CA2051663A1 - Neomorphogenese de cartilage in vivo a partir d'une culture cellulaire - Google Patents

Neomorphogenese de cartilage in vivo a partir d'une culture cellulaire

Info

Publication number
CA2051663A1
CA2051663A1 CA2051663A CA2051663A CA2051663A1 CA 2051663 A1 CA2051663 A1 CA 2051663A1 CA 2051663 A CA2051663 A CA 2051663A CA 2051663 A CA2051663 A CA 2051663A CA 2051663 A1 CA2051663 A1 CA 2051663A1
Authority
CA
Canada
Prior art keywords
growth
matrices
vivo
cells
cartilage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2051663A
Other languages
English (en)
Other versions
CA2051663C (fr
Inventor
Joseph P. Vacanti
Charles A. Vacanti
Robert S. Langer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Childrens Hospital
Massachusetts Institute of Technology
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2051663A1 publication Critical patent/CA2051663A1/fr
Application granted granted Critical
Publication of CA2051663C publication Critical patent/CA2051663C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/062—Apparatus for the production of blood vessels made from natural tissue or with layers of living cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/10—Mineral substrates
    • C12N2533/18—Calcium salts, e.g. apatite, Mineral components from bones, teeth, shells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/84—Bones; tendons; teeth; cartilage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915—Method or apparatus for preparing biological material
    • Y10S623/919—Bone

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Prostheses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002051663A 1989-04-17 1990-04-16 Neomorphogenese de cartilage in vivo a partir d'une culture cellulaire Expired - Lifetime CA2051663C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US339,155 1989-04-17
US07/339,155 US5041138A (en) 1986-11-20 1989-04-17 Neomorphogenesis of cartilage in vivo from cell culture

Publications (2)

Publication Number Publication Date
CA2051663A1 true CA2051663A1 (fr) 1990-10-18
CA2051663C CA2051663C (fr) 1996-08-06

Family

ID=23327755

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002051663A Expired - Lifetime CA2051663C (fr) 1989-04-17 1990-04-16 Neomorphogenese de cartilage in vivo a partir d'une culture cellulaire

Country Status (10)

Country Link
US (1) US5041138A (fr)
EP (1) EP0469070B1 (fr)
JP (1) JPH066155B2 (fr)
AT (1) ATE142511T1 (fr)
AU (1) AU635025B2 (fr)
CA (1) CA2051663C (fr)
DE (1) DE69028524T2 (fr)
DK (1) DK0469070T3 (fr)
ES (1) ES2095252T3 (fr)
WO (1) WO1990012603A1 (fr)

