 University Of Oslo Compositions et méthodes permettant de déterminer un plan d'action thérapeutique
WO2023152568A2 (fr) 2022-02-10 2023-08-17 Oslo Universitetssykehus Hf Compositions et méthodes de caractérisation du cancer du poumon
WO2023175434A1 (fr) 2022-03-15 2023-09-21 Diagenode S.A. Détection de l'état de méthylation d'un échantillon d'adn
WO2024020360A1 (fr) 2022-07-18 2024-01-25 Pairwise Plants Services, Inc. Plantes vertes de moutarde nommées 'pwrg-1', 'pwrg-2,' et 'pwsgc'
WO2024030985A1 (fr) 2022-08-04 2024-02-08 Abbott Laboratories Dosages pour la détection virale de la variole du singe

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DK171161B1 (da) * 1985-03-28 1996-07-08 Hoffmann La Roche Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve
US5043272A (en) * 1989-04-27 1991-08-27 Life Technologies, Incorporated Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers
US5106727A (en) * 1989-04-27 1992-04-21 Life Technologies, Inc. Amplification of nucleic acid sequences using oligonucleotides of random sequences as primers
US5112734A (en) * 1989-05-26 1992-05-12 Gene-Trak Systems Target-dependent synthesis of an artificial gene for the synthesis of a replicatable rna
US5455166A (en) * 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification

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US5270184A (en) 1993-12-14
DE69219727D1 (de) 1997-06-19
EP0543612A2 (fr) 1993-05-26
EP0543612A3 (en) 1993-07-14
CA2082842C (fr) 2001-01-09
AU662937B2 (en) 1995-09-21
JPH0876B2 (ja) 1996-01-10
JPH05276947A (ja) 1993-10-26
DE69219727T2 (de) 1997-11-27
EP0543612B1 (fr) 1997-05-14

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