JPS5649396A - Novel muramyldipeptide derivative - Google Patents
Novel muramyldipeptide derivativeInfo
- Publication number
- JPS5649396A JPS5649396A JP12501979A JP12501979A JPS5649396A JP S5649396 A JPS5649396 A JP S5649396A JP 12501979 A JP12501979 A JP 12501979A JP 12501979 A JP12501979 A JP 12501979A JP S5649396 A JPS5649396 A JP S5649396A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alanine
- compound
- acid residue
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A muramyldipeptide derivative of formula I [X is amino acid residue such as L-alanine, L-serine, etc.; Y is -OR or a group of formula II [R is (branched) lower to medium alkyl, etc.; n is 1-6]; A1 and A2 are H, medium to higher mycoloyl or (unsaturated bond-containing) synthetic fatty acid residue; excluding the case that X is L-alanine, A1 is H, and Y is methoxy, ethoxy, or propoxy]. EXAMPLE:N-Acetylmuramyl-L-alanyl-D-isoglutamine octyl ester. USE:Adjuvant-activating agent, preventive for microbism, and antineoplasmic agent. PROCESS:The compound of formula I is prepared by dissolving acylmuramic acid of formula III and the compound of formula IV in dimethylformamide, etc., adding N-hydroxysuccinimide and if necessary, triethylamine to the solution, and reacting at 0-60 deg.C for several hours to 2 days.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12501979A JPS5649396A (en) | 1979-09-28 | 1979-09-28 | Novel muramyldipeptide derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12501979A JPS5649396A (en) | 1979-09-28 | 1979-09-28 | Novel muramyldipeptide derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5649396A true JPS5649396A (en) | 1981-05-02 |
JPS6312879B2 JPS6312879B2 (en) | 1988-03-23 |
Family
ID=14899838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12501979A Granted JPS5649396A (en) | 1979-09-28 | 1979-09-28 | Novel muramyldipeptide derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5649396A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58188891A (en) * | 1982-04-14 | 1983-11-04 | バイエル・アクチエンゲゼルシヤフト | N-glycosylated carboxamide derivative, manufacture and use as drug |
JPS59172497A (en) * | 1983-03-22 | 1984-09-29 | Dai Ichi Seiyaku Co Ltd | Novel muramyl peptide derivative |
JPS61275299A (en) * | 1985-05-29 | 1986-12-05 | Akira Hasegawa | Deoxymuramyldipeptide derivative |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5273820A (en) * | 1975-12-10 | 1977-06-21 | Ciba Geigy Ag | Glucosamine derivative and its method of manufacturing |
-
1979
- 1979-09-28 JP JP12501979A patent/JPS5649396A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5273820A (en) * | 1975-12-10 | 1977-06-21 | Ciba Geigy Ag | Glucosamine derivative and its method of manufacturing |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58188891A (en) * | 1982-04-14 | 1983-11-04 | バイエル・アクチエンゲゼルシヤフト | N-glycosylated carboxamide derivative, manufacture and use as drug |
JPH0140036B2 (en) * | 1982-04-14 | 1989-08-24 | Bayer Ag | |
JPS59172497A (en) * | 1983-03-22 | 1984-09-29 | Dai Ichi Seiyaku Co Ltd | Novel muramyl peptide derivative |
JPS61275299A (en) * | 1985-05-29 | 1986-12-05 | Akira Hasegawa | Deoxymuramyldipeptide derivative |
Also Published As
Publication number | Publication date |
---|---|
JPS6312879B2 (en) | 1988-03-23 |
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