AU6733081A - 2-amino-3-(hydroxy(phenyl)methyl)phenyl acetic acids, salts, esters and amides. - Google Patents

2-amino-3-(hydroxy(phenyl)methyl)phenyl acetic acids, salts, esters and amides.

Info

Publication number
AU6733081A
AU6733081A AU67330/81A AU6733081A AU6733081A AU 6733081 A AU6733081 A AU 6733081A AU 67330/81 A AU67330/81 A AU 67330/81A AU 6733081 A AU6733081 A AU 6733081A AU 6733081 A AU6733081 A AU 6733081A
Authority
AU
Australia
Prior art keywords
phenyl
amides
hydroxy
esters
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU67330/81A
Other versions
AU538240B2 (en
Inventor
Henry Wayne Moran
William John Welstead
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of AU6733081A publication Critical patent/AU6733081A/en
Application granted granted Critical
Publication of AU538240B2 publication Critical patent/AU538240B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU67330/81A 1980-02-19 1981-02-16 2-amino-3-(hydroxy(phenyl)methyl)phenyl acetic acids, salts, esters and amides. Ceased AU538240B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12254480A 1980-02-19 1980-02-19
US122544 1998-07-24

Publications (2)

Publication Number Publication Date
AU6733081A true AU6733081A (en) 1981-08-27
AU538240B2 AU538240B2 (en) 1984-08-02

Family

ID=22403319

Family Applications (1)

Application Number Title Priority Date Filing Date
AU67330/81A Ceased AU538240B2 (en) 1980-02-19 1981-02-16 2-amino-3-(hydroxy(phenyl)methyl)phenyl acetic acids, salts, esters and amides.

Country Status (11)

Country Link
JP (1) JPS56131552A (en)
AU (1) AU538240B2 (en)
BE (1) BE887566A (en)
CA (1) CA1156655A (en)
CH (1) CH648283A5 (en)
DE (1) DE3105285A1 (en)
FR (1) FR2476071A1 (en)
GB (1) GB2071086B (en)
IL (1) IL61945A (en)
IT (1) IT1146744B (en)
NL (1) NL8100808A (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA805476B (en) * 1979-09-26 1981-11-25 Robins Co Inc A H 2-amino-3-benzoyl-phenylacetamides and cyclic homologues
IL64724A0 (en) * 1981-02-17 1982-03-31 Robins Co Inc A H 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them
US5475034A (en) * 1994-06-06 1995-12-12 Alcon Laboratories, Inc. Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
AR030345A1 (en) * 2000-08-14 2003-08-20 Alcon Inc METHOD OF TREATMENT OF DISORDERS RELATED TO ANGIOGENESIS
AR030346A1 (en) * 2000-08-14 2003-08-20 Alcon Inc METHOD OF TREATMENT OF NEURODEGENERATIVE DISORDERS OF THE RETINA AND HEAD OF OPTICAL NERVE
WO2002078681A2 (en) 2001-04-02 2002-10-10 Alcon, Inc. Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac
TWI358290B (en) 2004-12-02 2012-02-21 Alcon Inc Topical nepafenac formulations
CA2755314A1 (en) * 2009-03-12 2010-09-16 Medichem, S.A. New crystals of a benzoylbenzeneacetamide derivative
EP2389354A1 (en) * 2009-04-06 2011-11-30 Medichem, S.A. 2-{2-amino-3-ýhydroxy(phenyl)methyl¨phenyl} acetamide
CN106631881B (en) * 2016-09-08 2018-09-21 南京工业大学 2- (3-benzyl-2- (dimethylamino) phenyl) acetamide and its synthesis method and use
CN112794809B (en) * 2019-11-14 2023-12-29 南京济群医药科技股份有限公司 Preparation method of high-purity nepafenac intermediate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE400966B (en) * 1975-08-13 1978-04-17 Robins Co Inc A H PROCEDURE FOR PREPARING 2-AMINO-3- (OR 5-) BENZOYL-PHENYLETIC ACIDS
FR2366015A1 (en) * 1975-11-05 1978-04-28 Robins Co Inc A H Amino-benzoyl-phenylacetic acid derivs - antiinflammatory, hypocholesterolemic and blood platelet agglomeration inhibitory activity
ZA805476B (en) * 1979-09-26 1981-11-25 Robins Co Inc A H 2-amino-3-benzoyl-phenylacetamides and cyclic homologues

Also Published As

Publication number Publication date
IL61945A0 (en) 1981-02-27
FR2476071B1 (en) 1984-05-11
GB2071086B (en) 1984-02-08
IT8167177A0 (en) 1981-02-09
JPH0153266B2 (en) 1989-11-13
JPS56131552A (en) 1981-10-15
BE887566A (en) 1981-06-15
AU538240B2 (en) 1984-08-02
NL8100808A (en) 1981-09-16
DE3105285A1 (en) 1982-01-21
GB2071086A (en) 1981-09-16
CA1156655A (en) 1983-11-08
IL61945A (en) 1984-09-30
IT1146744B (en) 1986-11-19
FR2476071A1 (en) 1981-08-21
CH648283A5 (en) 1985-03-15

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