JPS5649396A - Novel muramyldipeptide derivative - Google Patents

Novel muramyldipeptide derivative

Info

Publication number
JPS5649396A
JPS5649396A JP12501979A JP12501979A JPS5649396A JP S5649396 A JPS5649396 A JP S5649396A JP 12501979 A JP12501979 A JP 12501979A JP 12501979 A JP12501979 A JP 12501979A JP S5649396 A JPS5649396 A JP S5649396A
Authority
JP
Japan
Prior art keywords
formula
alanine
compound
acid residue
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12501979A
Other languages
Japanese (ja)
Other versions
JPS6312879B2 (en
Inventor
Yuichi Yamamura
Tetsuo Shiba
Ichiro Azuma
Osamu Nagase
Hidemasa Ogawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP12501979A priority Critical patent/JPS5649396A/en
Publication of JPS5649396A publication Critical patent/JPS5649396A/en
Publication of JPS6312879B2 publication Critical patent/JPS6312879B2/ja
Granted legal-status Critical Current

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  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A muramyldipeptide derivative of formula I [X is amino acid residue such as L-alanine, L-serine, etc.; Y is -OR or a group of formula II [R is (branched) lower to medium alkyl, etc.; n is 1-6]; A1 and A2 are H, medium to higher mycoloyl or (unsaturated bond-containing) synthetic fatty acid residue; excluding the case that X is L-alanine, A1 is H, and Y is methoxy, ethoxy, or propoxy]. EXAMPLE:N-Acetylmuramyl-L-alanyl-D-isoglutamine octyl ester. USE:Adjuvant-activating agent, preventive for microbism, and antineoplasmic agent. PROCESS:The compound of formula I is prepared by dissolving acylmuramic acid of formula III and the compound of formula IV in dimethylformamide, etc., adding N-hydroxysuccinimide and if necessary, triethylamine to the solution, and reacting at 0-60 deg.C for several hours to 2 days.
JP12501979A 1979-09-28 1979-09-28 Novel muramyldipeptide derivative Granted JPS5649396A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12501979A JPS5649396A (en) 1979-09-28 1979-09-28 Novel muramyldipeptide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12501979A JPS5649396A (en) 1979-09-28 1979-09-28 Novel muramyldipeptide derivative

Publications (2)

Publication Number Publication Date
JPS5649396A true JPS5649396A (en) 1981-05-02
JPS6312879B2 JPS6312879B2 (en) 1988-03-23

Family

ID=14899838

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12501979A Granted JPS5649396A (en) 1979-09-28 1979-09-28 Novel muramyldipeptide derivative

Country Status (1)

Country Link
JP (1) JPS5649396A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58188891A (en) * 1982-04-14 1983-11-04 バイエル・アクチエンゲゼルシヤフト N-glycosylated carboxamide derivative, manufacture and use as drug
JPS59172497A (en) * 1983-03-22 1984-09-29 Dai Ichi Seiyaku Co Ltd Novel muramyl peptide derivative
JPS61275299A (en) * 1985-05-29 1986-12-05 Akira Hasegawa Deoxymuramyldipeptide derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5273820A (en) * 1975-12-10 1977-06-21 Ciba Geigy Ag Glucosamine derivative and its method of manufacturing

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5273820A (en) * 1975-12-10 1977-06-21 Ciba Geigy Ag Glucosamine derivative and its method of manufacturing

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58188891A (en) * 1982-04-14 1983-11-04 バイエル・アクチエンゲゼルシヤフト N-glycosylated carboxamide derivative, manufacture and use as drug
JPH0140036B2 (en) * 1982-04-14 1989-08-24 Bayer Ag
JPS59172497A (en) * 1983-03-22 1984-09-29 Dai Ichi Seiyaku Co Ltd Novel muramyl peptide derivative
JPS61275299A (en) * 1985-05-29 1986-12-05 Akira Hasegawa Deoxymuramyldipeptide derivative

Also Published As

Publication number Publication date
JPS6312879B2 (en) 1988-03-23

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