CA2042053A1 - Analogues monosaccharidiques de lipide a - Google Patents

Analogues monosaccharidiques de lipide a

Info

Publication number
CA2042053A1
CA2042053A1 CA2042053A CA2042053A CA2042053A1 CA 2042053 A1 CA2042053 A1 CA 2042053A1 CA 2042053 A CA2042053 A CA 2042053A CA 2042053 A CA2042053 A CA 2042053A CA 2042053 A1 CA2042053 A1 CA 2042053A1
Authority
CA
Canada
Prior art keywords
lipid
integer
monosaccharide
analogues
monosaccharide analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2042053A
Other languages
English (en)
Other versions
CA2042053C (fr
Inventor
Akira Hasegawa
Makoto Kiso
Shinichi Uesato
Masanobu Suzuki
Tomio Ishida
Yutaka Saito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Tobacco Inc
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Application granted granted Critical
Publication of CA2042053C publication Critical patent/CA2042053C/fr
Publication of CA2042053A1 publication Critical patent/CA2042053A1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Lubricants (AREA)
CA002042053A 1989-09-20 1990-09-20 Analogues monosaccharidiques de lipide a Expired - Fee Related CA2042053C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1-241866 1989-09-20
JP1241866A JPH0655749B2 (ja) 1989-09-20 1989-09-20 リピッドａ単糖類縁体

Publications (2)

Publication Number Publication Date
CA2042053C CA2042053C (fr) 1993-08-10
CA2042053A1 true CA2042053A1 (fr) 1993-08-10

Family

ID=17080690

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002042053A Expired - Fee Related CA2042053C (fr) 1989-09-20 1990-09-20 Analogues monosaccharidiques de lipide a

Country Status (6)

Country Link
US (1) US5191072A (fr)
EP (1) EP0444208A4 (fr)
JP (1) JPH0655749B2 (fr)
KR (1) KR940005344B1 (fr)
CA (1) CA2042053C (fr)
WO (1) WO1991004259A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU660325B2 (en) * 1991-10-11 1995-06-22 Eisai Co. Ltd. Anti-endotoxin compounds and related molecules and methods
US5530113A (en) * 1991-10-11 1996-06-25 Eisai Co., Ltd. Anti-endotoxin compounds
WO1993011139A1 (fr) * 1991-11-27 1993-06-10 Japan Tobacco Inc. Analogue de lipide a substitue en position 6
US6368604B1 (en) 1997-09-26 2002-04-09 University Of Maryland Biotechnology Institute Non-pyrogenic derivatives of lipid A
KR20010043248A (ko) 1998-05-06 2001-05-25 우에노 도시오 글루코피라노스 유도체를 유효 성분으로 하는 면역 억제제
WO2001025254A2 (fr) 1999-10-04 2001-04-12 University Of Maryland Biotechnology Institute Adjuvant comprenant un antagoniste de lipopolysaccharide
CN100335795C (zh) * 2002-05-07 2007-09-05 Emu潜水泵有限公司 尤其适用于泵的电机
EP1549322B1 (fr) 2002-05-09 2010-02-17 Oncothyreon Inc. Analogues du lipide a et d'autres ligands glucidiques
EP1710225A4 (fr) * 2004-01-28 2008-01-16 Idemitsu Kosan Co Compose carbonyle contenant un groupe alkyle ramifie longue chaine
CN101535345B (zh) * 2006-09-04 2013-09-11 大赛璐化学工业株式会社 多糖衍生物和含有该多糖衍生物的光学异构体用分离剂
AU2012222188A1 (en) 2011-02-24 2013-08-15 Oncothyreon Inc. MUC1 based glycolipopeptide vaccine with adjuvant
WO2013050413A1 (fr) 2011-10-03 2013-04-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés d'obtention d'une population de lymphocytes t régulateurs
WO2016109880A1 (fr) 2015-01-06 2016-07-14 Immunovaccine Technologies Inc. Mimétiques de lipide a, procédés de préparation, et leurs utilisations
WO2019175145A1 (fr) 2018-03-12 2019-09-19 Janssen Vaccines & Prevention B.V. Vaccins contre des infections des voies urinaires
KR20220107166A (ko) 2019-10-02 2022-08-02 얀센 백신스 앤드 프리벤션 비.브이. 스타필로코커스 펩티드 및 사용 방법
CN115038461A (zh) 2020-01-16 2022-09-09 杨森制药公司 FimH突变体、其组合物及其用途
WO2022153166A1 (fr) 2021-01-12 2022-07-21 Janssen Pharmaceuticals, Inc. Mutants fimh, compositions à base de celui-ci et leur utilisation
CA3215752A1 (fr) 2021-04-01 2022-10-06 Janssen Pharmaceuticals, Inc. Production de bioconjugues d'e. coli o18