Families Citing this family (361)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005161A (en) * 1986-01-28 1999-12-21 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
US5904717A (en) * 1986-01-28 1999-05-18 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5863531A (en) * 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5804178A (en) * 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
CA1340581C (fr) * 1986-11-20 1999-06-08 Joseph P. Vacanti Neomorphogenese chimerique d'organes par implatation cellulaire controlee, utilisant des matrices artificielles
US6309635B1 (en) * 1986-11-20 2001-10-30 Children's Medical Center Corp. Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
US5306311A (en) * 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US5735902A (en) * 1987-07-20 1998-04-07 Regen Biologics, Inc. Hand implant device
JP2820415B2 (ja) * 1988-03-14 1998-11-05 ティーエイチエム・バイオメディカル・インコーポレイテッド 生分解性および骨形成性を有する移植骨片代用組成体
CA2031532C (fr) * 1989-04-25 2003-02-25 Joseph P. Vacanti Methode d'implantation de masses importantes de cellules dans des matrices polymeriques
US5376118A (en) * 1989-05-10 1994-12-27 United States Surgical Corporation Support material for cell impregnation
DE3936568C2 (de) * 1989-11-03 1997-06-19 Karlheinz Prof Dr Dr Schmidt Wirkstoffkomplex für die Herstellung von biologischen Teilen in Form von Organen für Lebewesen; Verfahren zum Herstellen desselben und seine Verwendung
US5618531A (en) * 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
SE501217C2 (sv) * 1990-12-06 1994-12-12 Skandigen Ab Cellproliferationsmatris och användning därav
US5853746A (en) * 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
DE69219613T2 (de) * 1991-10-30 1997-11-27 Childrens Medical Center Vorvaskularisierte polymerimplantate für organtransplantation
US5433748A (en) * 1991-12-04 1995-07-18 Porex Technologies Corp. Auricular implant
US5610753A (en) * 1991-12-12 1997-03-11 Eastman Kodak Company Optical design of laser scanner to reduce thermal sensitivity
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US5326357A (en) * 1992-03-18 1994-07-05 Mount Sinai Hospital Corporation Reconstituted cartridge tissue
IT1260148B (it) * 1992-04-17 1996-03-28 Fidia Spa Impiego di preparazioni di acido ialuronico per la formazione di tessuto osseo
AU4543193A (en) * 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
US5916553A (en) * 1992-09-17 1999-06-29 Schmidt; Karlheinz Complex for inducing bone growth in the mastoid cavity
US5928635A (en) * 1994-12-07 1999-07-27 Schmidt; Karlheinz Process for producing active agent complexes
WO1994014390A1 (fr) * 1992-12-24 1994-07-07 Orbital Implant Technology Dispositif destine a un implant orbitaire
CA2114290C (fr) * 1993-01-27 2006-01-10 Nagabushanam Totakura Dispositif anti-adhesif post-chirurgical
US6689608B1 (en) 1993-02-01 2004-02-10 Massachusetts Institute Of Technology Porous biodegradable polymeric materials for cell transplantation
US5514378A (en) * 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
DE4306661C2 (de) * 1993-03-03 1995-04-20 Michael Dipl Biol Sittinger Verfahren zum Herstellen eines Implantates aus Zellkulturen
FR2708202B1 (fr) * 1993-07-26 1996-03-29 Pasteur Institut Implant biocompatible pour l'expression chez l'homme ou chez l'animal de substances déterminées.
EP0702723B1 (fr) 1993-04-21 2002-09-04 Institut Pasteur Implant biocompatible pour l'expression et la secretion in vivo d'un compose therapeutique
WO1994025079A1 (fr) * 1993-04-23 1994-11-10 Massachusetts Institute Of Technology Materiaux polymeres biodegradables poreux pour la transplantation cellulaire
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
EP2025353A2 (fr) 1993-04-30 2009-02-18 Massachusetts Institute of Technology Compositions de cellules de polysaccharide injectables
US5368051A (en) * 1993-06-30 1994-11-29 Dunn; Allan R. Method of regenerating articular cartilage
AU722956B2 (en) * 1993-07-07 2000-08-17 Smith & Nephew Plc Prosthesis
CA2166697A1 (fr) * 1993-07-07 1995-01-19 Sorrel Elizabeth Wolowacz Prothese implantable; trousse et dispositif permettant d'obtenir cette prothese
US5522895A (en) * 1993-07-23 1996-06-04 Rice University Biodegradable bone templates
US5393594A (en) * 1993-10-06 1995-02-28 United States Surgical Corporation Absorbable non-woven fabric
AU8095694A (en) * 1993-10-28 1995-05-22 Thm Biomedical, Inc. Improved process and device for treating and healing a bone void
US5916557A (en) * 1993-11-12 1999-06-29 The Trustees Of Columbia University In The City Of New York Methods of repairing connective tissues
US5629186A (en) * 1994-04-28 1997-05-13 Lockheed Martin Corporation Porous matrix and method of its production
US5723331A (en) * 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US5981825A (en) 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US7963997B2 (en) * 2002-07-19 2011-06-21 Kensey Nash Corporation Device for regeneration of articular cartilage and other tissue
US5855608A (en) * 1994-05-13 1999-01-05 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US8795242B2 (en) * 1994-05-13 2014-08-05 Kensey Nash Corporation Resorbable polymeric device for localized drug delivery
US8697108B2 (en) * 1994-05-13 2014-04-15 Kensey Nash Corporation Method for making a porous polymeric material
US5656450A (en) * 1994-05-27 1997-08-12 Board Of Regents, The University Of Texas System Activation of latent transforming growth factor β by matrix vesicles
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
EP0717630A1 (fr) * 1994-07-08 1996-06-26 SULZER Medizinaltechnik AG Procede de fabrication de materiaux pour greffe
EP0692227A1 (fr) * 1994-07-11 1996-01-17 SULZER Medizinaltechnik AG Implant en nappe
US6695848B2 (en) 1994-09-02 2004-02-24 Hudson Surgical Design, Inc. Methods for femoral and tibial resection
US8603095B2 (en) 1994-09-02 2013-12-10 Puget Bio Ventures LLC Apparatuses for femoral and tibial resection
WO1996008213A1 (fr) 1994-09-12 1996-03-21 Advanced Tissue Sciences, Inc. Cultures tridimensionnelles de cellules humaines sur des structures de valvules cardiaques, et leurs utilisations
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5713374A (en) 1995-02-10 1998-02-03 The Hospital For Joint Diseases Orthopaedic Institute Fixation method for the attachment of wound repair materials to cartilage defects
EP0727481B1 (fr) * 1995-02-16 2003-04-16 Forschungszentrum Jülich Gmbh Procédé de culture des cellules des organes
US5906934A (en) * 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
