ES8303405A1 - Procedimiento de preparacion de derivados de quinidina. - Google Patents

Procedimiento de preparacion de derivados de quinidina.

Info

Publication number
ES8303405A1
ES8303405A1 ES512372A ES512372A ES8303405A1 ES 8303405 A1 ES8303405 A1 ES 8303405A1 ES 512372 A ES512372 A ES 512372A ES 512372 A ES512372 A ES 512372A ES 8303405 A1 ES8303405 A1 ES 8303405A1
Authority
ES
Spain
Prior art keywords
group
quinidines
preparation
pharmaceutical application
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512372A
Other languages
English (en)
Other versions
ES512372A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nativelle SA Ets
Original Assignee
Nativelle SA Ets
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nativelle SA Ets filed Critical Nativelle SA Ets
Publication of ES8303405A1 publication Critical patent/ES8303405A1/es
Publication of ES512372A0 publication Critical patent/ES512372A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE QUINIDINA. CONSISTE EN EFECTUAR UNA HIDROGENACION, SOBRE UN COMPUESTO DE FORMULA GENERAL (II) SEGUIDO OPCIONALMENTE DE UNA ACILACION O UNA DESMETALIZACION. SE OBTIENE EL COMPUESTO (I) EN EL CUAL R ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO O UN GRUPO ACILO MIENTRAS QUE R ES HIDROGENO, UN GRUPO HIDROXI, UN GRUPO ALCOXI, UN GRUPO ACILOXI O UN GRUPO AROILOXI. LA HIDROGENIZACION PUEDE EFECTUARSE POR MEDIO DE UN CATALIZADOR A BASE PLATINO, PALADIO O RODIO O BIEN MEDIANTE NIQUEL DE RANEY. EL PALADIO O EL RODIO UTILIZADO COMO CATALIZADOR, SE DEPOSITA SOBRE UN SOPORTE TAL COMO CARBONO O ALUMINA. TRATAMIENTO DE ARRITMIAS CARDIACAS.
ES512372A 1981-05-20 1982-05-19 Procedimiento de preparacion de derivados de quinidina. Granted ES512372A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8110024A FR2506312A1 (fr) 1981-05-20 1981-05-20 Nouveaux derives de la quinidine, procede de preparation et application en therapeutique

Publications (2)

Publication Number Publication Date
ES8303405A1 true ES8303405A1 (es) 1983-02-16
ES512372A0 ES512372A0 (es) 1983-02-16

Family

ID=9258680

Family Applications (1)

Application Number Title Priority Date Filing Date
ES512372A Granted ES512372A0 (es) 1981-05-20 1982-05-19 Procedimiento de preparacion de derivados de quinidina.

Country Status (9)

Country Link
US (1) US4716171A (es)
EP (1) EP0066489B1 (es)
JP (1) JPS5815975A (es)
CA (1) CA1202631A (es)
DE (1) DE3267376D1 (es)
ES (1) ES512372A0 (es)
FR (1) FR2506312A1 (es)
GR (1) GR76409B (es)
IE (1) IE53515B1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2585366B1 (fr) * 1985-07-23 1987-09-11 Nativelle Sa Ets Procede d'hydroxylation par voie microbiologique de la quinine, de la quinidine, et de derives
US11649232B2 (en) * 2021-05-10 2023-05-16 Ares Pharmaceuticals, LLC Synthetic dimeric cinchona alkaloids against cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338320A (en) * 1978-11-15 1982-07-06 The Board Of Regents Of The University Of Nebraska Esters of 6'-hydroxycinchonine, and a method of treating arrythmia with them

Also Published As

Publication number Publication date
JPS5815975A (ja) 1983-01-29
FR2506312B1 (es) 1984-03-16
JPH0348193B2 (es) 1991-07-23
EP0066489B1 (fr) 1985-11-13
CA1202631A (fr) 1986-04-01
DE3267376D1 (en) 1985-12-19
IE53515B1 (en) 1988-12-07
US4716171A (en) 1987-12-29
ES512372A0 (es) 1983-02-16
FR2506312A1 (fr) 1982-11-26
EP0066489A1 (fr) 1982-12-08
IE821204L (en) 1982-11-20
GR76409B (es) 1984-08-10

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