HK89988A - Fluoromethylthiooxacephalosporins - Google Patents

Fluoromethylthiooxacephalosporins Download PDF

Info

Publication number
HK89988A
HK89988A HK899/88A HK89988A HK89988A HK 89988 A HK89988 A HK 89988A HK 899/88 A HK899/88 A HK 899/88A HK 89988 A HK89988 A HK 89988A HK 89988 A HK89988 A HK 89988A
Authority
HK
Hong Kong
Prior art keywords
carboxy
hydrogen
protecting group
hydroxyalkyl
antibacterial
Prior art date
Application number
HK899/88A
Other languages
English (en)
Inventor
Tsuji Teruji
Sata Hisao
Hamashima Yoshio
Original Assignee
Shionogi Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi Seiyaku Kabushiki Kaisha filed Critical Shionogi Seiyaku Kabushiki Kaisha
Publication of HK89988A publication Critical patent/HK89988A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
HK899/88A 1982-12-23 1988-11-03 Fluoromethylthiooxacephalosporins HK89988A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57234472A JPS59139385A (ja) 1982-12-23 1982-12-23 フルオロメチルチオオキサセフアロスポリン

Publications (1)

Publication Number Publication Date
HK89988A true HK89988A (en) 1988-11-11

Family

ID=16971542

Family Applications (1)

Application Number Title Priority Date Filing Date
HK899/88A HK89988A (en) 1982-12-23 1988-11-03 Fluoromethylthiooxacephalosporins

Country Status (26)

Country Link
US (1) US4532233A (en, 2012)
JP (1) JPS59139385A (en, 2012)
KR (1) KR890000095B1 (en, 2012)
AT (1) AT383807B (en, 2012)
AU (1) AU558547B2 (en, 2012)
BE (1) BE898541A (en, 2012)
CA (1) CA1236099A (en, 2012)
CH (1) CH656619A5 (en, 2012)
DE (1) DE3345989A1 (en, 2012)
DK (1) DK159447C (en, 2012)
ES (6) ES527595A0 (en, 2012)
FI (1) FI74016C (en, 2012)
FR (1) FR2538391B1 (en, 2012)
GB (1) GB2132198B (en, 2012)
HK (1) HK89988A (en, 2012)
HU (1) HU189014B (en, 2012)
IE (1) IE56401B1 (en, 2012)
IL (1) IL70488A (en, 2012)
IT (1) IT1160238B (en, 2012)
NL (1) NL192740C (en, 2012)
NO (1) NO167740C (en, 2012)
NZ (1) NZ206413A (en, 2012)
PH (1) PH19352A (en, 2012)
PT (1) PT77831B (en, 2012)
SE (2) SE461527B (en, 2012)
ZA (1) ZA838920B (en, 2012)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6045514A (ja) * 1983-08-22 1985-03-12 Shionogi & Co Ltd 安定な抗菌性凍結乾燥製剤
JP2004168775A (ja) * 2002-11-08 2004-06-17 Orchid Chemicals & Pharmaceuticals Ltd オキサセファロスポリンの改良合成法
CN100509819C (zh) 2004-02-20 2009-07-08 盐野义制药株式会社 氧头孢烯晶体
EP1996595A2 (en) * 2006-03-15 2008-12-03 CARTHESIA s.a.s. DI EMANUELA MIGLIAVACCA & C. PROCESS FOR THE PREPARATION OF (1-OXA- OR l-THIA-)3- CEPHEM DERIVATIVES AND RELATED INTERMEDIATES
CN102952149B (zh) * 2012-11-09 2015-06-24 浙江新和成股份有限公司 一种氟氧头孢中间体的一锅合成法
KR101314500B1 (ko) * 2012-12-28 2013-10-07 제일약품주식회사 안정성이 개선된 옥사세펨 제제 및 그 제조방법
CN103524534B (zh) * 2013-09-02 2016-08-17 上海龙翔生物医药开发有限公司 氟氧头孢钠的制备方法
CN104327100B (zh) * 2014-09-30 2016-09-28 华北制药河北华民药业有限责任公司 高纯度氟氧头孢钠制备工艺
CN105399755B (zh) * 2015-11-03 2018-05-11 浙江永宁药业股份有限公司 一种氟氧头孢酸的合成方法
CN105801601B (zh) * 2016-04-02 2018-01-26 丽珠医药集团股份有限公司 一种氟氧头孢钠合成方法
CN108424418A (zh) * 2017-02-15 2018-08-21 山东致纯医药科技有限公司 一种氟氧头孢钠杂质
KR102115644B1 (ko) * 2017-09-13 2020-05-27 주식회사 동도물산 7α-알콕시옥사세펨 중간체의 제조방법
CN110028522A (zh) * 2019-04-22 2019-07-19 山西千岫制药有限公司 一种氟氧头孢母核的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5419990A (en) * 1977-07-14 1979-02-15 Shionogi & Co Ltd Dihydrotriazinylthioxacephalosporin
JPS5690088A (en) * 1979-11-02 1981-07-21 Meiji Seika Kaisha Ltd Novel cephalosporin analog compound
JPS56103185A (en) * 1980-01-22 1981-08-18 Shionogi & Co Ltd Malonamidoxa-dethia-cephem compound