EP0735135A3 (fr) * 1995-03-31 1997-12-29 DIZG Deutsches Institüt für Zell- und Gewebeersatz gGmbH Couches de cellules et système de transport pour couches de cellules
US5904716A (en) * 1995-04-26 1999-05-18 Gendler; El Method for reconstituting cartilage tissue using demineralized bone and product thereof
US6123727A (en) 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5998162A (en) * 1995-05-18 1999-12-07 Biosil Ag Production of secondary metabolites with plant cells immobilized in a porous inorganic support
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US6132463A (en) * 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US5655546A (en) * 1995-06-07 1997-08-12 Halpern; Alan A. Method for cartilage repair
US5741685A (en) * 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5716413A (en) * 1995-10-11 1998-02-10 Osteobiologics, Inc. Moldable, hand-shapable biodegradable implant material
EP0862616B1 (fr) 1995-11-06 2008-07-30 Mount Sinai Hospital Tissu cartilagineux reconstitue et mineralise
US20020111695A1 (en) * 1995-11-06 2002-08-15 Mount Sinai Hospital Corporation Reconstituted mineralized cartilage tissue
DE69631490T2 (de) * 1995-11-09 2004-10-07 Univ Massachusetts Boston Wiederherstellung der gewebeoberfläche mit zusammensetzungen aus hydrogel-zellen
US6482231B1 (en) * 1995-11-20 2002-11-19 Giovanni Abatangelo Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative
US5842477A (en) * 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US6152964A (en) * 1996-03-01 2000-11-28 Isotis B.V. Method for in vitro production of bone
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
DE59710789D1 (de) * 1996-06-04 2003-10-30 Sulzer Orthopedics Ltd Verfahren zur herstellung von knorpelgewebe und von implantaten
US5964807A (en) 1996-08-08 1999-10-12 Trustees Of The University Of Pennsylvania Compositions and methods for intervertebral disc reformation
US20060025786A1 (en) * 1996-08-30 2006-02-02 Verigen Transplantation Service International (Vtsi) Ag Method for autologous transplantation
US6569172B2 (en) 1996-08-30 2003-05-27 Verigen Transplantation Service International (Vtsi) Method, instruments, and kit for autologous transplantation
US5989269A (en) 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
US5759190A (en) * 1996-08-30 1998-06-02 Vts Holdings Limited Method and kit for autologous transplantation
US20020173806A1 (en) * 1996-08-30 2002-11-21 Verigen Transplantation Service International (Vtsi) Ag Method for autologous transplantation
US5881733A (en) * 1996-09-13 1999-03-16 Depuy Orthopaedic Technology, Inc. Technique for osteocartilaginous transplantation in a mammalian joint
US5964805A (en) * 1997-02-12 1999-10-12 Stone; Kevin R. Method and paste for articular cartilage transplantation
US8728536B2 (en) * 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
US5919702A (en) * 1996-10-23 1999-07-06 Advanced Tissue Science, Inc. Production of cartilage tissue using cells isolated from Wharton's jelly
US5928945A (en) * 1996-11-20 1999-07-27 Advanced Tissue Sciences, Inc. Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage
JP4002299B2 (ja) 1996-12-10 2007-10-31 セラマット・インコーポレーテッド 組織処理用の改善されたヒドロゲル
US8480754B2 (en) 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US8083745B2 (en) 2001-05-25 2011-12-27 Conformis, Inc. Surgical tools for arthroplasty
US7618451B2 (en) * 2001-05-25 2009-11-17 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools facilitating increased accuracy, speed and simplicity in performing total and partial joint arthroplasty
US8735773B2 (en) 2007-02-14 2014-05-27 Conformis, Inc. Implant device and method for manufacture
US7534263B2 (en) 2001-05-25 2009-05-19 Conformis, Inc. Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty
US8545569B2 (en) 2001-05-25 2013-10-01 Conformis, Inc. Patient selectable knee arthroplasty devices
US9603711B2 (en) 2001-05-25 2017-03-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
US8771365B2 (en) 2009-02-25 2014-07-08 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs, and related tools
AU6661698A (en) 1997-02-20 1998-09-09 Gregory S. Keller Augmentation and repair of dermal, subcutaneous, and vocal cord tissue defects
US6001352A (en) * 1997-03-31 1999-12-14 Osteobiologics, Inc. Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
DE69818052T2 (de) 1997-03-31 2004-07-08 The Regents Of The University Of Michigan, Ann Arbor Offenporige bioabbaubare matrize
AU742613B2 (en) 1997-04-04 2002-01-10 Barnes-Jewish Hospital Neocartilage and methods of use
ATE218896T1 (de) 1997-07-16 2002-06-15 Isotis Nv Vorrichtung zur knochenbehandlung bestehend aus abbaubarem thermoplastischen copolyester und kultivierten zellen
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
CA2297489A1 (fr) 1997-07-30 1999-02-11 Emory University Nouvelle proteine de mineralisation osseuse, adn, vecteurs et systemes d'expressions
AU8681098A (en) 1997-08-01 1999-03-08 Massachusetts Institute Of Technology Three-dimensional polymer matrices
US6110209A (en) * 1997-08-07 2000-08-29 Stone; Kevin R. Method and paste for articular cartilage transplantation
DE69714035T2 (de) 1997-08-14 2003-03-06 Sulzer Innotec Ag, Winterthur Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren
US6077987A (en) * 1997-09-04 2000-06-20 North Shore-Long Island Jewish Research Institute Genetic engineering of cells to enhance healing and tissue regeneration
EP1042019B1 (fr) * 1997-10-31 2006-06-07 Children's Medical Center Corporation Reconstruction penienne
CA2221195A1 (fr) 1997-11-14 1999-05-14 Chantal E. Holy Matrice en polymere biodegradable
US6472210B1 (en) 1997-11-14 2002-10-29 Bonetec Corporation Polymer scaffold having microporous polymer struts defining interconnected macropores
AU1588099A (en) * 1997-11-17 1999-06-07 Beth Israel Deaconess Medical Center Hybrid tissues for tissue engineering
DE19803673A1 (de) 1998-01-30 1999-08-05 Norbert M Dr Meenen Biohybrider Gelenkflächenersatz
AU6664998A (en) * 1998-02-24 1999-09-15 Gerigene Medical Corporation Augmentation and repair of dermal, subcutaneous, and vocal cord tissue defects
WO1999047186A1 (fr) * 1998-03-18 1999-09-23 University Of Pittsburgh Matieres composites a base de chitosane contenant du glycosaminoglycane pour la reparation du cartilage
US6143293A (en) * 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
US6514522B2 (en) 1998-04-08 2003-02-04 Chondros, Inc. Polymer constructs
US6637437B1 (en) * 1998-04-08 2003-10-28 Johns Hopkins University Cell-culture and polymer constructs