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60501259A (ja) * 1983-05-06 1985-08-08 ウイスコンシン・アルムニ・リサ−チ・フアンデ−シヨン 免疫刺激活性をもつ単糖類化合物
JPS61126094A (ja) * 1984-11-26 1986-06-13 Toho Yakuhin Kogyo Kk リピドａの非還元側サブユニツト類縁体
JPS61126093A (ja) * 1984-11-26 1986-06-13 Toho Yakuhin Kogyo Kk リピドａの非還元側サブユニツト類縁体
JPS61172867A (ja) * 1985-01-29 1986-08-04 Toho Yakuhin Kogyo Kk リピドａの非還元側サブユニツトの類縁化合物
GR860379B (en) * 1985-02-22 1986-06-11 Akzo Nv Novel disaccharide and trisaccharide derivatives of the lipid a type
JPS61275299A (ja) * 1985-05-29 1986-12-05 Akira Hasegawa デオキシムラミルジペプチド誘導体
JPS62108895A (ja) * 1985-11-06 1987-05-20 Fuji Yakuhin Kogyo Kk 新規なグルコサミン誘導体
JPS6344588A (ja) * 1986-08-11 1988-02-25 Toho Yakuhin Kogyo Kk リピドａ単糖類縁体のレクタス型異性体
JPS62129292A (ja) * 1985-11-28 1987-06-11 Toho Yakuhin Kogyo Kk 生物活性を発現するリピドａ単糖類縁体
JPS6330495A (ja) * 1986-07-24 1988-02-09 Toho Yakuhin Kogyo Kk リピドａ単糖類縁体の立体異性体
US4746742A (en) * 1985-11-28 1988-05-24 Toho Yakuhin Kogyo Kabushiki Kaisha Analogs of nonreducing monosaccharide moiety of lipid A
JPS62129293A (ja) * 1985-11-28 1987-06-11 Toho Yakuhin Kogyo Kk 親水性のリピドａ単糖類縁体
JPS63179885A (ja) * 1985-12-06 1988-07-23 Ono Pharmaceut Co Ltd 新規なグリコピラノース誘導体
JPS6333391A (ja) * 1986-07-28 1988-02-13 Toho Yakuhin Kogyo Kk 新規なリピドａ単糖類縁体としての硫黄誘導体
ES2061544T3 (es) * 1987-05-01 1994-12-16 Ono Pharmaceutical Co Nuevos derivados de glucopiranosa.
JPH01146892A (ja) * 1987-12-03 1989-06-08 Toho Yakuhin Kogyo Kk 新規ホスホリルグルコサミン誘導体
JPH0225494A (ja) * 1988-07-12 1990-01-26 Akira Hasegawa グルコサミン誘導体
JPH0262888A (ja) * 1988-08-30 1990-03-02 Akira Hasegawa 新規なグルコサミン類
JPH0262889A (ja) * 1988-08-30 1990-03-02 Akira Hasegawa 新規なグルコサミン誘導体

Also Published As

Publication number Publication date
KR920701217A (ko) 1992-08-11
EP0444208A1 (fr) 1991-09-04
JPH03106894A (ja) 1991-05-07
JPH0655749B2 (ja) 1994-07-27
US5191072A (en) 1993-03-02
WO1991004259A1 (fr) 1991-04-04
CA2042053C (fr) 1993-08-10
KR940005344B1 (ko) 1994-06-17
EP0444208A4 (en) 1992-03-11

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