Also Published As

Publication number Publication date
SE470132B (sv) 1993-11-15
ES8703458A1 (es) 1987-02-16
CH656619A5 (de) 1986-07-15
AU2211383A (en) 1984-06-28
SE8307079D0 (sv) 1983-12-21
SE8802008D0 (sv) 1988-05-30
NL192740C (nl) 1998-01-06
NO834729L (no) 1984-06-25
FR2538391B1 (fr) 1986-12-19
IE56401B1 (en) 1991-07-17
FI834682L (fi) 1984-06-24
DK159447B (da) 1990-10-15
DK589583D0 (da) 1983-12-21
IL70488A (en) 1988-03-31
NO167740B (no) 1991-08-26
ES8505670A1 (es) 1985-06-01
ES534288A0 (es) 1985-06-01
ES8506024A1 (es) 1985-06-16
ES8708227A1 (es) 1987-10-01
JPS59139385A (ja) 1984-08-10
DE3345989A1 (de) 1984-06-28
KR840007007A (ko) 1984-12-04
ES8505672A1 (es) 1985-06-01
GB8333186D0 (en) 1984-01-18
DE3345989C2 (en, 2012) 1992-09-24
HU189014B (en) 1986-06-30
FI834682A0 (fi) 1983-12-19
ES534291A0 (es) 1987-02-16
ES8505671A1 (es) 1985-06-01
FR2538391A1 (fr) 1984-06-29
ES534289A0 (es) 1985-06-01
DK589583A (da) 1984-06-24
CA1259989C (en, 2012) 1989-09-26
KR890000095B1 (ko) 1989-03-07
BE898541A (fr) 1984-04-16
AT383807B (de) 1987-08-25
IL70488A0 (en) 1984-03-30
ES534290A0 (es) 1985-06-01
ATA446883A (de) 1987-01-15
PH19352A (en) 1986-04-02
NO167740C (no) 1991-12-04
ES556846A0 (es) 1987-10-01
FI74016C (fi) 1987-12-10
GB2132198B (en) 1986-10-01
ZA838920B (en) 1984-07-25
SE8307079L (sv) 1984-06-24
IT1160238B (it) 1987-03-04
FI74016B (fi) 1987-08-31
SE461527B (sv) 1990-02-26
DK159447C (da) 1991-04-08
AU558547B2 (en) 1987-02-05
SE8802008L (sv) 1988-05-30
IE832951L (en) 1984-06-23
IT8368343A0 (it) 1983-12-22
GB2132198A (en) 1984-07-04
JPS6225671B2 (en, 2012) 1987-06-04
HUT34200A (en) 1985-02-28
NL192740B (nl) 1997-09-01
NZ206413A (en) 1986-05-09
PT77831B (en) 1986-03-26
NL8304409A (nl) 1984-07-16
PT77831A (en) 1984-01-01
CA1236099A (en) 1988-05-03
US4532233A (en) 1985-07-30
ES527595A0 (es) 1985-06-16

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