US6378527B1 (en) * 1998-04-08 2002-04-30 Chondros, Inc. Cell-culture and polymer constructs
US6171610B1 (en) 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
US6027744A (en) * 1998-04-24 2000-02-22 University Of Massachusetts Medical Center Guided development and support of hydrogel-cell compositions
WO2000004941A1 (fr) * 1998-07-24 2000-02-03 Pharmacal Biotechnologies, Inc. Systeme et procede de reconstruction de tissus osseux
EP1104313A2 (fr) * 1998-08-14 2001-06-06 Verigen Transplantation Service International (VTSI) AG Methodes, instruments et materiau de transplantation de chondrocytes
US6132468A (en) * 1998-09-10 2000-10-17 Mansmann; Kevin A. Arthroscopic replacement of cartilage using flexible inflatable envelopes
ATE439806T1 (de) 1998-09-14 2009-09-15 Univ Leland Stanford Junior Zustandsbestimmung eines gelenks und schadenvorsorge
US7239908B1 (en) 1998-09-14 2007-07-03 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
KR100298846B1 (ko) * 1998-09-24 2003-10-22 한국원자력연구소 중화키토산스폰지또는중화키토산/콜라겐혼합스폰지를이용한인공진피
US7022522B2 (en) 1998-11-13 2006-04-04 Limin Guan Macroporous polymer scaffold containing calcium phosphate particles
US6918396B1 (en) * 1998-12-01 2005-07-19 Purdue Research Foundation Method for vocal cord reconstruction
IT1302534B1 (it) 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
US6291516B1 (en) 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
US7001746B1 (en) * 1999-01-29 2006-02-21 Artecel Sciences, Inc. Methods and compositions for the differentiation of human preadipocytes into adipocytes
DE19906172C1 (de) * 1999-02-08 2000-07-13 Ethicon Gmbh Resorbierbares Implantat
US6656489B1 (en) 1999-02-10 2003-12-02 Isotis N.V. Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material
US6197061B1 (en) * 1999-03-01 2001-03-06 Koichi Masuda In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage
DE19911326A1 (de) * 1999-03-15 2000-09-28 Fege Wolfgang Vorrichtung zum Züchten von menschlichem oder tierischem Gewebe
ES2199815T3 (es) 1999-03-19 2004-03-01 The Regents Of The University Of Michigan Mineralizacion y desarrollo celular supeerficial sobre biomateriales.
US6767928B1 (en) * 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
US6662805B2 (en) 1999-03-24 2003-12-16 The Johns Hopkins University Method for composite cell-based implants
EP1867348B1 (fr) 1999-03-25 2012-05-16 Metabolix, Inc. Dispositifs médicaux et applications de polymères polyhydroxyalkanoates
US6179840B1 (en) 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
US20020095157A1 (en) 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
US20020116063A1 (en) * 1999-08-02 2002-08-22 Bruno Giannetti Kit for chondrocyte cell transplantation
US7005274B1 (en) 1999-09-15 2006-02-28 Migenix Corp. Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass
US6450169B1 (en) * 1999-09-17 2002-09-17 Pi Medical, Inc. Braided implant for snoring treatment
US6303138B1 (en) * 1999-09-17 2001-10-16 Depuy Orthopaedics Endothelin-based compositions for enhancing connective tissue repair
US6390096B1 (en) * 1999-09-17 2002-05-21 Pi Medical, Inc. Needle with pre-loaded implant for snoring treatment
US6322590B1 (en) * 1999-11-09 2001-11-27 Michael J. Sillers Internal nasal implant
DE19959088A1 (de) * 1999-12-08 2001-06-13 Inst Textil & Faserforschung Medizintechnisches Produkt, Verfahren zu seiner Herstellung und Verwendung
US7560275B2 (en) * 1999-12-30 2009-07-14 Vbi Technologies, L.L.C. Compositions and methods for generating skin
US7575921B2 (en) * 1999-12-30 2009-08-18 Vbi Technologies, L.L.C. Spore-like cells and uses thereof
EP1918366A1 (fr) 2000-02-26 2008-05-07 Artecel, Inc. Cellules souches pleuripotent générées à partir de cellules stromales dérivées de tissus adipeux et utilisations associées
ES2300320T3 (es) 2000-02-26 2008-06-16 Artecel, Inc. Celulas madre pluripotentes generadas a partir de celulas del estroma derivadas de tejido adiposo y sus usos.
US7582292B2 (en) 2000-02-26 2009-09-01 Artecel, Inc. Adipose tissue derived stromal cells for the treatment of neurological disorders
US7115653B2 (en) * 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
US6683108B1 (en) 2000-03-30 2004-01-27 Curis, Inc. Agonists of hedgehog signaling pathways and uses related thereto
US20050070578A1 (en) * 2000-03-30 2005-03-31 Baxter Anthony David Small organic molecule regulators of cell proliferation
US6613798B1 (en) 2000-03-30 2003-09-02 Curis, Inc. Small organic molecule regulators of cell proliferation
US8852937B2 (en) * 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
AU2001255767A1 (en) 2000-04-28 2001-11-12 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro
US6645485B2 (en) * 2000-05-10 2003-11-11 Allan R. Dunn Method of treating inflammation in the joints of a body
US6454803B1 (en) 2000-05-23 2002-09-24 Romo, Iii Thomas External nasal valve batten implant device and method
DE10032808A1 (de) * 2000-06-30 2002-01-17 Tom Witascheck Vorrichtung zur multilayerartigen Zusammenführung unterschiedlicher Zelltypen in bestimmten Formen und Mustern zu Geweben oder Organen
US6719970B1 (en) * 2000-07-10 2004-04-13 Alkermes Controlled Therapeutics, Inc. Method of generating cartilage
CA2425120A1 (fr) 2000-09-14 2002-03-21 The Board Of Trustees Of The Leland Stanford Junior University Evaluation de l'etat d'une articulation et traitement afferent
AU2001290887B2 (en) 2000-09-14 2006-06-08 The Board Of Trustees Of The Leland Stanford Junior University Assessing condition of a joint and cartilage loss
US6908732B2 (en) 2000-10-13 2005-06-21 President & Fellows Of Harvard College Compounds and methods for regulating cell differentiation
US20020151050A1 (en) * 2000-10-30 2002-10-17 Vacanti Charles A. Isolation of spore-like cells from tissues exposed to extreme conditions
US7625580B1 (en) * 2000-11-28 2009-12-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US6852330B2 (en) * 2000-12-21 2005-02-08 Depuy Mitek, Inc. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6599323B2 (en) * 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
CA2365376C (fr) * 2000-12-21 2006-03-28 Ethicon, Inc. Utilisation d'implants en mousse renforces ayant une meilleure integrite pour la reparation et la regeneration de tissus mous
US20020127265A1 (en) * 2000-12-21 2002-09-12 Bowman Steven M. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
DE60219433D1 (de) * 2001-02-14 2007-05-24 Genzyme Corp Biokompatibles vlies für hämostase und gewebeaufbau
