CA2028960A1 - Derives nouveaux d'isoindole et leurs sels, processus de production et agent antitumoral constitue de ces composes - Google Patents

Derives nouveaux d'isoindole et leurs sels, processus de production et agent antitumoral constitue de ces composes

Info

Publication number
CA2028960A1
CA2028960A1 CA2028960A CA2028960A CA2028960A1 CA 2028960 A1 CA2028960 A1 CA 2028960A1 CA 2028960 A CA2028960 A CA 2028960A CA 2028960 A CA2028960 A CA 2028960A CA 2028960 A1 CA2028960 A1 CA 2028960A1
Authority
CA
Canada
Prior art keywords
same
salts
processes
producing
antitumor agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2028960A
Other languages
English (en)
Other versions
CA2028960C (fr
Inventor
Takashi Nagai
Isao Myoukan
Keishi Funaki
Kenji Ohta
Nobuhisa Taya
Shinji Miyabara
Masaaki Shibata
Hidetada Mikami
Takako Hori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2-288069A external-priority patent/JP3027599B2/ja
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of CA2028960A1 publication Critical patent/CA2028960A1/fr
Application granted granted Critical
Publication of CA2028960C publication Critical patent/CA2028960C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002028960A 1989-11-01 1990-10-31 Derives nouveaux d'isoindole et leurs sels, processus de production et agent antitumoral constitue de ces composes Expired - Fee Related CA2028960C (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP01-285548 1989-11-01
JP28554889 1989-11-01
JP02-205443 1990-08-02
JP20544390 1990-08-02
JP02-288069 1990-10-25
JP2-288069A JP3027599B2 (ja) 1990-08-02 1990-10-25 新規なイソインドール誘導体およびその塩

Publications (2)

Publication Number Publication Date
CA2028960A1 true CA2028960A1 (fr) 1991-05-02
CA2028960C CA2028960C (fr) 1999-01-19

Family

ID=27328497

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002028960A Expired - Fee Related CA2028960C (fr) 1989-11-01 1990-10-31 Derives nouveaux d'isoindole et leurs sels, processus de production et agent antitumoral constitue de ces composes

Country Status (11)

Country Link
US (1) US5166204A (fr)
BE (1) BE1004069A3 (fr)
CA (1) CA2028960C (fr)
CH (1) CH682151A5 (fr)
DE (1) DE4034687C2 (fr)
DK (1) DK261890A (fr)
FR (1) FR2655345B1 (fr)
GB (1) GB2239013B (fr)
IT (1) IT1242004B (fr)
NL (1) NL9002366A (fr)
SE (1) SE509700C2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9215361D0 (en) * 1992-07-20 1992-09-02 Wellcome Found Heterocyclic compounds
ATE172463T1 (de) * 1994-08-04 1998-11-15 Hoffmann La Roche Pyrrolocarbazol
EP0768311B1 (fr) * 1995-03-09 2003-08-06 Kyowa Hakko Kogyo Co., Ltd. Derives de pyrrolocarbazole
FR2751655B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de bis-imides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE19744257B4 (de) * 1997-10-07 2004-04-15 Zentaris Gmbh Beta-Carboline und deren Verwendung zur Behandlung von malignen und anderen, auf pathologischen Zellproliferationen beruhenden Erkrankungen
US7122679B2 (en) * 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
US20060276497A1 (en) * 2000-05-09 2006-12-07 Cephalon, Inc. Novel multicyclic compounds and the use thereof
JPWO2003051883A1 (ja) * 2001-12-18 2005-04-28 協和醗酵工業株式会社 インドール誘導体
MXPA04010617A (es) * 2002-04-26 2004-12-13 Warner Lambert Co Inhibidores de quinasa de puntos de control (wee1 y chk1).
CN100400529C (zh) * 2003-10-08 2008-07-09 中国科学院化学研究所 含氟芳香族有机四酸二酐及制备方法和用途
CA2559408C (fr) 2004-03-15 2014-05-13 Ptc Therapeutics, Inc. Derives de carboline utiles dans l'inhibition de l'angiogenese
US8076352B2 (en) * 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8076353B2 (en) * 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US7767689B2 (en) * 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
AU2005222627A1 (en) * 2004-03-15 2005-09-29 Ptc Therapeutics, Inc. Tetra-cyclic carboline derivatives for inhibiting angiogenesis
CA2588389A1 (fr) * 2004-11-23 2006-06-22 Ptc Therapeutics, Inc. Phenols substitues en tant qu'agents actifs inhibant la production de vegf
CN101103000B (zh) * 2004-11-23 2012-06-27 Ptc医疗公司 用于抑制vegf生成的咔唑、咔啉和吲哚衍生物
CN110464722B (zh) * 2019-06-06 2023-05-23 暨南大学 一类小分子化合物或其药学上可接受的盐在制备抗肿瘤转移药物中的应用
CN115594681A (zh) * 2022-10-21 2023-01-13 广州六顺生物科技有限公司（Cn） 一种异吲哚啉-1,3-二酮衍生物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007045A1 (fr) * 1987-03-09 1988-09-22 Kyowa Hakko Kogyo Co., Ltd. Derives de la substance physiologiquement active k-252
DE3833008A1 (de) * 1988-09-29 1990-04-05 Goedecke Ag Pyrrolocarbozol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel

Also Published As

Publication number Publication date
US5166204A (en) 1992-11-24
IT9048430A1 (it) 1992-05-01
CH682151A5 (fr) 1993-07-30
SE509700C2 (sv) 1999-02-22
DK261890D0 (da) 1990-10-31
DE4034687C2 (de) 1999-12-02
DK261890A (da) 1991-05-02
SE9003476D0 (sv) 1990-10-31
IT9048430A0 (it) 1990-10-31
GB2239013B (en) 1993-06-02
DE4034687A1 (de) 1991-05-02
GB2239013A (en) 1991-06-19
BE1004069A3 (fr) 1992-09-15
FR2655345B1 (fr) 1993-02-26
NL9002366A (nl) 1991-06-03
CA2028960C (fr) 1999-01-19
SE9003476L (sv) 1992-05-01
IT1242004B (it) 1994-02-02
FR2655345A1 (fr) 1991-06-07
GB9023568D0 (en) 1990-12-12

Similar Documents

Publication Publication Date Title
CA2028960A1 (fr) Derives nouveaux d'isoindole et leurs sels, processus de production et agent antitumoral constitue de ces composes
CA2168016A1 (fr) Derive de benzimidazol
CA2259977A1 (fr) Derives de taxane et medicaments les contenant
CA2173150A1 (fr) Nouveau derive peptidique
EP0358154A3 (fr) Dérivé de cyclobutane et procédé pour sa production
CA2131571A1 (fr) Bisphosphines pour catalyseurs d'hydrogenation asymetriques
CA2012955A1 (fr) Substance be-13793c antitumorale
CA2173418A1 (fr) Benzonitriles et benzofluorures
CA2099970A1 (fr) Compose pour le traitement du syndrome de sjoegren
CA2042053A1 (fr) Analogues monosaccharidiques de lipide a
AU4484989A (en) Water soluble 1,2-diaminocyclohexane platinum (iv) complexes as antitumor agents
CA2530543A1 (fr) Analogues de l'illudine utilises comme agents anti-tumoraux
AU7956291A (en) New salt form
CA2220094A1 (fr) Procede pour produire des derives de la guanidine, intermediaires de ces derives et leur preparation
MX9703917A (es) Derivados de acrilamida y proceso para su produccion.
CA2048896A1 (fr) Derives fluoroethylcamptothecine
CA2092045A1 (fr) Derives de l'erythromycine, leur preparation et leur usage
CA2219311A1 (fr) Derives de 10,13,15-trioxatricyclo[9.2.1.1.9.6]pentadecanone, methode de preparation et compositions pharmaceutiques a base de ces derives
CA2170645A1 (fr) Procede de preparation du n-methyl-3-(1-methyl-4-piperidinyl)-14-indole-5-ethanesulfonamide
CA2013519A1 (fr) Derives sulfonyl de thieno-triazolo-diazepine, procede de preparation et composes therapeutiques les contenant
CA2028514A1 (fr) Traitement de la depression
ZA881430B (fr)
CA2011238A1 (fr) Traitement pharmaceutique
CA2018794A1 (fr) Sels d'addition acides de cephem cristallins et procede de preparation
EP0393462A3 (fr) L'acide 2-halogène-pyridine-6-sulfonique et ses sels

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed