CA1156655A - 2-amino-3-[hydroxy(phenyl)methyl] phenylacetic acids, esters and amides - Google Patents

2-amino-3-[hydroxy(phenyl)methyl] phenylacetic acids, esters and amides

Info

Publication number
CA1156655A
CA1156655A CA000371185A CA371185A CA1156655A CA 1156655 A CA1156655 A CA 1156655A CA 000371185 A CA000371185 A CA 000371185A CA 371185 A CA371185 A CA 371185A CA 1156655 A CA1156655 A CA 1156655A
Authority
CA
Canada
Prior art keywords
amino
compound
loweralkyl
process according
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000371185A
Other languages
English (en)
French (fr)
Inventor
William J. Welstead, Jr.
Henry W. Moran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Application granted granted Critical
Publication of CA1156655A publication Critical patent/CA1156655A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000371185A 1980-02-19 1981-02-18 2-amino-3-[hydroxy(phenyl)methyl] phenylacetic acids, esters and amides Expired CA1156655A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12254480A 1980-02-19 1980-02-19
US122,544 1980-02-19

Publications (1)

Publication Number Publication Date
CA1156655A true CA1156655A (en) 1983-11-08

Family

ID=22403319

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000371185A Expired CA1156655A (en) 1980-02-19 1981-02-18 2-amino-3-[hydroxy(phenyl)methyl] phenylacetic acids, esters and amides

Country Status (11)

Country Link
JP (1) JPS56131552A (de)
AU (1) AU538240B2 (de)
BE (1) BE887566A (de)
CA (1) CA1156655A (de)
CH (1) CH648283A5 (de)
DE (1) DE3105285A1 (de)
FR (1) FR2476071A1 (de)
GB (1) GB2071086B (de)
IL (1) IL61945A (de)
IT (1) IT1146744B (de)
NL (1) NL8100808A (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA805476B (en) * 1979-09-26 1981-11-25 Robins Co Inc A H 2-amino-3-benzoyl-phenylacetamides and cyclic homologues
IL64724A0 (en) * 1981-02-17 1982-03-31 Robins Co Inc A H 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them
US5475034A (en) * 1994-06-06 1995-12-12 Alcon Laboratories, Inc. Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
AR030345A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes relacionados con angiogenesis
AR030346A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico
WO2002078681A2 (en) 2001-04-02 2002-10-10 Alcon, Inc. Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac
TWI358290B (en) 2004-12-02 2012-02-21 Alcon Inc Topical nepafenac formulations
CA2755314A1 (en) * 2009-03-12 2010-09-16 Medichem, S.A. New crystals of a benzoylbenzeneacetamide derivative
EP2389354A1 (de) * 2009-04-06 2011-11-30 Medichem, S.A. 2-{2-amino-3-[hydroxy(phenyl)methyl]phenyl}-acetamid
CN106631881B (zh) * 2016-09-08 2018-09-21 南京工业大学 2-（3-苄基-2-（二甲基氨基）苯基）乙酰胺及合成方法和用途
CN112794809B (zh) * 2019-11-14 2023-12-29 南京济群医药科技股份有限公司 一种高纯度奈帕芬胺中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE400966B (sv) * 1975-08-13 1978-04-17 Robins Co Inc A H Forfarande for framstellning av 2-amino-3-(eller 5-)bensoyl-fenylettiksyror
FR2366015A1 (fr) * 1975-11-05 1978-04-28 Robins Co Inc A H Nouveaux acides amino-2 benzoyl-3 (5 et 6) phenylacetiques et leurs esters et sels de metaux alcalins, utiles notamment comme anti-inflammatoires, et leur procede de preparation
ZA805476B (en) * 1979-09-26 1981-11-25 Robins Co Inc A H 2-amino-3-benzoyl-phenylacetamides and cyclic homologues

Also Published As

Publication number Publication date
IL61945A0 (en) 1981-02-27
FR2476071B1 (de) 1984-05-11
GB2071086B (en) 1984-02-08
IT8167177A0 (it) 1981-02-09
JPH0153266B2 (de) 1989-11-13
JPS56131552A (en) 1981-10-15
BE887566A (fr) 1981-06-15
AU6733081A (en) 1981-08-27
AU538240B2 (en) 1984-08-02
NL8100808A (nl) 1981-09-16
DE3105285A1 (de) 1982-01-21
GB2071086A (en) 1981-09-16
IL61945A (en) 1984-09-30
IT1146744B (it) 1986-11-19
FR2476071A1 (fr) 1981-08-21
CH648283A5 (fr) 1985-03-15

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