CA2438193A1 (fr) * 2001-02-26 2002-09-06 Duke University Nouveaux dendrimeres et leurs utilisations biomedicales
US8062377B2 (en) 2001-03-05 2011-11-22 Hudson Surgical Design, Inc. Methods and apparatus for knee arthroplasty
US20030171546A1 (en) * 2001-04-30 2003-09-11 City Of Hope Chimeric immunoreceptor useful in treating human cancers
US8439926B2 (en) 2001-05-25 2013-05-14 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
CA2447694A1 (fr) 2001-05-25 2002-12-05 Imaging Therapeutics, Inc. Methodes et compositions d'arthroplastie
AU2002335747B2 (en) * 2001-09-15 2009-01-29 Rush University Medical Center Stratified cartilage tissue and methods to engineer same
US20030165473A1 (en) * 2001-11-09 2003-09-04 Rush-Presbyterian-St. Luke's Medical Center Engineered intervertebral disc tissue
US7160725B2 (en) * 2001-11-13 2007-01-09 Curis, Inc. Hedgehog signaling promotes the formation of three dimensional cartilage matrices
US20030138873A1 (en) * 2002-01-22 2003-07-24 Koichi Masuda Tissue engineered cartilage for drug discovery
MXPA04005940A (es) * 2002-01-22 2004-09-13 Pfizer Acidos 3-(imidazolil)-2-aminopropanoicos.
US20030220692A1 (en) * 2002-02-09 2003-11-27 Shapiro Irving M. Preparations of nucleus pulposus cells and methods for their generation, identification, and use
US8271202B1 (en) 2002-02-11 2012-09-18 Fernandez Dennis S Modified host bio-data management
US20040131582A1 (en) * 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
CA2485350C (fr) 2002-04-08 2014-08-19 Millenium Biologix Inc. Systeme automatise de genie tissulaire comportant des capteurs relies a un microprocesseur
US7655674B2 (en) 2002-04-22 2010-02-02 The Johns Hopkins University Modulators of hedgehog signaling pathways, compositions and uses related thereto
US7931687B2 (en) * 2002-05-13 2011-04-26 Articular Engineering, Llc Tissue engineered osteochondral implant
US20030228287A1 (en) * 2002-06-07 2003-12-11 Regents Of The University Of California Maintenance of islet cells
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
JP4353510B2 (ja) * 2002-09-09 2009-10-28 株式会社カネカ 組織再生用支持体及びその製造方法
US20040136968A1 (en) * 2002-09-27 2004-07-15 Verigen Ag Autologous cells on a support matrix for tissue repair
AU2003275326A1 (en) * 2002-09-30 2004-04-23 Massachussetts Eye And Ear Infirmary In vitro culture of tissue structures
TWI231755B (en) * 2002-10-07 2005-05-01 Conformis Inc An interpositional articular implant and the method for making the same
JP4664205B2 (ja) 2002-10-15 2011-04-06 アイアールエム エルエルシー 骨形成を誘導する組成物および方法
WO2004034890A2 (fr) * 2002-10-17 2004-04-29 Vacanti, Joseph, P. Matiere de support biologique
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
WO2004039248A2 (fr) * 2002-10-31 2004-05-13 The General Hospital Corporation Reparation ou remplacement de tissus ou d'organes
WO2004043305A1 (fr) 2002-11-07 2004-05-27 Conformis, Inc. Procedes pour determiner les dimensions et formes de menisques, et pour mettre au point un traitement
JP5028086B2 (ja) 2003-02-24 2012-09-19 マリン ポリマー テクノロジーズ，インコーポレーテッド 細胞−ポリマー繊維組成物及びその使用
US8197837B2 (en) 2003-03-07 2012-06-12 Depuy Mitek, Inc. Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
US7794408B2 (en) 2003-03-28 2010-09-14 Ethicon, Inc. Tissue collection device and methods
US8221781B2 (en) * 2003-04-11 2012-07-17 Etex Corporation Osteoinductive bone material
US7067123B2 (en) * 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7488348B2 (en) 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US10583220B2 (en) * 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
US7897384B2 (en) * 2003-09-08 2011-03-01 Ethicon, Inc. Chondrocyte therapeutic delivery system
US7927599B2 (en) * 2003-09-08 2011-04-19 Ethicon, Inc. Chondrocyte therapeutic delivery system
US8257963B2 (en) * 2007-06-01 2012-09-04 Depuy Mitek, Inc. Chondrocyte container and method of use
US7611473B2 (en) 2003-09-11 2009-11-03 Ethicon, Inc. Tissue extraction and maceration device
US8034003B2 (en) 2003-09-11 2011-10-11 Depuy Mitek, Inc. Tissue extraction and collection device
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
CN1913929A (zh) * 2003-12-10 2007-02-14 细胞生物工程公司 用于软组织特征重建的方法和组合物
EP2338442B1 (fr) 2003-12-11 2013-01-30 Isto Technologies Inc. Système chondral particulier
CA2535169A1 (fr) 2003-12-31 2005-07-21 Osteotech, Inc. Compositions de matrice osseuse ameliorees et methodes associees
US8021368B2 (en) 2004-01-14 2011-09-20 Hudson Surgical Design, Inc. Methods and apparatus for improved cutting tools for resection
US7857814B2 (en) 2004-01-14 2010-12-28 Hudson Surgical Design, Inc. Methods and apparatus for minimally invasive arthroplasty
US20060030854A1 (en) 2004-02-02 2006-02-09 Haines Timothy G Methods and apparatus for wireplasty bone resection
US8114083B2 (en) 2004-01-14 2012-02-14 Hudson Surgical Design, Inc. Methods and apparatus for improved drilling and milling tools for resection
US7815645B2 (en) 2004-01-14 2010-10-19 Hudson Surgical Design, Inc. Methods and apparatus for pinplasty bone resection
US20060030855A1 (en) * 2004-03-08 2006-02-09 Haines Timothy G Methods and apparatus for improved profile based resection
US11395865B2 (en) * 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US20060275273A1 (en) * 2004-02-20 2006-12-07 Seyedin Mitchell S Intervertebral Disc Repair, Methods and Devices Therefor
KR101218454B1 (ko) * 2004-04-15 2013-01-04 에텍스 코포레이션 세팅 지연 칼슘 포스페이트 페이스트
US8657881B2 (en) * 2004-04-20 2014-02-25 Depuy Mitek, Llc Meniscal repair scaffold
US8137686B2 (en) 2004-04-20 2012-03-20 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8221780B2 (en) 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
US7446131B1 (en) 2004-06-10 2008-11-04 The United States Of America As Represented By The Secretary Of Agriculture Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
CA2897218A1 (fr) 2004-06-17 2006-01-26 Thrasos Innovation, Inc. Composes associes au facteur de differenciation tissulaire et leurs analogues
US20050288796A1 (en) * 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
US20090142307A1 (en) * 2004-07-09 2009-06-04 Athanasiou Kyriacos A Shape-Based Approach for Scaffoldless Tissue Engineering
US7351423B2 (en) * 2004-09-01 2008-04-01 Depuy Spine, Inc. Musculo-skeletal implant having a bioactive gradient
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20060097422A1 (en) * 2004-11-08 2006-05-11 Diamond Andrew J Method for performing surgery and appliances produced thereby
US9981063B2 (en) * 2004-11-24 2018-05-29 Mayo Foundation For Medical Education And Research Biosynthetic composite for osteochondral defect repair
