CA1199324A - Phenyl substituted pyrido¬1,4|benzodiazepines and intermediates therefor - Google Patents

Phenyl substituted pyrido¬1,4|benzodiazepines and intermediates therefor

Info

Publication number
CA1199324A
CA1199324A CA000394367A CA394367A CA1199324A CA 1199324 A CA1199324 A CA 1199324A CA 000394367 A CA000394367 A CA 000394367A CA 394367 A CA394367 A CA 394367A CA 1199324 A CA1199324 A CA 1199324A
Authority
CA
Canada
Prior art keywords
pyrido
phenyl
benzodiazepine
amino
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000394367A
Other languages
English (en)
French (fr)
Inventor
Chandler R. Taylor, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Application granted granted Critical
Publication of CA1199324A publication Critical patent/CA1199324A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA000394367A 1981-09-24 1982-01-18 Phenyl substituted pyrido¬1,4|benzodiazepines and intermediates therefor Expired CA1199324A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30508081A 1981-09-24 1981-09-24
US305,080 1981-09-24
US395,218 1982-07-06

Publications (1)

Publication Number Publication Date
CA1199324A true CA1199324A (en) 1986-01-14

Family

ID=23179241

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000394367A Expired CA1199324A (en) 1981-09-24 1982-01-18 Phenyl substituted pyrido¬1,4|benzodiazepines and intermediates therefor

Country Status (27)

Country Link
JP (1) JPS5865290A (es)
KR (1) KR890000764B1 (es)
BE (1) BE891666A (es)
CA (1) CA1199324A (es)
CH (1) CH651833A5 (es)
DE (1) DE3150522A1 (es)
DK (3) DK186282A (es)
EG (1) EG15904A (es)
ES (6) ES8303348A1 (es)
FI (1) FI71935C (es)
FR (1) FR2515183B1 (es)
GR (1) GR78473B (es)
HU (2) HU189426B (es)
IE (1) IE52493B1 (es)
IL (1) IL64284A (es)
IN (1) IN156080B (es)
IT (1) IT1146728B (es)
LU (1) LU83865A1 (es)
NL (1) NL8200549A (es)
NO (1) NO157700C (es)
NZ (1) NZ198999A (es)
PH (2) PH17847A (es)
PL (6) PL143596B1 (es)
PT (1) PT74286B (es)
SE (2) SE448629B (es)
YU (1) YU46128B (es)
ZA (1) ZA817866B (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3825549A (en) * 1972-10-24 1974-07-23 Squibb & Sons Inc Certain dihydropyrido(2,1-b)(1,3)benzodi-azepines and benzodiazocines
DE2424811C3 (de) * 1974-05-22 1981-08-20 Dr. Karl Thomae Gmbh, 7950 Biberach Pyrido-benzodiazepinone, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
SE422799B (sv) * 1975-05-28 1982-03-29 Merck & Co Inc Analogiforfarande for framstellning av 1,3-dihydroimidazo (4,5-b)pyridin-2-oner

Also Published As

Publication number Publication date
KR890000764B1 (ko) 1989-04-05
ES8308563A1 (es) 1983-09-16
DK403487D0 (da) 1987-08-03
PL234426A1 (en) 1984-01-02
DK403387D0 (da) 1987-08-03
GR78473B (es) 1984-09-27
BE891666A (fr) 1982-04-16
PL241409A1 (en) 1984-05-21
PL139381B1 (en) 1987-01-31
FR2515183A1 (fr) 1983-04-29
IL64284A0 (en) 1982-02-28
FR2515183B1 (fr) 1986-11-14
IT8168605A0 (it) 1981-12-09
HUT34732A (en) 1985-04-28
FI71935C (fi) 1987-03-09
HU187393B (en) 1985-12-28
IE52493B1 (en) 1987-11-25
NO157700C (no) 1988-05-04
ZA817866B (en) 1982-10-27
SE8600688D0 (sv) 1986-02-17
NO157700B (no) 1988-01-25
ES516051A0 (es) 1983-09-16
YU62582A (en) 1986-04-30
SE8600688L (sv) 1986-02-17
PL143597B1 (en) 1988-02-29
PL143322B1 (en) 1988-02-29
PT74286A (en) 1982-02-01
ES507971A0 (es) 1983-02-01
ES8607726A1 (es) 1986-06-01
HU189426B (en) 1986-07-28
PL241410A1 (en) 1984-01-02
PL138859B1 (en) 1986-11-29
IE812769L (en) 1983-03-24
SE455305B (sv) 1988-07-04
SE448629B (sv) 1987-03-09
EG15904A (en) 1987-03-30
PL143596B1 (en) 1988-02-29
ES543328A0 (es) 1986-06-01
YU46128B (sh) 1993-05-28
ES526563A0 (es) 1986-02-01
IT1146728B (it) 1986-11-19
ES8504148A1 (es) 1985-04-01
SE8106573L (sv) 1983-03-25
CH651833A5 (fr) 1985-10-15
PH17847A (en) 1985-01-09
LU83865A1 (fr) 1983-09-02
NZ198999A (en) 1987-07-31
FI813976L (fi) 1983-03-25
DK403487A (da) 1987-08-03
PH20536A (en) 1987-02-09
JPS5865290A (ja) 1983-04-18
IL64284A (en) 1986-12-31
NO813839L (no) 1983-03-25
DK403387A (da) 1987-08-03
DE3150522A1 (de) 1983-04-07
PT74286B (en) 1983-06-27
DK186282A (da) 1983-03-25
PL137068B1 (en) 1986-04-30
FI71935B (fi) 1986-11-28
ES8303348A1 (es) 1983-02-01
ES8604531A1 (es) 1986-02-01
ES516052A0 (es) 1984-01-16
ES526562A0 (es) 1985-04-01
ES8402295A1 (es) 1984-01-16
KR830009058A (ko) 1983-12-17
IN156080B (es) 1985-05-11
NL8200549A (nl) 1983-04-18

