CA2057524A1 - Dihydro-isoquinoline derivatives - Google Patents

Dihydro-isoquinoline derivatives

Info

Publication number
CA2057524A1
CA2057524A1 CA002057524A CA2057524A CA2057524A1 CA 2057524 A1 CA2057524 A1 CA 2057524A1 CA 002057524 A CA002057524 A CA 002057524A CA 2057524 A CA2057524 A CA 2057524A CA 2057524 A1 CA2057524 A1 CA 2057524A1
Authority
CA
Canada
Prior art keywords
compound
ester
formula
acid addition
addition salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002057524A
Other languages
English (en)
French (fr)
Inventor
Reto Naef
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2057524A1 publication Critical patent/CA2057524A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
CA002057524A 1990-12-13 1991-12-12 Dihydro-isoquinoline derivatives Abandoned CA2057524A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9027055 1990-12-13
GB909027055A GB9027055D0 (en) 1990-12-13 1990-12-13 Organic compounds

Publications (1)

Publication Number Publication Date
CA2057524A1 true CA2057524A1 (en) 1992-06-14

Family

ID=10686945

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002057524A Abandoned CA2057524A1 (en) 1990-12-13 1991-12-12 Dihydro-isoquinoline derivatives

Country Status (25)

Country Link
US (1) US5177085A (OSRAM)
EP (1) EP0490823B1 (OSRAM)
JP (1) JPH0764820B2 (OSRAM)
KR (1) KR920012040A (OSRAM)
AT (1) ATE145201T1 (OSRAM)
AU (1) AU643575B2 (OSRAM)
CA (1) CA2057524A1 (OSRAM)
CZ (1) CZ281669B6 (OSRAM)
DE (1) DE69123124T2 (OSRAM)
DK (1) DK0490823T3 (OSRAM)
ES (1) ES2093694T3 (OSRAM)
FI (1) FI915844L (OSRAM)
GB (1) GB9027055D0 (OSRAM)
GR (1) GR3022034T3 (OSRAM)
HU (1) HUT61729A (OSRAM)
IE (1) IE914325A1 (OSRAM)
IL (1) IL100328A (OSRAM)
MX (1) MX9102502A (OSRAM)
MY (1) MY129941A (OSRAM)
NZ (1) NZ240936A (OSRAM)
PL (1) PL168329B1 (OSRAM)
PT (1) PT99775B (OSRAM)
RU (1) RU2060992C1 (OSRAM)
TW (1) TW201736B (OSRAM)
ZA (1) ZA919858B (OSRAM)

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US6245774B1 (en) 1994-06-21 2001-06-12 Celltech Therapeutics Limited Tri-substituted phenyl or pyridine derivatives
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US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
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GB9526243D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9526245D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
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WO1997034473A1 (en) * 1996-03-21 1997-09-25 The Trustees Of Columbia University In The City Of New York Craf1 (traf-3) isoforms and uses thereof
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GB9622363D0 (en) * 1996-10-28 1997-01-08 Celltech Therapeutics Ltd Chemical compounds
GB9625184D0 (en) * 1996-12-04 1997-01-22 Celltech Therapeutics Ltd Chemical compounds
ID19155A (id) * 1996-12-13 1998-06-18 Tanabe Seiyaku Co Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya
JP2001507349A (ja) * 1996-12-23 2001-06-05 セルテック セラピューティックス リミテッド 縮合多環式２−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用
AU6230098A (en) * 1997-02-27 1998-09-18 Tanabe Seiyaku Co., Ltd. Isoquinolinone derivatives, process for preparing the same, and their use as phosphodiesterase inhibitors
GB9705361D0 (en) * 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
JP2001510825A (ja) 1997-07-25 2001-08-07 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規テトラゾール誘導体
EP1023269A4 (en) * 1997-09-30 2001-06-27 Molecular Design Int BETA3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USE
IT1296985B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
IT1302677B1 (it) * 1998-10-15 2000-09-29 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
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US6924292B2 (en) * 2000-03-23 2005-08-02 Takeda Chemical Industries, Ltd. Furoisoquinoline derivatives, process for producing the same and use thereof
WO2002040449A1 (en) * 2000-11-14 2002-05-23 Altana Pharma Ag Dihydroisoquinolines as novel phosphodiesterase inhibitors
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JP2005537312A (ja) * 2002-08-17 2005-12-08 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規のフェナントリジン
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US6596734B1 (en) 2002-10-11 2003-07-22 Molecular Design International, Inc. Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
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BRPI0415497A (pt) * 2003-10-16 2006-12-26 Hoffmann La Roche composto processo para a sua preparação , composição farmacêutica que compreende o mesmo, utilização de um composto e método para o tratamento de diabetes do tipo ii
ES2400823T3 (es) 2004-02-18 2013-04-12 Takeda Gmbh Nuevas hidroxi-6-fenilfenantridinas sustituidas con guanidinilo como inhibidores eficaces de fosfodiesterasa (PDE) 4
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Also Published As

Publication number Publication date
FI915844A0 (fi) 1991-12-11
CS375791A3 (en) 1992-06-17
US5177085A (en) 1993-01-05
AU8898591A (en) 1992-06-18
MX9102502A (es) 1992-06-01
DE69123124D1 (de) 1996-12-19
TW201736B (OSRAM) 1993-03-11
ZA919858B (en) 1993-06-14
PL292738A1 (en) 1992-12-14
EP0490823A1 (en) 1992-06-17
JPH04275276A (ja) 1992-09-30
ES2093694T3 (es) 1997-01-01
DK0490823T3 (OSRAM) 1997-02-17
ATE145201T1 (de) 1996-11-15
CZ281669B6 (cs) 1996-12-11
AU643575B2 (en) 1993-11-18
PT99775B (pt) 1999-05-31
RU2060992C1 (ru) 1996-05-27
HU913760D0 (en) 1992-02-28
IE914325A1 (en) 1992-06-17
FI915844A7 (fi) 1992-06-14
DE69123124T2 (de) 1997-05-15
JPH0764820B2 (ja) 1995-07-12
PL168329B1 (pl) 1996-02-29
MY129941A (en) 2007-05-31
NZ240936A (en) 1993-09-27
GR3022034T3 (en) 1997-03-31
IL100328A (en) 1995-12-08
IL100328A0 (en) 1992-09-06
FI915844L (fi) 1992-06-14
EP0490823B1 (en) 1996-11-13
PT99775A (pt) 1992-11-30
KR920012040A (ko) 1992-07-25
HUT61729A (en) 1993-03-01
GB9027055D0 (en) 1991-02-06

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Legal Events

Date Code Title Description
FZDE Discontinued