JP2006289062A (ja) * 2005-03-18 2006-10-26 Pentax Corp 肥大化能を有する軟骨細胞と足場を用いた骨補填材料
US20060224244A1 (en) * 2005-03-31 2006-10-05 Zimmer Technology, Inc. Hydrogel implant
US20060235542A1 (en) * 2005-04-15 2006-10-19 Zimmer Technology, Inc. Flexible segmented bearing implant
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US20070036842A1 (en) * 2005-08-15 2007-02-15 Concordia Manufacturing Llc Non-woven scaffold for tissue engineering
JP5292533B2 (ja) * 2005-08-26 2013-09-18 ジンマー・インコーポレイテッド インプラントおよび関節疾患の治療、置換および治療方法
US7799087B2 (en) * 2005-08-31 2010-09-21 Zimmer Gmbh Implant
EP1924146A4 (fr) * 2005-09-02 2012-05-02 Interface Biotech As Procede pour l'implantation cellulaire
EP1926459B1 (fr) 2005-09-19 2015-01-07 Histogenics Corporation Matrice support de cellules dont la densite des pores et la porosite sont definies specifiquement de maniere uniforme verticalement et organisees de maniere non aleatoire, et procede de preparation de celle-ci
EP1764117A1 (fr) 2005-09-20 2007-03-21 Zimmer GmbH Implant pour la réparation de défauts cartilagineux et son procédé de préparation
SI2497780T1 (sl) 2005-09-20 2015-08-31 Thrasos Innovation, Inc. Spojine, povezane s TDF, in njihovi analogi
US20070088444A1 (en) * 2005-10-13 2007-04-19 Robert A Hodorek Method for repairing a bone defect using a formable implant which hardens in vivo
AU2006307647B2 (en) * 2005-10-24 2012-09-13 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method and device for synovial cell-charged collagen membrane or gel
SI1948259T1 (sl) * 2005-10-26 2017-07-31 Genesis Technologies Limited Acelularni bioabsorbljivi tkivni regeneracijski matriksi, proizvedeni z inkubiranjem acelularnih proizvodov krvi
US8911759B2 (en) 2005-11-01 2014-12-16 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
CA2640759A1 (fr) * 2005-11-09 2007-05-18 Zimmer Gmbh Implant
EP1951158A4 (fr) 2005-11-21 2010-03-31 Vertegen Inc Dispositifs et procédés de traitement de facettes articulaires lombaires, d'articulations uncovertébrales, d'articulations costovertébrales et d'autres articulations
US8105581B2 (en) 2005-12-01 2012-01-31 The Scripps Research Institute Compositions and methods for inducing neuronal differentiation
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
US8444968B2 (en) * 2005-12-07 2013-05-21 Isto Technologies, Inc. Cartilage repair methods
ES2377885T3 (es) * 2005-12-27 2012-04-02 Genentech, Inc. Uso de antagonistas de hedgehog cinasa para inhibir la señalización de hedgehog y para tratar cáncer
US20090022775A1 (en) * 2006-01-24 2009-01-22 Basf Se Polymer backbone for producing artificial tissue
US20070179607A1 (en) * 2006-01-31 2007-08-02 Zimmer Technology, Inc. Cartilage resurfacing implant
US8623026B2 (en) 2006-02-06 2014-01-07 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief
CN105030297A (zh) 2006-02-06 2015-11-11 康复米斯公司 患者可选择的关节成形术装置和手术器具
WO2007090790A2 (fr) * 2006-02-09 2007-08-16 Zimmer Gmbh Prothèse
NZ589814A (en) 2006-03-20 2012-03-30 Tigenix Nv Methods to maintain, improve and restore the cartilage phenotype of chondrocytes
WO2007109747A2 (fr) * 2006-03-21 2007-09-27 Wyeth Procédés et compositions destinés à un antagonisme de rage
WO2007126455A2 (fr) 2006-04-05 2007-11-08 Genentech, Inc. Méthode d'utilisation du boc/cdo pour moduler l'émission des signaux du hedgehog
US8632601B2 (en) * 2006-04-28 2014-01-21 Zimmer, Gmbh Implant
US20090214474A1 (en) * 2006-11-01 2009-08-27 Barbara Brooke Jennings Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
US20080103116A1 (en) * 2006-11-01 2008-05-01 Jennings-Spring Barbara L Method of treatment and compositions of D-chiro inositol and phosphates thereof
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
WO2008086147A1 (fr) * 2007-01-05 2008-07-17 The Brigham And Women's Hospital, Inc. Compositions et procédés pour la réparation et la régénération du cartilage et/ou d'os
CA2618125A1 (fr) * 2007-02-08 2008-08-08 Zimmer, Inc. Implant interphalangien proximal a base d'hydrogel
EP2591756A1 (fr) 2007-02-14 2013-05-15 Conformis, Inc. Dispositif d'implant et procédé de fabrication
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
EP3878949B1 (fr) 2007-04-07 2025-06-04 Whitehead Institute for Biomedical Research Reprogrammation de cellules somatiques
AU2008240191B2 (en) * 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
WO2008137115A1 (fr) 2007-05-03 2008-11-13 The Brigham And Women's Hospital, Inc. Cellules souches multipotentes et leurs utilisations
WO2008157412A2 (fr) 2007-06-13 2008-12-24 Conformis, Inc. Guide d'incision chirurgical
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
WO2008157492A2 (fr) 2007-06-15 2008-12-24 Osteotech, Inc. Os spongieux déminéralisé ostéo-inducteur
AU2008265850B2 (en) 2007-06-15 2014-06-26 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
EP2167148B1 (fr) 2007-06-15 2017-12-27 Warsaw Orthopedic, Inc. Procédé de traitement d'un tissu
WO2009009684A1 (fr) 2007-07-10 2009-01-15 Osteotech, Inc. Système d'administration
CA2693767C (fr) 2007-07-12 2023-10-17 Discgenics Compositions de cellules souches de disque adulte et methodes de traitement de maladie degenerative des disques
US8979935B2 (en) * 2007-07-31 2015-03-17 Zimmer, Inc. Joint space interpositional prosthetic device with internal bearing surfaces
US8062655B2 (en) 2007-08-31 2011-11-22 Phillips Plastics Corporation Composite scaffold structure
ES2446544T3 (es) * 2007-10-19 2014-03-10 Warsaw Orthopedic, Inc. Composiciones de matrices óseas desmineralizadas y métodos
EP2214736B1 (fr) * 2007-10-29 2014-03-05 Zimmer, Inc. Implants médicaux et procédés de délivrance d'agents biologiquement actifs
US8431158B2 (en) 2007-11-26 2013-04-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions comprising fibrous polypeptides and polysaccharides
US8167787B2 (en) * 2008-01-03 2012-05-01 Revent Medical, Inc. Partially erodable systems for treatment of obstructive sleep apnea
EP3095470A1 (fr) 2008-02-07 2016-11-23 Shahar Cohen Compositions d'extrait compartimental pour génie tissulaire
US8682052B2 (en) 2008-03-05 2014-03-25 Conformis, Inc. Implants for altering wear patterns of articular surfaces
CN102006841A (zh) * 2008-03-05 2011-04-06 肯弗默斯股份有限公司 边缘匹配的关节植入物
WO2009111069A1 (fr) * 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Produits de recombinaison spongieux, particules de cartilage et associations de produits de recombinaison spongieux et de particules de cartilage