Similar Documents

Publication Publication Date Title
CA1083149A (en) Derivatives of 10,11-dihydrobenzo 4,5 cyclohepta l,2- b -pyrazolo 4,3-e pyridine-5 (1h)ones
WO1986001510A1 (en) Tricyclic oxindole antiinflammatory agents
US4447361A (en) Aryl substituted pyrido[1,4]benzodiazepines
CA1199324A (en) Phenyl substituted pyrido¬1,4|benzodiazepines and intermediates therefor
Hino et al. Agents Acting on the Central Nervous System.: Synthesis of 3-Phenyl-2-piperazinyl-1-benzazocines, 3-Substituted-2-piperazinyl-1-benzazepines and Related Compounds
US4560510A (en) Process and intermediates for the preparation of aryl substituted pyrido[1,4]benzodiazepines
US4480100A (en) [2-[(Nitropyridinyl)amino]phenyl]arymethanones
CA2048003A1 (en) Tricyclic pyridone derivatives
US4556667A (en) Aryl substituted pyrido[1,4]benzodiazepines and their use as antidepressives
US4495183A (en) Aryl substituted pyrido[1,4]benzodiazepines for treatment of depression
US4668675A (en) 2-[(amino-pyridinyl)amine]phenyl]aryl methanones, their thioxomethyl, ketal or thioketal analogs
EP0076017B1 (en) Phenyl substituted pyrido(1,4)benzodiazepines and intermediates therefor
Kökösi et al. Nitrogen bridgehead compounds. Part 19. Synthesis of polymethylenepyrimidin‐4‐ones
US4558132A (en) Nitro, amino and aroylamino-N-phenylpyridinamines in a process for preparing pyrido[1,4]benzodiazepines
US4698430A (en) Nitro, amino and aroylamino-n-phenylpyridinamines
US4311700A (en) Pyrimidobenzodiazepinones, their use and medicaments containing them
US4628100A (en) Intermediates for the preparation of aryl substituted pyrido[1,4]benzodiazepines
CA1087182A (en) Substituted 1-piperazinyl-triazolo-thieno-1,4- diazepines
US4518603A (en) [2-[(Nitropyridinyl)amino]phenyl]arylmethanones in a process for preparing pyrido[1,4]benzodiazepines
CA1262353A (en) Aromatic ketone derivative intermediates for the preparation of antidepressant pyrido [1,4] benzodiazepines
NO872271L (no) (2-((aminopyridinyl)amino(fenyl)-arylmethanoner.
Zhao et al. A Novel Approach to the Synthesis of 1-Substituted-3, 6-diaryl-imidazo [1, 5-b] pyridazines
NO872691L (no) Nye nitro-, amino- og aroylamino-n-fenylpyridinaminer.
NO880084L (no) Utgangsmaterialer for fremstilling av pyrido(1,4)benzodiazepiner.
NO900286L (no) Fremgangsmaate for fremstilling av en pyridobenzodiazepinforbindelser.

Legal Events

Date Code Title Description
MKEX Expiry