CA1262400A - Process for the manufacture of glucosamine derivatives - Google Patents

Process for the manufacture of glucosamine derivatives

Info

Publication number
CA1262400A
CA1262400A CA000267474A CA267474A CA1262400A CA 1262400 A CA1262400 A CA 1262400A CA 000267474 A CA000267474 A CA 000267474A CA 267474 A CA267474 A CA 267474A CA 1262400 A CA1262400 A CA 1262400A
Authority
CA
Canada
Prior art keywords
denotes
carbamoyl
methyl
benzyl
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000267474A
Other languages
English (en)
French (fr)
Inventor
Gerhard Baschang
Albert Hartmann
Jaroslav Stanek
Alex Sele
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ciba Geigy Investments Ltd
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of CA1262400A publication Critical patent/CA1262400A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA000267474A 1975-12-10 1976-12-08 Process for the manufacture of glucosamine derivatives Expired CA1262400A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1604275A CH613709A5 (en) 1975-12-10 1975-12-10 Process for the preparation of glucosamine derivatives
CH16042/75 1975-12-10

Publications (1)

Publication Number Publication Date
CA1262400A true CA1262400A (en) 1989-10-17

Family

ID=4414012

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000267474A Expired CA1262400A (en) 1975-12-10 1976-12-08 Process for the manufacture of glucosamine derivatives

Country Status (30)

Country Link
JP (1) JPS5273820A (es)
AR (2) AR224091A1 (es)
AT (1) AT365607B (es)
AU (1) AU508764B2 (es)
BE (1) BE849214A (es)
CA (1) CA1262400A (es)
CH (2) CH613709A5 (es)
CS (4) CS205027B2 (es)
DD (1) DD129781A5 (es)
DE (1) DE2655500A1 (es)
DK (1) DK154654C (es)
ES (2) ES454118A1 (es)
FI (1) FI64164C (es)
FR (1) FR2361902A1 (es)
GB (1) GB1570625A (es)
GR (1) GR61647B (es)
HK (1) HK32883A (es)
HU (1) HU177970B (es)
IE (1) IE44190B1 (es)
IL (1) IL51076A (es)
MY (1) MY8400123A (es)
NL (1) NL7613666A (es)
NO (1) NO144850C (es)
NZ (1) NZ182837A (es)
PL (4) PL110787B1 (es)
PT (1) PT65946B (es)
SE (1) SE445923B (es)
SG (1) SG11083G (es)
SU (3) SU660589A3 (es)
ZA (1) ZA767333B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10717703B2 (en) 2017-08-21 2020-07-21 Celgene Corporation Processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186194A (en) * 1973-10-23 1980-01-29 Agence Nationale De Valorisation De La Recherche (Anvar) Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents
US4370265A (en) * 1974-10-22 1983-01-25 Agence Nationale De Valorisation Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents
CH636887A5 (en) * 1976-04-26 1983-06-30 Syntex Inc Process for the preparation of novel immunological adjuvant compounds
EP0002677B1 (en) 1977-12-02 1982-10-13 Takeda Chemical Industries, Ltd. Glucosamine-peptide derivatives and their pharmaceutical compositions
US4397844A (en) * 1978-02-24 1983-08-09 Ciba-Geigy Corporation Antigen derivatives and processes for their preparation
EP0003833B2 (de) * 1978-02-24 1990-12-19 Ciba-Geigy Ag Antigenderivate, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate
FR2420545A1 (fr) * 1978-03-20 1979-10-19 Anvar Nouveaux esters de l'acide n-acetyl-muramyl-aminoacyl-glutamique ou des derives de substitution de celui-ci a proprietes anti-infectieuses et/ou d'adjuvants immunologiques
FR2442241A2 (fr) * 1978-03-20 1980-06-20 Anvar Nouveaux composes esters de muramyl-peptide, leur preparation et les compositions pharmaceutiques les contenant, notamment sous forme de liposomes
FR2428050A1 (fr) * 1978-06-05 1980-01-04 Anvar Oligomeres de composes du type muramyl-peptide et medicaments les contenant
FR2428051A1 (fr) * 1978-06-05 1980-01-04 Anvar Nouveaux composes du type muramyl-peptide et medicaments les contenant
FR2446292A1 (fr) * 1979-01-12 1980-08-08 Anvar Muramyl-peptides fixes sur polymeres peptidiques et medicaments les contenant
US4256735A (en) * 1979-01-29 1981-03-17 Merck & Co., Inc. Immunologically active dipeptidyl saccharides and methods of preparation
FR2449697A1 (fr) 1979-02-20 1980-09-19 Anvar Nouveaux muramyl-peptides substitues sur un azote peptidique et medicaments les contenant
JPS55111499A (en) * 1979-02-21 1980-08-28 Takeda Chem Ind Ltd Glucosamine derivative and its preparation
JPS5618996A (en) * 1979-06-21 1981-02-23 Dai Ichi Seiyaku Co Ltd Muramyldipeptide derivative
FI75578C (fi) 1979-07-25 1988-07-11 Ciba Geigy Ag Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider.
JPS5649396A (en) * 1979-09-28 1981-05-02 Dai Ichi Seiyaku Co Ltd Novel muramyldipeptide derivative
EP0026746B1 (de) * 1979-10-02 1985-04-10 Ciba-Geigy Ag Kombinationspräparate zur Anwendung in einem Verfahren zur Steigerung der Wirkung von Antibiotika, antibiotische Präparate mit gesteigerter Wirksamkeit und Verfahren zu deren Herstellung
FI803077A (fi) 1979-10-12 1981-04-13 Ciba Geigy Ag Foerfarande foer framstaellning av myramylpeptider
US4409209A (en) * 1979-10-12 1983-10-11 Ciba-Geigy Corporation Novel phosphorylmuramyl peptides and processes for the manufacture thereof
US4406889A (en) * 1980-02-15 1983-09-27 Ciba-Geigy Corporation Derivatives of aldohexoses, intermediates, processes for their manufacture, preparations containing such compounds, and their use
US4368190A (en) * 1980-04-17 1983-01-11 Merck & Co., Inc. Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation
US4310514A (en) 1980-05-05 1982-01-12 Merck & Co., Inc. Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation
EP0056560A1 (de) * 1981-01-19 1982-07-28 Ciba-Geigy Ag Antibiotische Präparate mit gesteigerter Wirksamkeit, Verfahren zu deren Herstellung und Verfahren zur Steigerung der antibiotischen Wirkung von Antibiotika
GR78246B (es) * 1981-01-23 1984-09-26 Ciba Geigy Ag
JPS6042398A (ja) * 1983-08-18 1985-03-06 Toshiyuki Hamaoka ムラミルジペプチド活性エステル誘導体
EP0541486A1 (de) * 1991-11-07 1993-05-12 Ciba-Geigy Ag Polycyclische Konjugate
WO2006118327A1 (ja) * 2005-04-27 2006-11-09 Oxygenix Co Ltd カチオン性アミノ酸型脂質
WO2016138286A1 (en) 2015-02-26 2016-09-01 Stc.Unm Irgm and precision autophagy controls for antimicrobial and inflammatory disease states and methods of detection of autophagy
US10927147B2 (en) 2015-12-10 2021-02-23 Bharat Biotech International Limited Muramyl peptide derivative compound, synthesis and uses thereof
WO2017103944A1 (en) * 2015-12-15 2017-06-22 Bharat Biotech International Limited Novel muramyl peptide derivative compound, synthesis and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186194A (en) * 1973-10-23 1980-01-29 Agence Nationale De Valorisation De La Recherche (Anvar) Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10717703B2 (en) 2017-08-21 2020-07-21 Celgene Corporation Processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate
US11505522B2 (en) 2017-08-21 2022-11-22 Celgene Corporation Processes for the preparation of (S)-tert-butyl 4,5- diamino-5-oxopentanoate
US11912644B2 (en) 2017-08-21 2024-02-27 Celgene Corporation Processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate

Also Published As

Publication number Publication date
NO144850B (no) 1981-08-17
IL51076A0 (en) 1977-02-28
SU747430A3 (ru) 1980-07-23
GB1570625A (en) 1980-07-02
GR61647B (en) 1978-12-05
CS205027B2 (en) 1981-04-30
PL110353B1 (en) 1980-07-31
PL110787B1 (en) 1980-07-31
DK154654C (da) 1989-05-08
HK32883A (en) 1983-09-02
BE849214A (fr) 1977-06-09
JPS638118B2 (es) 1988-02-19
PL194291A1 (pl) 1978-10-23
NL7613666A (nl) 1977-06-14
CS205025B2 (en) 1981-04-30
DE2655500A1 (de) 1977-06-23
SE445923B (sv) 1986-07-28
AU2042276A (en) 1978-06-15
AR224091A1 (es) 1981-10-30
HU177970B (en) 1982-02-28
SG11083G (en) 1983-09-16
DK154654B (da) 1988-12-05
IL51076A (en) 1980-09-16
CS205026B2 (en) 1981-04-30
ES454118A1 (es) 1978-03-01
FI64164C (fi) 1983-10-10
DE2655500C2 (es) 1988-12-22
IE44190L (en) 1977-06-10
NZ182837A (en) 1978-07-28
SU1060118A3 (ru) 1983-12-07
DK552476A (da) 1977-06-11
FI64164B (fi) 1983-06-30
DD129781A5 (de) 1978-02-08
PL110794B1 (en) 1980-07-31
IE44190B1 (en) 1981-09-09
FI763541A (es) 1977-06-11
AR220686A1 (es) 1980-11-28
CH614718A5 (en) 1979-12-14
MY8400123A (en) 1984-12-31
NO764191L (es) 1977-06-13
CS205028B2 (en) 1981-04-30
PT65946A (en) 1977-01-01
ZA767333B (en) 1977-11-30
PL112672B1 (en) 1980-10-31
AU508764B2 (en) 1980-04-03
NO144850C (no) 1981-11-25
SE7613851L (sv) 1977-06-11
AT365607B (de) 1982-02-10
PT65946B (en) 1978-06-14
ATA909276A (de) 1981-06-15
CH613709A5 (en) 1979-10-15
SU660589A3 (ru) 1979-04-30
ES465514A1 (es) 1978-09-16
JPS5273820A (en) 1977-06-21
FR2361902A1 (fr) 1978-03-17
FR2361902B1 (es) 1980-11-07

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