ES8604531A1 - Procedimiento para preparar pirido(1,4)benzodiazepinas - Google Patents
Procedimiento para preparar pirido(1,4)benzodiazepinasInfo
- Publication number
- ES8604531A1 ES8604531A1 ES526563A ES526563A ES8604531A1 ES 8604531 A1 ES8604531 A1 ES 8604531A1 ES 526563 A ES526563 A ES 526563A ES 526563 A ES526563 A ES 526563A ES 8604531 A1 ES8604531 A1 ES 8604531A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- hydrogen
- phenyl
- alkyl group
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE PIRIDO 1,4BENZODIAZEPINAS Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE Y, Z, AR Y R PUEDEN SER VARIOS TIPOS DE RADICALES; Y N VALE 0 O 1. CONSISTE EN LA REACCION DE HIDROLISIS DE UN COMPUESTO DE FORMULA (II), EN LA QUE Q PUEDE SER UNO DE VARIOS TIPOS DE RADICALES, ALC1 REPRESENTA UNA CADENA HIDROCARBONADA DE 1 A 8 ATOMOS DE CARBONO, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA HIDROLISIS SE LLEVA A CABO EN DISOLUCION ACUOSA DE UN ACIDO O UNA BASE, A TEMPERATURA Y PRESION NORMALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIDEPRESIVOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30508081A | 1981-09-24 | 1981-09-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8604531A1 true ES8604531A1 (es) | 1986-02-01 |
| ES526563A0 ES526563A0 (es) | 1986-02-01 |
Family
ID=23179241
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507971A Expired ES8303348A1 (es) | 1981-09-24 | 1981-12-15 | Procedimiento para preparar (2-(amonopiridinil)-amino-fenil-arilmetanonas. |
| ES516051A Granted ES516051A0 (es) | 1981-09-24 | 1982-09-29 | "procedimiento para preparar pirido (1,4) benzodiazepinas". |
| ES516052A Expired ES8402295A1 (es) | 1981-09-24 | 1982-09-29 | "procedimiento para preparar pirido (1,4) benzodiazepinas". |
| ES526562A Expired ES8504148A1 (es) | 1981-09-24 | 1983-10-19 | Procedimiento para preparar pirido(1,4)benzodiazepinas |
| ES526563A Expired ES8604531A1 (es) | 1981-09-24 | 1983-10-19 | Procedimiento para preparar pirido(1,4)benzodiazepinas |
| ES543328A Expired ES8607726A1 (es) | 1981-09-24 | 1985-05-21 | Procedimiento para preparar pirido(i,4)benzodiazepinas |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507971A Expired ES8303348A1 (es) | 1981-09-24 | 1981-12-15 | Procedimiento para preparar (2-(amonopiridinil)-amino-fenil-arilmetanonas. |
| ES516051A Granted ES516051A0 (es) | 1981-09-24 | 1982-09-29 | "procedimiento para preparar pirido (1,4) benzodiazepinas". |
| ES516052A Expired ES8402295A1 (es) | 1981-09-24 | 1982-09-29 | "procedimiento para preparar pirido (1,4) benzodiazepinas". |
| ES526562A Expired ES8504148A1 (es) | 1981-09-24 | 1983-10-19 | Procedimiento para preparar pirido(1,4)benzodiazepinas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES543328A Expired ES8607726A1 (es) | 1981-09-24 | 1985-05-21 | Procedimiento para preparar pirido(i,4)benzodiazepinas |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS5865290A (es) |
| KR (1) | KR890000764B1 (es) |
| BE (1) | BE891666A (es) |
| CA (1) | CA1199324A (es) |
| CH (1) | CH651833A5 (es) |
| DE (1) | DE3150522A1 (es) |
| DK (3) | DK186282A (es) |
| EG (1) | EG15904A (es) |
| ES (6) | ES8303348A1 (es) |
| FI (1) | FI71935C (es) |
| FR (1) | FR2515183B1 (es) |
| GR (1) | GR78473B (es) |
| HU (2) | HU189426B (es) |
| IE (1) | IE52493B1 (es) |
| IL (1) | IL64284A (es) |
| IN (1) | IN156080B (es) |
| IT (1) | IT1146728B (es) |
| LU (1) | LU83865A1 (es) |
| NL (1) | NL8200549A (es) |
| NO (1) | NO157700C (es) |
| NZ (1) | NZ198999A (es) |