AU2009246474B2 (en) 2008-05-12 2015-04-16 Conformis, Inc. Devices and methods for treatment of facet and other joints
US8707960B2 (en) * 2008-05-12 2014-04-29 Revent Medical, Inc. Partially erodable systems for treatment of obstructive sleep apnea
US8733363B2 (en) * 2010-03-19 2014-05-27 Revent Medical, Inc. Systems and methods for treatment of sleep apnea
US9439801B2 (en) 2012-06-29 2016-09-13 Revent Medical, Inc. Systems and methods for treatment of sleep apnea
KR20100056718A (ko) * 2008-11-20 2010-05-28 한국과학기술연구원 형상회복력을 갖는 고탄성 생분해성 고분자 지지체 및 이를이용한 관절 연골 손상의 치료
EP2370093A4 (fr) * 2008-11-28 2012-08-29 Zensun Shanghai Science And Technology Ltd Neureguline et cellules souches cardiaques
US9456890B2 (en) 2009-01-15 2016-10-04 The Curators Of The University Of Missouri Scaffold for bone and tissue repair in mammals
US8353966B2 (en) 2009-01-15 2013-01-15 The Curators Of The University Of Missouri Scaffold for bone and tissue repair in mammals
US9011537B2 (en) 2009-02-12 2015-04-21 Warsaw Orthopedic, Inc. Delivery system cartridge
US8808297B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
US8808303B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
EP2405865B1 (fr) 2009-02-24 2019-04-17 ConforMIS, Inc. Systèmes automatisés four la fabrication des implants et instruments adaptés individuellement au patient
US9017334B2 (en) 2009-02-24 2015-04-28 Microport Orthopedics Holdings Inc. Patient specific surgical guide locator and mount
US12383287B2 (en) 2009-02-24 2025-08-12 Microport Orthopedics Holdings, Inc. Systems and methods for installing an orthopedic implant
WO2010111278A1 (fr) 2009-03-23 2010-09-30 The Texas A&M University System Compositions de cellules souches mésenchymateuses pour régénérer l'os
JP2012523897A (ja) 2009-04-16 2012-10-11 コンフォーミス・インコーポレイテッド 靭帯修復のための患者固有の関節置換術の装置
WO2010137021A2 (fr) 2009-05-27 2010-12-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procédé de génération de tissu conjonctif
EP2266985A1 (fr) 2009-06-26 2010-12-29 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Dérivés de pyrimidine tricycliques en tant qu'antagonistes Wnt
EP2266984A1 (fr) 2009-06-26 2010-12-29 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Pyrido[2,3-d]pyrimidines en tant qu' antagoniste du Wnt pour le traitement du cancer et de l'arthrite
US9744123B2 (en) * 2009-06-30 2017-08-29 Kensey Nash Corporation Biphasic implant device providing gradient
US10016278B2 (en) * 2009-06-30 2018-07-10 Dsm Ip Assets B.V. Biphasic implant device providing joint fluid therapy
US20100331998A1 (en) * 2009-06-30 2010-12-30 Ringeisen Timothy A Electrokinetic device for tissue repair
US8551775B2 (en) 2009-11-12 2013-10-08 Vbi Technologies, L.L.C. Subpopulations of spore-like cells and uses thereof
WO2011064773A1 (fr) 2009-11-24 2011-06-03 Collplant Ltd. Procédé de production de fibres de collagène
CA2782137A1 (fr) 2009-12-11 2011-06-16 Conformis, Inc. Implants orthopediques mis au point pour un patient et specifiques a un patient
EP2542249A4 (fr) 2010-03-05 2013-08-07 Tissue Genesis Inc Procédés et compositions destinés à favoriser l'intégration de tissu et l'inoculation de cellules stromales adipeuses dans un tissu transplanté et un tissu pénien fabriqué et transplanté
WO2011116382A2 (fr) * 2010-03-19 2011-09-22 Revent Medical Inc. Systèmes et méthodes pour le traitement de l'apnée du sommeil
WO2011121096A1 (fr) 2010-03-31 2011-10-06 Dkfz Deutsches Krebsforschungszentrum Dérivés de pyrazolo[1,5-a]pyrimidine comme antagonistes de la voie wnt
EP2571464A4 (fr) 2010-05-21 2014-08-06 Revent Medical Inc Systèmes et procédés de traitement de l'apnée du sommeil
WO2012018545A2 (fr) 2010-07-26 2012-02-09 Revent Medical, Inc. Systèmes et méthodes de traitement de l'apnée du sommeil
US8668739B2 (en) 2010-08-20 2014-03-11 Zimmer, Inc. Unitary orthopedic implant
EP2638025B1 (fr) 2010-11-12 2020-02-05 Deutsches Krebsforschungszentrum (DKFZ) Dérivés de chromène et leurs analogues à titre d'antagonistes de la voie wnt
WO2012066543A2 (fr) 2010-11-16 2012-05-24 Collplant Ltd. Structures collagéniques et leur procédé de fabrication
WO2012112694A2 (fr) 2011-02-15 2012-08-23 Conformis, Inc. Modélisation, analyse et utilisation de données anatomiques d'implants adaptés à des patients, conception, outils et procédures chirurgicales
US10086043B2 (en) 2011-04-03 2018-10-02 The General Hospital Corporation Efficient protein expression in vivo using modified RNA (MOD-RNA)
US9486226B2 (en) 2012-04-18 2016-11-08 Conformis, Inc. Tibial guides, tools, and techniques for resecting the tibial plateau
US9675471B2 (en) 2012-06-11 2017-06-13 Conformis, Inc. Devices, techniques and methods for assessing joint spacing, balancing soft tissues and obtaining desired kinematics for joint implant components
US20140072611A1 (en) 2012-09-07 2014-03-13 Fibrocell Technologies, Inc. Methods and Compositions for Treating Post-Cardial Infarction Damage
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
EP3260142B1 (fr) * 2015-03-18 2023-04-26 FUJIFILM Corporation Matériau pour la régénération du cartilage et procédé pour le produire
USD781421S1 (en) * 2015-09-11 2017-03-14 Matrix Surgical Holdings, LLC Surgical implant for a human ear
US11447745B2 (en) 2017-09-01 2022-09-20 Lonza Walkersville, Inc. End-to-end cell therapy automation
CN112752847B (zh) 2018-09-28 2025-03-28 奥克泰生物科技股份有限公司 磁性分离
KR20210108406A (ko) 2018-12-21 2021-09-02 론자 워커스빌 아이엔씨. 바이러스 벡터의 자동화된 생산
SG11202106384YA (en) 2018-12-21 2021-07-29 Octane Biotech Inc Carousel for modular biologic production units
CN119685160A (zh) 2018-12-28 2025-03-25 奥克泰生物科技股份有限公司 具有受控环境区的细胞培养和组织工程系统
KR20210125510A (ko) 2019-02-08 2021-10-18 론자 워커스빌 아이엔씨. 자동화 생물반응기에서 사용하기 위한 세포 농축 방법 및 장치
JP2022531871A (ja) 2019-05-29 2022-07-12 ライト メディカル テクノロジー インコーポレイテッド 置換足関節の脛骨インプラント部品を受容するための脛骨の準備
CN114729292A (zh) 2019-10-24 2022-07-08 奥克泰生物科技股份有限公司 具有经改进的细胞接触表面的细胞培养室
WO2021096850A1 (fr) 2019-11-11 2021-05-20 Lonza Walkersville, Inc. Procédés de contrôle qualité pour le traitement automatisé de cellules
WO2021146015A1 (fr) 2020-01-17 2021-07-22 Wright Medical Technology, Inc. Outils, systèmes et procédés de guidage
JP2023530919A (ja) 2020-06-17 2023-07-20 ヤンセン バイオテツク，インコーポレーテツド 多能性幹細胞の製造のための材料及び方法
JP2023535334A (ja) * 2020-07-16 2023-08-17 ユニバーシティ オブ ユタ リサーチ ファウンデーション 軟骨細胞シート並びにそれらの製造及び使用方法
US12440227B2 (en) 2021-02-24 2025-10-14 Wright Medical Technology, Inc. Preparing a tibia for receiving tibial implant component of a replacement ankle
JP7774794B2 (ja) * 2021-06-17 2025-11-25 学校法人近畿大学 人工耳介および人工軟骨組織の骨格構造

