ES2178102T3 - Dispositivo para la generacion de tejido oseo, que comprende un termoplastico de copoliester biodegradable y celulas cultivadas. - Google Patents
Dispositivo para la generacion de tejido oseo, que comprende un termoplastico de copoliester biodegradable y celulas cultivadas.Info
- Publication number
- ES2178102T3 ES2178102T3 ES98202360T ES98202360T ES2178102T3 ES 2178102 T3 ES2178102 T3 ES 2178102T3 ES 98202360 T ES98202360 T ES 98202360T ES 98202360 T ES98202360 T ES 98202360T ES 2178102 T3 ES2178102 T3 ES 2178102T3
- Authority
- ES
- Spain
- Prior art keywords
- ester units
- chain ester
- copolyester
- copoliester
- oseo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920001169 thermoplastic Polymers 0.000 title 1
- 239000004416 thermosoftening plastic Substances 0.000 title 1
- 125000004185 ester group Chemical group 0.000 abstract 4
- 229920001634 Copolyester Polymers 0.000 abstract 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 101100001670 Emericella variicolor andE gene Proteins 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000002449 bone cell Anatomy 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004956 cyclohexylene group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000278 osteoconductive effect Effects 0.000 abstract 1
- 210000005009 osteogenic cell Anatomy 0.000 abstract 1
- 230000002188 osteogenic effect Effects 0.000 abstract 1
- 210000004663 osteoprogenitor cell Anatomy 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- -1 poly(oxyalkylene) Polymers 0.000 abstract 1
- 229920006344 thermoplastic copolyester Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3821—Bone-forming cells, e.g. osteoblasts, osteocytes, osteoprogenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3633—Extracellular matrix [ECM]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3847—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Polyesters Or Polycarbonates (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
LA INVENCION SE REFIERE A UN DISPOSITIVO DE REGENERACION OSEA, QUE COMPRENDE UN MATERIAL DE SOPORTE FORMADO POR UN COPOLIESTER TERMOPLASTICO SEGMENTADO PARA UNION DE HUESOS, OSTEOCONDUCTIVO, BIOACTIVO Y CELULAS OSTEOPROGENITORAS U OSTEOGENICAS CULTIVADAS, ESPECIALMENTE CELULAS OSEAS. EL COPOLIESTER ESTA FORMADO BASICAMENTE POR UNA MULTIPLICIDAD DE UNIDADES DE ESTER DE CADENA LARGA REPETITIVAS, Y POR UNIDADES DE ESTER DE CADENA CORTA, DE FORMA QUE LAS UNIDADES DE ESTER DE CADENA LARGA CONSTITUYEN DEL 35 AL 80 % EN PESO DEL COPOLIESTER, Y ESTAN REPRESENTADAS MEDIANTE LA FORMULA: Y LAS CADENAS DE ESTER CORTAS ESTAN REPRESENTADAS MEDIANTE LA FORMULA: DONDE L ES UN GRUPO DIVALENTE QUE PERMANECE TRAS LA ELIMINACION DE LOS GRUPOS HIDROXILO TERMINALES A PARTIR DE UN POLI(OXIALQUILEN)GLICOL CON UN PESO MOLECULAR MEDIO ENTRE 300 Y 3000; R ES UN GRUPO DIVALENTE QUE PERMANECE TRAS LA ELIMINACION DE LOS GRUPOS CARBOXILO A PARTIR DE UN ACIDO DICARBOXILICO CON UN PESO MOLECULAR MEDIO INFERIOR A 300; Q ESUN GRUPO ALQUILENO DE 1-6 ATOMOS DE CARBONO Y/O UN GRUPO FENILENO O CICLOHEXILENO; Y E ES UN GRUPO ALQUILENO DE 2-6 ATOMOS DE CARBONO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97202214 | 1997-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2178102T3 true ES2178102T3 (es) | 2002-12-16 |
Family
ID=8228565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98202360T Expired - Lifetime ES2178102T3 (es) | 1997-07-16 | 1998-07-14 | Dispositivo para la generacion de tejido oseo, que comprende un termoplastico de copoliester biodegradable y celulas cultivadas. |
Country Status (5)
Country | Link |
---|---|
US (1) | US6228117B1 (es) |
AT (1) | ATE218896T1 (es) |
CA (1) | CA2243248A1 (es) |
DE (1) | DE69805920T2 (es) |
ES (1) | ES2178102T3 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6395036B1 (en) | 1998-04-06 | 2002-05-28 | Isis Innovation Limited | Composite material and methods of making the same |
KR20020013480A (ko) * | 1998-12-04 | 2002-02-20 | 추후기재 | 사람 뇌의 내피세포 및 성장배지 및 원시 cd34+cd38-골수 간세포의 증가방법 |
US6656489B1 (en) * | 1999-02-10 | 2003-12-02 | Isotis N.V. | Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material |
JP2004531292A (ja) * | 2001-01-02 | 2004-10-14 | アドヴァンスト セラミックス リサーチ インコーポレイテッド | 生物医学的に適用される組成物及び方法 |
US20060094112A1 (en) * | 2001-03-07 | 2006-05-04 | Omotunde Babalola | Biological scaffold |
US6884432B2 (en) * | 2002-04-25 | 2005-04-26 | Mayo Foundation For Medical Education And Research | Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery |
US20060140914A1 (en) * | 2002-10-31 | 2006-06-29 | The General Hospital Corporation | Repairing or replacing tissues or organs |
EP1748744A4 (en) * | 2004-05-11 | 2011-08-03 | Synthasome Inc | TISSUE SCAFFOLDING |
WO2005114322A2 (en) * | 2004-05-12 | 2005-12-01 | Massachusetts Institute Of Technology | Manufacturing process, such as three-dimensional printing, including solvent vapor filming and the like |
US7682578B2 (en) | 2005-11-07 | 2010-03-23 | Geo2 Technologies, Inc. | Device for catalytically reducing exhaust |
US7682577B2 (en) | 2005-11-07 | 2010-03-23 | Geo2 Technologies, Inc. | Catalytic exhaust device for simplified installation or replacement |
US7722828B2 (en) | 2005-12-30 | 2010-05-25 | Geo2 Technologies, Inc. | Catalytic fibrous exhaust system and method for catalyzing an exhaust gas |
US20090259263A1 (en) | 2008-04-11 | 2009-10-15 | Biomet Microfixation, Inc. | Apparatus and methods of fixating bone |
EP2625263B1 (en) | 2010-10-08 | 2020-03-11 | Terumo BCT, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
CN103224629B (zh) * | 2013-05-15 | 2014-06-18 | 福州赛孚玛尼环保科技有限公司 | 一种净化用甘蔗渣的化学改性方法 |
WO2015073918A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
US10227623B2 (en) | 2013-11-24 | 2019-03-12 | E I Du Pont De Nemours And Company | High force and high stress destructuring of cellulosic biomass |
EP3122866B1 (en) | 2014-03-25 | 2019-11-20 | Terumo BCT, Inc. | Passive replacement of media |
DE102014008476A1 (de) | 2014-06-05 | 2015-12-17 | Michael Jagodzinski | Herstellung einer Komponente zur Züchtung eines Gelenkflächenimplantats, Züchtung und Implantation eines Gelenkflächenimplantats |
EP3198006B1 (en) | 2014-09-26 | 2021-03-24 | Terumo BCT, Inc. | Scheduled feed |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
EP3464565A4 (en) | 2016-05-25 | 2020-01-01 | Terumo BCT, Inc. | CELL EXPANSION |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
EP3656842A1 (en) | 2017-03-31 | 2020-05-27 | Terumo BCT, Inc. | Cell expansion |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5266480A (en) | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
US4963489A (en) | 1987-04-14 | 1990-10-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
US5041138A (en) | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
NL8802178A (nl) | 1988-09-02 | 1990-04-02 | Stichting Tech Wetenschapp | Prothetische voortbrengsels met botbindende eigenschappen. |
US5226914A (en) | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
JPH05103827A (ja) | 1991-10-15 | 1993-04-27 | Nippon Sherwood Kk | 生体活性アパタイト膜をコーテイングした生体インプラント部材 |
ATE227963T1 (de) | 1992-04-24 | 2002-12-15 | Osteotech Inc | Vorrichtung zum vermeiden von gewebeadhäsionen |
US5399665A (en) | 1992-11-05 | 1995-03-21 | Massachusetts Institute Of Technology | Biodegradable polymers for cell transplantation |
US5522895A (en) | 1993-07-23 | 1996-06-04 | Rice University | Biodegradable bone templates |
US5569250A (en) * | 1994-03-01 | 1996-10-29 | Sarver; David R. | Method and apparatus for securing adjacent bone portions |
US5629186A (en) * | 1994-04-28 | 1997-05-13 | Lockheed Martin Corporation | Porous matrix and method of its production |
US5972703A (en) | 1994-08-12 | 1999-10-26 | The Regents Of The University Of Michigan | Bone precursor cells: compositions and methods |
DE4435680A1 (de) | 1994-10-06 | 1996-04-11 | Merck Patent Gmbh | Poröse Knochenersatzmaterialien |
US5688531A (en) | 1994-12-23 | 1997-11-18 | Ramot University Authority For Applied Research And Industrial Development, Ltd. | Method for regulating bone forming cells |
US5489306A (en) | 1995-01-03 | 1996-02-06 | Gorski; Jerrold M. | Graduated porosity implant for fibro-osseous integration |
US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
CA2237890C (en) | 1995-11-16 | 2011-03-29 | Case Western Reserve University | In vitro chondrogenic induction of human mesenchymal stem cells |
-
1998
- 1998-07-14 ES ES98202360T patent/ES2178102T3/es not_active Expired - Lifetime
- 1998-07-14 DE DE69805920T patent/DE69805920T2/de not_active Expired - Fee Related
- 1998-07-14 AT AT98202360T patent/ATE218896T1/de not_active IP Right Cessation
- 1998-07-15 CA CA002243248A patent/CA2243248A1/en not_active Abandoned
- 1998-07-15 US US09/116,177 patent/US6228117B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69805920T2 (de) | 2003-01-02 |
ATE218896T1 (de) | 2002-06-15 |
CA2243248A1 (en) | 1999-01-16 |
US6228117B1 (en) | 2001-05-08 |
DE69805920D1 (de) | 2002-07-18 |
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