CA1113392A - Luminescent immunoassay - Google Patents
Luminescent immunoassayInfo
- Publication number
- CA1113392A CA1113392A CA316,349A CA316349A CA1113392A CA 1113392 A CA1113392 A CA 1113392A CA 316349 A CA316349 A CA 316349A CA 1113392 A CA1113392 A CA 1113392A
- Authority
- CA
- Canada
- Prior art keywords
- luminescent
- substance
- labelled
- antibodies
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/553—Metal or metal coated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Inorganic Chemistry (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA374,108A CA1116079A (en) | 1977-11-17 | 1981-03-27 | Immunoassay with fluorescent label excited by luminescent reaction |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4783977 | 1977-11-17 | ||
| GB47839/77 | 1977-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1113392A true CA1113392A (en) | 1981-12-01 |
Family
ID=10446427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA316,349A Expired CA1113392A (en) | 1977-11-17 | 1978-11-16 | Luminescent immunoassay |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4478817A (en, 2012) |
| CA (1) | CA1113392A (en, 2012) |
| CH (2) | CH640061A5 (en, 2012) |
| DE (2) | DE2849708A1 (en, 2012) |
| FR (1) | FR2409516B1 (en, 2012) |
| GB (1) | GB2095830B (en, 2012) |
| SE (1) | SE7811630L (en, 2012) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU533026B2 (en) * | 1979-10-26 | 1983-10-27 | Dynasciences Corp. | Passively adsorbing immuno-reactive haptens to solid phases |
| DE2947459C2 (de) * | 1979-11-24 | 1983-06-23 | Battelle-Institut E.V., 6000 Frankfurt | Vorrichtung zum in-situ-Nachweis von in Bodenbelägen vermuteten giftigen Substanzen |
| ATE8130T1 (de) * | 1980-08-25 | 1984-07-15 | Kabivitrum Ab | Peptidsubstrate zum bestimmen der proteaseaktivitaet. |
| GB2112779B (en) * | 1981-12-11 | 1986-10-15 | Welsh Nat School Med | Aryl acridinium esters as luminescent labelling materials |
| JPS59500252A (ja) * | 1982-03-03 | 1984-02-23 | ブリティッシュ・テクノロジー・グループ・リミテッド | 増強ルミネツセンスおよび発光分析 |
| ES8607563A1 (es) * | 1983-10-13 | 1986-06-01 | Univ Georgia Res Found | Un metodo para detectar una interaccion ligante |
| US4647531A (en) * | 1984-02-06 | 1987-03-03 | Ortho Diagnostic Systems, Inc. | Generalized cytometry instrument and methods of use |
| ATE56096T1 (de) * | 1984-03-15 | 1990-09-15 | Immunex Corp | Test zur sofortigen feststellung von liganden, testsatz und seine herstellung. |
| FR2562252B1 (fr) * | 1984-03-27 | 1988-01-22 | Inst Nat Sante Rech Med | Procede de dosage immunoenzymatique sans etape de separation et reactifs et necessaires pour sa mise en oeuvre |
| US4977080A (en) * | 1984-04-06 | 1990-12-11 | Minnesota Mining And Manufacturing Co. | Chemiluminescent methods and a kit therefor involving a beta-lactam |
| EP0165072A3 (en) * | 1984-06-15 | 1986-12-30 | Mast Immunosystems, Inc. | Specific binding assay reagent medium, test kit and process |
| US4687747A (en) * | 1984-07-02 | 1987-08-18 | Mallinckrodt, Inc. | Phenanthridinium ester as a labelling compound in luminometric immunoassay |
| US5422266A (en) * | 1984-12-31 | 1995-06-06 | University Of Georgia Research Foundation, Inc. | Recombinant DNA vectors capable of expressing apoaequorin |
| US5155216A (en) * | 1985-08-15 | 1992-10-13 | Amoco Corporation | Nucleic acids labeled with a chemiluminescent acridine ester |
| DE3537877A1 (de) * | 1985-10-24 | 1987-04-30 | Geiger Reinhard | Luciferin-derivate und immunoassays unter einsatz derartiger luciferin-derivate |
| DE3545398A1 (de) * | 1985-12-20 | 1987-06-25 | Boehringer Mannheim Gmbh | Verfahren zur steigerung der quanten-ausbeute bei der oxidation von luminol durch peroxide in gegenwart von peroxidase |
| CA1293725C (en) * | 1986-05-08 | 1991-12-31 | Universite Laval | Luminescent cyclic hydrazides for analytical assays |