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144126A (en) * 1975-05-21 1979-03-13 Beecham Group Limited Cell culture method
US4228243A (en) * 1978-07-13 1980-10-14 Toray Industries, Inc. Cell culture propagation apparatus
US4713070A (en) * 1978-11-30 1987-12-15 Sumitom Electric Industries, Ltd. Porous structure of polytetrafluoroethylene and process for production thereof
US4356261A (en) * 1980-04-22 1982-10-26 Rush-Presbyterian-St. Luke's Medical Center Anti-invasion factor containing cultures
US4553272A (en) * 1981-02-26 1985-11-19 University Of Pittsburgh Regeneration of living tissues by growth of isolated cells in porous implant and product thereof
US4485097A (en) * 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
IL68218A (en) * 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US4609551A (en) * 1984-03-20 1986-09-02 Arnold Caplan Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
US4778749A (en) * 1984-06-01 1988-10-18 Karyon Technology, Inc. Tissue culture and production in permeable gels
US4757017A (en) * 1984-09-14 1988-07-12 Mcw Research Foundation, Inc. In vitro cell culture system
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US4627853A (en) * 1985-05-29 1986-12-09 American Hospital Supply Corporation Method of producing prostheses for replacement of articular cartilage and prostheses so produced
JPS6211459A (ja) * 1985-07-09 1987-01-20 株式会社アドバンス 複合インプラント材
BR8606816A (pt) * 1985-08-09 1987-10-13 M & T Chemicals Inc Processo de ativacao para formar eletrodeposicoes de cromo aderentes a partir de banhos de cromo eficazes de alta energia sobre substratos de metal
DE3689650T2 (de) * 1985-12-17 1994-05-26 United States Surgical Corp Bioresorbierbare Polymere von hohem Molekulargewicht und Implantate davon.
JPH0761278B2 (ja) * 1986-09-19 1995-07-05 住友製薬株式会社 成長因子の軟骨成長促進活性の測定法
SU1407178A1 (ru) * 1986-10-03 1990-08-30 Липецкое станкостроительное производственное объединение Роликова опора
CA1340581C (fr) * 1986-11-20 1999-06-08 Joseph P. Vacanti Neomorphogenese chimerique d'organes par implatation cellulaire controlee, utilisant des matrices artificielles
JPS63196595A (ja) * 1987-02-10 1988-08-15 Ajinomoto Co Inc 抗腫瘍活性物質の製造方法
JPS63196273A (ja) * 1987-02-10 1988-08-15 Sumitomo Electric Ind Ltd 細胞培養用基材
EP0282746A1 (fr) * 1987-02-19 1988-09-21 Takeda Chemical Industries, Ltd. Procédé de préparation de tissu cultivé de manière artificielle
US4846835A (en) * 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage
US4880429A (en) * 1987-07-20 1989-11-14 Stone Kevin R Prosthetic meniscus
US4904259A (en) * 1988-04-29 1990-02-27 Samuel Itay Compositions and methods for repair of cartilage and bone

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ATE142511T1 (de) 1996-09-15
AU635025B2 (en) 1993-03-11

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