CA1236099A - FLUOROMETHYLTHIOOXACEPHALOSPORINS - Google Patents
FLUOROMETHYLTHIOOXACEPHALOSPORINSInfo
- Publication number
- CA1236099A CA1236099A CA000443807A CA443807A CA1236099A CA 1236099 A CA1236099 A CA 1236099A CA 000443807 A CA000443807 A CA 000443807A CA 443807 A CA443807 A CA 443807A CA 1236099 A CA1236099 A CA 1236099A
- Authority
- CA
- Canada
- Prior art keywords
- carboxy
- hydrogen
- protecting group
- hydroxyalkyl
- antibacterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940124350 antibacterial drug Drugs 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- -1 methylthioacetamido Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000554185A CA1259989A (en) | 1982-12-23 | 1987-12-11 | Fluoromethylthiooxacephalosporins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57234472A JPS59139385A (ja) | 1982-12-23 | 1982-12-23 | フルオロメチルチオオキサセフアロスポリン |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000554185A Division CA1259989A (en) | 1982-12-23 | 1987-12-11 | Fluoromethylthiooxacephalosporins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA1236099A true CA1236099A (en) | 1988-05-03 |
| CA1259989C CA1259989C (en, 2012) | 1989-09-26 |
Family
ID=16971542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000443807A Expired CA1236099A (en) | 1982-12-23 | 1983-12-20 | FLUOROMETHYLTHIOOXACEPHALOSPORINS |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4532233A (en, 2012) |
| JP (1) | JPS59139385A (en, 2012) |
| KR (1) | KR890000095B1 (en, 2012) |
| AT (1) | AT383807B (en, 2012) |
| AU (1) | AU558547B2 (en, 2012) |
| BE (1) | BE898541A (en, 2012) |
| CA (1) | CA1236099A (en, 2012) |
| CH (1) | CH656619A5 (en, 2012) |
| DE (1) | DE3345989A1 (en, 2012) |
| DK (1) | DK159447C (en, 2012) |
| ES (6) | ES527595A0 (en, 2012) |
| FI (1) | FI74016C (en, 2012) |
| FR (1) | FR2538391B1 (en, 2012) |
| GB (1) | GB2132198B (en, 2012) |
| HK (1) | HK89988A (en, 2012) |
| HU (1) | HU189014B (en, 2012) |
| IE (1) | IE56401B1 (en, 2012) |
| IL (1) | IL70488A (en, 2012) |
| IT (1) | IT1160238B (en, 2012) |
| NL (1) | NL192740C (en, 2012) |
| NO (1) | NO167740C (en, 2012) |
| NZ (1) | NZ206413A (en, 2012) |
| PH (1) | PH19352A (en, 2012) |
| PT (1) | PT77831B (en, 2012) |
| SE (2) | SE461527B (en, 2012) |
| ZA (1) | ZA838920B (en, 2012) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6045514A (ja) * | 1983-08-22 | 1985-03-12 | Shionogi & Co Ltd | 安定な抗菌性凍結乾燥製剤 |
| JP2004168775A (ja) * | 2002-11-08 | 2004-06-17 | Orchid Chemicals & Pharmaceuticals Ltd | オキサセファロスポリンの改良合成法 |
| CN100509819C (zh) | 2004-02-20 | 2009-07-08 | 盐野义制药株式会社 | 氧头孢烯晶体 |
| EP1996595A2 (en) * | 2006-03-15 | 2008-12-03 | CARTHESIA s.a.s. DI EMANUELA MIGLIAVACCA & C. | PROCESS FOR THE PREPARATION OF (1-OXA- OR l-THIA-)3- CEPHEM DERIVATIVES AND RELATED INTERMEDIATES |
| CN102952149B (zh) * | 2012-11-09 | 2015-06-24 | 浙江新和成股份有限公司 | 一种氟氧头孢中间体的一锅合成法 |
| KR101314500B1 (ko) * | 2012-12-28 | 2013-10-07 | 제일약품주식회사 | 안정성이 개선된 옥사세펨 제제 및 그 제조방법 |
| CN103524534B (zh) * | 2013-09-02 | 2016-08-17 | 上海龙翔生物医药开发有限公司 | 氟氧头孢钠的制备方法 |