| US4777128A (en) * | 1986-05-27 | 1988-10-11 | Ethigen Corporation | Fluorescence immunoassay involving energy transfer between two fluorophores |
| FR2602592B1 (fr) | 1986-08-06 | 1989-06-30 | Alain Baret | Utilisation du systeme enzymatique xanthine-oxydase en immuno-analyse, procedes de dosage correspondants et coffrets de reactifs necessaires pour la mise en oeuvre de ces procedes. |
| FR2617974B1 (fr) * | 1987-07-07 | 1992-11-13 | Stabiligen | Procede de dosage immunologique par bio- ou chimio- luminescence |
| DE3737649A1 (de) * | 1987-11-06 | 1989-05-24 | Inst Zellforschung Und Biolumi | Verfahren zur bestimmung der lumineszenz von zellkulturen sowie vorrichtung zur durchfuehrung des verfahrens |
| JPH01219563A (ja) * | 1988-02-27 | 1989-09-01 | Doujin Kagaku Kenkyusho:Kk | 化学発光の写真法による検出方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3366572A (en) * | 1965-03-09 | 1968-01-30 | American Cyanamid Co | Oxidation of chemiluminescent substances |
| CA1025772A (en) * | 1972-06-26 | 1978-02-07 | Ivar Giaever | Method and apparatus for detection and purification of proteins and antibodies |
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| US3992631A (en) * | 1975-02-27 | 1976-11-16 | International Diagnostic Technology, Inc. | Fluorometric system, method and test article |
| US4011219A (en) * | 1975-03-28 | 1977-03-08 | Chugai Seiyaku Kabushiki Kaisha | Phthalazine derivatives and salts thereof |
| IN142734B (en, 2012) * | 1975-04-28 | 1977-08-20 | Miles Lab | |
| US4041146A (en) * | 1975-05-01 | 1977-08-09 | General Electric Company | Method for detection of biological particles |
| US4181650A (en) * | 1975-08-25 | 1980-01-01 | Maier Charles L Jr | Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids |
| US4036946A (en) * | 1975-10-20 | 1977-07-19 | Marcos Kleinerman | Immunofluorometric method for measuring minute quantities of antigens, antibodies and other substances |
| US4020151A (en) * | 1976-02-17 | 1977-04-26 | International Diagnostic Technology, Inc. | Method for quantitation of antigens or antibodies on a solid surface |
| US4128628A (en) * | 1976-03-12 | 1978-12-05 | University Of Virginia Alumni Patents Foundation | Automated immunoassay |
| US4025310A (en) * | 1976-05-28 | 1977-05-24 | International Diagnostic Technology, Inc. | Method for reading a wet fluorescent surface |
| GB1578275A (en) * | 1977-06-14 | 1980-11-05 | Maier C | Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids |
| US4208479A (en) * | 1977-07-14 | 1980-06-17 | Syva Company | Label modified immunoassays |
| US4160645A (en) * | 1977-07-14 | 1979-07-10 | Syva Company | Catalyst mediated competitive protein binding assay |
-
1978
- 1978-11-10 SE SE7811630A patent/SE7811630L/xx unknown
- 1978-11-13 CH CH1163678A patent/CH640061A5/fr not_active IP Right Cessation
- 1978-11-14 GB GB8133207A patent/GB2095830B/en not_active Expired
- 1978-11-14 US US05/961,389 patent/US4478817A/en not_active Expired - Lifetime
- 1978-11-16 CA CA316,349A patent/CA1113392A/en not_active Expired
- 1978-11-16 DE DE19782849708 patent/DE2849708A1/de active Granted
- 1978-11-16 DE DE2858792A patent/DE2858792C2/de not_active Expired - Lifetime
- 1978-11-17 FR FR7832459A patent/FR2409516B1/fr not_active Expired
-
1983
- 1983-12-14 CH CH667283A patent/CH645725A5/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB2095830B (en) | 1983-03-23 |
| US4478817A (en) | 1984-10-23 |
| FR2409516A1 (fr) | 1979-06-15 |
| DE2849708C2 (en, 2012) | 1990-04-26 |
| CH645725A5 (fr) | 1984-10-15 |
| FR2409516B1 (fr) | 1985-05-17 |
| DE2858792C2 (en, 2012) | 1991-08-22 |
| DE2849708A1 (de) | 1979-05-23 |
| SE7811630L (sv) | 1979-05-18 |
| GB2095830A (en) | 1982-10-06 |
| CH640061A5 (fr) | 1983-12-15 |
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