JPS5519236A - Muramyl dipeptide derivative - Google Patents

Muramyl dipeptide derivative

Info

Publication number
JPS5519236A
JPS5519236A JP9189378A JP9189378A JPS5519236A JP S5519236 A JPS5519236 A JP S5519236A JP 9189378 A JP9189378 A JP 9189378A JP 9189378 A JP9189378 A JP 9189378A JP S5519236 A JPS5519236 A JP S5519236A
Authority
JP
Japan
Prior art keywords
formula
compound
muramyl dipeptide
reacted
dipeptide derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9189378A
Other languages
Japanese (ja)
Other versions
JPS6225680B2 (en
Inventor
Yuichi Yamamura
Tetsuo Shiba
Ichiro Azuma
Shoichi Kusumoto
Osamu Nagase
Tsuneo Nichima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP9189378A priority Critical patent/JPS5519236A/en
Publication of JPS5519236A publication Critical patent/JPS5519236A/en
Publication of JPS6225680B2 publication Critical patent/JPS6225680B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:A muramyl dipeptide derivative of formula I: [X is amino acid, e.g. L-alanine, L-sevine, or L-valine; Y is compound of formula VI or VII (R1 is H, lower alkyl, carboxamide, or carboxyl group; n is an integer 1-6; A is medium or higher mycoloyl group; C is 20W60C synthetic higher fatty acid residue)].
EXAMPLE: N-Acetylmuramyl-L-alanyl-D-isoglutamine 2-mycomycoloyloxy-ethylamide.
USE: Carcinostatics having immunological adjuvant and antitumor activities.
PROCESS: The dipeptide of muramic acid of formula II is reacted with a compound of formula IV to give the objective compound of formula I. Alternatively, muramic acid of formula III is reacted with a compound of formula V.
COPYRIGHT: (C)1980,JPO&Japio
JP9189378A 1978-07-27 1978-07-27 Muramyl dipeptide derivative Granted JPS5519236A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9189378A JPS5519236A (en) 1978-07-27 1978-07-27 Muramyl dipeptide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9189378A JPS5519236A (en) 1978-07-27 1978-07-27 Muramyl dipeptide derivative

Publications (2)

Publication Number Publication Date
JPS5519236A true JPS5519236A (en) 1980-02-09
JPS6225680B2 JPS6225680B2 (en) 1987-06-04

Family

ID=14039233

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9189378A Granted JPS5519236A (en) 1978-07-27 1978-07-27 Muramyl dipeptide derivative

Country Status (1)

Country Link
JP (1) JPS5519236A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59172497A (en) * 1983-03-22 1984-09-29 Dai Ichi Seiyaku Co Ltd Novel muramyl peptide derivative
US5877147A (en) * 1993-10-08 1999-03-02 Peptech (Uk) Limited Compounds for medicinal use

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01126988U (en) * 1988-02-17 1989-08-30

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59172497A (en) * 1983-03-22 1984-09-29 Dai Ichi Seiyaku Co Ltd Novel muramyl peptide derivative
US5877147A (en) * 1993-10-08 1999-03-02 Peptech (Uk) Limited Compounds for medicinal use

Also Published As

Publication number Publication date
JPS6225680B2 (en) 1987-06-04

Similar Documents

Publication Publication Date Title
IE801342L (en) Peptides
AU4799793A (en) Beta -aminoalkyl and beta -n-peptidylaminoalkyl boronic acids
ES8202792A1 (en) and phenoxy-amino acids and phenoxy-peptide esters suitable as substrates therefor, process for their production and their use in producing the agents.
EP0305958A3 (en) N-acylated-n-substituted aminobenzoates and glycine esters
IE811130L (en) Arylethanolamine derivatives.
JPS55138391A (en) New synthetic method of peptide derivative
JPS5519236A (en) Muramyl dipeptide derivative
IE801340L (en) Immunostimulant tripeptides
JPS56110661A (en) Preparation of n-benzyloxycarbonyl-l-aspartic acid
BG103319A (en) Method for the preparation of hydroxamic acids
JPS6492A (en) Novel glycerin derivative, production thereof, hypotensor containing said derivative
JPS5649396A (en) Novel muramyldipeptide derivative
AU7051181A (en) Purify starting materials in making amphotensides
IL84195A0 (en) The synthesis of peptide amino-alkylamides and peptide hydrazides by the solid-phase method and novel compounds thus produced
JPS6490164A (en) Novel spergualin-related compound and production thereof
JPS5645449A (en) Novel peptide, its pharmaceutically acceptable salt and preparation of the same
DE3471938D1 (en) Antibiotics, method for their preparation, their use as medicines and intermediates for their preparation
JPS53108923A (en) Epoxysuccinylamino acid derivative
IL66689A (en) N-(n'-chloroethyl-n'-nitrosocarbamoyl)-oligopeptide esters and amides and method for their preparation
JPS5515420A (en) Thiosemicarbazone derivative and its preparation
EP0169937A3 (en) Process for the preparation of alpha-l-aspartyl-l-phenylalanine alkyl esters
JPS57175150A (en) Synthesis of dipeptide containing methylene group
JPS5618948A (en) Peptide derivative
JPS55151555A (en) Proline derivatives and their production
JPS5283506A (en) Novel muramyl dipeptide fatty acid esters