| PH (2) | PH17847A (es) |
| PL (6) | PL138859B1 (es) |
| PT (1) | PT74286B (es) |
| SE (2) | SE448629B (es) |
| YU (1) | YU46128B (es) |
| ZA (1) | ZA817866B (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3825549A (en) * | 1972-10-24 | 1974-07-23 | Squibb & Sons Inc | Certain dihydropyrido(2,1-b)(1,3)benzodi-azepines and benzodiazocines |
| DE2424811C3 (de) * | 1974-05-22 | 1981-08-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Pyrido-benzodiazepinone, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| SE422799B (sv) * | 1975-05-28 | 1982-03-29 | Merck & Co Inc | Analogiforfarande for framstellning av 1,3-dihydroimidazo (4,5-b)pyridin-2-oner |
-
1981
- 1981-11-05 SE SE8106573A patent/SE448629B/sv not_active IP Right Cessation
- 1981-11-12 NO NO813839A patent/NO157700C/no unknown
- 1981-11-12 ZA ZA817866A patent/ZA817866B/xx unknown
- 1981-11-13 IL IL64284A patent/IL64284A/xx unknown
- 1981-11-13 IN IN1261/CAL/81A patent/IN156080B/en unknown
- 1981-11-17 GR GR66553A patent/GR78473B/el unknown
- 1981-11-18 PH PH26507A patent/PH17847A/en unknown
- 1981-11-25 IE IE2769/81A patent/IE52493B1/en unknown
- 1981-12-09 IT IT68605/81A patent/IT1146728B/it active
- 1981-12-10 FI FI813976A patent/FI71935C/fi not_active IP Right Cessation
- 1981-12-15 HU HU843212A patent/HU189426B/hu not_active IP Right Cessation
- 1981-12-15 ES ES507971A patent/ES8303348A1/es not_active Expired
- 1981-12-15 HU HU813777A patent/HU187393B/hu not_active IP Right Cessation
- 1981-12-21 DE DE19813150522 patent/DE3150522A1/de not_active Withdrawn
- 1981-12-23 PL PL1981234426A patent/PL138859B1/pl unknown
- 1981-12-23 PL PL1981241409A patent/PL139381B1/pl unknown
- 1981-12-23 PL PL1981253538A patent/PL143596B1/pl unknown
- 1981-12-23 PL PL1981253540A patent/PL143322B1/pl unknown
- 1981-12-23 PL PL1981253539A patent/PL143597B1/pl unknown
- 1981-12-23 FR FR8124111A patent/FR2515183B1/fr not_active Expired
- 1981-12-23 PL PL1981241410A patent/PL137068B1/pl unknown
- 1981-12-30 BE BE0/206969A patent/BE891666A/fr not_active IP Right Cessation
-
1982
- 1982-01-05 LU LU83865A patent/LU83865A1/fr unknown
- 1982-01-12 EG EG11/82A patent/EG15904A/xx active
- 1982-01-14 JP JP57004813A patent/JPS5865290A/ja active Pending
- 1982-01-15 PT PT74286A patent/PT74286B/pt unknown
- 1982-01-18 CA CA000394367A patent/CA1199324A/en not_active Expired
- 1982-02-02 KR KR8200420A patent/KR890000764B1/ko active
- 1982-02-12 NL NL8200549A patent/NL8200549A/nl not_active Application Discontinuation
- 1982-02-18 NZ NZ198999A patent/NZ198999A/en unknown
- 1982-03-23 YU YU62582A patent/YU46128B/sh unknown
- 1982-04-15 CH CH2288/82A patent/CH651833A5/fr not_active IP Right Cessation
- 1982-04-26 DK DK186282A patent/DK186282A/da not_active Application Discontinuation
- 1982-09-29 ES ES516051A patent/ES516051A0/es active Granted
- 1982-09-29 ES ES516052A patent/ES8402295A1/es not_active Expired
-
1983
- 1983-10-19 ES ES526562A patent/ES8504148A1/es not_active Expired
- 1983-10-19 ES ES526563A patent/ES8604531A1/es not_active Expired
-
1984
- 1984-08-17 PH PH31120A patent/PH20536A/en unknown
-
1985
- 1985-05-21 ES ES543328A patent/ES8607726A1/es not_active Expired
-
1986
- 1986-02-17 SE SE8600688A patent/SE455305B/sv not_active IP Right Cessation
-
1987
- 1987-08-03 DK DK403487A patent/DK403487D0/da not_active Application Discontinuation
- 1987-08-03 DK DK403387A patent/DK403387D0/da not_active Application Discontinuation
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