| CN104327100B (zh) * | 2014-09-30 | 2016-09-28 | 华北制药河北华民药业有限责任公司 | 高纯度氟氧头孢钠制备工艺 |
| CN105399755B (zh) * | 2015-11-03 | 2018-05-11 | 浙江永宁药业股份有限公司 | 一种氟氧头孢酸的合成方法 |
| CN105801601B (zh) * | 2016-04-02 | 2018-01-26 | 丽珠医药集团股份有限公司 | 一种氟氧头孢钠合成方法 |
| CN108424418A (zh) * | 2017-02-15 | 2018-08-21 | 山东致纯医药科技有限公司 | 一种氟氧头孢钠杂质 |
| KR102115644B1 (ko) * | 2017-09-13 | 2020-05-27 | 주식회사 동도물산 | 7α-알콕시옥사세펨 중간체의 제조방법 |
| CN110028522A (zh) * | 2019-04-22 | 2019-07-19 | 山西千岫制药有限公司 | 一种氟氧头孢母核的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5419990A (en) * | 1977-07-14 | 1979-02-15 | Shionogi & Co Ltd | Dihydrotriazinylthioxacephalosporin |
| JPS5690088A (en) * | 1979-11-02 | 1981-07-21 | Meiji Seika Kaisha Ltd | Novel cephalosporin analog compound |
| JPS56103185A (en) * | 1980-01-22 | 1981-08-18 | Shionogi & Co Ltd | Malonamidoxa-dethia-cephem compound |
-
1982
- 1982-12-23 JP JP57234472A patent/JPS59139385A/ja active Granted
-
1983
- 1983-11-28 ES ES527595A patent/ES527595A0/es active Granted
- 1983-11-28 NZ NZ206413A patent/NZ206413A/en unknown
- 1983-11-30 ZA ZA838920A patent/ZA838920B/xx unknown
- 1983-12-06 AU AU22113/83A patent/AU558547B2/en not_active Expired
- 1983-12-13 GB GB08333186A patent/GB2132198B/en not_active Expired
- 1983-12-14 IE IE2951/83A patent/IE56401B1/en not_active IP Right Cessation
- 1983-12-15 PT PT77831A patent/PT77831B/pt unknown
- 1983-12-16 FR FR8320221A patent/FR2538391B1/fr not_active Expired
- 1983-12-19 FI FI834682A patent/FI74016C/fi not_active IP Right Cessation
- 1983-12-20 DE DE3345989A patent/DE3345989A1/de active Granted
- 1983-12-20 CA CA000443807A patent/CA1236099A/en not_active Expired
- 1983-12-20 IL IL70488A patent/IL70488A/xx not_active IP Right Cessation
- 1983-12-21 DK DK589583A patent/DK159447C/da not_active IP Right Cessation
- 1983-12-21 SE SE8307079A patent/SE461527B/sv not_active IP Right Cessation
- 1983-12-21 AT AT0446883A patent/AT383807B/de not_active IP Right Cessation
- 1983-12-21 NO NO834729A patent/NO167740C/no unknown
- 1983-12-22 PH PH30022A patent/PH19352A/en unknown
- 1983-12-22 HU HU834424A patent/HU189014B/hu unknown
- 1983-12-22 BE BE0/212107A patent/BE898541A/fr not_active IP Right Cessation
- 1983-12-22 NL NL8304409A patent/NL192740C/nl not_active IP Right Cessation
- 1983-12-22 US US06/564,553 patent/US4532233A/en not_active Expired - Lifetime
- 1983-12-22 IT IT68343/83A patent/IT1160238B/it active
- 1983-12-23 CH CH6917/83A patent/CH656619A5/de not_active IP Right Cessation
- 1983-12-23 KR KR1019830006137A patent/KR890000095B1/ko not_active Expired
-
1984
- 1984-07-13 ES ES534291A patent/ES8703458A1/es not_active Expired
- 1984-07-13 ES ES534288A patent/ES534288A0/es active Granted
- 1984-07-13 ES ES534289A patent/ES534289A0/es active Granted
- 1984-07-13 ES ES534290A patent/ES534290A0/es active Granted
-
1986
- 1986-07-01 ES ES556846A patent/ES8708227A1/es not_active Expired
-
1988
- 1988-05-30 SE SE8802008A patent/SE470132B/sv not_active IP Right Cessation
- 1988-11-03 HK HK899/88A patent/HK89988A/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |