ES2178102T3 - Dispositivo para la generacion de tejido oseo, que comprende un termoplastico de copoliester biodegradable y celulas cultivadas. - Google Patents

Dispositivo para la generacion de tejido oseo, que comprende un termoplastico de copoliester biodegradable y celulas cultivadas.

Info

Publication number
ES2178102T3
ES2178102T3 ES98202360T ES98202360T ES2178102T3 ES 2178102 T3 ES2178102 T3 ES 2178102T3 ES 98202360 T ES98202360 T ES 98202360T ES 98202360 T ES98202360 T ES 98202360T ES 2178102 T3 ES2178102 T3 ES 2178102T3
Authority
ES
Spain
Prior art keywords
ester units
chain ester
copolyester
copoliester
oseo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98202360T
Other languages
English (en)
Inventor
Bruijn Joost Dick De
Yvonne Pearl Bovell
Den Brink Jennigje Van
Blitterswijk Clemens Anton Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Isotis NV
Original Assignee
Isotis NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isotis NV filed Critical Isotis NV
Application granted granted Critical
Publication of ES2178102T3 publication Critical patent/ES2178102T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3821—Bone-forming cells, e.g. osteoblasts, osteocytes, osteoprogenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3847—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Abstract

LA INVENCION SE REFIERE A UN DISPOSITIVO DE REGENERACION OSEA, QUE COMPRENDE UN MATERIAL DE SOPORTE FORMADO POR UN COPOLIESTER TERMOPLASTICO SEGMENTADO PARA UNION DE HUESOS, OSTEOCONDUCTIVO, BIOACTIVO Y CELULAS OSTEOPROGENITORAS U OSTEOGENICAS CULTIVADAS, ESPECIALMENTE CELULAS OSEAS. EL COPOLIESTER ESTA FORMADO BASICAMENTE POR UNA MULTIPLICIDAD DE UNIDADES DE ESTER DE CADENA LARGA REPETITIVAS, Y POR UNIDADES DE ESTER DE CADENA CORTA, DE FORMA QUE LAS UNIDADES DE ESTER DE CADENA LARGA CONSTITUYEN DEL 35 AL 80 % EN PESO DEL COPOLIESTER, Y ESTAN REPRESENTADAS MEDIANTE LA FORMULA: Y LAS CADENAS DE ESTER CORTAS ESTAN REPRESENTADAS MEDIANTE LA FORMULA: DONDE L ES UN GRUPO DIVALENTE QUE PERMANECE TRAS LA ELIMINACION DE LOS GRUPOS HIDROXILO TERMINALES A PARTIR DE UN POLI(OXIALQUILEN)GLICOL CON UN PESO MOLECULAR MEDIO ENTRE 300 Y 3000; R ES UN GRUPO DIVALENTE QUE PERMANECE TRAS LA ELIMINACION DE LOS GRUPOS CARBOXILO A PARTIR DE UN ACIDO DICARBOXILICO CON UN PESO MOLECULAR MEDIO INFERIOR A 300; Q ESUN GRUPO ALQUILENO DE 1-6 ATOMOS DE CARBONO Y/O UN GRUPO FENILENO O CICLOHEXILENO; Y E ES UN GRUPO ALQUILENO DE 2-6 ATOMOS DE CARBONO.
ES98202360T 1997-07-16 1998-07-14 Dispositivo para la generacion de tejido oseo, que comprende un termoplastico de copoliester biodegradable y celulas cultivadas. Expired - Lifetime ES2178102T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97202214 1997-07-16

Publications (1)

Publication Number Publication Date
ES2178102T3 true ES2178102T3 (es) 2002-12-16

Family

ID=8228565

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98202360T Expired - Lifetime ES2178102T3 (es) 1997-07-16 1998-07-14 Dispositivo para la generacion de tejido oseo, que comprende un termoplastico de copoliester biodegradable y celulas cultivadas.

Country Status (5)

Country Link
US (1) US6228117B1 (es)
AT (1) ATE218896T1 (es)
CA (1) CA2243248A1 (es)
DE (1) DE69805920T2 (es)
ES (1) ES2178102T3 (es)

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US6395036B1 (en) * 1998-04-06 2002-05-28 Isis Innovation Limited Composite material and methods of making the same
MXPA01005564A (es) * 1998-12-04 2003-07-14 Naval Medical Res Ct Celulas del endotelio cerebral humano en medio de crecimiento y metodo para expansion de celulas de tallo de medula osea cd34+cd38-nativas.
US6656489B1 (en) * 1999-02-10 2003-12-02 Isotis N.V. Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material
DE60238241D1 (de) * 2001-01-02 2010-12-23 Advanced Ceramics Res Inc Zusammensetzungen und verfahren für biomedizinische anwendungen
US20060094112A1 (en) * 2001-03-07 2006-05-04 Omotunde Babalola Biological scaffold
US6884432B2 (en) * 2002-04-25 2005-04-26 Mayo Foundation For Medical Education And Research Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery
US20060140914A1 (en) * 2002-10-31 2006-06-29 The General Hospital Corporation Repairing or replacing tissues or organs
CA2566765C (en) * 2004-05-11 2011-08-23 Synthasome Inc. Hybrid tissue scaffolds containing extracellular matrix
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US7682578B2 (en) 2005-11-07 2010-03-23 Geo2 Technologies, Inc. Device for catalytically reducing exhaust
US7722828B2 (en) 2005-12-30 2010-05-25 Geo2 Technologies, Inc. Catalytic fibrous exhaust system and method for catalyzing an exhaust gas
US20090259263A1 (en) * 2008-04-11 2009-10-15 Biomet Microfixation, Inc. Apparatus and methods of fixating bone
EP2625263B1 (en) 2010-10-08 2020-03-11 Terumo BCT, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
CN103224629B (zh) * 2013-05-15 2014-06-18 福州赛孚玛尼环保科技有限公司 一种净化用甘蔗渣的化学改性方法
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
US20150147786A1 (en) 2013-11-24 2015-05-28 E I Du Pont De Nemours And Company High force and high stress destructuring for starch biomass processing
EP3613841B1 (en) 2014-03-25 2022-04-20 Terumo BCT, Inc. Passive replacement of media
DE102014008476A1 (de) 2014-06-05 2015-12-17 Michael Jagodzinski Herstellung einer Komponente zur Züchtung eines Gelenkflächenimplantats, Züchtung und Implantation eines Gelenkflächenimplantats
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
EP3601521A2 (en) 2017-03-31 2020-02-05 Terumo BCT, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion

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Also Published As

Publication number Publication date
US6228117B1 (en) 2001-05-08
ATE218896T1 (de) 2002-06-15
CA2243248A1 (en) 1999-01-16
DE69805920D1 (de) 2002-07-18
DE69805920T2 (de) 2003-01-02

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